Novel Omega-3 And Omega-6 Fatty Acid Compositions And Uses Thereof

  • Published: Jun 28, 2012
  • Earliest Priority: Oct 12 2010
  • Family: 12
  • Cited Works: 6
  • Cited by: 0
  • Cites: 5
  • Additional Info: Cited Works Full text

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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)

(19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2012 (19.04.2012)

(10) International Publication Number

PO

PCT

WO 2012/049222 A 3

(51) International Patent Classification: A61K 31/4415 (2006.01) A61K 33/30 (2006.01) A61K 33/04 (2006.01) A61P 25/28 (2006.01) A61K 36/82 (2006.01) A61K 31/355 (2006.01) A61K 31/202 (2006.01) A23L 1/30 (2006.01) (21) International Application Number:
PCT/EP201 1/067838

(74) Agent: LECCA, Patricia; Cabinet LECCA, 2 1 rue de F e camp, F-75012 Paris (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.

(22) International Filing Date:
12 October 201 1 (12.10.201 1)

(25) Filing Language: (26) Publication Language: (30) Priority Data: 61/392,106 12 October 20 10 ( 12 . 10.20 10) 61/445,736 2 3 February 201 1 (23.02.201 1)

English English

(84) Designated States (unless otherwise indicated, for every kind o regional protection available): ARIPO (BW, GH, f GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, (71) Applicant (for all designated States except US): VIFOR TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, SA [CH/CH]; Route de Moncor 10, PO Box, CH-1752 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Villars-sur-Glane (CH). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors; and SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (75) Inventors/ Applicants (for US only): TERREAUX, Chris¬ GW, ML, MR, NE, SN, TD, TG). tian [CH/CH]; Route du Vignoble 18, CH-1803 Chardonne (CH). HOMBERGER, Eleonora [CH/CH]; Published: Dorneckweg 12, CH-4147 Aesch (CH). KRIWET, — with international search report (Art. 21(3)) Burkhard [DE/DE]; Mozartweg 3 , D-79639 Gren— before the expiration of the time limit for amending the zach-Wyhlen (DE). ECKERT, Anne [DE/CH]; University claims and to be republished in the event of receipt o f Psychiatric Hospital, Neurobiology Laboratory for Brain amendments (Rule 48.2(h)) Ageing and Mental Health, Wilhelm Klein-Strasse 27, CH4056 Basel (CH). (88) Date of publication of the international search report: 2 8 June 2012

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(54) Title: NOVEL OMEGA- 3 AND OMEGA-6 FATTY ACID COMPOSITIONS AND USES THEREOF (57) Abstract: A composition for use in preventing and/or treating and/or reducing organic, including symptomatic, mental dis orders, comprising: a) Docosahexaenoic acid (DHA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; b) Eicosapentaenoic acid (EPA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; c) y-linolenic acid (GLA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; and at least one vitamin selected from vitamin B6, folic acid, vitamin B12, vitamin E , and/or vitamin D , at least one mineral which i s selenium and/or zinc, optionally other vitamins, and optionally a polyphenolic plant extract with antioxidant properties.

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A . CLASSIFICATION

O F SUBJECT

MATTER

INV.
ADD.
According

A61K31/4415 A61P25/28
t o International

A61K33/04 A61K31/355

A61K36/82 A23L1/30
and IPC

A61K31/202

A61K33/30

Patent Classification

(IPC) o r t o both national classification

B . FIELDS SEARCHED Minimum documentation searched (classification system followed b y classification symbols)

A61K

A61P

A23L

Documentation

searched

other than minimum documentation

t o the extent that such documents

are included

in the fields searched

Electronic data base consulted

during the international

search (name o f data base and, where practicable,

search terms used)

EPO-Internal

,

CHEM ABS

Data,

BIOSIS,

EMBASE, WPI Data

C . DOCUMENTS Category*

CONSIDERED

T O B E RELEVANT with indication, where appropriate, o f the relevant passages Relevant t o claim No.

Citation o f document,

Y

E P 1 800 675 A l (NUTRICIA NV [NL] ) 2 7 June 2007 (2007-06-27) c l aims 8,9 ; exampl e s 1-3
W0

1-22

Y

01/84961

AMANDA J0HANNE

A2 (NUTRICIA NV [NL] ; KI LIAAN [NL] ; HAGEMAN ROBERT J0HAN

1-22

JO) 15 November 2001 (2001-11-15) c l aims ; exampl e s 1 , 2

Y

DE

2 0 2007 013532 Ul

(0RTH0M0L

1-22

PHARMAZEUTISCHE VERTR [DE] ) 13 December 2007 (2007-12-13) c l aims 1 , 19 ; exampl e s 1 , 2

Y

E P 0 440 341 A l (EFAM0L HOLDINGS [GB] SCOTIA HOLDINGS PLC [GB] ) 7 August 1991 (1991-08-07) c l aims ; exampl e s

1-22

-/-X|
Further documents are listed i n the continuation : "T" later document published after the international filing date o r priority date and not i n conflict with the application but cited t o understand the principle o r theory underlying the invention "X" document o f particular relevance; the claimed invention cannot b e considered novel o r cannot b e considered t o involve a n inventive step when the document is taken alone "Y" document o f particular relevance; the claimed invention cannot b e considered t o involve a n inventive step when the document is combined with one o r more other such documents, such combination being obvious t o a person skilled i n the art "&" document search member o f the same patent family search report o f Box C .

XI

See patent family annex.

* Special categories

o f cited documents

"A" document defining the general state o f the art which is not considered t o b e o f particular relevance "E" earlier application filing date o r patent but published o n o r after the international

"L" documentwhich may throw doubts o n priority claim(s) orwhich is cited t o establish the publication date o f another citation o r other special reason (as specified) "O" document means referring t o a n oral disclosure, use, exhibition o r other

"P" document published prior t o the international the priority date claimed Date o f the actual completion o f the international

filing date but later than

Date o f mailing o f the international

4 May 2012
Name and mailing address o f the ISA/ European Patent Office, P.B. 5818 Patentlaan N L - 2280 H V Rijswijk Tel. (+31-70) 340-2040, Fax: (+31-70) 340-3016 2

16/05/2012
Authorized officer

Pacreu

Largo,

Marta

C(Continuation). Category*

DOCUMENTS CONSIDERED T O B E RELEVANT Relevant to claim No.

Citation of document, with indication, where appropriate, of the relevant passages

Y

WO

02/052955 Al (HUNZA DI PISTOLESI ELVI RA E C [IT] ; PISTOLESI ELVI RA [IT] ) 1 1 July 2002 (2002-07-11) pages 6 , 15 , 16; exampl e 1 "The effects o f omega-3 fatty aci d s monotherapy i n Al zheimer ' s d i sease and mi l d cogni t i v e impai rment: A prel imi nary randomi zed doubl e-bl i n d p l acebo-control l e d study" , PROGRESS I N NEUR0-PSYCH0PHARMAC0L0GY & BIOLOGICAL PSYCHIATRY, OXFORD, GB, vol . 3 2 , no. 6 , 1 August 2008 (2008-08-01) , pages 1538-1544, XP023181335 , ISSN : 0278-5846, D0I : 10. 1016/J . PNPBP.2008.05 .015 [retri eved o n 2008-05-25] abstract Di scussi o n
FREUND-LEVI YVONNE ET AL: "omega-3 fatty aci d treatment i n 174 pati ents wi t h mi l d t o moderate Al zheimer d i sease: OmegAD study - A randomi zed doubl e-bl i n d tri a l " ,
CHIU C C ET AL:

1-22

Y

1-22

Y

1-22

ARCHIVES O F NEUROLOGY, vol . 6 3 , no. 10, October

2006 (2006-10) pages 1402-1408, El , XP002675303 , ISSN : 0003-9942 abstract Resul t s and Di scussi o n

,

Y

HASHIMOTO M ET AL: " Effects of admi n i strati o n o f f i s h sausage enri ched wi t h docosahexaenoi c aci d o n cogni t i v e functi o n i n e l derly peopl e wi t h very mi l d dementi a " , ALZHEIMER ' S & DEMENTIA: THE JOURNAL O F THE ALZHEIMER ' SASSOCIATION , ELSEVI ER, NEW YORK, NY, US, vol . 6 , no. 4 , 1 July 2010 (2010-07-01) , page S174, XP027439073 , ISSN : 1552-5260, D0I : 10. 1016/J .JALZ.2010.05 .549 [retri eved o n 2010-07-01] abstract

1-22

-/--

C(Continuation).
Category*

DOCUMENTS CONSIDERED TO B E RELEVANT
Relevant to claim No.

Citation of document, with indication, where appropriate, of the relevant passages

KIDD P M : "Al zheimer ' s d i sease, amnesti c mi l d cogni t i v e impai rment, and age-associ ated memory impai rment: Current understandi n g and progress toward i ntegrati v e preventi on" , ALTERNATIVE MEDICINE REVI EW, THORNE RESEARCH INC. , SANDPOINT, US, vol . 13 , no. 2 , 1 June 2008 (2008-06-01) , pages 85-115 , XP009158591 , ISSN : 1089-5159 page 9 5 - page 100
DARVESH A S ET AL: "Oxi dati v e stress and A l zheimer ' s d i sease: Di etary polyphenol s a s potenti a l therapeuti c agents" ,

1-22

1-22

EXPERT REVI E W O F NEUROTHERAPEUTICS, FUTURE DRUGS, LONDON , GB,

vol . 10, no. 5 , 1 January 2010 (2010-01-01) 729-745 , XP009135022 , ISSN : 1473-7175 page 736 - page 737

, pages

K . REZAI -ZADEH : "Green Tea Epi gal l ocatechi n-3-Gal l ate (EGCG) Modul ates Amyl o i d Precursor Protei n Cl eavage and Reduces Cerebral Amyl o i dosi s i n A l zheimer Transgeni c Mi ce" , JOURNAL O F NEUR0SCI ENCE, vol . 2 5 , no. 38, 2 1 September 2005 (2005-09-21) , pages 8807-8814, XP55001561 , ISSN : 0270-6474, D0I : 10. 1523/JNEUROSCI . 1521-05 .2005 abstract

1-22

Patent document cited in search report

Publication date

Patent family member(s)

Publication date

E P 1800675

Al

27-06-2007

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CN CN CN CN CN CN CN

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EP EP EP EP EP EP EP EP EP EP EP EP EP ES PT US US US US US US

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Patent family member(s)

Publication date

PT
US US US US
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E Bl Al Al Al
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01- 09-2009 05-06-2007 30-08-2007 14- 08-2008 02- 12-2010 15- 11-2001

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