Compounds And Methods For Diagnosis And Immunotherapy Of Tuberculosis


Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.

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Document History
  • Publication: May 3, 2011
  • Application: Jun 27, 2006
    US US 47625406 A
  • Priority: Jun 27, 2006
    US US 47625406 A
  • Priority: Feb 26, 2001
    US US 79330601 A
  • Priority: Aug 8, 2000
    US US 22382800 P
  • Priority: Feb 25, 2000
    US US 18503700 P
  • Priority: May 5, 1998
    US US 7301098 A
  • Priority: May 20, 1997
    US US 85938197 A

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