Non-human Transgenic Mammalian Animal Expressing Human Egfr Specifically In Lungs

Abstract

[Problem] To provide transgenic mice in which h-EGFR is expressed specifically in the lungs, and which spontaneously develop lung cancer. [Solution] A non-human transgenic mammalian animal (specifically, a transgenic mouse) in which a human [L858R] epidermal growth factor receptor ([L858R]-h-EGFR) gene, which includes an entire genetic region of 28 exons and 27 introns, is inserted downstream of the expression promoter region thereof. When doing so, it is preferable that the expression promoter region includes a tetracycline response element (TRE), and that the non-human transgenic mammal has a reverse tetracycline-controlled transactivator (rtTA) gene inserted downstream of the expression promoter of the lung-specific expression gene in the mammal.


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Document History
  • Publication: Feb 16, 2017
  • Application: Aug 5, 2016
    WO JP 2016073053 W
  • Priority: Aug 10, 2015
    JP 2015158369 A

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