Prodrug Derivatives Of Acids Using Alcohols With Homotopic Hydroxy Groups And Methods For Their Preparation And Use

  • Published: Nov 8, 2007
  • Earliest Priority: Apr 26 2006
  • Family: 5
  • Cited Works: 0
  • Cited by: 9
  • Cites: 0
  • Additional Info: Full text Published

This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula (I) wherein (II) is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.

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