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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 1 December 2003 (31.12.2003) (51) International Patent Classification: A61K 31/70 (2006.01) AOlN 63/00 (2006.01) (21) International Application Number: PCT/US2003/019147 (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 10/179,589 10/268,833 17 June 2003 (17.06.2003) PCT (10) International Publication Number W O 2004/000213 A3 (81) Designated States (national): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW (84) Designated States (regional): ARIPO patent (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian patent (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European patent (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR), OAPI patent (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). English English 2 5 June 2002 (25.06.2002) 10 October 2002 (10.1 0.2002) US US (71) Applicants: DENTAL MARKETING SPECIALISTS, INC. [US/US]; 7364 East Crimson Sky Trail, Scottsdale, AZ 85262 (US). BAINS, Jerry, W. [US/US]; Irrevocable Trust, 39096 N . 102nd Way, Scottsdale, AZ 85262 (US). BAINS, Salee, C. [US/US]; Irrevocable Trust, 39096 N . 102nd Way, Scottsdale, AZ 85262 (US). (72) Inventor: ELIA, James P.; 7364 East Crimson Sky Trail, Scottsdale, AZ 85262 (US). (74) Agent: WHITE, Gerald K.; Gerald K . White & A s so ciates, RC, 205 W Randolph Street, Suite 835, Chicago, I l 60606 (US). Published: — with international search report — before the expiration of the time limit for amending the claims and to be republished in the event o receipt of f amendments (88) Date of publication of the international search report: 7 February 2008 (15) Information about Correction: Previous Correction: see Notice of 13 January 2005 (54) Title: METHOD FOR GROWING HUMAN ORGANS, TREATING DISEASES, AND INCREASING LONGEVITY (57) Abstract: In one aspect, techniques for controlling and directing organogenesis and for enhancing the performance of organs are included. Enhancement may be direct or indirect and utilizes energy, enhancement compositions, and/or living organisms to enhance the cells and/or cell products produced b y organs and suborgans. I n another aspect, diseases such a s cancer, HIV/ AIDS, diabetes, infectious diseases, a s well a s diseases related to the immune and autoimmune systems, are treated through the formation and/or enhancement of the function of organs and suborgans of human patients. An important organ for such purpose i s the thymus. INTERNATIONAL SEARCH REPORT A. IPC: International application No. PCT/US03/19147 CLASSIFICATION O F SUBJECT MATTER A61K 31/70( 2006.01);A01N 63/00( 2006.01) USPC: According 514/12,44;424/93.1 t o International Patent Classification (IPC) o r t o both national classification and IPC B. FIELDS SEARCHED (classification system followed b y classification symbols) Minimum documentation searched U.S. : 514/12,44;424/93.1 Documentation searched other than minimum documentation t o the extent that such documents are included i n the fields searched Electronic data base consulted during the international search (name o f data base and, where practicable, search terms used) C. DOCUMENTS ' A, P A A CONSIDERED o f document, (BOYD) T O B E RELEVANT with indication, where appropriate, o f the relevant passages Relevant t o claim No. 2 7 June 2002 (27.06.2002) o f thymic epithelium b y keratinocyte growth during factor thymus and 1-23,45-109,1 15124,160 and 161 1-23,45-109,1 15124,160 and 161 1-23,45-109,1 15124,160 and 161 Category Citation U S 20020081276 ERICKSON, E . e t al. Regulation Blood 2002 100: 3269-3278 S U e t al., Hoxa3 and paxl regulate epithelial parathyroid organogenesis. Dev Biol. 2001 Aug 15;236(2):3 16-29. ZHANG e t al., Thymic epithelial Cell Res. 2007 Jan;17(l):50-55. progenitor cell death and proliferation cells and thymus regeneration: a n update. 1-23,45-109,1 15124,160 and 161 D * "A" "E" "L" Further documents Special categories are listed i n the continuation o f cited documents o f Box C . T to b e o f "X" See patent family annex. document particular defining the general state o f the ait which i s not considered relevance o r patent published o n o r after the international later document published after the international filing date o r priority date and not i n conflict with the application but cited t o understand the principle o r theory underlying the invention document o f particular relevance, the claimed invention cannot b e considered novel o r cannot b e considered t o involve a n inventive step when the document i s taken alone document o f particular relevance, the claimed invention cannot b e considered t o mvolve a n inventive step when the document i s combined with one o r more other such documents, such combination being obvious t o a person skilled i n the art document member o f the same patent family earlier application filing date document which may throw doubts o n priority claun(s) o r which i s cited t o establish the publication date o f another citation o r other special reason (as specified) document referring t o a n oral disclosure, use, exhibition o r other means "Y" "O" "P" document published p π o r t o the international priority date claimed filing date but later than the "&" Date o f the actual completion 2 0 March 2007 (20.03.2007) Name and mailing address o f the international search D a t e o f iii a ii l ini g o f t h e i nut e r ni at i o ni a l s e aur c hi i e p o r t e υ i m i ii υ i m li r i u u i αi i r c µu i NOVJM? o f the ISA/US ISA/US Aui D>aanniieell C.. Gam Telephone No. J ■ Mail Stop PCT, Arm Commissioner o f Patents P O Box 1450 Alexandria, Virginia 22313-1450 βtt, PhD . * """" 571 272 1600 Facsimile No. (5711 273-3201 Form PCT/ISA/210 (second sheet) (July 1998)