US 8840537 B2 - Non-invasive Treatment Of Bronchial Constriction - The Lens - Free & Open Patent and Scholarly Search

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US 8840537 B2

Non-invasive Treatment Of Bronchial Constriction

Published: Sep 23, 2014
Earliest Priority: Aug 19 2010
Family: 22
Cited Works: 72
Cited by: 3
Cites: 102
Additional Info: Cited Works Full text Published

Abstract

Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease include non-invasive nerve stimulators. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

Claims

A method of treating bronchial constriction in a patient comprising:
positioning one or more magnetic coils within a container of a conducting fluid such that the one or more magnetic coils are surrounded by the conducting fluid;

positioning a surface of the container against an outer skin surface of a neck of the patient; and

applying a magnetic field to the one or more magnetic coils to induce one or more electrical impulses at or near a vagus nerve of the patient, wherein the one or more electrical impulses are sufficient to stimulate activity of afferent nerve fibers within the vagus nerve such that a magnitude of constriction of bronchial smooth muscle is decreased.
The method set forth in claim 1 wherein the one or more electrical impulses are induced by a time-varying magnetic field, and wherein the magnetic field is transmitted non-invasively.
The method of claim 1 wherein the bronchial constriction is associated with asthma.
The method of claim 1 wherein the bronchial constriction is associated with anaphylaxis.
The method of claim 1 wherein the bronchial constriction is associated with chronic obstructive pulmonary disease.
The method of claim 1 wherein applying the one or more electrical impulses is carried out without substantially stimulating a set of nerve fibers within the vagus nerve that are responsible for increasing the magnitude of constriction of smooth muscle.
The method of claims 6 wherein the set of nerve fibers comprises parasympathetic cholinergic nerve fibers.
The method of claim 6 wherein the set of nerve fibers compriseefferent fibers of the vagus nerve.
The method of claim 1 wherein the one or more electrical impulses have a frequency between 15 Hz to 50 Hz.
The method of claim 1 wherein the one or more electrical impulses have a pulsed on-time of between 50 to 500 microseconds.
The method of claim 1 wherein the conducting fluid is a conducting gel.
The method of claim 1 wherein the conducting fluid contains ferromagnetic particles.
The method of claim 1 wherein the conducting fluid is a magnetorheological fluid.
The method of claim 1 wherein the conducting fluid is a combination of a magnetorheological fluid and a ferrofluid.

Owners (US)

Electrocore Llc (Mar 18 2013)
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Applicants

Simon Bruce J
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Errico Joseph P
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Raffle John T
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Mendez Steven
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Electrocore Llc
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Inventors

Simon Bruce J
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Errico Joseph P
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Raffle John T
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Mendez Steven
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CPC Classifications

A61N2/002
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600/13
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Document History

Publication: Sep 23, 2014
US 8840537 B2
Application: Feb 1, 2011
US 201113018558 A
Priority: Feb 1, 2011
US 201113018558 A
Priority: Aug 19, 2010
US 85956810 A
Priority: Nov 4, 2009
US 61217709 A
Priority: Mar 20, 2009
US 40813109 A
Priority: Nov 1, 2006
US 59134006 A
Priority: Jun 16, 2006
US 81431306 P
Priority: Mar 28, 2006
US 78656406 P
Priority: Feb 10, 2006
US 77236106 P
Priority: Nov 10, 2005
US 73600105 P
Priority: Nov 10, 2005
US 73600205 P

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