{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"187-883-270-982-571","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"187-883-270-982-571","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11620,"type":"PATENT","title":"Icahn School of Medicine at Mount Sinai - Patent Portfoilo","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3154,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8295,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Icalh* medici*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
Search Applicants and Owners separately: Icalh* medici*
Select more for logical variants. Add to collection.
Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
wherein the isolated nucleic acid molecule further comprises a second MRE sequence; and\n
wherein both of the MRE sequences correspond to miR-93 and are inserted into the coding sequence of influenza virus protein NP, wherein the first MRE sequence is at the nucleotide sequence encoding NP amino acids 62-69 and the second MRE sequence is at the nucleotide sequence encoding NP amino acids 258-265."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 34, wherein the first MRE sequence comprises the nucleotide sequence 5′-ACAATTGAACGAATGGTACTTTCT-3′ (SEQ ID NO: 107)."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 34, wherein the second MRE sequence comprises the nucleotide sequence 5′-TTCCTTGCACGGTCAGCACTTATA-3′ (SEQ ID NO: 111)."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second MRE sequence; and\n
wherein both of the MRE sequences correspond to miR-92 and are inserted into the coding sequence of influenza virus protein NS1, wherein the first MRE sequence is at the nucleotide sequence encoding NS1 amino acids 131-137 and the second MRE sequence is at the nucleotide sequence encoding NS1 amino acids 150-156."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 37, wherein the first MRE sequence comprises the nucleotide sequence 5′-AAGGCCAACTTCAGTGTAATA-3′ (SEQ ID NO: 97)."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 37, wherein the second MRE sequence comprises the nucleotide sequence 5′-TTCACCGAGGAAGGTGCAATA-3′ (SEQ ID NO: 101)."],"number":39,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second and a third MRE sequence; and\n
wherein all three of the MRE sequences which correspond to miR-92 and are inserted into the coding sequence of influenza virus protein HA, wherein the first MRE sequence is at the nucleotide sequence encoding HA amino acids 68-74, the second MRE sequence is at the nucleotide sequence encoding HA amino acids 195-201, and the third MRE sequence is at the nucleotide sequence encoding HA amino acids 526-532."],"number":40,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 40, wherein the first MRE sequence comprises the nucleotide sequence 5′-CTACAGTTGGGGAAGTGCAAT-3′ (SEQ ID NO: 83)."],"number":41,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 40, wherein the second MRE sequence comprises the nucleotide sequence 5′-AACGCCTATGTAAGTGTAGTA-3′ (SEQ ID NO: 87)."],"number":42,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 40, wherein the third MRE sequence comprises the nucleotide sequence 5′-TTGGTCAGTTTAGGTGCAATA-3′ (SEQ ID NO: 91)."],"number":43,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second and a third MRE sequence; and\n
wherein all three of the MRE sequences correspond to miR-19 and are inserted into the coding sequence of influenza virus protein HA, wherein the first MRE sequence is at the nucleotide sequence encoding HA amino acids 15-22, the second MRE sequence is at the nucleotide sequence encoding HA amino acids 561-568, and the third MRE sequence is at the nucleotide sequence encoding HA amino acids 327-334."],"number":44,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 44, wherein the first MRE sequence comprises the nucleotide sequence 5′-GCCAGTGCTGACACAATTTGCATA-3′ (SEQ ID NO: 45)."],"number":45,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 44, wherein the second MRE sequence comprises the nucleotide sequence 5′-TCTTTGCAGTGCAGGATTTGCATA-3′ (SEQ ID NO: 49)."],"number":46,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 44, wherein the third MRE sequence comprises the nucleotide sequence 5′-TTGCGUATGGTCACAGGTTTGCGC-3′ (SEQ ID NO: 53)."],"number":47,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second MRE sequence; and\n
wherein both of the MRE sequences which correspond to miR-16 and are inserted into the coding sequence of influenza virus protein HA, wherein the first MRE sequence is at the nucleotide sequence encoding HA amino acids 2-9 and the second MRE sequence is at the nucleotide sequence encoding HA amino acids 439-445."],"number":48,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 48, wherein the first MRE sequence comprises the nucleotide sequence 5′-AAGGCCAACCTATTAGTGCTGCTA-3′ (SEQ ID NO: 21)."],"number":49,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 48, wherein the second MRE sequence comprises the nucleotide sequence 5′-AACGCCGAACTATTAGTGCTGCTA-3′ (SEQ ID NO: 25)."],"number":50,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second and a third MRE sequence; and\n
wherein all three of the MRE sequences which correspond to miR-34 and are inserted into the coding sequence of influenza virus protein PA, wherein the first MRE sequence is at the nucleotide sequence encoding PA amino acids 426-433, the second MRE sequence is at the nucleotide sequence encoding PA amino acids 634-641, and the third MRE sequence is at the nucleotide sequence encoding PA amino acids 709-716."],"number":51,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 51, wherein the first MRE sequence comprises the nucleotide sequence 5′-GATGAGATCGGTGAAGACGTTGCC-3′ (SEQ ID NO: 69)."],"number":52,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 51, wherein the second MRE sequence comprises the nucleotide sequence 5′-GGCAAGGTATGTAGGACACTGTTA-3′ (SEQ ID NO: 73)."],"number":53,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 51, wherein the third MRE sequence comprises the nucleotide sequence 5′-TTCTTCCTGACTCATGCACTGTCA-3′ (SEQ ID NO: 77)."],"number":54,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second MRE sequence; and\n
wherein both of the MRE sequences which correspond to miR-25 and are inserted into the coding sequence of influenza virus protein M1, wherein the first MRE sequence is at the nucleotide sequence encoding M1 amino acids 111-118 and the second MRE sequence is at the nucleotide sequence encoding M1 amino acids 127-134."],"number":55,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 55, wherein the first MRE sequence comprises the nucleotide sequence 5′-GGTGCCAAAGAGATAAGTGCAAGT-3′ (SEQ ID NO: 59)."],"number":56,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 55, wherein the second MRE sequence comprises the nucleotide sequence 5′-ATATACAACAGGATGGGTGCAGTG-3″ (SEQ ID NO: 63)."],"number":57,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and a first MRE sequence inserted within said coding sequence, wherein the MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises a second and a third MRE sequence; and\n
wherein all three of the MRE sequences correspond to miR-17 and are inserted into the coding sequence of influenza virus protein PB1, wherein the first MRE sequence is at the nucleotide sequence encoding PB1 amino acids 374-381, the second MRE sequence is at the nucleotide sequence encoding PB1 amino acids 418-424, and the third MRE sequence is at the nucleotide sequence encoding PB1 amino acids 677-683."],"number":58,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 58, wherein the first MRE sequence comprises the nucleotide sequence 5′-GCCAGCATTGATCTTAAGTACTTT-3′ (SEQ ID NO: 31)."],"number":59,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 58, wherein the second MRE sequence comprises the nucleotide sequence 5′-GTGTTGGGTGTAAGCATTTTG-3′ (SEQ ID NO: 35)."],"number":60,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 58, wherein the third MRE sequence comprises the nucleotide sequence 5′-ACCAGCCAAAGAGGCGTTTTG-3′ (SEQ ID NO: 39)."],"number":61,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3′ untranslated region (3′ UTR) comprising a first MRE sequence inserted between the stop codon of the transcript and the polyadenylation site, wherein the first MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises second, third, and fourth MRE sequences; and\n
wherein all four of the MRE sequences correspond to miR-142 and are inserted into an artificial 3′ UTR of influenza virus protein NP, wherein each of the MRE sequences are found between the viral stop codon and the polyA tail sequence."],"number":62,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 62, wherein each of the four MRE sequences comprises the nucleotide sequence 5′-TCCATAAAGTAGGAAACACTACA-3′ (SEQ ID NO: 159)."],"number":63,"annotation":false,"claim":true,"title":false},{"lines":["An isolated nucleic acid molecule comprising an influenza virus coding sequence and an artificial 3′ untranslated region (3′ UTR) comprising a first MRE sequence inserted between the stop codon of the transcript and the polyadenylation site, wherein the first MRE sequence is selected such that the MFE of MRE interaction with its corresponding microRNA is less than −25 kcal/mol;\n
wherein the isolated nucleic acid molecule further comprises second, third, and fourth MRE sequences; and\n
wherein all four of the MRE sequences which correspond to miR-142 and are inserted into an artificial 3′ UTR of influenza virus protein NS1, wherein each of the MRE sequences is found between the viral stop codon and the polyA tail sequence but before a duplicated NS2/NEP ORF."],"number":64,"annotation":false,"claim":true,"title":false},{"lines":["The nucleic acid molecule of claim 64, wherein each of the four MRE sequences comprises the nucleotide sequence 5′-TCCATAAAGTAGGAAACACTACA-3′ (SEQ ID NO: 159)."],"number":65,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}