Abstract

The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.


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Document History
  • Publication: Feb 29, 2000
  • Application: Dec 29, 1995
    US US 58071395 A
  • Priority: Dec 29, 1995
    US US 58071395 A
  • Priority: Jun 27, 1995
    US US 37322495 A
  • Priority: May 18, 1994
    US US 9405746 W
  • Priority: May 18, 1993
    US US 6285093 A

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