{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"186-251-120-128-466","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"186-251-120-128-466"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11703,"type":"PATENT","title":"Tel Aviv University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6197,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8357,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Add to collection. Total patents: 4719
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(i) a sole electrical lead coated with an insulator forming a passivation layer, or multiple electrical leads each being either coated with an insulator forming a passivation layer or imprinted on a carrier and coated with an insulator forming a passivation layer;\n
(ii) an adhesive layer consisting of an upper adhesive layer and optionally a lower adhesive layer; and\n
(iii) interleukin-1 receptor antagonist (IL-1ra), wherein said lower adhesive layer, when present, is covalently linked to the surface of said passivation layer; said upper adhesive layer is covalently linked to said lower adhesive layer, when present, or to the surface of said passivation layer; and the IL-1ra is covalently linked to said upper adhesive layer and actively inhibits scarring on or around the surface of said electrode when implanted into the CNS."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, comprising the multiple electrode leads imprinted on the carrier, wherein said carrier is coated with said insulator."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, wherein:\n
(i) said insulator is a silicon-based insulator, metal oxide, or polymer;\n
(ii) said lower adhesive layer, when present, comprises amino functional alkoxysilane, mercapto functional alkoxysilane, aminoalkanethiol, carboxyalkanethiol, carboxyalkyldisulfide, succinimidyl ester, or ferrocenylalkanethiol;\n
(iii) said upper adhesive layer comprises succinaldehyde, glutaraldehyde, adipaldehyde, heptanedial, octanedial, cyanoacrylate type adhesives, fibrin glue, gelatin-resorcin aldehyde type adhesives, or polyelectrolyte multilayers of hyaluronic acid and chitosan, coupled with surface-immobilized cell-adhesive arginine-glycine-aspartic acid peptide;\n
(iv) said carrier is a silicon-based insulator, metal oxide, or polymer; or\n
(v) each one of said electrical leads is made of a material selected from the group consisting of a metal, preferably a noble metal, a metal alloy, a metalloid, and a conducting ceramic material."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 3, wherein:\n
(i) said silicon-based insulator is silicon nitride, silicon dioxide, or silicon oxynitride; said metal oxide is aluminum oxide, tantalum oxide, or hafnium oxide; and said polymer is a polyimide, or a plastic;\n
(ii) said metal is gold, platinum, iridium, osmium, silver, palladium, rhodium or ruthenium, mercury, polonium, copper, bismuth, technetium, rhenium, or antimony;\n
(iii) said metal alloy is selected from the group consisting of nitrides of refractory metals, metal borides, metal carbides, metal silicides, beryllides, metal selenides, metal phosphides, metal chromides, mixtures of the aforesaid, ternary alloys of the aforesaid with other elements, non-toxic nickel alloys, and quaternary alloys;\n
(iv) said metalloid is boron, silicon, germanium, arsenic, antimony, tellurium, or polonium; or\n
(v) said conducting ceramic material is a metal nitride, a metal carbide, a metal boride, a metal silicide, a metal beryllide, a metal selenide, a metal phosphide, a metal chromate, a metal-silicon nitride, a metal-silicon carbide, a metal-silicon boride, or a mixture thereof."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 3, wherein: (i) said amino functional alkoxysilane has the formula H2N—(C1-C8)alkylene-Si(OR1)3 or H2N—(C1-C8)alkylene-SiR2(OR1)2; (ii) said mercapto functional alkoxysilane has the formula HS—(C1-C8)alkylene-Si(OR1)3 or HS—(C1-C8)alkylene-SiR2(OR1)2; (iii) said aminoalkanethiol has the formula H2N—(C1-C8)alkylene-SH; (iv) said carboxyalkanethiol has the formula HOOC—(C1-C8)alkylene-SH; (v) said hydroxyalkanethiol has the formula HO—(C1-C8)alkylene-SH; (vi) said carboxyalkyldisulfide has the formula HOOC—(C1-C8)alkylene-S—S—(C1-C8)alkylene-COOH; or (vii) said ferrocenylalkanethiols has the formula ferrocenyl-(C1-C8)alkylene-SH, wherein R1 each independently is (C1-C4)alkyl; and R2 each independently is (C1-C4)alkyl or H."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 3, wherein said insulator is silicon nitride; said lower adhesive layer comprises 3-aminopropyltrimethoxysilane; said upper adhesive layer comprises glutaraldehyde; or said electrical lead each is made of titanium-nitride."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 3, wherein said metal is a noble metal."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, comprising a multi-channel with the multiple electrical leads, optionally configured as an implantable multi electrode array (MEA) and are imprinted on a carrier and coated with said insulator forming a passivation layer."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The multi-channel electrode according to claim 8, comprising 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 electrical leads, optionally configured as an implantable MEA, having a long shaft."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The multi-channel electrode according to claim 5, configured as an implantable MEA and comprising:\n
(i) 10 electrical leads arranged on a penetrating tip, wherein said electrical leads are made of a conductive ceramic material, imprinted on silicon nitride as a carrier and coated with silicon nitride as an insulator forming a passivation layer; or\n
(ii) 14 electrical leads arranged on a penetrating tip, wherein said electrical leads are made of a noble metal, imprinted on and coated with a polyimide."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The multi-channel electrode according to claim 10, wherein said conductive ceramic material is titanium-nitride."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, wherein said electrode is a single-shank electrode, or a member of a vector electrode or a three-dimensional electrode."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, wherein each one of said electrical leads is made of titanium-nitride; said insulator is silicon nitride; said lower adhesive layer comprises 3-aminopropyltrimethoxysilane; said upper adhesive layer comprises glutaraldehyde; and said carrier, when present, is made of silicon nitride."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The electrode according to claim 1, comprising a single channel with the sole electrical lead."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for central nervous system (CNS) recording and/or CNS stimulation in an individual suffering from a CNS dysfunction, disease or disorder, or CNS injury, said method comprising the steps of:\n
implanting into the CNS of said individual at least one electrode each independently according to claim 1; and\n
recording and/or stimulating said CNS with said at least one electrode."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the at least one electrode is implanted in deep brain structures, further comprising receiving signals from the at least one electrode for deep brain recording, transmitting signals to the at least one electrode for deep brain stimulation, or both receiving signals from and transmitting signals to the at least one electrode for both deep brain recording and deep brain stimulation."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein the signals are received and/or transmitted in a manner configured for (i) treatment of a brain dysfunction, a brain disease or disorder, or a brain injury; (ii) electrotherapy; or (iii) establishing a brain computer interface, or a brain machine interface."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein (a) the individual is in need of treatment of said brain dysfunction, wherein said brain dysfunction is associated with an autoimmune disease, head trauma or neuronal trauma, or said brain dysfunction causes chronic pain or phantom limb pain; or (b) the individual is in need of treatment of said brain disease or disorder, wherein said brain disease or disorder is Parkinson's disease, epilepsy, dystonia, essential tremor, Tourette syndrome, a mental disorder, or an anxiety disorder; or said brain disease or disorder is associated with brain degradation or age-related brain degeneration."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein in said at least one electrode said insulator is silicon nitride; said lower adhesive layer comprises 3-aminopropyltrimethoxysilane; said upper adhesive layer comprises glutaraldehyde; or said electrical lead each is made of titanium-nitride."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein in said at least one electrode each one of said electrical leads is made of titanium-nitride; said insulator is silicon nitride; said lower adhesive layer comprises 3-aminopropyltrimethoxysilane; said upper adhesive layer comprises glutaraldehyde; and said carrier, when present, is made of silicon nitride."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein said at least one electrode is a single-channel electrode comprising a sole electrical lead."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein said at least one electrode is a multi-channel electrode comprising multiple electrical leads, optionally configured as an implantable multi electrode array (MEA) wherein said electrical leads are imprinted on a carrier and coated with said insulator forming a passivation layer."],"number":22,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}