Pharmaceutical Compositions

Abstract

Novel methods for treating or reducing the likelihood of acquiring symptoms or diseases due to the menopause, in postmenopausal women, particularly osteoporosis, vaginal atrophy and dryness, hypogonadism, diminished libido, skin atrophy, connective tissue disease, urinary incontinence, breast, endometrial, ovarian and uterine cancers, hot flashes, loss of muscle mass, insulin resistance, fatigue, loss of energy, aging, physical symptoms of menopause, in susceptible warm-blooded animals including humans involving administration of a sex steroid precursor are disclosed. Said method comprising novel ways of administering and dosing dehydroepiandrosterone (DHEA) in order to take advantage of positive androgenic effects in the vaginal layers lamina propia and/or the layer muscularis, without undesirably causing systemic estrogenic effects in order to avoid the risk of breast and uterine cancer. Pharmaceutical compositions for delivery of active ingredient(s) useful to the invention are also disclosed.


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Document History
  • Publication: Feb 17, 2015
  • Application: Jul 9, 2012
    US US 201213544407 A
  • Priority: Jul 9, 2012
    US US 201213544407 A
  • Priority: Aug 7, 2008
    US US 22184708 A
  • Priority: Aug 13, 2007
    US US 96467307 P
  • Priority: Aug 10, 2007
    US US 96427007 P

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