Amphiphilic Materials And Liposome Formulations Thereof

Abstract

Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.


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Document History
  • Publication: May 6, 2008
  • Application: Feb 27, 2004
    US US 78892004 A
  • Priority: Feb 27, 2004
    US US 78892004 A
  • Priority: Jun 11, 2001
    US US 87936801 A
  • Priority: Aug 13, 1997
    US US 91297897 A
  • Priority: Aug 14, 1996
    US US 2438296 P

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