Klotho Variant Polypeptides And Uses Thereof In Therapy

Abstract

Disclosed are Klotho variant proteins in which residue Glu414 and/or residue Asp238 is substituted with an amino acid different than L-Glu or L-Asp, respectively, as well as polynucleotides encoding the variant proteins, and the use thereof in therapy, especially for the treatment of cancers, especially breast cancer and pancreatic cancer.


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Document History
  • Publication: Oct 24, 2013
  • Application: Apr 16, 2013
    WO IB 2013053001 W
  • Priority: Jan 15, 2013
    US US 201361752694 P
  • Priority: Apr 16, 2012
    US US 201261624443 P

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