G-protein Coupled Receptor 83 As A Molecular Switch For The Induction Of Regulatory (immunosuppressive) T-cells


The present invention makes use of the role of the G-protein coupled receptor 83 (GPCR83) in the induction of regulatory T cells (Tregs) during the course of ongoing immune response. The present invention relates to means and methods for identifying compounds that are interacting with the GPCR83 polypeptide, and to compounds capable of functioning as immunomodulators in mammals, in particular humans. In addition, the present invention relates to methods of treatment of a subject, in particular a human, suffering from an undesired immunoreaction.

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Document History
  • Publication: Jul 31, 2008
  • Application: Dec 19, 2007
    WO EP 2007011206 W
  • Priority: Jan 22, 2007
    US US 62551607 A

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