US 10350270 B2 - Interleukin-15 Compositions And Uses Thereof - The Lens

Interleukin-15 Compositions And Uses Thereof

Published: Jul 16, 2019
Earliest Priority: Oct 14 2014
Family: 13
Cited Works: 238
Cited by: 0
Cites: 102
Sequences: 41
Additional Info: Cited Works Full text Published Sequence

Data obtained from: USPTO Fulltext

41 sequences found in this patent (in total)

Download sequences in fasta format: 36 peptides 5 nucleotides

Displaying 1 - 10 of 41 sequences

SEQ ID NO

Length

Sequence Type

Locations

Declared organism

Determined organism

Occurrence

Tools

SEQ ID NO

Length

162

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

synthetic construct
synthetic construct
Public DB hit
GI:60811495
AAX36174

Hit length
163 aa

E Value
1.37E-88

BLAST Score
329.3 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
AAX36174

99.39% cov

Alignment Length
162 aa

CIGAR string
162M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:10835153
NP_000576

Hit length
162 aa

E Value
1.49E-88

BLAST Score
329.3 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_000576

100% cov

Alignment Length
162 aa

CIGAR string
162M mismatches: 0 - insertions: 0 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332217297
XP_003257797

Hit length
162 aa

E Value
3.86E-87

BLAST Score
324.7 bits

Similarity

98.77%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
XP_003257797

100% cov

Alignment Length
162 aa

CIGAR string
99MN4MN57M mismatches: 2 - insertions: 0 - deletions: 0
Pongo abelii
Pongo abelii
Public DB hit
GI:297674394
XP_002815214

Hit length
162 aa

E Value
6.69E-87

BLAST Score
323.9 bits

Similarity

98.77%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
XP_002815214

100% cov

Alignment Length
162 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:113461953
NP_001038196

Hit length
162 aa

E Value
4.31E-78

BLAST Score
294.7 bits

Similarity

97.53%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_001038196

100% cov

Alignment Length
162 aa
Chlorocebus aethiops
Chlorocebus aethiops
Public DB hit
GI:729829
P40221

Hit length
162 aa

E Value
1.39E-77

BLAST Score
293.1 bits

Similarity

96.91%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
P40221

100% cov

Alignment Length
162 aa
Macaca thibetana
Macaca thibetana
Public DB hit
GI:75077435
Q4U0U2

Hit length
162 aa

E Value
1.46E-77

BLAST Score
292.7 bits

Similarity

96.91%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
Q4U0U2

100% cov

Alignment Length
162 aa
Chlorocebus sabaeus
Chlorocebus sabaeus
Public DB hit
GI:208436708
ACI28911
1 of 2 hits reported for Chlorocebus sabaeus.

Hit length
162 aa

E Value
5.14E-77

BLAST Score
291.2 bits

Similarity

96.3%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
ACI28911

100% cov

Alignment Length
162 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296195503
XP_002745375

Hit length
162 aa

E Value
1.97E-70

BLAST Score
269.2 bits

Similarity

94.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
XP_002745375

100% cov

Alignment Length
162 aa
Marmota monax
Marmota monax
Public DB hit
GI:81871964
Q5WQV8
1 of 2 hits reported for Marmota monax.

Hit length
162 aa

E Value
2.25E-69

BLAST Score
265.8 bits

Similarity

89.38%

Coverage

98.77%

Alignment (schematic)

SEQ ID NO 1

98.77% cov
Q5WQV8

98.77% cov

Alignment Length
160 aa
Marmota himalayana
Marmota himalayana
Public DB hit
GI:218526447
B3F0J0

Hit length
162 aa

E Value
7.19E-69

BLAST Score
263.8 bits

Similarity

88.75%

Coverage

98.77%

Alignment (schematic)

SEQ ID NO 1

98.77% cov
B3F0J0

98.77% cov

Alignment Length
160 aa
Equus caballus
Equus caballus
Public DB hit
GI:255652849
NP_001157458
1 of 2 hits reported for Equus caballus.

Hit length
162 aa

E Value
5.37E-68

BLAST Score
261.2 bits

Similarity

93.12%

Coverage

98.77%

Alignment (schematic)

SEQ ID NO 1

98.77% cov
NP_001157458

98.77% cov

Alignment Length
160 aa
Ovis aries
Ovis aries
Public DB hit
GI:57619196
NP_001009734

Hit length
162 aa

E Value
4.47E-67

BLAST Score
258.1 bits

Similarity

88.89%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_001009734

100% cov

Alignment Length
162 aa
Canis lupus familiaris
Canis lupus familiaris
Public DB hit
GI:308235935
NP_001184117

Hit length
162 aa

E Value
1.27E-66

BLAST Score
256.5 bits

Similarity

91.98%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_001184117

100% cov

Alignment Length
162 aa

Occurrence

812 times in PatSeqDB

in 130 extended families
(32 referenced in claims)
in 146 simple families
(36 referenced in claims)
in 646 documents

Tools

SEQ ID NO

Length

135

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

synthetic construct
synthetic construct
Public DB hit
GI:60832796
AAX37025
1 of 3 hits reported for synthetic construct.

Hit length
136 aa

E Value
1.28E-71

BLAST Score
273.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
AAX37025

99.26% cov

Alignment Length
135 aa

CIGAR string
135M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:26787986
NP_751915
1 of 5 hits reported for Homo sapiens.

Hit length
135 aa

E Value
1.34E-71

BLAST Score
273.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
NP_751915

100% cov

Alignment Length
135 aa

CIGAR string
135M mismatches: 0 - insertions: 0 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332217301
XP_003257799
1 of 2 hits reported for Nomascus leucogenys.

Hit length
135 aa

E Value
3.44E-70

BLAST Score
268.5 bits

Similarity

98.52%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_003257799

100% cov

Alignment Length
135 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297674392
XP_002815213
1 of 2 hits reported for Pongo abelii.

Hit length
135 aa

E Value
1.23E-62

BLAST Score
243.4 bits

Similarity

98.52%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002815213

100% cov

Alignment Length
135 aa
Chlorocebus aethiops
Chlorocebus aethiops
Public DB hit
GI:729829
P40221

Hit length
162 aa

E Value
1.67E-55

BLAST Score
219.5 bits

Similarity

96.8%

Coverage

92.59%

Alignment (schematic)

SEQ ID NO 2

92.59% cov
P40221

77.16% cov

Alignment Length
125 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:113461953
NP_001038196

Hit length
162 aa

E Value
2.06E-55

BLAST Score
219.2 bits

Similarity

96.8%

Coverage

92.59%

Alignment (schematic)

SEQ ID NO 2

92.59% cov
NP_001038196

77.16% cov

Alignment Length
125 aa
Macaca thibetana
Macaca thibetana
Public DB hit
GI:75077435
Q4U0U2

Hit length
162 aa

E Value
6.3E-55

BLAST Score
217.6 bits

Similarity

95.24%

Coverage

93.33%

Alignment (schematic)

SEQ ID NO 2

93.33% cov
Q4U0U2

77.78% cov

Alignment Length
126 aa
Chlorocebus sabaeus
Chlorocebus sabaeus
Public DB hit
GI:208436708
ACI28911

Hit length
162 aa

E Value
6.8E-55

BLAST Score
217.6 bits

Similarity

96%

Coverage

92.59%

Alignment (schematic)

SEQ ID NO 2

92.59% cov
ACI28911

77.16% cov

Alignment Length
125 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296195501
XP_002745374

Hit length
135 aa

E Value
1.51E-54

BLAST Score
216.5 bits

Similarity

94.07%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002745374

100% cov

Alignment Length
135 aa

Occurrence

140 times in PatSeqDB

in 23 extended families
(3 referenced in claims)
in 30 simple families
(5 referenced in claims)
in 91 documents

Tools

SEQ ID NO

Length

114

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

synthetic construct
synthetic construct
Public DB hit
GI:145286528
ABP52093
1 of 3 hits reported for synthetic construct.

Hit length
445 aa

E Value
7.3E-60

BLAST Score
234.2 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
ABP52093

25.62% cov

Alignment Length
114 aa

CIGAR string
114M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:2143256
CAA71044
1 of 6 hits reported for Homo sapiens.

Hit length
136 aa

E Value
5.36E-59

BLAST Score
231.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
CAA71044

83.82% cov

Alignment Length
114 aa

CIGAR string
114M mismatches: 0 - insertions: 0 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332217297
XP_003257797
1 of 2 hits reported for Nomascus leucogenys.

Hit length
162 aa

E Value
4.28E-57

BLAST Score
224.9 bits

Similarity

98.25%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
XP_003257797

70.37% cov

Alignment Length
114 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297674394
XP_002815214
1 of 2 hits reported for Pongo abelii.

Hit length
162 aa

E Value
2.67E-49

BLAST Score
199.1 bits

Similarity

98.25%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
XP_002815214

70.37% cov

Alignment Length
114 aa
Chlorocebus aethiops
Chlorocebus aethiops
Public DB hit
GI:729829
P40221

Hit length
162 aa

E Value
4.75E-48

BLAST Score
194.9 bits

Similarity

96.49%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
P40221

70.37% cov

Alignment Length
114 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:113461953
NP_001038196

Hit length
162 aa

E Value
4.83E-48

BLAST Score
194.9 bits

Similarity

96.49%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
NP_001038196

70.37% cov

Alignment Length
114 aa
Macaca thibetana
Macaca thibetana
Public DB hit
GI:75077435
Q4U0U2

Hit length
162 aa

E Value
1.59E-47

BLAST Score
193 bits

Similarity

95.61%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
Q4U0U2

70.37% cov

Alignment Length
114 aa
Chlorocebus sabaeus
Chlorocebus sabaeus
Public DB hit
GI:208436708
ACI28911
1 of 2 hits reported for Chlorocebus sabaeus.

Hit length
162 aa

E Value
1.66E-47

BLAST Score
193 bits

Similarity

95.61%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
ACI28911

70.37% cov

Alignment Length
114 aa

Occurrence

645 times in PatSeqDB

in 78 extended families
(26 referenced in claims)
in 90 simple families
(27 referenced in claims)
in 295 documents

Tools

SEQ ID NO

Length

489

Sequence Type

nucleotide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

124 times in PatSeqDB

in 27 extended families
(7 referenced in claims)
in 32 simple families
(9 referenced in claims)
in 123 documents

Tools

SEQ ID NO

Length

408

Sequence Type

nucleotide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

19 times in PatSeqDB

in 4 families
in 18 documents

Tools

SEQ ID NO

Length

345

Sequence Type

nucleotide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

54 times in PatSeqDB

in 9 extended families
in 12 simple families
in 54 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Artificial

Determined organism

Occurrence

854 times in PatSeqDB

in 199 extended families
(26 referenced in claims)
in 214 simple families
(30 referenced in claims)
in 807 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Artificial

Determined organism

Occurrence

1858 times in PatSeqDB

in 433 extended families
(96 referenced in claims)
in 504 simple families
(101 referenced in claims)
in 1732 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Artificial

Determined organism

Occurrence

497 times in PatSeqDB

in 105 extended families
(1 referenced in claims)
in 107 simple families
(1 referenced in claims)
in 481 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Artificial

Determined organism

Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332259417
XP_003278786
1 of 3 hits reported for Nomascus leucogenys.

Hit length
269 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_003278786

5.95% cov

Alignment Length
16 aa

CIGAR string
16M mismatches: 0 - insertions: 0 - deletions: 0
Apis mellifera
Apis mellifera
Public DB hit
GI:328778440
XP_623903
1 of 2 hits reported for Apis mellifera.

Hit length
380 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_623903

4.21% cov

Alignment Length
16 aa
Acyrthosiphon pisum
Acyrthosiphon pisum
Public DB hit
GI:328706300
XP_003243055

Hit length
393 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_003243055

4.07% cov

Alignment Length
16 aa
Anolis carolinensis
Anolis carolinensis
Public DB hit
GI:327280468
XP_003224974
1 of 6 hits reported for Anolis carolinensis.

Hit length
254 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_003224974

6.3% cov

Alignment Length
16 aa
Sus scrofa
Sus scrofa
Public DB hit
GI:311275740
XP_003134888
1 of 4 hits reported for Sus scrofa.

Hit length
234 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_003134888

6.84% cov

Alignment Length
16 aa
Ailuropoda melanoleuca
Ailuropoda melanoleuca
Public DB hit
GI:301762932
XP_002916868

Hit length
268 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_002916868

5.97% cov

Alignment Length
16 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297715929
XP_002834296
1 of 3 hits reported for Pongo abelii.

Hit length
251 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_002834296

6.37% cov

Alignment Length
16 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:297288644
XP_001092687
1 of 3 hits reported for Macaca mulatta.

Hit length
468 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_001092687

3.42% cov

Alignment Length
16 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296204454
XP_002749410
1 of 2 hits reported for Callithrix jacchus.

Hit length
256 aa

E Value
1.66E-2

BLAST Score
42.7 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 10

100% cov
XP_002749410

6.25% cov

Alignment Length
16 aa

Occurrence

5205 times in PatSeqDB

in 1053 extended families
(220 referenced in claims)
in 1193 simple families
(232 referenced in claims)
in 4165 documents

Tools

41 sequences found in this patent (in total)

Filter sequences

Displaying 1 - 10 of 41 sequences

synthetic construct

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Homo sapiens

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Nomascus leucogenys

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Pongo abelii

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Macaca mulatta

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Chlorocebus aethiops

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Macaca thibetana

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Chlorocebus sabaeus

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Callithrix jacchus

Public DB hit