Methods For Purifying Cells Derived From Pluripotent Stem Cells

Abstract

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.


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Document History
  • Publication: Jun 25, 2019
  • Application: May 14, 2018
    US US 201815978918 A
  • Priority: May 14, 2018
    US US 201815978918 A
  • Priority: Feb 28, 2011
    US US 201113036476 A
  • Priority: Mar 1, 2010
    US US 30919310 P

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