Conformational And Topological Protein Regulation


Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

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Document History
  • Publication: May 9, 2006
  • Application: Aug 3, 2004
    US US 91144604 A
  • Priority: Aug 3, 2004
    US US 91144604 A
  • Priority: Dec 15, 2000
    US US 73917900 A
  • Priority: Dec 16, 1999
    US US 17235099 P
  • Priority: Dec 15, 1999
    US US 17101299 P

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