{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"180-315-120-486-425","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"180-315-120-486-425","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12063,"type":"PATENT","title":"Wayne State University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2773,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8588,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Wayne State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2610
Search Applicants and Owners separately:Wayne State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2610
A and A′ are individually selected from the group consisting of optionally substituted C4-C14 aryl and heteroaryl wherein heteroatoms of heteroaryl A and/or A′ are selected from the group consisting of O, N, and S;\n
Z is a chemical bond or —Y—(CH2)o—;\n
Y is NH or O;\n
o is 0, 1, 2, 3, or 4;\n
R is H, C1-8 alkyl, C2-8 alkenyl, or C2-8 alkynyl;\n
W is —OH or —NHR;\n
B is optionally substituted C4-C14 aryl or optionally substituted C4-C14 heteroaryl; and\n
n and m are each independently 0, 1, 2, 3, or 4."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein:\n
any carbon of —(CH2)n may be substituted by —OR4 or —COOR5;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R5 is C1-18 alkyl or C2-18 alkylene."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein A and A′ are both unsubstituted phenyl."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, having formula IIa:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, having a formula selected from the group consisting of:\n\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
R1, R6, and R7 are each independently C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, having a formula selected from the group consisting of:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
m is 0-4;\n
B is selected from the group consisting of:\n\np is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A compound having a formula selected from the group consisting of:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
m and n are 0-4;\n
X is H, OH, NH2, or NHR;\n
Z1 and Y1 are C- or N-atom;\n
Z is selected from the group consisting of a chemical bond and —Y—(CH2)o—;\n
Y is NH or O;\n
o is 0, 1, 2, 3, or 4;\n
A and A′ are individually selected from the group consisting of optionally substituted C4-C14 aryl and heteroaryl wherein heteroatoms of heteroaryl A and/or A′ are selected from the group consisting of O, N, and S, wherein at least one of A and A′ are selected from the group consisting of:\n\n
p is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A compound having formula VII:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
m is 0-4;\n
X is —H, —OH, —NH2, or —NHR;\n
A is selected from the group consisting of:\n\n
p is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings; and\n
B is selected from the group consisting of"],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, having a formula selected from the group consisting of:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
m is 0-4;\n
X is H, OH, NH2, or NHR;\n
at least one of A and A′ are selected from the group consisting of:\n\n
p is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings;\n
B is selected from the group consisting of:"],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, having a formula selected from the group consisting of:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
m is 0-4,\n
X is H, OH, NH2, or NHR;\n
Z is a chemical bond or —Y—(CH2)o—;\n
Y is NH or O;\n
o is 0, 1, 2, 3, or 4;\n
at least one of A and A′ are selected from the group consisting of:\n\n
p is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings; and\n
B is selected from the group consisting of:"],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein at least one of A and A′ are selected from the group consisting of:\n
p is 0-6;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R2 has the meaning of R1 and also a 5 or 6 membered heterocycle containing 1 or more heteroatoms selected from the group consisting of N, O, and S;\n
X2 is N, O, or S;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 11 wherein B is selected from the group consisting of:"],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A compound selected from the group consisting of:\n
Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-hydroxy-benzyl)-amine;\n
Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(1H-iodo-5-ylmethyl)-amine;\n
Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-amino-benzyl)-amine;\n
Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-dichloro-benzyl)-amine;\n
(2S,4R,5R)-2-benzhydryl-5-(4-methoxy-benzylamino)-tetrahydropyran-4-ol-);\n
(2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(2,4-dimethoxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(3,5-dimethoxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(4-hydroxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-amino]-tetrahydropyran-4-ol (−);\n
(2R,4S, 5S)-2-benzhydryl-5-(4-hydroxy-benzylamino)-tetrahydro-pyran-4-ol (+);\n
(2R,4S, 5S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-amino]-tetrahydropyran-4-ol (+);\n
cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-hydroxy-benzyl)-amine (−); and\n
cis-(3R,6R)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-hydroxy-benzyl)-amine (+)."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A compound selected from the group consisting of:\n
(2S,4R,5R)-2-benzhydryl-5-(4-methoxy-benzylamino)-tetrahydropyran-4-ol(−);\n
(2S,4R,5R)-2-benzhydryl-5-(4-fluoro-benzylamino)-tetrahydro-pyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(2,4-dimethoxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(3,5-dimethoxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-(4-hydroxy-benzylamino)-tetrahydropyran-4-ol (−);\n
(2S,4R,5R)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-amino]-tetrahydropyran-4-ol (−);\n
(2R,4S, 5S)-2-benzhydryl-5-(4-hydroxy-benzylamino)-tetrahydro-pyran-4-ol (+);\n
(2R,4S, 5 S)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-amino]-tetrahydropyran-4-ol (+);\n
cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-hydroxy-benzyl)-amine (−); and\n
cis-(3R,6R)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-hydroxy-benzyl)-amine (+)."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A compound having a formula selected from the group consisting of:\nor a pharmaceutically acceptable salt, ester, carbamate, imide, or amide thereof, wherein:\n
A is selected from the group consisting of optionally substituted C4-C14 aryl and heteroaryl wherein heteroatoms of heteroaryl A and/or A′ are selected from the group consisting of O, N, and S,\n
n and m are each independently 0, 1, 2, 3, or 4;\n
B is optionally substituted C4-C14 aryl or optionally substituted C4-C14 heteroaryl;\n
R1 is C1-4 alkyl, C2-6 alkenyl, C2-6 optionally halogenated alkynyl, C2-6 hydroxyalkynyl, halo, —CN, —COOR4, —OH, —NO2, —NH2, —NHR4, —SO2NH2, —NHSO2R8, —OCF3, or —OR8;\n
R4 is H, C1-18 alkyl, C5-10 cycloalkyl, or C2-18 alkylene; and\n
R8 is C1-8 alkyl, C5-6 cycloalkyl, C2-8 alkenyl, or a 5 or 6-member aromatic ring including heterocyclic rings."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein A and A′ are an optionally substituted phenyl, napthyl, anthryl, furanyl, thienyl, or pridinyl group."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 16 wherein B is an optionally substituted phenyl, napthyl, anthryl, furanyl, thienyl, or pridinyl group."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein B is an optionally substituted phenyl, napthyl, anthryl, furanyl, thienyl, or pridinyl group."],"number":18,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}