{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"179-451-541-369-666","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"179-451-541-369-666"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8877,"type":"PATENT","title":"New York Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15466,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8211,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
(a) comprising one or more OspC polypeptides from each of Borrelia burgdorferi families A, B, I, and K; or
(b) further comprising at least one OspC polypeptide from the group consisting of: Borrelia afzelii family A and Borrelia afzelii family B, wherein Borrelia afzelii family A is characterized by the ospC gene sequence of Borrelia afzelii strain Pgau and ospC genes having at least 98% identity with said gene and Borrelia afzelii family B is characterized by the ospC gene sequence of Borrelia afzelii strain DK5 and ospC genes having at least 98% identity with said gene; or
(c) wherein said OspC polypeptide comprises the OspC protein variable region encoded by nucleotides 150-519 of an ospC gene; or
(d) wherein said OspC polypeptide is encoded by a nucleic acid comprising nucleotide 26 to about nucleotide 621 of an ospC gene; or
(e) wherein said OspC polypeptide is encoded by a nucleic acid comprising nucleotide 53 to nucleotide 570 of an ospC gene; or
(f) wherein at least two of said OspC polypeptides are fused together in a single protein, encoded by a single nucleic acid, wherein polypeptides in said fusion protein are not found in the same configuration in a naturally occurring OspC protein."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The composition of Claim 2, wherein
(a) Borrelia burgdorferi OspC family A comprises strains B31, CA4, HII, IPI, IP2, IP3, L5, PIF, Pka, Txgw and strains containing ospC allele OC1; or
(b) Borrelia burgdorferi OspC family B comprises strains 35B808, 61BV3, BUR, DK7, PB3, ZS7 and strains containing ospC genes OC2 and OC3; or
(c) Borrelia burgdorferi OspC family I comprises strain HB 19, strains containing ospC gene OC10, and GenBank accession number L42893; or
(d) Borrelia burgdorferi OspC family K comprises strains 272, 28354, KIPP, MUL, strains containing ospC gene OC12 and OC 13, and GenBank accession number U08284; or
(e) Borrelia afzelii OspC family A comprises strains Pbo, Pwud, PKO, Pgau, DK2, DK3, DK21, DK8, Bfox and JSB; or
(f) Borrelia afzelii OspC family B comprises strains DK5, ACA1, DK9, XB18h, Ple and 134M."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["Use of a composition for the manufacture of a medicament for immunizing an animal against disseminated Lyme Disease, wherein said composition comprises one or more OspC polypeptides from at least two Borrelia burgdorferi OspC families selected from the group consisting of: A, B, I and K, excepting the combination consisting of two OspC polypeptides wherein one OspC polypeptide is from family A and the second OspC polypeptide is from family I, wherein Borrelia burgdorferi OspC family A is characterized by GenBank accession number AF029860 and ospC genes having at least 98% identity with GenBank accession number AF029860, Borrelia burgdorferi OspC family B is characterized by GenBank accession number AF029861 and ospC genes having at least 98% identity with GenBank accession number AF029861, Borrelia burgdorferi OspC family I is characterized by GenBank accession number AF029869 and ospC genes having at least 98% identity with GenBank accession number AF029869, and Borrelia burgdorferi OspC family K is characterized by GenBank accession number U08284 and ospC genes having at least 98% identity with GenBank accession number U08284 such that the animal generates an immune response to the OspC polypeptides."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The use of Claim 4 wherein said composition further comprises one or more OspC polypeptides selected from the group consisting of: Borrelia afzelii family A and Borrelia afzelii family B, wherein Borrelia afzelii family A is characterized by the ospC gene sequence of Borrelia afzelii strain Pgau and ospC genes having at least 98% identity with said gene and Borrelia afzelii family B is characterized by the ospC gene sequence of Borrelia afzelii strain DK5 and ospC genes having at least 98% identity with said gene."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The use of Claim 4 or 5, wherein
(a) said composition comprises one or more OspC polypeptides from each of Borrelia burgdorferi families A, B, I, and K; or
(b) one or more of said OspC polypeptides comprises the OspC protein variable region encoded by nucleotides 150-519 of an ospC gene; or
(c) one or more of said OspC polypeptides is encoded by a nucleic acid comprising nucleotide 26 to nucleotide 621 of an ospC gene; or
(d) one or more of said OspC polypeptide or fragment thereof is encoded by a nucleic acid comprising nucleotide 53 to nucleotide 570 of an ospC gene; or
(e) at least two of said OspC polypeptides are fused together in a single protein, encoded by a smgle nucleic acid, wherein polypeptides in said fusion protein are not found in the same configuration in a naturally occurring OspC protein."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The use of any one of Claims 4-6, wherein
(a) Borrelia burgdorferi OspC family A comprises strains B31, CA4, HII, IPI, IP2, IP3, L5, PIF, Pka, Txgw and strains containing ospC allele OC1; or
(b) Borrelia burgdorferi OspC family B comprises strains 35B808, 61BV3, BUR, DK7, PB3, ZS7 and strains containing ospC genes OC2 and OC3; or
(c) Borrelia burgdorferi OspC family I comprises strain HB19, strains containing ospC gene OC10, and GenBank accession number L42893; or
(d) Borrelia burgdorferi OspC family K comprises strains 272, 28354, KIPP, MUL, strains containing ospC gene OC12 and OC 13, and GenBank accession number U08284; or
(e) Borrelia afzelii OspC family A comprises ospC strains Pbo, Pwud, PKO, Pgau, DK2, DK3, DK21, DK8, Bfox and JSB; or
(f) Borrelia afzelii OspC family B comprises strains DK5, ACA1, DK9, XB18h, Ple and 134M."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting, in a host sample, an immune response to Borrelia associated with disseminated Lyme Disease comprising;
a) contacting the host sample with a composition comprising OspC polypeptides from disseminated Lyme Disease-associated strains of Borrelia, such that anti-OspC antibodies, if present in said sample, bind to said OspC polypeptides, wherein said composition comprises one or more OspC polypeptides from at least two Borrelia burgdorferi OspC families selected from the group consisting of: A, B, I and K, excepting the combination consisting of two OspC polypeptides wherein one OspC polypeptide is from family A and the second OspC polypeptide is from family I wherein Borrelia burgdorferi OspC family A is characterized by GenBank accession number AF029860 and ospC genes having at least 98% identity with GenBank accession number AF029860, Borrelia burgdorferi OspC family B is characterized by GenBank accession number AF029861 and ospC genes having at least 98% identity with GenBank accession number AF029861, Borrelia burgdorferi OspC family I is characterized by GenBank accession number AF029869 and ospC genes having at least 98% identity with GenBank accession number AF029869, and Borrelia burgdorferi OspC family K is characterized by GenBank accession number U08284 and ospC genes having at least 98% identity with GenBank accession number U08284; and
b) detecting antibodies that have bound said OspC peptides; thereby detecting an immune response to Borrelia associated with disseminated Lyme disease."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of Claim 8, wherein said composition further comprises one or more OspC polypeptides from the group consisting of: Borrelia afzelii OspC family A and Borrelia afzelii family B, wherein Borrelia afzelii family A is characterized by the ospC gene sequence of Borrelia afzelii strain Pgau and ospC genes having at least 98% identity with said gene and Borrelia afzelii family B is characterized by the ospC gene sequence of Borrelia afzelii strain DK5 and ospC genes having at least 98% identity with said gene."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of Claim 8 or 9, wherein
(a) said composition comprises one or more OspC polypeptides from each of Borrelia burgdorferi families A, B, I, and K; or
(b) one or more of said OspC polypeptides comprises the OspC protein variable region encoded by nucleotides 150-519 of an ospC gene ; or
(c) one or more of said OspC polypeptides is encoded by a nucleic acid comprising nucleotide 26 to nucleotide 621 of an ospC gene; or
(d) one or more of said OspC polypeptides is encoded by a nucleic acid comprising nucleotide 53 to nucleotide 570 of an ospC gene; or
(e) at least two of said OspC polypeptides are fused together in a single protein, encoded by a single nucleic acid, wherein polypeptides in said fusion protein are not found in the same configuration in a naturally occurring OspC protein."],"number":10,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}