{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"178-816-837-340-005","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"178-816-837-340-005"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10798,"type":"PATENT","title":"Ghent University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3552,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8263,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Ghent Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents:107
Search Applicants and Owners separately: \"Ghent Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents:107
measuring the level of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a biological sample taken from said subject, and\n
comparing said level of transmembrane type 1 neuregulin-1 with a reference level of transmembrane type 1 neuregulin-1 obtained from a sample of healthy tissue of a subject,\n
wherein said tumor-associated mesenchymal cells are spindle-shaped, mesenchymal, non-cancer cells which are bone-marrow derived or recruited from other compartments and tissues within the human body and which are present around the cancer cells in a biological sample taken from said subject; and\n
administering a treatment for colorectal cancer upon a determination that transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a sample from the subject is significantly increased as compared to that of said healthy tissue."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1,\n
wherein said method incorporates the decision whether or not a patient having colorectal cancer would benefit from a therapy based on the prevention of neuregulin-1 activity or the prevention of the tyrosine kinase activity of HER3, and wherein said significantly increased level of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a sample of the patient as compared to that of said healthy tissue indicates that said patient would benefit from a therapy based on the prevention of neuregulin-1 activity or the prevention of the tyrosine kinase activity of HER3, or,\n
wherein said method incorporates the decision or determination whether a patient having colorectal cancer has developed resistance to a therapy based on the prevention of HER1 activity, and wherein said significantly increased level of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a sample of the patient as compared to that of said healthy tissue indicates that said patient has resistance to a therapy based on the prevention of the tyrosine kinase activity of HER 1."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1 wherein said biological sample is colorectal cancer tissue taken from said subject."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1 wherein said transmembrane type 1 neuregulin-1 is measured by immunohistochemistry on frozen samples."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1 wherein said level of transmembrane type 1 neuregulin-1 is significantly increased when more than 25% of said tumor-associated mesenchymal cells within said sample contain transmembrane type 1 neuregulin-1 staining."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1 wherein a worse prognosis corresponds to having a significantly increased chance to belong to the higher cancer stages according to the Union for International Cancer Control, and/or, to having a significantly increased chance to have an increased invasion depth of the tumor, and/or, to have a significantly increased chance to have a decreased progression-free survival."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1, further comprising identifying tumor-associated mesenchymal cells in a biological sample from said subject."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 7, wherein the biological sample is stained using Mayer's hematoxylin solution."],"number":8,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}