{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"178-656-978-238-768","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"178-656-978-238-768"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11720,"type":"PATENT","title":"University of Iowa - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3930,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8373,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Add to collection. Total patents: 3686
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delivering to the subject a precursor RNA interference trigger molecule that directs cleavage of a HBV RNA via RNA interference (RNAi) wherein:\n
a fully processed RNAi trigger molecule is about 19 to 29 nucleotides in length;\n
one strand of the fully processed RNAi trigger molecule comprises a nucleotide sequence having sufficient complementarity to the HBV RNA for the RNAi trigger molecule to direct cleavage of the HBV RNA via RNA interference;\n
wherein the fully processed RNAi trigger molecule is selected from SEQ ID NO: 9 through SEQ ID NO: 23; and\n
inhibiting expression or levels of HBV mRNA by cleavage of HBV RNA molecules in the subject therefore inhibiting HBV infection in the subject."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the fully processed RNAi trigger molecules are incorporated into a micro RNA (miRNA)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the fully processed RNAi trigger molecules are incorporated into short hairpin RNA (shRNA)."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the RNAi triggers target approximately 3.5, 2.1, 2, 4, or 0.7 kilo base pair RNAs of the HBV, or any subset thereof."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the inhibition of HBV occurs in a mouse."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the inhibition of the virus HBV occurs in a human."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the fully processed RNAi trigger molecule is selected from one or more of SEQ ID NO:9, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO: 16."],"number":7,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}