Polymorphisms In The Human Genes For Oct1 And Their Use In Diagnostic And Therapeutic Applications

  • Published: Jan 15, 2009
  • Earliest Priority: Aug 23 2002
  • Family: 11
  • Cited Works: 0
  • Cited by: 0
  • Cites: 7
  • Sequences: 67
  • Additional Info: Full text Sequence

The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.

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Document History
  • Publication: Jan 15, 2009
  • Application: Jul 30, 2008
    US US 22124108 A
  • Priority: Jul 30, 2008
    US US 22124108 A
  • Priority: Nov 14, 2005
    US US 52536005 A
  • Priority: Aug 22, 2003
    EP EP 0309356 W
  • Priority: Aug 23, 2002
    EP EP 02018904 A

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