Inhibition Of The Tumorigenic Potential Of Tumor Stem Cells By Lif And Bmps

Abstract

The present disclosure includes methods and compositions for the treatment or prevention of diseases and disorders characterized by excessive or misregulated cellular proliferations, including methods for the treatment of tumors. The methods involve the use of pharmaceutical compositions comprising at least one agent selected from the group consisting of a LIF preparation, a BMP preparation, a BMPR signalling activator, and a LIFR signalling activator. The disclosure also includes LIF preparations, BMP preparations, BMPR signalling activator, and LIFR signalling activators, and methods for the identification of LIF preparations, BMP preparations, BMPR signalling activator, and LIFR signalling activators. The disclosure also includes pharmaceutical compositions comprising at least one agent selected from the group consisting of a LIF preparation, a BMP preparation, a BMPR signalling activator, and a LIFR signalling activator.


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Document History
  • Publication: Aug 22, 2017
  • Application: Nov 16, 2015
    US US 201514942157 A
  • Priority: Nov 16, 2015
    US US 201514942157 A
  • Priority: Jul 19, 2006
    US US 99621406 A
  • Priority: Jul 19, 2006
    IB IB 2006002296 W
  • Priority: Jul 19, 2005
    US US 70085905 P

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