Fungal Efflux Pump Inhibitors

Abstract

The use of compounds of the milbemycin class as inhibitors of efflux pumps in microbes or other cells is described, along with pharmaceutical compositions incorporating a milbemycin. Also described is a method of screening for compounds which inhibit a CDR1, CDR2, BEN, or FLU1 efflux pump or a pump with components having a high level of protein level sequence similarity with the components of those efflux pumps.


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Document History
  • Publication: Dec 17, 2002
  • Application: Oct 1, 1998
    US US 16460998 A
  • Priority: Oct 1, 1998
    US US 16460998 A
  • Priority: Oct 2, 1997
    US US 6132297 P

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