Protein Binding Domains Stabilizing Functional Conformational States Of Gpcrs And Uses Thereof

Abstract

The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, it provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains hereof can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, also encompassed are the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.


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Document History
  • Publication: Sep 27, 2016
  • Application: Jul 18, 2011
    US US 201113810652 A
  • Priority: Jul 18, 2011
    US US 201113810652 A
  • Priority: Jul 18, 2011
    EP EP 2011062287 W
  • Priority: Sep 6, 2010
    GB GB 201014715 A
  • Priority: Jul 16, 2010
    US US 39978110 P

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