{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"173-331-585-588-460","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"173-331-585-588-460","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10787,"type":"PATENT","title":"Rutgers University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7108,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8257,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Rutgers Univ*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4935
Search Applicants and Owners separately: Dartmouth colle*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2346
Search Applicants and Owners separately: \"Rutgers Univ*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4935
Search Applicants and Owners separately: Dartmouth colle*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2346
b) contacting said cell with an effective amount of a compound having the structure:\n\n
wherein Y is hydroxy, methoxy, ethyl-amino, or\n\n
a pharmaceutically acceptable salt or tautomer thereof; and\n
c) culturing the cell."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the cell is of human origin."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the cell is of bovine, equine, canine, feline, murine, rat or chick origin."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising incubating said cell with a growth factor."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the growth factor is TGF-β1, TGF-β2, TGF-β1.2, VEGF, insulin-like growth factor I or II, BMP2, BMP4, or BMP7."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the growth factor is parathyroid hormone, calcitonin, interleukin-6, or interleukin-11."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising purifying said cell after step (b)."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising implanting said cell in vivo after step (b) and/or step (c)."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein bone is formed by said cell."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the cell is an osteoblast."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method of providing bone tissue to a mammal comprising:\n
a) providing a bone-producing cell;\n
b) contacting said cell with an effective amount of a compound having the structure:\n\n
wherein Y is hydroxy, methoxy, ethyl-amino, or\n\n
a pharmaceutically acceptable salt or tautomer thereof;\n
c) culturing the cell to form bone; and\n
d) implanting said bone to said subject."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein the bone formed in step (c) is part of a three-dimensional matrix."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein the three-dimensional matrix is one or more of alginate gels, collagen gels, or fibrin gels."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein the three-dimensional matrix comprises one or more of polylactic acid, polyglycolic acid or PGLA."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein the three-dimensional matrix comprises one or more of hydroxyapatite or other apatitic compounds, devitalized animal bone, devitalized human bone, or porous ceramic structures."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein the mammal has cancer bone disease, localized osteolysis due to cancer and to myeloma, degenerative cartilage conditions, osteoarthritis, osteoporosis, Vitamin D deficiency, Osteotitis deformans, or Von Recklinghausen's Disease."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein the cell is of human origin."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein the cell is of bovine, equine, canine, feline, murine, rat or chick origin."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method for producing bone ex vivo comprising:\n
a) providing a bone-producing cell;\n
b) contacting said cell with an effective amount of a compound having the structure:\n\n
wherein Y is hydroxy, methoxy, ethyl-amino, or\n\n
a pharmaceutically acceptable salt or tautomer thereof; and\n
c) culturing the cell to form bone."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["A method of repairing bone damage in a patient having a bone defect, bone trauma, osteoarthritis, osteoporosis, or Vitamin D deficiency, comprising administering to said patient an amount of a compound effective to repair bone damage, said compound having the structure:\n
wherein Y is hydroxy, methoxy, ethyl-amino, or\n\n
a pharmaceutically acceptable salt or tautomer thereof."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["A method for stimulating a cartilage-forming cell comprising:\n
a) providing a cartilage-producing or osteochondrogenic cell;\n
b) contacting said cell with an effective amount of a compound having the structure:\n\n
or\n
a pharmaceutically acceptable salt or tautomer thereof; and\n
c) culturing the cell."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A method of repairing cartilage damage in a patient having cartilage disease or cartilage trauma comprising administering to said patient an amount of a compound effective to repair cartilage damage, said compound having the structure:\nor a pharmaceutically acceptable salt or tautomer thereof."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 22, wherein the patient is human."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 22, wherein cartilage is formed."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the compound is administered to a wound."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the compound is administered to a bone disease site."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient has bone trauma."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient has a bone defect."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 28, wherein the bone defect is the result of a birth defect."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient is human."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein bone is formed."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the bone trauma is a fracture."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 28, wherein the bone defect is the result of cancer surgery."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient has osteoarthritis."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient has osteoporosis."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the patient has Vitamin D deficiency."],"number":36,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}