Compositions And Methods For Delivery Of Nucleic Acids To Hepatocytes


Disclosed are recombinant baculoviruses that are used to deliver hepatocyte expressable nucleic acid constructs specifically to hepatocytes. Also provided are a variety of recombinant baculovirus vectors which comprise at least one oligosaccharide processing enzyme gene and a hepatocyte expressible nucleic acid segment. The invention also provides methods of using the expression systems and recombinant baculoviruses, particularly in the treatment of liver diseases and/or infections.


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