Tumor Suppressor Car-1


The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the corresponding transcript suggests that it may be involved in yet others. Thus, one aspect of the invention is the diagnosis of CAR-1-related malignancies. The full length cDNA for CAR-1, as well as oligonucleotides derived therefrom, are disclosed. Screening methods for modulators of CAR-1 function and expression, as well as methods for cancer therapy, are described.

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Document History
  • Publication: Jan 30, 2007
  • Application: Jun 15, 2005
    US US 15323805 A
  • Priority: Jun 15, 2005
    US US 15323805 A
  • Priority: Aug 9, 2001
    US US 92709101 A
  • Priority: Aug 23, 2000
    US US 22756000 P
  • Priority: Aug 10, 2000
    US US 22503300 P

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