M.tb Open Reading Frame Rv2659c And Uses Thereof


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Specific genetic deletions are identified in mycobacteria isolates, including variations in the M.tuberculosis genome between isolates, and numerous deletions present in BCG as compared to M.tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M.tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of the vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) is deleted from M.bovis or M.tuberculosis to attenuate the pathogenic bacteria.


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Document History
  • Publication: Mar 4, 2009
  • Application: Aug 10, 1999
    EP EP 08017907 A
  • Priority: Aug 10, 1999
    EP EP 99939702 A
  • Priority: May 25, 1999
    US US 31819199 A
  • Priority: Aug 25, 1998
    US US 9793698 P

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