Methods For Treating Tweak-related Conditions

Abstract

The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.


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Document History
  • Publication: Aug 13, 2013
  • Application: Apr 3, 2009
    US US 41775509 A
  • Priority: Apr 3, 2009
    US US 41775509 A
  • Priority: Sep 13, 2005
    US US 51080405 A
  • Priority: Apr 9, 2003
    US US 0311350 W
  • Priority: Apr 9, 2002
    US US 37161102 P

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