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MARCEL P [US], et al"},"lens_id":"159-048-917-858-316","srep_office":"US","category":[],"us_category":[],"cited_phase":"SEA","rel_claims":[],"sequence":1}},{"npl":{"num":1,"text":"Corn et al, Chem. Rev., vol. 94, pp. 107-125 (1994).","npl_type":"a","external_id":["10.1021/cr00025a004"],"record_lens_id":"130-906-931-608-124","lens_id":["170-626-255-366-936","130-906-931-608-124"],"sequence":2,"category":[],"us_category":[],"cited_phase":"SEA","rel_claims":[],"srep_office":"US"}},{"npl":{"num":2,"text":"The online dictionary at AskDefine.com ([retrieved on Jun. 25, 2012]; retrieved from the Internet:
interspersing a probe nanostructure with a target of interest, such that the probe nanostructure interacts with the target of interest, and wherein the probe nanostructure formed of a crystal material having a unit cell with no inversion symmetry such that it generates a second harmonic emission when radiated by an excitation source;\n
radiating the probe nanostructure with an external excitation source such that the crystal material of the probe nanostructure generates a second harmonic emission;\n
detecting the second harmonic emission from the nanoprobe; and\n
wherein the at least one probe nanostructure generates the second harmonic emission regardless of the attachment and orientation of the probe nanostructure to the target."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the probe nanostructure is a nanocrystal selected from the group consisting of organic, inorganic and combinations thereof."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the target of interest is selected from the group consisting of an antigen, a peptide sequence, a nucleic acid sequence, RNA and DNA."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the target of interest is indicative of the presence of one of either a specific medical condition or a specific pathogenesis."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the probe nanostructure is one of either directly attached to or introduced into the target of interest."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the probe nanostructure is conjugated to a probe molecule that is sensitive to the presence of the target of interest."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the probe nanostructure is attached to a therapeutic agent."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the step of radiating is conducted while the probe nanostructure is in vivo."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 8, wherein the emissions from the probe nanostructure are utilized to determine the biodistribution of the target of interest."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the target of interest is collected in one of either a liquid or solid sample."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising interspersing an exciter nanostructure to the target of interest, said exciter nanostructure designed to produce an enhanced electrical field of a specified frequency when exposed to an excitation source, wherein the probe nanostructure generates a second harmonic resonance emission when brought within range of the enhanced electrical field of said exciter nanostructure."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the excitation source is selected from the group consisting of continuous wave, modulated and pulsed lasers."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A method of field resonance enhanced second harmonic detection comprising:\n
attaching an exciter nanostructure to a target of interest, said exciter nanostructure designed to produce an enhanced electrical field of a specified frequency when exposed to an excitation source;\n
attaching a probe nanostructure to the target of interest, said probe nanostructure formed of a crystal material having a unit cell with no inversion symmetry such that it generates a second harmonic resonance emission when brought within range of the enhanced electrical field of said exciter nanostructure;\n
radiating the structure of interest with an external excitation source such that the crystal material of the probe nanostructure generates a second harmonic emission;\n
detecting the second harmonic emission from the nanoprobe; and\n
wherein the at least one probe nanostructure generates the second harmonic emission regardless of the attachment and orientation of the probe nanostructure to the target."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 13, wherein the exciter nanostructure is a metal nanostructure selected from the group consisting of nanorods, nanospheres or nanoshells."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 13, wherein the probe nanostructure and the emitter nanostructure are both attached to a single target of interest."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 13, wherein the probe nanostructure is a nanocrystal selected from the group consisting of organic, inorganic and combinations thereof."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the nanocrystal is selected from the group consisting of BaTiO3, SiC, ZnO, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, GaAs, GaSb, GaP, GaN, InSb, LiNbO3, KNbO3, KTiOPO4, Fe(IO3)3, Au, Ag, N-(4-nitrophenyl)-(L)-prolinol, urea, 4-Nitroaniline, 2-Methyl-4-nitroaniline, 3-Methyl-4-methoxy-4′-nitrostilbene, β-BaB2O4, LiB3O5, LiNbO3, KTiOPO4, AgGaS2, AgGaSe2, ZnGeP2, GaSe, KH2PO4, NH4H2PO4, KD2PO4, CsLiB6O10, KTiOAsO4, KNbO3, LiTaO3, RbTiOAsO4, BaTiO3, MgBaF4, GaAs, BiB3O6, K2Al2B2O7, KBe2BO3F2, BaAlBO3F2, La2CaB10O19, GdCa4O(BO3)3, YCa4O(BO3)3, Li2B4O7, LiRbB4O7, CdHg(SCN)4, RbTiOPO4, LiInS2, LiInSe2, KB5O8.4H2O, CsB3O5, C4H7D12N4PO7, a-HIO3, LiCOOH.H2O, CsH2AsO4, CsD2AsO4, RbH2PO4, CsTiOAsO4, Ba2NaNb5O15, K3Li2Nb5O15, CO(NH2)2, LiIO3, Ag3AsS3, HgGa2S4, CdGeAs2, Ti3AsSe3."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 13, wherein the excitation source is selected from the group consisting of continuous wave, modulated and pulsed lasers."],"number":18,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}