Cdnas Coding For The Gamma Subunit Of The High-affinity Receptor For Immunoglobulin E


Disclosed herein is the isolation and sequencing of the cDNA coding for the gamma subunit of the high-affinity receptor for immunoglobulin E (IgE) on mast cells and basophils. Also disclosed is the expression of the receptor when the cDNA for its alpha , beta and gamma subunits are simultaneously contransfected. This success in expression of IgE binding permits detailed analysis of the IgE-receptor interaction and thus enables the development of therapeutically effective inhibitors.

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Document History
  • Publication: May 3, 1990
  • Application: Oct 18, 1989
    WO US 8904628 W
  • Priority: Oct 18, 1988
    US US 25906588 A

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