{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"167-244-531-465-85X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"167-244-531-465-85X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11646,"type":"PATENT","title":"UT M. D. Anderson Cancer Center - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4091,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8312,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:anderson cancer texas
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a) administering to the subject an effective amount of a composition comprising a metal ion-labeled bis-aminoethanethiol (BAT)-targeting ligand conjugate, wherein the targeting ligand is an agent that mimics glucose; and\n
b) detecting a signal from the site."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the metal ion-labeled BAT-targeting ligand conjugate comprises more than one targeting ligand."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the metal ion-labeled BAT-targeting ligand conjugate comprises two targeting ligands."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the BAT comprises two carboxylic acid moieties."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein a targeting ligand is conjugated to one of the carboxylic acid moieties of the BAT."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein a first targeting ligand is conjugated to one of the carboxylic acid moieties of the BAT and a second targeting ligand is conjugated to another carboxylic acid moiety of the BAT."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the metal ion-labeled BAT-targeting ligand conjugate is a metal ion-labeled BC-targeting ligand conjugate."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the metal ion is a radionuclide."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the radionuclide is 99mTc, 188Re, 186Re, 183Sm, 166Ho, 90Y, 89Sr, 67Ga, 68Ga, 111In, 153Gd, 59Fe, 225Ac, 212Bi, 211At, 62Cu, or 64Cu."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein a radioactive signal from the administered targeting ligand conjugate localizes in the target cells."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein detecting comprises performing emission tomography."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11 wherein the emission tomography is positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), or CT."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein the emission tomography is PET."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein the emission tomography is SPECT."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a mammal."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the mammal is a human."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein the site is the myocardium of the heart."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein the site is an area of ischemia or hypoxia."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the site is an area of inflammation."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 19, wherein the area of inflammation is an infection."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the site is an area of ischemia or hypoxia."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the radioactive signal from the administered composition localizes at the site."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the agent that mimics glucose is glucosamine, deoxyglucose, neomycin, kanamycin, gentamicin, paromycin, amikacin, tobramycin, netilmicin, ribostamycin, sisomicin, micromicin, lividomycin, dibekacin, isepamicin, astromicin, or an aminoglycoside."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 23, wherein the agent that mimics glucose is glucosamine or deoxyglucose."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein the metal ion-labeled BAT-targeting ligand conjugate is 99mTc-labeled EC-glucosamine."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The metho of claim 1, wherein said metal ion-labeled bis-aminoethanethiol (BAT) dicarboxylic acid-targeting ligand conjugate comprises a linker conjugating the BAT dicarboxylic acid to the targeting ligand."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein the linker comprises a water soluble peptide, glutamic acid, aspartic acid, bromo ethylacetate, ethylene diamine, or lysine."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 26, wherein said linker is glutamate peptide or poly-glutamic acid."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the radionuclide-labeled bis-aminoethanethiol (BAT)-targeting ligand conjugate is a radionuclide-labeled ethylenedicysteine-targeting ligand conjugate."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the metal ion-labeled-labeled bis-aminoethanethiol (BAT)-targeting ligand conjugate further comprises a linker conjugating a carboxylic acid moiety of the BAT to the targeting ligand."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 30, wherein the linker comprises a water soluble peptide, glutamic acid, aspartic acid, bromo ethylacetate, ethylene diamine, lysine, glutamate peptide or poly-glutamic acid."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein detecting is performed from about 10 minutes to about 4 hours after administering to the subject the effective amount of the composition."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["A method of delivering a radionuclide into target cells of the heart of a human subject, comprising:\n
a) obtaining a composition comprising a radionuclide-labeled bis-aminoethanethiol (BAT)-targeting ligand conjugate, wherein the targeting ligand is an agent that mimics glucose; and\n
b) administering the conjugate to the subject, wherein the conjugate is taken up into the target cells of the subject and."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the radionuclide-labeled BAT-targeting ligand conjugate comprises more than one targeting ligand."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the radionuclide-labeled BAT-targeting ligand conjugate comprises two targeting ligands."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the BAT comprises two carboxylic acid moieties."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 36, wherein a targeting ligand is conjugated to one of the carboxylic acid moieties of the BAT."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 37, wherein a targeting ligand is conjugated to each of the carboxylic acid moieties of the BAT."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the radiolabeled BAT-targeting ligand conjugate is a radiolabeled BC-targeting ligand conjugate."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein radioactive signal from the administered targeting ligand conjugate localizes in the target cells."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the radionuclide is 99mTc, 188Re, 186Re, 183Sm, 166Ho, 90Y, 89Sr, 67Ga, 68Ga, 111In, 153Gd, 59Fe, 225Ac, 212Bi, 211At, 62Cu, or 64Cu."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the agent that mimics glucose is glucosamine, deoxyglucose, neomycin, kanamycin, gentamicin, paromycin, amikacin, tobramycin, netilmicin, ribostamycin, sisomicin, micromicin, lividomycin, dibekacin, isepamicin, astromicin, or an aminoglycoside."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 42, wherein the agent that mimics glucose is glucosamine or deoxyglucose."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein the radiolabeled BAT-targeting ligand conjugate is 99 mTc-labeled EC-glucosamine."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein said radionuclide-labeled bis-aminoethanethiol (BAT) dicarboxylic acid-targeting ligand conjugate comprises a linker conjugating the BAT dicarboxylic acid to the targeting ligand."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 45, wherein the linker comprises a water soluble peptide, glutamic acid, aspartic acid, bromo ethylacetate, ethylene diamine, or lysine."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 45, wherein said linker is glutamate peptide or poly-glutamic acid."],"number":47,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}