Modified Compstatin With Improved Stability And Binding Properties


Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These cyclic compounds are modified to improve stability while maintaining substantially equivalent complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs in which the disulfide bond between C2 and C12 is modified via a thioether bond to form a cystathionine.


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Document History
  • Publication: May 31, 2012
  • Application: Sep 21, 2011
    WO US 2011/0052442 W
  • Priority: Sep 23, 2010
    US US 38571110 P

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