Tnp-470 Polymer Conjugates And Use Thereof

Abstract

The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably, the polymer has a molecular weight no greater than 60 kDa. Most preferably, the polymer has a molecular weight in the range of 15 kDa to 40 kDa.


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Document History
  • Publication: Feb 19, 2008
  • Application: Mar 24, 2005
    US US 51100905 A
  • Priority: Mar 24, 2005
    US US 51100905 A
  • Priority: Apr 10, 2003
    US US 0310976 W
  • Priority: Sep 30, 2002
    US US 41470502 P
  • Priority: Apr 11, 2002
    US US 37179102 P

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