{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"166-960-282-096-854","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"166-960-282-096-854","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8901,"type":"PATENT","title":"University of Michigan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8216,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
a) providing nucleic acid from a subject; and\n
b) detecting methylation status of CD40L in said nucleic acid;\nwherein said methylation status of CD40L is correlated with the presence or absence of said autoimmune or chronic inflammatory disease in said subject."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said method detects methylation status of the 5′ untranslated region of CD40L."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising detecting methylation status of one or more of CD70, perform CD11a, CD11c, IgE FCRγ1, and CD30."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said detecting comprises using a kit comprising reagents sufficient for detecting methylation status of CD40L in a subject."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said method detects methylation status of the −350 to −400 region of CD40L."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said method detects methylation status of the 125 to −400region of CD40L."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the presence of demethylated CD40L in said subject, when compared to the methylation of CD40L in a healthy subject, is indicative of the presence of an autoimmune or chronic inflammatory disease."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the presence of demethylated CD40L in said subject, when compared to the methylation of CD40L in a healthy subject, is indicative of the presence of an autoimmune or chronic inflammatory disease."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said detecting comprises use of a polymerase chain reaction."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein said polymerase chain reaction is methylation sensitive."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said detecting comprises differential antibody binding, oligonucleotide binding assays, or use of a microarray."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said detecting comprises restriction enzyme digestion."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein said kit comprises a positive control that indicates CD40L methylation status."],"number":13,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}