Vaccines For Blocking Transmission Of Plasmodium Vivax


The present invention relates to novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.

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Document History
  • Publication: Mar 20, 2007
  • Application: Dec 4, 1998
    US US 55496098 A
  • Priority: Dec 4, 1998
    US US 55496098 A
  • Priority: Dec 4, 1998
    US US 9825742 W
  • Priority: Dec 5, 1997
    US US 6759697 P
  • Priority: May 1, 1997
    US US 4528397 P

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