Catalytic Domain Of Adam33 And Methods Of Use Thereof

Abstract

The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.


Claims
Download PDF
Document Preview
Document History
  • Publication: Apr 24, 2007
  • Application: Dec 19, 2003
    US US 74120403 A
  • Priority: Dec 19, 2003
    US US 74120403 A
  • Priority: Jan 15, 2003
    US US 44026303 P
  • Priority: Dec 19, 2002
    US US 43480202 P
  • Priority: Dec 19, 2002
    US US 43483002 P

Download Citation


Sign in to the Lens

Feedback