Inhibition Of Tnfalpha-initiated Neutrophil Response


The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFalpha)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNFalpha-stimulated superoxide anion generation and IL-1beta release by human PMN.

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Document History
  • Publication: Mar 9, 2004
  • Application: Jan 11, 2002
    US US 4449902 A
  • Priority: Jan 11, 2002
    US US 4449902 A
  • Priority: Mar 14, 2000
    US US 52529100 A
  • Priority: Mar 18, 1999
    US US 12520599 P

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