{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"160-923-372-433-42X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"160-923-372-433-42X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10791,"type":"PATENT","title":"The Hebrew University of Jerusalem - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7593,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8259,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
\n\nA-L-B Formula I\n\n
wherein:\n
B is a biopolymer which is a polypeptide comprising at least one resilin amino acid sequence;\n
L is a linking moiety; and\n
A is a dihydroxyphenyl moiety having the general formula II:\n\n
wherein each of R1-R5 is independently selected from the group consisting of hydrogen and hydroxyl, and at least two of R1-R5 are hydroxyl."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, wherein at least one of R1-R5 is hydrogen."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, wherein at least 90% of the total amount of dihydroxyphenyl moieties of the polymer are not crosslinked."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, wherein said dihydroxyphenyl moiety and said linking moiety form a part of a DOPA residue."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, wherein said dihydroxyphenyl moiety and said linking moiety do not form a part of a DOPA residue."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, comprising a plurality of said dihydroxyphenyl moiety."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 6, wherein a ratio of molecular weight of the polymer to dihydroxyphenyl moieties comprised by the polymer is in a range of from 1.5 KDa per dihydroxyphenyl moiety to 12 KDa per dihydroxyphenyl moiety."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 6, being a polypeptide wherein a percentage of amino acid residues of said polypeptide which comprise said dihydroxyphenyl moiety is in a range of from 0.5% to 5%."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The polymer of claim 1, exhibiting an adhesiveness to a surface, said adhesiveness comprising resistance to stress of 1 KPa in a direction perpendicular to said surface."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A method of preparing the polymer of claim 5, wherein said linking moiety is attached to said biopolymer via a covalent bond formed between a reactive group in said linking moiety and a functional group on said biopolymer, the method comprising:\n
a) providing a compound comprising said dihydroxyphenyl moiety and said reactive group; and\n
b) contacting said compound with a biopolymer comprising at least one of said functional group, said biopolymer comprising at least one resilin amino acid sequence, to form said covalent bond,\n
thereby preparing the polymer."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A method of preparing the polymer of claim 1, the method comprising:\n
a) providing a biopolymer comprising at least one hydroxyphenyl moiety, said biopolymer comprising at least one resilin amino acid sequence; and\n
b) oxidizing at least one of said at least one hydroxyphenyl moiety to form said dihydroxyphenyl moiety,\n
thereby preparing the polymer."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said oxidizing is effected by contacting said biopolymer with a tyrosine hydroxylase."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein at least 90% of the total amount of dihydroxyphenyl moieties of said polymer are not crosslinked."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein said oxidizing is effected by a Fenton reaction."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method of generating a crosslinked adhesive, the method comprising contacting the polymer of claim 1 with an oxidizing agent, to thereby crosslink said dihydroxyphenyl moieties of said polymer."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method of binding a first agent to a second agent, the method comprising contacting the first agent with said second agent in a presence of the polymer of claim 1 and an oxidizing agent."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein said contacting is effected in vivo."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A kit comprising:\n
a) an adhesive comprising the polymer of claim 1; and\n
b) an oxidizing agent."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A crosslinked polymer having the general formula III:\n
\n\nB′-L′-A′-A″-L″-B″ Formula III\n\n
wherein:\n
B′ and B″ are each independently a biopolymer which is a polypeptide comprising at least one resilin amino acid sequence;\n
L′ and L″ are each a linking moiety; and\n
A′-A″ is a pair of crosslinked dihydroxyphenyl moieties, said pair having a formula selected from the group consisting of:\n\n\n
wherein each of R′1-R′5 and R″1-R″5 is independently selected from the group consisting of hydrogen and hydroxy, and at least two of R′1-R′5 and at least two of R″1-R″5 are hydroxy,\n
with the proviso that said biopolymer is not blended with a polysaccharide."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The crosslinked polymer of claim 19, comprising a plurality of said pair of crosslinked dihydroxyphenyl moieties."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The crosslinked polymer of claim 19, exhibiting an adhesiveness to a surface, said adhesiveness comprising resistance to shear stress of 1.5 MPa."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The crosslinked polymer of claim 19, exhibiting an adhesiveness to a surface, said adhesiveness comprising resistance to stress of 10 KPa in a direction perpendicular to said surface."],"number":22,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}