Mesothelin Antibody Protein Fusions And Methods Of Use

Abstract

The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease.


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Document History
  • Publication: May 17, 2011
  • Application: Nov 6, 2008
    US US 29110408 A
  • Priority: Nov 6, 2008
    US US 29110408 A
  • Priority: Aug 4, 2008
    US US 18563108 A
  • Priority: Apr 18, 2008
    US US 4619508 P
  • Priority: Feb 2, 2007
    US US 2007/0061554 W
  • Priority: Feb 2, 2006
    US US 76462006 P

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