Recombinant Canine Thyroid Stimulating Hormone And Methods Of Production And Use Thereof

Abstract

The invention includes a nucleic acid having a sequence at least 98% homologous to SEQ ID NO: 1, which encodes the alpha subunit of canine thyroid stimulating hormone (TSH). The invention also includes a nucleic acid having a sequence at least 98% homologous to SEQ ID NO: 2, which encodes the beta subunit of canine TSH. The invention also includes a method of producing an recombinant canine thyroid stimulating hormone (rcTSH) subunit by expressing a nucleic acid having a sequence of SEQ ID NO: 1 and a nucleic acid having a sequence of SEQ ID NO: 2 in a transgenic insect cell modified to sialylate proteins and producing a sialylated rcTSH subunit. The insect cell may be a lepidopteran cell. The rcTSH may be used for diagnosis and treatment. It may be used to diagnose canine hypothyroidism.


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Document History
  • Publication: Jan 20, 2009
  • Application: May 12, 2006
    US US 38308106 A
  • Priority: May 12, 2006
    US US 38308106 A
  • Priority: Feb 23, 2006
    US US 36106406 A
  • Priority: Feb 23, 2005
    US US 65657605 P

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