Substituted Indole Acid Derivatives As Inhibitors Of Plasminogen Activator Inhibitor-1 (pai-1)

Abstract

This invention provides compounds of the formula: wherein: X is a chemical bond, -CH<SUB>2</SUB>- or -C(O)-; R<SUB>1 </SUB>is alkyl, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, pyridinyl, -CH<SUB>2</SUB>-pyridinyl, phenyl or benzyl; R<SUB>2 </SUB>is H, alkyl, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, or perfluoroalkyl; R<SUB>3 </SUB>is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, -NH<SUB>2</SUB>, or -NO<SUB>2</SUB>; R<SUB>4 </SUB>is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or -CH<SUB>2</SUB>-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.


Claims
Owners (US)

Information currently unavailable.

Download PDF
Document Preview
Document History
  • Publication: May 6, 2008
  • Application: Mar 29, 2006
    US US 39189306 A
  • Priority: Mar 29, 2006
    US US 39189306 A
  • Priority: Jun 18, 2002
    US US 17415902 A
  • Priority: Jun 20, 2001
    US US 29965701 P

Download Citation


Sign in to the Lens

Feedback