Targeted Therapeutic Proteins

Abstract

Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.


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Document History
  • Publication: Dec 8, 2009
  • Application: Nov 3, 2004
    US US 98126704 A
  • Priority: Nov 3, 2004
    US US 98126704 A
  • Priority: Nov 3, 2003
    US US 51699003 P
  • Priority: May 29, 2003
    US US 0317211 W
  • Priority: Feb 6, 2003
    US US 44573403 P
  • Priority: Oct 16, 2002
    US US 27253102 A
  • Priority: Oct 16, 2002
    US US 27248302 A
  • Priority: Sep 6, 2002
    US US 40881602 P
  • Priority: Jun 5, 2002
    US US 38601902 P
  • Priority: May 29, 2002
    US US 38445202 P

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