Matrix Metalloproteinase Inhibitors

  • Published: May 18, 2011
  • Earliest Priority: Aug 22 2006
  • Family: 63
  • Cited Works: 7
  • Cited by: 0
  • Cites: 21
  • Additional Info: Cited Works Published
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Abstract

The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.


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Document History
  • Publication: May 18, 2011
  • Application: Aug 21, 2007
    EP EP 10196009 A
  • Priority: Aug 21, 2007
    EP EP 07826082 A
  • Priority: Aug 22, 2006
    IN IN 1880DE2006 A

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