{"search_session":{},"preferences":{"l":"fr","queryLanguage":"fr"},"patentId":"150-946-914-706-138","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"150-946-914-706-138"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10802,"type":"PATENT","title":"Brown University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4664,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8267,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
A is a polymerase III active site-binding moiety selected from the group consisting of:in which each of R 1 and R 2 , independently, is hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or —L—B; each of R 3 and R 4 , independently, is hydrogen, C 1-3 alkyl, halo, C 1-3 haloalkyl, or —L—B; m is 1 or 2; and n is 0, 1, or 2; provided that at least one of R 1 , R 2 , R 3 , and R 4 , is —L—B;
L is a linker; and
B is a zinc finger-reactive moiety selected from the group consisting of:wherein each of R a and R b , independently, is hydrogen, C 1-6 alkyl, phenyl, C 1-6 hydroxyalkyl, C 1-6 haloalkyl, amine, or —L—A; and p is 1, 2, 3, or 4; provided that either one of R a and R b is —L—A, and R a and R b are not —L—A simultaneously; or a salt thereof."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein A is of the formula: in which
R 1 is hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or —L—B; each of R 3 and R 4 , independently, is hydrogen, C 1-3 alkyl, halo, C 1-3 haloalkyl, or —L—B; and n is 0, 1, or 2; provided that at least one of R 1 , R 3 , and R 4 , is —L—B;or a salt thereof."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein L is a direct bond or a C 1-8 alkylene chain; the alkylene chain optionally containing 1 to 5 —O—, —S—, —NR—, —C(═O)—O—, —C(═S)—O—, or —C(═O)—NR—; R being hydrogen or C 1-3 alkyl; or a salt thereof."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 2 , wherein R 1 is —L—B."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 4 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein A is of the formula: in which
R 1 is hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or —L—B; each of R 3 and R 4 , independently, is hydrogen, C 1-3 alkyl, halo, C 1-3 haloalkyl, or —L—B; and n is 0, 1, or 2; provided that at least one of R 1 , R 3 , and R 4 , is —L—B;or a salt thereof."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 6 , wherein R 1 is —L—B."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein A is of the formula: in which
each of R 1 and R 2 , independently, is hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or —L—B; each of R 3 and R 4 , independently, is hydrogen, C 1-3 alkyl, halo, C 1-3 haloalkyl, or —L—B; m is 1 or 2; and n is 0, 1, or 2; provided that at least one of R 1 , R 2 , R 3 , and R 4 , is —L—B;or a salt thereof."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 9 , wherein R 1 is —L—B."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 10 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 9 , wherein R 2 is —L—B."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 12 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein A is in which
each of R 1 and R 2 , independently, is hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or —L—B; each of R 3 and R 4 , independently, is hydrogen, C 1-3 alkyl, halo, C 1-3 haloalkyl, or —L—B; m is 1 or 2; and n is 0, 1, or 2; provided that at least one of R 1 , R 2 , R 3 , and R 4 , is —L—B;or a salt thereof."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 14 , wherein R 1 is —L—B."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 15 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 14 , wherein R 2 is —L—B."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 17 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 , wherein R 3 is ethyl, halo, or C 1-3 haloalkyl and R 4 is methyl."],"number":19,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}