Method For Treatment Of Macular Degeneration By Modulating P2y12 Or P2x7 Receptors

Abstract

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the eye of the patient. Further, this method is achieved by modulating the action of the P2X7 and/or P2Y12 receptors of the RPE cells, specifically decreasing the acidity (pHL) of the RPE lysosomes by administering selected receptor antagonists affecting the action of the P2X7 and/or P2Y12 receptors of the RPE. Methods for selecting and quantifying the effectiveness of drugs to restore pHL and determine outer segment clearance rates is also provided using a high through-put screening protocol.


Claims
Owners (US)

Information currently unavailable.

Download PDF
Document Preview
Document History
  • Publication: Sep 9, 2014
  • Application: Apr 27, 2012
    US US 201213457749 A
  • Priority: Apr 27, 2012
    US US 201213457749 A
  • Priority: Apr 28, 2011
    US US 201161480055 P
  • Priority: Apr 3, 2009
    US US 41832809 A
  • Priority: Oct 3, 2007
    US US 2007/0021211 W
  • Priority: Aug 23, 2007
    US US 96608607 P
  • Priority: Oct 3, 2006
    US US 84905006 P

Sign in to the Lens

Feedback