Small Rna Molecules, Precursors Thereof, Means And Methods For Detecting Them, And Uses Thereof In Typing Samples

Title: Small RNA molecules, precursors thereof, means and methods for detecting them, and uses thereof in typing samples.

Cancer of the colorectal part of the gastrointestinal tract is a frequently occurring disorder. In a first stage a benign tumour (adenoma) occurs which can turn into a malignant cancer (adenocarcinoma). Not all adenomas progress to carcinomas. In fact this progression into a carcinoma happens in only a small subset of tumours. Initiation of genomic instability is a crucial step and occurs in two ways in colorectal cancer (Lengauer et al. (1998) Nature, 396, 643-649). DNA mismatch repair deficiency leading to microsatellite instability (abbreviated as MSI or MIN), has been most extensively studied (di Pietro et al. (2005) Gastroenterol., 129, 1047-1059), and explains about 15% of adenoma to carcinoma progression. MSI tumours occur due to defects in the DNA mismatch repair genes (MMR), which promote tumour progression due to the accumulation of mutations and epigenetic changes. In the other 85% of cases where colorectal adenomas progress to carcinomas, genomic instability occurs at the chromosomal level (CIN) giving rise to aneuploidy. While for a long time these chromosomal aberrations have been regarded as random noise, secondary to cancer development, it has now been well established that these DNA copy number changes occur in specific patterns and are associated with different clinical behaviour (Hermsen et al. (2002). Gastroenterol. 123, 1109-1119). Chromosomal aberrations frequently reported in colorectal cancers are 7pq, 8q, 13q, 2Oq gains and 4pq, 5q, 8p, 15q, 17p, 18q losses. It was shown that 8q, 13q and 2Oq gains and 8p, 15q, 17p and 18q losses, are associated with progression of colorectal adenomas to carcinomas (Hermsen et al. (2002) cited above). In summary, colorectal cancer results from the accumulation of chromosomal aberrations, mutations and epigenetic changes ultimately causing alterations in gene expression at the RNA and protein level. Recent investigations have shown that a novel class of non-coding RNA molecules called microRNAs (miRNAs) also can act as oncogenes and tumour suppressors during cancer development. These non- coding RNAs contribute to tumour progression due to changes in their expression. Microarray based profiling studies have shown in a number of different tumor tissues and tumor cell lines, that miRNAs are differentially expressed. This differential expression, in some cases, was correlated to type of tumor and could be used to distinguish normal versus aberrant (tumor) tissue (Bloomston et al. (2007) JAMA 297:1901-1908), Iorio et al. (2005) Cancer Res. 65:7065-7070. In some cases, the unique small RNA profile correlated with prognosis (Yanaihara et al. (2006) Cancer Cell 9: 189-198, Calin et al. (2005) N. Engl. J. Med. 353:1793-1801). Importantly, expression profiling studies in chronic lymphocytic leukemia have shown that miRNAs signatures can classify leukemia samples according to their developmental history and categorize poorly differentiated tumours more accurately than mRNA expression profiles (Calin et al. (2005) N. Engl. J. Med. 353:1793-1801).

Therefore, these experiments reveal that the accumulation of specific combinations of chromosomal aberrations, epigenetic changes and mutations that characterize a tumour, determine its miRNA expression signature and vice versa. Consequently, miRNA expression profiles are a powerful tool for diagnosis, determining prognosis, progression risk and response to therapy of human cancers.

It is an object of the invention to molecularly identify and characterize the above described progression of adenomas into adenocarcinomas in as early a stage as possible, to allow early stage and more specific treatment of (pre-)malignant tumors while avoiding unnecessary surgical intervention. It is a further object of the invention to identify, high- risk pre-malignant colorectal tumors at a stage when the malignant phenotype (i.e. invasion and metastastis) has not yet emerged. At such a stage there usually are no symptoms yet that evoke clinical evaluation resulting in in situ optical analysis or microscopic analysis of biopsy or resection material. Current diagnostic procedures for early detection of colorectal cancer include colonoscopy, sigmoidoscopy and fecal tests such as faecal occult blood test (FOBT) and DNA faeces tests. Colonoscopy and sigmoidoscopy are not only quite uncomfortable for the patient, but specificity is low since many non- progressive adenomas are detected. Secondly, sensitivity is hampered by experience and devotion (retraction time) of the endoscopist and shape of the tumors (flat lesions go undetected more easily than polypoid). In addition, sigmoidoscopy only covers part of the large intestine. Polypectomies, endoscopic resections or biopsies during colonoscopy are performed when colorectal tumors/lesions are identified to confirm the nature of these lesions by histological analysis. Existing commercial fecal based tests have yielded promising results but need further improvement. FOBT (Faecal Occult Blood Test) is the most recognized method of selecting high risk individuals, and has been demonstrated to reduce death from colorectal cancer at the population level when applied in a population based screening program. Unfortunately, with FOBT a considerable percentage of the tumours is missed and the already bleeding tumour is often discovered at a relatively late stage. DNA faeces tests so far have mainly focused on detecting point mutations in only a limited number of genes, i.e. KRas, APC and p53. kRas mutations have proven not to be very informative, and testing for APC and p53 mutations is technically demanding, and thus expensive. In addition, substantial numbers of CRC do not carry these mutations.

More recently, DNA micro array -based tumor gene expression profiles have been used for cancer diagnosis. However, studies have been limited to a few cancer types and have spanned multiple technology platforms complicating comparison among different datasets. Expression analysis performed at the protein level has a number of drawbacks, the first being linked to the origin of the samples, i.e. the need for an invasive colonoscopy. The present invention shows that small RNAs (miRNAs and other small RNAs) can serve as informative biomarkers for early detection / secondary prevention of colorectal cancer and biological classification of established colorectal cancer in order to facilitate therapeutic decision making. As miRNAs and other small RNAs are produced from longer precursors it is also possible to use the precursor as a biomarker. As these RNA molecules are typically detected in groups, for instance, using (micro) arrays, the present invention also provides collection of probes for the detection of miRNAs, other small RNAs and/or precursors thereof. These collections are not only useful for the detection of said biomarkers in the context of colorectal cancer. They are also useful in other diagnostic tests to type or classify samples of nucleic acid. MiRNAs and other small RNAs are oligonucleotides of between 15 and 200 bases, preferably between 15-100 bases. Typically these RNAs are between 18 and 27 bases.

The invention therefore provides a collection of probes or primers for detecting at least 5, preferably at least 10, more preferably at least 20 of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre- miRNA sequences). In a preferred embodiment said collection of probes or primers comprises probes or primers for at least 100, more preferably at least 500 of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre-miRNA sequences). Preferably said collection of probes or primers comprises at least one probe for each of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre-miRNA sequences). In a preferred embodiment said collection of probes or primers comprises probes or primers for detecting nucleic acid molecules of table 23 (the miRNA and star sequences). Collections of these probes or primers more accurately classify samples, presumable because these molecules and not the precursors are functional in a cell. In a preferred embodiment a collection of probes of the invention comprises the nucleic acid sequences identified in table 21. These collections are particularly suited for diagnostic tests. The expression levels of nucleic acid molecules identified in table 23 or in table 24 can be determined by labelling the small RNA complement of a sample, for example by direct chemical crosslinking of label to the RNA backbone, end-labelling by adapter ligation or RNA extension, and subsequent hybridization to reverse complement DNA probes (for instance as depicted in table 21) under stringent conditions using state-of- the-art techniques. Other, potentially more sensitive methods for small RNA detection have been described, including the use of DNA-modified probes (e.g. locked-nucleic-acid LNA probes) for hybridization and nucleic acid amplification-based methods using primers specific for the nucleic acid molecules identified in table 23 or in table 24. A preferred method of amplification is real-time PCR. Means and methods for amplifying miRNA or other small RNA molecules and precursors thereof are described in Lee et al (2006) Int. J. Cancer VoI 120, pp 1046-1054; Gaur et al (2007) Cancer Res Vol. 67, pp. 2456-2468; Bandres et al (2006) Molecular Cancer VoI 5: 29). Hybridization is preferably performed under stringent conditions. Hybridization stringency regulates the percentage of nucleotides which must match on two unrelated single- stranded nucleic acid molecules before they will base pair with each other to form a duplex, given a certain set of physical and chemical conditions. The hybridization stringency is used to determine when a hybridization probe and a target nucleic acid will come together, and can be set by the researcher by varying the conditions. In general, if the percentage of matching nucleotides is lower than 90 percent, the two single- stranded nucleic acid molecules are considered nonhomologous and any hybridization is considered nonstringent. Conditions which can be used for stringent hybridization of the probes and primers of the invention are known to person skilled in the art. Other conditions can be obtained by a person skilled in the art by comparing hybridization of the probe or primer with a sequence that has more than 10 percent mismatches with the target sequence. In this way conditions can be selected that allow discrimination between the amount of hybridization to the unmodified target sequence and the sequence having 10 % mismatches. Typically, though not necessarily, not all of the probes give a signal when analysing nucleic acid samples. However, starting with a collection of probes of the invention one can easily compare levels of nucleic acid of table 23 or table 24, for instance through hybridization of the respective probes and select probes for inclusion in the diagnostic test on the basis of the levels of hybridization. An obtained pattern for the levels of the nucleic acids such as the pattern obtained for the levels of hybridization to the respective probes is indicative for the type of sample tested. Different types of samples give different patterns and can thus be classified on the basis of pattern. To this end the invention provides the use of a collection of probes or primers of the invention for detecting the levels of at least 10 nucleic acid molecules of table 23 or table 24, preferably through detecting hybridization of nucleic acid from a sample to a collection of probes of the invention. The same types of samples often show a limited amount of variation with respect to the patterns they produce. It is possible to select probes or primers that produce more homogeneous patterns by testing a number of samples. To this end in a preferred embodiment the invention provides a method for selecting probes for testing nucleic acid samples said method comprising hybridizing nucleic acid from a representative number of said samples to a collection of probes according to the invention, quantifying hybridization of said probes with nucleic acid in said representative number of samples, and selecting a subset of probes from said collection of probes, that (characteristically) hybridizes to nucleic acid of said sample or that (characteristically) not hybridize to said nucleic acid of said sample. The characteristic pattern can comprise specifically detected and/or specifically not detected small RNAs. The selected subset of probes can be used to determine whether a test sample is likely to be of the type of sample the probes are selected for. The selected subset of probes are detectable and thus identify nucleic acid molecules of table 23 or table 24 that are present in the representative number of samples. These identified nucleic acid molecules can subsequently further be detected by a number of other methods as discussed herein above. One, non-limiting other method is real-time PCR using primers that are specific for the particular nucleic acid molecules. The likelihood of a correct typing of the sample improves when the method of selection involves two different types of samples and probes or primers are selected that detect differences in the levels of nucleic acid molecules, preferably through exhibit differential levels of hybridization between the two types of samples. Typically one type of sample is used as a reference whereas the other is of the same type as the type the test sample is to be tested. To select probes the invention provides a method for selecting a collection of probes that discriminates between at least two types of samples comprising nucleic acid from cells said method comprising hybridizing nucleic acid from a representative number of samples of said at least two types of samples to a collection of probes according to the invention, - quantifying hybridization of said probes with nucleic acid in said samples, and selecting a subset of probes from said collection of probes, that discriminates between said at least two types of samples. The selected subset of probes identify nucleic acid molecules of table 23 or table 24 that are differentially present in the at least two samples. These identified nucleic acid molecules can subsequently further be detected using a number of other methods as discussed herein above. One, non-limiting other method is realtime PCR using primers that are specific for the particular nucleic acid molecules. Collections of probes or primers of the invention are particularly suited for typing human cells, thus preferably said cells are human cells. They are further suited for inclusion into a test that distinguishes, types and/or discriminates between different types of samples. Diagnostic tests are preferred. Such tests are able to identify, distinguish, type and/or discriminate samples from an individual. The at least two samples can be derived from different parts of the body, however, preferably the at least two samples are from the same tissue but different in for instance, developmental stage or disease stage. The at least two samples do not have to be derived from the same body or individual. In fact, often the test sample and a reference sample are derived from different individuals. A method of selecting probes can distinguish 2 samples (when they are different). In a diagnostic test it will often not be a comparison of two samples, but merely a comparison of the expression profile (hybridization levels) of the test sample with the predefined levels found based upon the training set of the diagnostic test. These last levels will lead to a classification rule (algorithm) in a computer program and the expression levels found in a test sample will be classified according to that rule. So in practice, the actual test no longer requires a comparison between a reference and a test sample, but only the comparison with a reference.

The predictive value of classifiers as described above can be further improved. A first way would be to increase the sample set this reduces noise and leads to the selection of more predictive small RNAs. This can in some cases increase the accuracy of prediction and decrease the error rate. However, in other cases the predictive value of a diagnostic test has already reached its limit and increasing the sample set will not result in a more accurate predictive set. A further way to improve the predictive value of a diagnostic test of the invention is to combine the dataset based on the microarray data with other data sets. For example, a diagnostic test of the invention may combine data based on the small RNA expression levels with array CGH data obtained from the same samples. This can result in a more accurate prediction of disease state. A further option is to use combined diagnostic tests in a step-wise procedure, where the first diagnostic test will have the best predictive value. For some individuals that are difficult to classify with a method of the invention, a further diagnostic test will follow that will ultimately result in a diagnosis of the disease state. Where the second test on its own might not have given a clear answer, in combination with a method of the invention, a defined and reliable diagnosis can be given also for individuals or samples that are difficult to classify with high confidence with a method of the invention.

A sample can comprise cells. In a preferred embodiment the sample comprises colon cells, colon derived tumor cells or nucleic acid derived therefrom.

Typically, however, a sample has undergone some type of manipulation prior to analysing the presence or absence therein of a miRNA, a small RNA and/or hairpin RNA according to the invention. Such manipulation, typically, though not necessarily comprises isolation of at least (part oi) the nucleic acid of the cells. The nucleic acid in a sample may also have undergone some type of amplification and/or conversion prior to analysis with a method of the invention. miRNA or a small RNA or a precursor thereof can be detected directly via complementary probe specific for said miRNA or small RNA or indirectly. Indirect forms include, but are not limited to conversion into DNA or protein and subsequent specific detection of the product of the conversion. Conversion can also involve several conversions. For instance, RNA can be converted into DNA and subsequently into RNA which in turn can be translated into protein. Of course such conversions may involve adding the appropriate signal sequences such as promoters, translation initiation sites and the like. Other non-limiting examples include amplification, with or without conversion of said miRNA or small RNA in said sample for instance by means of PCR or NASBA or other nucleic acid amplification method. All these indirect methods have in common that the converted product retains at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA, for instance in the nucleic acid sequence or in the amino acid sequence or other sequence. Indirect methods can further comprise that nucleotides or amino acids other than occurring in nature are incorporated into the converted and/or amplified product. Such products are of course also within the scope of the invention as long as they comprise at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA. By at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA is meant that the converted product (or an essential part thereoi) is characteristic for the miRNA, a small RNA and/or hairpin RNA of which the presence or absence is to be determined. A preferred small RNA is a miRNA. A hairpin RNA is herein also referred to as a precursor of a miRNA. The hairpin does not have to contain the entire sequence of the precursor but contains at least the stem loop structure.

A diagnostic test of the invention is particularly suited for distinguishing, typing and/or discriminating between different stages of disease. A diagnostic test of the invention preferably comprises a test that detects illness in an animal, preferably a primate, more preferably a human. A diagnostic test or a set/collection of probes of the invention is particularly suited to discriminate between different types of colon cells. A diagnostic test or a set/collection of probes of the invention are particularly suited to discriminate between samples comprising nucleic acid of normal colon cells, colon adenoma cells and/or colon carcinoma cells. A diagnostic test of the invention is particularly suited for distinguishing, typing and/or discriminating samples of different stages of tumorigenesis. Thus preferably at least one of said at least two types of samples comprises nucleic acid from tumor cells. In a particularly preferred embodiment said tumor cells are colon tumor cells. A tumor or tumour is an abnormal growth or mass of tissue. A tumor can be either malignant or benign. Preferred benign tumors are pre-malignant tumors, preferably adenomas. Nearly all tumors are examples of neoplasia, although certain developmental malformations or inflammatory masses may occasionally be referred to as tumors. This latter meaning is not intended herein. Tumors are typically caused by mutations in DNA of cells, which interfere with a cell's ability to regulate and limit cell division. Some of these mutations involve loss or gain of large parts of chromosomes (typically at least 100 megabases). Such loss or gain mutations often involve chromosome arms. An accumulation of mutations is needed for a tumor to emerge. Mutations that activate oncogenes or repress tumor suppressor genes can eventually lead to tumors. Cells have mechanisms that repair DNA and other mechanisms that cause the cell to destroy itself by apoptosis if DNA damage gets too severe. Mutations that repress the genes for these mechanisms can also eventually lead to cancer. A mutation in one oncogene or one tumor repressor gene is usually not enough for a tumor to occur. A combination of a number of mutations is necessary. As a result of the transformation tumor cells express genes and RNAs at levels that differ from their normal counterpart. The same holds true for different stages of tumorigenesis. Later stages express genes and RNAs at different levels when compared to less progressed stages. In the present invention it was further found that tumor progression can be monitored by determining the level of RNA using a collection of probes of the invention. It was found that differences in the level of RNA in samples of different stages of the same type of tumor (e.g. colorectal epithelial neoplasia) produce different signatures that can be used to predict tumor progression. Thus differences in the level of specific RNAs of a tumor at a certain stage can be used to predict progression thereof, particularly within a specific time span. The prediction is more accurate for progression within two years, particularly within a year, more in particular within 6 months from the moment the sample was taken. A diagnostic test of the invention can thus be used to determine a prognosis for the individual or the future behaviour of the tumor. A diagnostic test of the invention is particularly suited to characterise a tumor. The invention therefore provides the use of a test of the invention, preferably a diagnostic test of the invention, for characterising a tumor. A diagnostic test of the invention can also be used to predict therapy outcome or efficacy of treatment or be used to follow the effect of a therapy. The invention therefore provides the use of a test of the invention, preferably a diagnostic test of the invention for predicting therapy outcome or predicting efficacy of treatment or for following an effect of a therapy. The invention further provides a kit for a diagnostic test of the invention said kit comprising a collection of probes or primers of the invention.

A tumor is preferably a tumor of the anus, bladder, bile duct, bone, brain, breast, cervix, colon/rectum, endometrium, esophagus, eye, gallbladder, head/neck, liver, kidney, larynx, lung, mediastinum (chest), mouth, ovaries, pancreas, penis, prostate, skin, small intestine, stomach, tailbone, testicles or of the thyroid. A tumor is preferably a papilloma/carcinoma, a choriocarcinoma, an endodermal sinus tumor, a teratoma, a adenoma/adenocarcinoma, dysplasia, hyperplasia, intraepithelial neoplasia, squamous cell carcinoma, undifferentiated carcinoma, transitional cell carcinoma, carcinoma not otherwise specified, a soft tissue sarcoma, a melanoma, a fibroma/fibrosarcoma, lipoma/liposarcoma, a leiomyoma/leiomyosarcoma, a rhabdomyoma/rhabdomyosarcoma, a mesothelioma, an angioma/angiosarcoma, an osteoma/osteosarcoma, a chondroma/chondrosarcoma, a glioma or a lymphoma/leukaemia.

The invention further provides a method for selecting probes or primers of the invention for testing nucleic acid samples. Subsets of probes or primers are preferably selected from the collection of probes or primers for the nucleic acids of table 23 and/or table 24. A probe or a primer for a nucleic acid molecule of table 23 or table 24 is specific for said nucleic acid molecule when used under stringent conditions. Probes are preferably selected from the collection of probes of table 21. The selection is preferably done by comparing at least two types of samples with each other. As mentioned herein above, it is preferred that at least one of said types of samples is a particular type of tumor. Preferably said type of sample is a particular stage of tumor type. Preferred stages are the benign stage of a tumor, the progressed but not yet metastasized stage and the metastasized stage. Thus the progressed (i.e. locally invasive) but not yet metastasized stage and the respective metastasized stages (i.e. locoregional lymph node metastasis and metastasis to distant organs). It is preferred that at least one other type of sample is a reference sample. The reference sample can be any type of sample. It is preferred that when the test type of sample is of a human, the reference sample type is also human. In one preferred embodiment said reference sample comprises normal cells, preferably from the type of cells that the tumor originated from. Normal cells, counterpart ect. are used herein typically to refer to unaffected cells, counterpart etc, such as are preferably obtained from a healthy individual. In another preferred embodiment said normal cells are obtained from an affected individual but from a site that is not affected by the disease. In a preferred embodiment said normal cells are of the same type of cells that the test sample is derived from and that are suspected of containing diseased cells. In another preferred embodiment the reference sample is the same type of tumor but at a different stage of progression. In yet another preferred embodiment the reference sample is of a different tissue, preferably from blood. In a preferred embodiment the sample and the reference (sample) is a blood sample. A preferred type of blood sample is whole blood, preferably peripheral whole blood or a fraction thereof. A preferred fraction is the fraction of peripheral blood mononuclear cells (PBMC). The small RNA or precursors do not have to be present in intact cells in the blood but can also be present in free form or associated with cell debris or in protein bound complexes. Thus in another preferred embodiment said blood sample comprises serum or plasma. Plasma and serum are particularly suited to detect a nucleic acid molecule of table 23 or table 24 that is not normally present in blood cells. A tumor sample can be obtained in a number of ways. A preferred sample is a biopsy sample. Another preferred sample is a fine needle aspirate (FNA), stool or faeces sample. Such samples contain cells and cell derivatives from which RNA can be prepared. These samples are particularly useful when the individual is suffering from or suspected of suffering from a colon tumor. The invention thus further provides method for detecting cells in a faeces sample comprising detecting small RNA or precursors therefore in said sample. The small RNA or precursors therefore do not have to be present in intact cells in faeces but can also be associated with cell debris or in protein bound complexes. The invention thus further provides method for detecting small RNA or precursors thereof in a faeces sample comprising detecting small RNA in said sample. In a preferred embodiment said method comprises detecting the level of nucleic acid molecules identified in table 8, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 23, table 24 and/or table 34. Preferably the level of the nucleic acid molecules identified in table 11a and/or table lib is detected. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 12a, table 12b, table 12c and/or table 34 is detected.

Many tumors, particularly at the later stages shed cells into the blood stream. These cells can be detected. Using a method for selecting probes of the invention it is possible to select probes that distinguish, type or discriminate samples of blood from healthy individuals from samples of blood from individuals that suffer from a particular type of tumor. Further provided is a method for detecting cells in a sample of blood or a fractionated part thereof, comprising detecting small RNA in said sample. The sample itself does not have to contain cells. Particularly in blood it is possible that cells can be detected that have shed the indicative nucleic acid into the blood stream, for instance upon death of said cell. Detection of this nucleic acid in the blood, plasma or serum is indicative for the cell that has shed nucleic acid in the blood stream. The cells to be detected are preferably tumor cells, more preferably colon tumor cells. In a preferred embodiment the level of nucleic acid molecules identified in table 13, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, or table 18c, table 23, table 24 and/or table 35 is detected. Preferably the level of the nucleic acid molecules identified in table 16a and/or table 16b is detected. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 18a, table 18b, table 18c and/or table 35 is detected.

The selection methods described herein above yield collections of probes or primers that can be used to distinguish, type and/or discriminate samples containing nucleic acid from cells. As a result the invention provides collections of probes or primers that are obtainable by such a method. In a further aspect the invention provides a subset comprising at least ten probes for the nucleic acids of table 23 and/or table 24. The invention further provides a collection of probes comprising the nucleic acid molecules identified in table 21. A subset of probes is preferably a subset of the collection of the probes of table 21. In a preferred embodiment said subset comprises at least 10 of the probes of table 21.

In a particularly preferred embodiment the invention provides a subset of probes of the collection of probes of table 21, comprising and/or consisting of the probes identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c or table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b and/ or table 33. In another preferred embodiment said subset of probes from the collection of probes of table 21, comprises and/or consists of the probes identified in table 8 or table 13. In a particularly preferred embodiment the invention provides a subset of probes or primers for detecting nucleic acid molecules of table 23 or table 24, comprising and/or consisting of probes or primers for the nucleic acid molecules identified in table 1, table 2a,table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/ or table 35. In another preferred embodiment said subset of probes or primers for detecting nucleic acid molecules of table 23 or table 24, comprises and/or consists of the probes or primers for the nucleic acid molecules identified in table 8 or table 13.

The invention further provides a method for determining whether a sample comprises nucleic acid from a particular type of cells said method comprising hybridising nucleic acid from said sample to a collection of probes for the nucleic acid molecules as identified in table 1, table 2a,table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18, table 19c, table 19d, table 20, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/ or table 35, quantifying hybridization of said probes with nucleic acid in said samples, and comparing the result of said quantification with a reference. In a preferred embodiment said cells are tumor cells or suspected of being tumor cells. Preferably said cells are colon cells. The invention further provides a subset of probes or primers according to the invention, comprising probes or primers for each of the nucleic acids identified in table 1, table 2a,table 2b,table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 20, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/ or table 35. Further provided is a subset of probes or primers from the collection of probes or primers of the invention, comprising probes or primers for each of the nucleic acids identified in table 8 or table 13. In a preferred embodiment said cells are tumor cells or suspected of being tumor cells. Preferably wherein said cells are colon cells.

A nucleic acid molecule of the invention such as a probe or primer often can contain a nucleotide analogue. Many analogues are presently available that mimic at least some of the base pairing characteristics of the "standard" nucleotides A, C, G, T and U. Alternatively, nucleotide analogues such as inosine can be incorporated into a nucleic acid molecule of the invention. Other types for analogues include LNA, PNA, morpholino and the like. Further methods for the specific detection of nucleic acid include but are not limited to specific nucleic acid amplification methods such as polymerase chain reaction (PCR) and NASBA. Such amplification methods typically use one or more specific primers. A primer or probe preferably comprises between 12-40 nucleotides having at least 90% sequence identity to a sequence as depicted in table 23 or table 24, or the complement thereof. A probe, primer or nucleic acid molecule of the invention is preferably single stranded. However, for shipping, production and or therapeutic purposes a double stranded molecule is sometimes preferred. For example a miRNA or small RNA is processed in the cell in double stranded form. Such analogues are considered to be a functional equivalent of a nucleic acid molecule such as a probe or a primer of the invention, when they exhibit the same hybridization characteristics under stringent conditions in kind, not necessarily in amount.

The invention further provides a method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 1 in said sample, and comparing the result of said quantification with a reference.

Further provided is a method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 2a,table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table lib, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/ or table 35 in said sample, and comparing the result of said quantification with a reference. In this embodiment it is preferred that said reference is a quantification of the levels of the same nucleic acid molecules for a sample comprising nucleic acid from adenocarcinoma cells or from normal cells.

The invention further provides a method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table lib, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference. In this embodiment it is preferred that the level of the nucleic acid molecules identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table lib, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 is quantified. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 4c, table 4d, table 7a, table 25a and/or table 26 is quantified. In this embodiment it is preferred that said reference is a quantification of the levels of the same nucleic acid molecules for a sample comprising nucleic acid from adenoma cells or from normal cells. In a preferred embodiment said normal cells are brushed cells from normal colon mucosa.

In one aspect the invention provides a method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 1, quantifying hybridization of said probes with nucleic acid in said samples, and comparing the result of said quantification with a reference. In another aspect the invention provides a method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 2a,table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table lib, table 12 a and c, table 14a, table 14b, table 16a, table 16b, table 18a and c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/or table 35,,, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference. In a preferred embodiment said reference is a quantification of a hybridization of a reference sample with said collection of probes. Preferably said reference sample comprises nucleic acid from adenocarcinoma cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table lib, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 20, table 21, table 25a, table 26, table 27, table 34 and/ or table 35. In another preferred embodiment said reference sample comprises nucleic acid from normal cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified table 2a,table 2b, table 2c, table 2d, table 5a, table 9a, table 9b, table 12a, table 14a, table 14b, table 18a, table 20 and/or table 21.

In another aspect the invention provides a method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table lib, table 12b and c, table 15a, table 15b, table 16a, table 16b, table 18b and c, table 19c, table 19d, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35,, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference. In a preferred embodiment said reference is a sample comprising nucleic acid from adenoma cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table lib, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. . In another preferred embodiment said reference is a sample comprising nucleic acid from normal cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 3a, table 3b, table 3c, table 3d, table 6a, table 10a, table 10b, table 12b, table 15a, table 15b, table 18b, table 19c, table 19d and/or 21. In a preferred embodiment said normal cells are blood cells or brush cells from normal colon.

It has been found that probes or primers for miRNAs, small RNAs and/or their precursors are particularly suited for detecting cells that have a chromosomal aberration. The invention thus further provides the use of a collection of probes or primers for miRNAs, small RNAs or their precursors, for classifying cells as cells that contain a chromosomal aberration. These aberrations typically involve a significant part of a chromosome. The aberrations can be the direct origin of the miRNA or small RNA that is being tested for.

Alternatively, as miRNA and small RNA regulate the expression of other transcription units and are themselves derived from transcription, the aberration can be detected through its action on the levels of particular miRNA, small RNA or the precursor thereof in a cell. This aspect of the invention is particularly suited for detecting tumor cells that have chromosomal aberrations, and consequently are prone to progression from a premalignant to malignant stage, or have already done so. Preferably said tumor cells are colon tumor cells. This aspect can be used to detect aberrations involving segments of DNA in a chromosome that encode one or multiple small RNAs. In principle it is possible to detect even smaller aberrations. A particularly preferred type of aberration is the loss or gain of a part of a chromosome, preferably a gain of 7pq, 8q, 13q or 2Oq or a loss of 4pq, 5q, 8p 15q, 17p or 18q, particularly preferred is a loss of chromosome 8p or 17p. In a preferred embodiment said loss of a chromosome 8p or 17p is detected using at least one probe or primer for nucleic acid molecules of table 23 or table 24, as identified in table 19c (for loss of 8p) or table 19d (for loss of 17p). Preferably said loss of a chromosome 8p or 17p is detected using at least 5, more preferably at least 10 and most preferred all of the probes or primers for nucleic acid molecules of table 23 or table 24, as identified in table 19c (for loss of 8p) or table 19d (for loss of 17p). A sample can be any type of sample as long as it contains nucleic acid. It is preferred that said sample contains complex nucleic acid, preferably nucleic acid derived from a cell. A collection of probes of the invention can be used to analyze any type of nucleic acid, be it DNA, RNA or an analogue thereof having the same hybridization characteristics in kind not necessarily in amount. In a preferred embodiment said nucleic acid comprises RNA derived from cells. This aspect of the invention is useful for determining levels of different RNAs in the cells. In a particularly preferred embodiment the sample is enriched for RNA, preferably for RNA that is smaller than 500 nucleotides. In a particularly preferred embodiment said sample is enriched for RNA that is about 200 nucleotides. Thus in a preferred embodiment a collection of probes or primers of the invention, or a method of the invention involving detecting of a nucleic acid molecule of table 23 or table 24, is used to detect RNA in a sample, preferably small RNA.

MiRNAs and other small RNAs are found to be relevant for the tumorigenic state of a tumor. The invention provides miRNA precursors thereof that are up or down regulated in a tumor when compared to normal cells, or up or down regulated in a progressed form of said tumor when compared to the less progressed state. It is thus possible to counteract this level by increasing the level when it is down regulated or decreasing the level when it is upregulated. In this way it is possible to intervene with the tumor or the tumor state. Thus the invention further provides a method for the treatment and/or prevention of a disease in an individual comprising administering to said individual at least one nucleic acid molecule of table 23 or table 24, at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, or a functional equivalent of said at least one nucleic acid molecule. Preferably said individual is suffering from colon cancer or is at risk of suffering therefrom. Said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is preferably a nucleic acid molecule of table 2a,table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d or table 20, table 25a, table 26, table 27, table 34 and/ or table 35, or a functional equivalent thereof. For the treatment of disease, it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table lib, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/ or table 35 or a functional equivalent thereof. For treatment it is particularly preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 19c, table 19d, table 20, table 26, table 27 and/or table 33, or a functional equivalent thereof. In a particularly preferred embodiment it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof is a nucleic acid molecule of table 4c, table 4d, table 19c, table 26, table 27 and/or table 33. Using at least one of these nucleic acid molecules for the treatment it is possible to modify cells of a progressed tumor (preferably an adenocarcinoma tumor) such that they become less progressed (preferably resembling a more adenoma phenotype). For the prevention of disease, it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 2a,table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table lib, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/ or table 35 or a functional equivalent thereof. For prevention it is preferred that at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, comprises a nucleic acid molecule of table 2a, table 2b, table 2c, table 2d, table 4a, table 5a, table 7a, table 20, table 25a, table 26 and/ or table 27 or a functional equivalent thereof. Using at least one nucleic acid molecule for prevention of disease it is possible to modify cells of a benign stage such that the propensity for tumor progression is reduced in these cells.

In case of a nucleic acid molecule that is downregulated it is preferred that said nucleic acid molecule is provided to the cell wherein it is downregulated. To this end it is preferred that said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2d, table 3d, table 4d, table 19c, table 19d, table 27 or table 33. In a preferred embodiment said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2d, table 3d, table 4d, or table 27 or a functional equivalent thereof. These preferred nucleic acid molecules are highly correlated with the tumor or tumor stage and or thus effective in a larger fraction of the tumors (stage). In case of a nucleic acid molecule that is up regulated it is preferred that said nucleic acid molecule is reduced in the cell wherein it is up regulated. To this end it is preferred that said at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2c, table 3c, table 4c or table 19c or table 19d. Preferably said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2c, table 3c or table 4c, or a functional equivalent thereof. These preferred nucleic acid molecules are highly correlated with the tumor or tumor stage and or thus effective in a larger fraction of the tumors (stage). In one embodiment the invention provides a pharmaceutical composition, comprising as an active agent at least one nucleic acid molecule of table 23a or table 24a, or a nucleic acid molecule comprising the reverse complement of at least one nucleic acid molecule of table 23a or table 24a or a functional equivalent of such nucleic acid molecules, and optionally a pharmaceutically acceptable carrier. A pharmaceutical composition according to the invention further optionally comprises another additive. Such another additive can for example be a preservative or a colorant. Alternatively an additive is a known pharmaceutically active compound. A carrier is any suitable pharmaceutical carrier. A preferred carrier is a compound that is capable of increasing the efficacy of a nucleic acid molecule to enter a target-cell. Examples of such compounds are liposomes, particularly cationic liposomes. A composition is for example a tablet, an ointment or a cream. Preferably a composition is an injectable solution or an injectable suspension. In one embodiment the invention provides a pharmaceutical composition according to the invention for diagnostic applications. In another embodiment the invention provides a pharmaceutical composition according to the invention for therapeutic applications. In a preferred embodiment the invention provides a pharmaceutical composition according to the invention, as a modulator for a developmental or pathogenic disorder. In a preferred embodiment said developmental or pathogenic disorder is cancer. A miRNA molecule for example functions as a suppressor gene or as a regulator of translation of a gene. A method for the treatment of an individual to obtain therein a described effect, wherein said individual is provided with a small RNA, precursor thereof, or the reverse complement thereof as described herein, is similarly a use of said small RNA, precursor thereof, or the reverse complement for the preparation of a medicament for obtaining said described effect. A pharmaceutical preferably comprises a pharmaceutically acceptable carrier or excipient. A functional equivalent of a nucleic acid molecule of table 23a, for the purpose as a pharmaceutical, is preferably a nucleic acid comprising at least 12 and preferably at least 18 consecutive bases of the nucleic acid molecule of table 23a. The functional equivalent nucleic acid may have 1 or 2, preferably only 1 mismatch with the nucleic acid of table 23a. Preferably there are no mismatches in said consecutive stretch.

A functional equivalent of a nucleic acid of table 24a is a nucleic acid having at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to a nucleic acid of table 24a. The sequence of the small RNA therein is preferably a nucleic acid comprising at least 12 and preferably at least 18 consecutive bases of the small RNA nucleic acid molecule of table 23a. The corresponding small RNA part preferably comprises no more than 2 nucleic acid mismatches. In a particularly preferred embodiment the sequence of the small RNA in said functional equivalent is exactly the same as the sequence thereof given in table 23a.

A functional equivalent of a nucleic acid molecule comprising the reverse complement a nucleic acid molecule of table 23a is preferably a nucleic acid comprising the reverse complementary sequence of at least 12 and preferably at least 18 consecutive bases of the nucleic acid molecule of table 23a. The functional equivalent nucleic acid may have 1 or 2, preferably only 1 mismatch with the reverse complement nucleic acid of table 23a. Preferably there are no mismatches in said consecutive complementary stretch. A functional equivalent of the reverse complement a nucleic acid molecule of table 24 is a nucleic acid of which its reverse complement has at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to a nucleic acid of table 24a.

A nucleic acid molecule for use as a pharmaceutical is preferably a nucleic acid molecule as identified in table 2d, 3d, 4d, 19c, 19d, 28a, table 28b, table 30, table 32a, table 32b, or 33. Preferably said nucleic acid molecule is also identified in table 19c, table 19d, table 20, table 26 and/or table 27.

A nucleic acid molecule that comprises a reverse complement of a nucleic acid of table 23a is preferably a nucleic acid molecule as identified in table 2c, table 3c, table 4c, table 31a or table 31b. Preferably said nucleic acid molecule is also identified in table 20, table 26 and/or table 27.

A nucleic acid molecule for use as a pharmaceutical as described herein can be an RNA molecule, a DNA molecule, a hybrid thereof or other be modified. For instance, many variants of the naturally occurring bases are known and many more will likely be developed. These synthetic bases can share the same hydrogen bonding characteristics with it natural counterpart. These synthetic bases can be incorporated into a nucleic acid of the invention. A nucleic acid molecule of the invention therefore can include one or more of such synthetic bases. A nucleic acid molecule of the invention can be modified to obtain a desired effect. Examples of nucleic acid molecules comprising such modifications are locked nucleic acid modifications (LNA), morpholino modifications and other modifications. Furthermore, the backbone can be modified to provide resistance to RNAseH. A nucleic acid molecule of the invention may comprise modifications to obtain a variety of effects. For instance, the nucleic acid molecule may be modified to enhance stability, hybridization characteristics, cellular uptake, circulation half life, and targeting of the nucleic acid.

A nucleic acid molecule according to the invention is administered by any suitable known method. The mode of administration of a pharmaceutical composition of course depends on its form. In a preferred embodiment a solution is injected in a tissue. A nucleic acid molecule according to the invention is introduced in a target cell by any known method in vitro or in vivo. Said introduction is for example established by a gene transfer technique known to the person skilled in the art, such as electroporation, microinjection, DEAE-dextran, calcium phosphate, cationic liposomes or viral methods.

A nucleic acid of the invention, such as a small RNA, a miRNA, a precursor thereof or the reverse complement of the mentioned molecules can be administered directly to a cell or an individual, or through a gene delivery vehicle. The gene delivery vehicle preferably comprises an expression cassette containing a promoter and other transcription regulatory and signaling sequences to express the small RNA, a miRNA, a precursor thereof or the reverse complement thereof. The gene delivery vehicle is preferably a viral vector or a plasmid.

The invention further provides the use of a nucleic acid molecule of table 23 or table 24, as a drug target. Preferably provided is the use of a nucleic acid molecule of table 3a, table 4a, table 20, table 26, table 27 or table 33, as a drug target. Also provided is the use of a nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, for identifying a molecular process in a cell that is contributing to a disease or a disease state. Preferably provided is the use of a nucleic acid molecule of table 3a, table 4a, table 20, table 26, table 27 or table 33, for identifying a molecular process in a cell that is contributing to a disease or a disease state.

In yet another embodiment the invention provides a collection of nucleic acid molecules comprising the nucleic acid molecules of table 23 or table 24. Also provided is a subset of this collection of nucleic acids comprising at least 10 of the nucleic acids identified in table 23 or table 24. In a preferred embodiment said subset comprises the nucleic acid molecules identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table lib, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. In a particularly preferred embodiment said subset comprises the nucleic acid molecules identified in table 2d, table 3d, table 4d, table 26, table 27 and/or table 33. In another preferred embodiment said subset comprises the nucleic acid molecules identified in table 8 or table 13.

A probe or primer of the invention can be longer than the region of complementarity with the sequence of table 23 or table 24. For a probe, the reverse complement of the sequence depicted in table 23 or table 24 is preferably incorporated into another nucleic acid. This separates the probe sequence from a surface to which it is attached. Such a probe typically exhibits improved hybridization characteristics. A probe or primer of the invention contains at least 7 consecutive nucleotides that together are the reverse complement of a sequence of the same length in the nucleic acid molecule of table 23 or table 24. Preferably said probe or primer contains at least 12, more preferably at least 16 of such consecutive nucleotides. In a particularly preferred embodiment said probe comprises the reverse complement of the entire sequence given for the nucleic acid molecule of table 23 or table 24. A probe or primer specific for a nucleic acid molecule of table 23 may have 1 or 2, preferably only 1 mismatch (in the consecutive stretch of complementarity) with the nucleic acid of table 23 it is specific for. Preferably there are no mismatches in said consecutive stretch. A probe or primer for that is specific for a nucleic acid of table 24 comprises at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to the reverse complement of the nucleic acid comprising the region of complementarity of the corresponding nucleic acid of table 24. A primer is typically though not necessarily between 10-30 nucleotides long. A primer can contain one or more nucleotides in addition to the region of complementarity. These sequences can, for instance, be used to attach a label.

A collection of probes of the invention is preferably associated or physically linked to a solid surface. The solid surface is preferably a microarray. In another preferred embodiment a collection of probes is associated or physically linked to a collection of beads. Preferably, the individual probe are associated or physically linked to different beads such that each bead contains essentially one probe.

A collection of probes or primers of the invention preferably comprises probes or primers specific for nucleic acid molecules of table 23a or table 24a. A collection of the invention, of course preferably contains different nucleic acid molecules. When herein a collection is said to have at least a certain number of nucleic acid molecules given in the tables, or probes or primers specific therefore, it is preferred that at least said certain number of these nucleic acid molecules, probes or primers is different. In addition to this number of different ones there may be additional identical ones. A collection of probes or primers or a subset thereof of the invention are preferably used for the detection of one or more nucleic acid molecules of table 23 or table 24. However, such collections can also serve other purposes, for instance therapeutic purposes. When herein reference is made to a collection of probes or primers of the invention, this typically also includes subsets of collection of probes and primers. The same holds true for collections of nucleic acid molecules or the reverse complement thereof. The invention further provides a collection of nucleic acid molecules comprising the reverse complement of the nucleic acid molecules of table 23 or table 24. A non-limiting use of such collection is a collection of probes for the molecules of table 23 or table 24.

A collection of probes or a subset of probes of the invention preferably comprises no more than 15.000 different probes, preferably no more than 12.000 probes, preferably no more than 10.000 and more preferably no more than 7.000 probes, particularly for probes specific for nucleic acid molecules of table 23a or table 24a. Said preferred maximum amounts are increased by 1000 when also the probes specific for nucleic acid molecules of table 23b or table 24b are included. In a particularly preferred embodiment the collection of probes comprises a maximum of 5000 probes, preferably a maximum of 4000 probes, preferably a maximum of 3000 probes, preferably a maximum of 2000 probes, preferably a maximum of 1000 probes, preferably a maximum of 500 probes. A subset of probes or the invention is preferably present in an array. Preferably a micro-array. Preferably a collection of proves of the invention is associated with a solid surface.

In a preferred aspect the invention provides a collection of probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and/or 6a. These collections are particularly suited to discriminate colorectal adenoma cells from normal colon cells (table 5a), colorectal carcinoma cells from normal colon cells (table 6a), and colorectal adenoma cells from colorectal carcinomal cells (table 25a). In a preferred embodiment said collection of probes or primer comprises probes or primers for detecting each of the nucleic acid molecules of table 25a and table 5a. Particularly preferred is a collection of probes or primers, comprising probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and table 6a. Preferably said collections of probes or primers are used for discriminating between normal colorectal tissue, colorectal adenoma and colorectal adenocarcinoma. In the present invention it was found that the small RNA of table 23 or the precursors thereof of table 24 are particularly suited to map micro alterations in the chromosomal DNA. It was found that colon carcinoma contain various characteristic micro-deletions and micro-gains (amplifications) of chromosomal DNA. Micro in this context means deletions or gains of less than 3 megabases of chromosomal DNA. Several locations were identified in colon carcinoma cells that are subject micro-deletions and/or microgains. The invention thus further provides a method for determining whether a colon cell comprises a deletion of less than 3 megabases in chromosomal region Ip32.2, Iq21.1, Iq22, 6p22.2, 7pl5.2, Ilpl5.5, 16ql2.2 or 17p 13.1 comprising determining whether said cell comprises a deletion of DNA coding for a small RNA as identified in table 28a, or a precursor thereof. Said microdeletions can be detected in various ways including PCR and other amplification strategies using primers that are specific for the deletion or the boundaries thereof. Preferably said method comprises the step that nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof. Preferably said small RNA is a small RNA as identified in table 28b. A method of this embodiment is particularly suited for typing a cell as a colon carcinoma cell. Thus a colon cell comprising a deletion as indicated herein above is a colon carcinoma cell. Thus a method of this embodiment preferably further comprises typing said cell as a colon carcinoma cell. Preferably said small RNA is a small RNA as identified in table 30. The micro- deletion characterised by the small RNAs of table 30 are characteristic for microsatellite stable colon carcinoma cells. A method of this embodiment thus preferably further comprises typing said cell as a microsatellite stable colon carcinoma cell.

In another preferred embodiment said small RNA is a small RNA as identified in table 32a or table 32b. Micro-deletions characterised by the absence of these small RNA or the corresponding precursors characterise microsatellite instable colon carcinoma cells. Preferably said small RNA is a small RNA as identified in table 32b. A method of this embodiment thus preferably further comprises typing said (colon) cell as a micros ate llite instable colon carcinoma cell.

The invention further provides a method for determining whether a colon cell comprises an additional chromosomal copy of less than 3 megabases of chromosomal region 5q31.3, 8p21.3, 9p21.3, lOplδ.l or 16ql3 comprising determining whether said cell comprises an additional copy of DNA coding for a small RNA as identified in table 29a, or a precursor thereof. Said microgains can be detected in various ways including PCR and other amplification strategies using primers that are specific for the amplified regions or the boundaries thereof. Preferably said method comprises a step wherein nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof. In a preferred embodiment said small RNA is a small RNA as identified in table 29b. Colon cells containing such microgains are colon carcinoma cells. Thus a method of the invention preferably further comprises typing said cell as a colon carcinoma cell. In a preferred embodiment said small RNA is a small RNA as identified in table 31a or table 31b. Preferably a small RNA is a small RNA as identified in table 31b. Microgains characterised by gains of these latter small RNA or precursors thereof are characteristic for microsate llite stable colon carcinoma cells. Thus preferably said embodiment further comprises typing said cell as a microsatellite stable colon carcinoma cell.

The invention further provides a method for the treatment of an individual suffering from a colon tumor comprising administering to said individual a nucleic acid comprising a nucleic acid as identified in table 28a, table 28b, table 30, table 32a, table 32b, or 33 or the precursor of said nucleic acid, or the reverse complement of a nucleic acid as identified in table 31b or a functional equivalent of said nucleic acid. By administering this nucleic acid a small RNA that is present in said (micro) deletion (table 28, table 30, table 32 and table 33) is provided to the colon carcinoma cell thereby supplementing the reduced level of said small RNA in said cell and thereby reducing a tumorigenic state thereof. Preferably said nucleic acid is a nucleic acid as identified in table 28b, table 32b or table 33.

By administering the reverse complement of a small RNA that is present in said microgain (table 31), the colon carcinoma cell is provided with a means for reducing the expression of the overexpressed therein. This reduces the tumorogenic state of said colon carcinoma cell. Preferably said nucleic acid comprises the reverse complement of a small RNA of table 31. Preferably the reverse complement of a small RNA of table 31b.

In a preferred embodiment the nucleic acid is provided as a nucleic acid encoding a precursor for the nucleic acid. The nucleic acid may be administered as indicated herein above. In brief, it may be administered as such and/or in the context of a gene delivery vehicle.

Examples

Example 1 MATERIALS AND METHODS

Samples

67 snap frozen human colorectal tumours (36 non-progressed adenomas and 31 adenocarcinomas) and ten samples of human normal colorectal epithelium obtained from histopathologically tumor free resection margins of colorectal cancer resection specimens were collected prospectively at the VU - University Medical Center (VUmc), Amsterdam, The Netherlands (Table 22). In addition, stool and blood samples from two other patients with colorectal cancer were collected. All samples were used in compliance with the institution's ethical regulations.

Total RNA isolation

RNA isolation was done using TRIzol and following the manufacture's protocol.

Briefly, tumours samples were homologized in 2 ml Trizol using a homogenizer. 0.4 ml chloroform was added to each sample and the tube was shaken vigorously. After 3 min of incubation at room temperature, the samples were centrifuged for 10 min at 12,000 rpm at 4°C. The upper aqueous phase was transferred to a new tube and 1 ml of isopropanol was added. Then the samples were incubated at room temperature for 10 min and centrifuged for 10 min at 12,000 rpm at 4 °C. The supernatant was removed by decanting and the pellets were washed by adding 1 ml of 70% ethanol and centrifuging for 5 min at 7, 500 rpm at 4°C. After the 70% ethanol was removed by decanting, the pellet was briefly spun down to remove the remaining ethanol using a sharp tip. Last, the pellet was dissolved in 100 μl RNAse-free water. Total RNA was cleanup performed using the RNeasy Mini Kit (QIAgen) and according to the manufacture's protocol. Briefly, a lysis buffer (RLT) was added and mixed well. After adding 100% ethanol the samples were transferred to an RNeasy Mini spin column and centrifuging for 15 s at >10,000 rpm. The flow-through was discarded and washing of the spin column was done twice with the RPE Buffer by centrifuging for 15 s (first washing) and 2 min (second washing) at > 10, 000 rpm. RNA was finally eluted in a new 1.5 ml tube in 2x 30 ul of RNase-free water by centrifuging for 1 min at >10,000 rpm and stored at -80°C until use. The quantity of the RNA samples was measured using a spectrophotometer and the quality was evaluated in by visual inspection on an agarose gel (1%).

RNA labeling and isolation of fraction of small RNA (<100 nt) RNA labeling and small RNA enrichement was done according Kreatech Biotechnologies' protocol (Kreatech, Amsterdam, The Netherlands). Labelled total RNA was prepared using 500 ng of total RNA as starting material, 0.5 μl of Cy3-ULS/ Cy5-ULS, 0.33 μl of 10x labeling buffer solution and water to a final volume of 3.3 μl. The mix was incubated 15 min at 85 °C and then placed on ice. Clean-up of the samples was carried out using KREApure columns. Columns were prepared for use by resuspending the column material using a vortex, inserting the column in a 2 ml collection tube and centrifuging 1 min at 20,80Og. Then the flow-through was discarded and the column was rewashed by adding 300 μl of water and centrifuging 1 min at 20,80Og. After cleaning, the column was placed into a new 1.5 ml tube and the ULS-labelled total material was pipetted onto the column and centrifuged 1.5 min at 20.80Og. The flow-through containing the labeled total RNA was placed on ice and 1 μl was taken to determine the degree of labelling by measuring the OD260 and OD550 (for Cy3-ULS) or OD650 (for Cy3-ULS). After labeling, the material was subjected to small RNA isolation by adding RNAses-free water to a 50 μl volume, 250 μl lysis buffer, 1.75 μl B-mercapto ethanol, 25 μl 2M sodium acetate (pH 4) and 175 μl ethanol (100%). The samples were then loaded into a RNA-binding column placed into a 2 ml collection tube and centrifuged at 16,00Og 30-60 sec. Following centrifugation, the column was discarded and 583 μl of 100% ethanol was added to the flow-through. Then, each sample was loaded into a new RNA-binding column placed into a 2 ml collection tube and centrifuged 30-60 sec at 16,00Og. Two loads of approximately 700 μl each were needed. Next, samples were washed first with 500 μl of low-salt wash buffer and centrifuged at 16.00Og for 30 sec and after discarding the flow-through with 300 μl of low-salt wash buffer were added and centrifuged at 16.00Og for 30 sec. After discarding the flow-through, 500 μl of fresh 80% ethanol was added in the column and centrifuged 30-60 sec followed by an additional 2 min centrifugation to dry the membrane. Last, 20 μl of RNAse-free water preheated at 60 °C directly onto the center of the column, incubated at room temperature for 2 min and centrifuged at 16.00Og for lmin. Last, the column was reloaded with the flow-through onto the center of the column, incubated 2 min at room temperature and centrifuged at 16.00Og for lmin. The flow- through containing the labeled small RNA fraction was kept on ice until used.

Hybridization procedures

Each of the small RNA enriched samples labeled with Cy3 was hybridized against a reference pool labeled with Cy5 containing total RNA from the above described tissue samples tumour samples, 61 tumor cell lines (59 tumor cell lines from the NCI-60 panel plus 2 other colorectal tumor cell lines) and placenta tissue. The rationale behind this common pool is to provide a reference signal to which all experiments can be compared. To make sure that a fold-change for every candidate miRNA can be calculated, the reference pool should give a positive signal for every candidate, which is ensured by including every sample in this pool.

The samples were prepared for hybridization by mixing equimolar amounts of Cy3 and Cy5-labelled samples Hybridization took place to a single subgrid of the 8xl5K Agilent microarray under standard conditions. Prior hybridization, each sample was heated at 60 °C in the dark for 2 min, centrifuged at 13,000rpm for lmin and place on ice until it was loaded on the array. Hybridization took place at 37°C for 17 hours at 10 rpm. Post hybridization washes were done at room temperature after careful removal of cover into the Wash solution 1 were the slides were kept for 1 min and then transfer to Wash solution 2, and wash for lmin. Last, the slides were immersed into wash solution 3 for 30 sec and then dried by air. Images of the arrays were acquired by scanning at 5 micron resolution (Agilent DNA Microarray scanner G2505B- Agilent technologies, Palo Alto, USA).

Array design

Design of the microarray was based on 474 human pre-miRNA sequences from miRBase 9.1 and 3315 human pre-miRNA sequences from PCT/NL2006/0000010. Positions of mature miRNA sequences within pre- miRNA were known from previous public and private cloning data. In cases where only the mature sequence corresponding to one of the arms of the pre- miRNA was known, the corresponding star sequence was predicted by folding the pre-miRNA using RNAfold (Vienna RNA package, Hofacker IL. (2003) Vienna RNA secondary structure server. Nucleic Acids Res. 31(13):3429-31) and selecting the sequence from the hairpin stem based on Dicer/Drosha cleaving properties (2 nt 3' overhang) and the position of cloned mature miRNA sequence. The first 22 nt of every cloned and predicted mature miRNAs were used for designing probes complementary to the respective miRNAs. In cases where the mature miRNA was shorter than 22 nt, it was extended with the corresponding sequence from the pre-miRNA. Agilent custom microarrays (Wolber PK, Collins PJ, Lucas AB, De Witte A, Shannon KW. (2006). The Agilent in situ-synthesized microarray platform. Methods Enzymol. 2006;410:28-57) were designed with 60 nt probe sequences. Every probe carries spacers (CGATCTTT) and two copies of miRNA- specific sequence: 5' - 22nt-miR - CGATCTTT - 22nt-miR - CGATCTTT - 3' where 22nt-miR is the reverse -complemented sequence of mature miRNAs selected as describe above. In addition, 13 non-overlapping 5S and 13 U6 22nt sequences were included into array as controls. These sequences were manually selected from proprietary small RNA cloning data. In total the array contained (2 x 474) + (2 x 3315) + 13 + 13 = 7604 probe sequences that were put in duplicates on every subgrid of the 8xl5k Agilent custom microarrays. A complete list of all probes included in the microarray is given in Table 21

Data analysis

Array processing and spot-calling was performed automatically using Agilent's FeatureExtraction software (9.5.3). Background subtractions, array normalization and extraction of gene expression values were performed by limma package from Bioconductor (Tables 1, 8 and 13).

Cluster analyses (Figure 1-3)

Supervised cluster analysis was done using TIGR multi experiment viewer

(TMe v), applying complete linkage and using Euclidian distances as metric

Other statistical analyses

For comparing miRNA expression levels in colorectal adenomas and colorectal carcinomas, colorectal adenomas and controls, and colorectal carcinomas and controls a Wilcoxon signed-rank sum test was used with a threshold p-value of 0.2. For comparing miRNA expression levels in colorectal tumors with and without defined chromosomal aberrations (i.e. 8p loss, 13q loss, 15q loss, 17p loss, 18q loss and 2Oq gain) a Wilcoxon signed-rank sum test was used with a threshold p-value of 0.3. To correct for multiple comparisons a Benjamini-Hochberg correction was performed in all analyses. Indicator miRNAs in blood or faeces (Tables 9-11 and 14-16) Differentially expressed miRNAs (Tables 2-4) were compared to miRNAs expressed in faeces (Table 8) or blood (Table 13). Small RNAs that were expressed differentially in a significant manner (BH <0.2) in tissue and detectable in faeces or blood (signal/background >2) were listed.

Classification analysis (Tables 5-7)

For multivariate classification of samples based on small RNA expression levels, PAM (prediction analysis for microarrays) software was used.. PAM produces a classification rule using multiple variables (i.e. small RNAs) for optimal classification of predefined categories of samples (e.g. adenomas versus adenocarcinomas). PAM (Tibshirani et al. (2002) Proc Natl Acad Sci USA.99:6567-72.) is a nearest centroid classification-type algorithm. The training data is used to compute so-called class centroids. The centroid is a multivariate (since all expressed small RNAs are used) generalization of a median. Basically, a new sample would be classified to the class to which the squared distance is minimal.

Nearest shrunken centroid classification makes one important modification to standard nearest centroid classification. It "shrinks" each of the class centroids toward the overall centroid for all classes by an amount we call the threshold. This shrinkage consists of moving the centroid towards zero by a threshold, setting it equal to zero if it hits zero. After shrinking the centroids, the new sample is classified by the usual nearest centroid rule, but using the shrunken class centroids. This shrinkage does automatic selection of the most relevant small RNAs.

The error rates are computed by 10-fold cross-validation: 10 samples are left out of the training procedure and their class label is predicted as descibed above. The procedure is set up such that each sample is left out exactly once. The confusion table then displays the number of correct and erronous classifications for both classes.

Pairwise comparisons were performed (control vs adenoma, control vs carcinoma and adenoma vs carcinoma) followed by feature selection. Then, cross-validated misclassification errors were computed (see the confusion tables 5b-7b). This shows which miRNAs were vital for a high accuracy of prediction the type of tissue (control vs adenoma vs carcinoma) and the accuracy of the prediction (%). Subsequently, the selected feature miRNAs were eliminated from the data and the classification was redone. The cross- validated misclassification errors were computed again. An increase in error shows that the accuracy of the classification relies on the presence of the featured miRNAs.

RESULTS Small RNA fraction detectable in colorectal tissue

A large set of novel small RNAs have recently been experimentally identified at the Hubrecht Institute, Utrecht, The Netherlands, and classified as candidate miRNAs using computational analysis (e.g. stable hairpin formation of the precursor) (Berezikov et al. (2005) Cell 120:21-24, Berezikov et al. (2006) Nature Gen. 38: 1375-1377, Berezikov et al. (2006) Genome Res. 16: 1289- 1298, PCT/NL2006/0000010). Earlier studies have shown that expression profiling of small RNAs can be used to classify tumors and use it as a diagnostic tool. In colorectal cancer, early diagnosis could make an enormous difference in life expectancy, morbidity and mortality. To determine whether these novel small RNAs, which are suspected to be miRNAs, are differentially expressed in different types of cancer, analysis of the expression of these small RNAs was performed in different colorectal tissues. The signals detected for the miRNAs and small RNAs obtained for the tissue samples were compared to signals obtained using the reference sample. Table 1 shows the result of this comparison. In total, 1296 probes produced signal with difference between maximum and minimum values above 4 in Iog2 scale, indicating substantial differential expression of corresponding small RNAs in at least some of the investigated colorectal tissues.

Differentially expressed small RNAs in diseased colorectal tissue versus healthy colorectal tissue

In order to determine which small RNAs might serve as disease markers and may consequently be used for diagnostic purposes, detection signals of the analyzed small RNAs were compared between colorectal adenomas and control samples, colorectal adenocarcinomas and control samples and colorectal adenomas and adenocarcinomas. This comparison resulted in a list of small RNAs that are differentially expressed between the respective categories analysed (Tables 2-4). Moreover, Tables 2b-4b demonstrate which of the differentially expressed small RNAs are upregulated and which are downregulated. In summary, a comparison of colorectal adenomas and control samples showed that 1554 small RNAs are differentially expressed, of which 50 are upregulated (Table 2c) and 1504 are downregulated (Table 2d) in adenomas. The comparison of colorectal adenocarcinomas and control samples demonstrated that 105 small RNAs are differentially expressed (Table 3a), of which 23 are upregulated (Table 3c) and 82 are downregulated (Table 3d) in adenocarcinomas. Lastly, comparing colorectal adenomas and adenocarcinomas resulted in a list of 1080 small RNAs that are differentially expressed (Table 4a), of which 1 is upregulated (Table 4c) and 1079 are downregulated (Table 4d) in adenocarcinomas. When the statistical analysis was performed under more stringent criteria (p<0.1), a list of 384 small RNAs was selected, that are most significantly differentially expressed between adenoma and adenocarcinoma (Table 26). All of these small RNAs were downregulated in adenocarcinomas. The significance of these results is reiterated by the fact that, when cluster analysis (Euclidean) is performed, using all differentially expressed small RNAs, two distinct clusters are formed (Figure I-III). Figure Ia shows cluster analysis based on all differentially expressed small RNAs between control and adenomas. Cluster analysis shows two distinct clusters: one which included mostly adenomas (Cluster II) and one including mostly controls (Cluster I). This demonstrates that on the basis of the differentially expressed small RNAs it is possible to distinguish these two different tissue types. Statistical analysis (Figure Ib) demonstrates that the different tissue samples are assigned to the correct cluster in a significant manner. Importantly, the cluster analysis was repeated with a lower number of differentially expressed small RNAs (p< 0.1, p<0.05 and p<0.025 or best 23 predictive, differentially expressed small RNAs) as a result of more stringent statistical criteria (p value linked to the differentially expressed small RNAs is decreased). The results of those analyses show that it remains possible to distinguish, in a significant manner, two clusters containing mainly controls in one and mainly adenomas in the other (Figure lc-h), although the clusters do change somewhat when the number of included small RNAs decreases. Figures II and III, clustering adenocarcinoma and control samples and adenoma and adenocarcinoma samples respectively, show similar results as described for Figure I. These data imply that the selected small RNAs that are differentially expressed have great value for diagnostic purposes and will be further developed as such.

In conclusion, these results show differences in small RNA content between the respective categories of samples (normal colorectal epithelium, adenomas and adenocarcinomas) tested . They further show that the selected small RNAs that are differentially expressed have great value for clinical diagnostic purposes and will be further developed as such. Based on the expression of the different small RNAs identified above, it becomes possible to classify an unknown tissue sample into a normal category an adenoma category or an adenocarcinoma category depending on its small RNA type expression profile. Such a comparison may then result in an accurate diagnosis of normal vs adenoma vs adenocarcinoma. In addition, individual or groups of small RNAs may actually drive (the set of upregulated small RNAs, table 2c, table 3c and table 4c) or inhibit (downregulated small RNAs, table 2d, table 3d, table 4d) the transition from adenoma to carcinoma and may therefore function as targets for therapy.

Classification of diseased colorectal tissue

The subpopulations of small RNAs that are differentially expressed as identified above are still relatively large. This might hamper its use as a diagnostic tool in practice. Therefore, we determined which of the differentially expressed small RNAs are actually most predictive in its classification of a tissue sample in the categories normal, adenoma or adenocarcinoma. The selection of the most predictive small RNAs for multivariate classification of samples based on small RNA expression levels, PAM (prediction analysis for microarrays) software was used.. PAM produces a classification rule using multiple variables (i.e. small RNAs) for optimal classification of predefined categories of samples (e.g. adenomas versus adenocarcinomas). It is well- known that with these high dimensional data one may obtain competitive classifiers with (almost) no overlapping features (small RNAs in this case). To assess the importance of the selected small RNAs as a set, we deleted these from the data set and repeated the classification procedure. We observe that the error rates drop substantially, which indicates that the initial set of small RNA does contain features which are essential for discriminating the two groups. The results of these analyses are shown in Tables 5-7. These tables show lists of small RNAs that have a high predictive value. They are ranked, with the first being the small RNA with the highest predictive value. This predictive value is represented by the largest difference between the adenoma score and the adenocarcinoma score as listed in Tables 5a-7a. The predictive value and power of the complete set of small RNAs selected is due to the combination of these particular small RNAs. Table 5a shows that 55 from the selection of 1554 differentially expressed small RNAs in colorectal adenoma vs control are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.212, table 5b). This is exemplified by the fact that the accuracy rate decreases to 65% (overall error rate 0.349) when these 55 small RNAs are not included in the small RNA population used to classify tissue, demonstrating that these 55 contain good classifiers, to accurately predict the type of tissue analyzed. Table 6a shows that 79 from the selection of 105 differentially expressed small RNAs in adenocarcinoma vs control samples are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.198, Table 6b). This is exemplified by the fact that the accuracy rate decreases to 65% (overall error rate 0.365) when these 79 small RNAs are not included in the small RNA population used to classify tissue. Importantly, when these good predictors are excluded, it results in wrongly classifying 8 controls as an adenocarcinoma compared to 2 wrongly classified controls when the good predictors are included: the false positive rate increases significantly from 0.222 to 0.888. These data show that these 79 probably contain good classifiers, to accurately predict the type of tissue analyzed. Table 7a shows that 26 from the selection of 105 differentially expressed small RNAs in colorectal adenomas vs adenocarcinomas are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.198, table 7b). This is exemplified by the fact that the accurary rate decreases to 65% (overall error rate 0.365) when these 26 small RNAs are not included in the small RNA population used to classify tissue. Moreover, exclusion of these small RNAs results in the increase of the false negative rate of 0.258 to 0.483 as indicated by double the adenocarcinomas that are wrongly classified as adenomas when excluding the 26 small RNAs. These results show that these 26 contain good classifiers to accurately predict the type of tissue analyzed. In conclusion, the described small RNAs (Tables 5a-7a) are minimal sets of small RNAs part or all of which are included in a diagnostic test, which could classify an unknown sample into the different categories (normal, colorectal adenoma, adenocarcinoma). The above described PAM analysis resulted in a classification rule that may be used in a diagnostic application. Such an application makes use of the small RNA content and expression profiles of an unknown sample which will be compared to the above identified combination of small RNAs using advanced algorithms. This calculates whether the final value is below or above a certain threshold that determines the consequent diagnosis. The threshold depends on the required specificity and sensitivity of the final diagnostic test.

Detection of small RNAs in faeces and blood

To design a functional and practical diagnostic test it is important to take into account the type of sample that is to be analyzed. Existing commercial tests are based on the analysis of stool samples. They have yielded promising results but need further improvement. Fecal occult blood test is the most recognized method of selecting high risk individuals. Unfortunately, with FOBT a considerable percentage of the tumours is missed and the already bleeding tumour is often discovered at a relatively late stage. A diagnostic test based on the detection of small RNA can be performed using tissue samples (biopsies) as described above. However, it is preferred to use test samples that can be obtained by less invasive measures. Stool samples and blood samples obtained from suspected colorectal patients could qualify. We therefore tested whether small RNAs derived from the tumor tissue are traceable in either blood or faeces. Therefore, we first determined if it was possible to extract small RNAs from blood and faces. The results are shown in tables 8 and 13. It shows the ratio of detection signal of the different small RNAs over background. For this calculation, processed background and signal values produced by FeatureExtraction software (Agilent) were used. We considered all signals with a ratio of 2 over background a significant signal. It demonstrates that 3759 small RNAs can be detected in stool sample and 3644 small RNAs in whole blood obtained from a patient with a colorectal adenocarcinoma. Interestingly, of some hairpin RNAs both arms of the hairpin could be detected, where one arm is higher expressed than the other, clearly resembling endogenous miRNA processing, where the mature strand gives stronger signals than the star sequence (see tables 8b and 13b). Secondly, we analyzed which small RNA, expressed in faeces and blood, are differentially expressed in comparing the three categories (colorectal adenomas and control samples, colorectal adenocarcinomas and control samples and colorectal adenomas and adenocarcinomas). These analyses should indicate which small RNAs are indicative of abnormality and can be detected in faeces or blood. They are based on the combination of Tables 8 and 13, including all small RNAs expressed twice above background, and Tables 2-4 , including all differentially expressed small RNAs (p<0.2). A summary of Tables 9-11 for faeces and 14-16 for blood is given below (Table 17). The table shows that it is possible to recover small RNAs in blood and faeces that are also differentially expressed in tissue. In conclusion, both blood and faeces obtained from suspected colorectal patients are suitable samples for use in diagnostic small RNA based microarray tests. This is once again exemplified by the fact that part of the group of small RNAs identified as good classifiers can also be detected in faeces (Table 12) and blood (Table 18). Importantly, a comparison of these subsets presumable derived from colorectal cancer cells and detected in blood and faeces, learns that blood and faeces have 85-90% of these predictive small RNAs in common. This shows that these small RNAs are indeed derived from colorectal adenocarcinoma cells and more importantly, that both blood and faeces are suitable for detecting colorectal carcinoma derived small RNAs.

Correlation of expression of small RNAs with chromosomal aberrations The colorectal tissue samples used in this study have further been characterized on other molecular levels. By means of array CGH analysis it had been determined which of the above studied adenomas and adenocarcinomas are characterized by chromosome instability, and which aberrations specifically. It was shown that 8q, 13q and 2Oq gains and 8p, 15q, 17p and 18q losses, are associated with progression of colorectal adenomas to carcinomas (Hermsen et al. (2002) cited above). Therefore, we determined whether the chromosomal aberrations frequently reported in colorectal cancer are correlated with the expression of small RNAs. Table 19 shows that two typical chromosomal aberrations, loss of X8p and loss of X17p, correspond to significant expression of 219 and 15 small RNAs respectively. One could view the significance of this correlation of small RNA expression with certain chromosomal aberration in two manners; the first would regard small RNAs correlated with certain chromosomal aberrations as indicators for those aberrations and could therefore be used in diagnostic tests based on such chromosomal instabilities. The second way of regarding this correlation is to take into account the biological consequences. The loss of X8p and X17p affected expression of these particular small RNAs. This could either be a direct consequence: these small RNAs are encoded by the part of these chromosomes that is lost. It could also be an indirect effect: the chromosomes that are lost encode for genes that regulate the expression of these small RNAs. Moreover, the fact that loss of these chromosomes affects clinical behaviour of tumors may suggest that the small RNAs, correlated with this loss, have a biological function in the process of tumorigenesis.

Currently, the small RNA expression profiles identified in these 68 colorectal tissue samples have been analyzed to identify good clinical classifier and correlated with small RNAs recovered from faeces and blood obtained from colorectal adenocarcinoma patients, to determine if a diagnostic small RNA based test would be feasible. Moreover, these expression profiles were combined with array CGH data, determining whether chromosomal aberrations can be correlated with certain small RNAs. It is hypothesized that the small RNAs correlated with loss of X8p and X17p (as identified in table 19) will also have a biological function, since loss of these chromosomal aberrations is correlated with clinical prognosis. Therefore, in the future, these small RNAs will be studied in more detail to test that hypothesis. Importantly, the correlation between small RNA expression profiles and already available mRNA expression profiles will be determined shortly. This may give indications on which genes are targeted by the small RNAs that are identified in colorectal adenomas and adenocarcinomas. It is of particular interest to determine the target genes of small RNAs that are differentially expressed between adenomas and adenocarcinomas. These small RNAs may be involved in progression to adenocarcinomas and may form interesting targets for drug discovery. Consequently, the small RNA gene targets may therefore also be of great interest.

Example 2

MATERIALS AND METHODS

For materials and methods for the PAM analysis, represented in table 25, we refer to the materials and methods as presented under example 1.

RESULTS To confirm the classifier as listed in table 7a, the PAM analysis was performed again, this time using a double cross validation to assure accurate prediction of the most predictive small RNAs. The small RNAs as listed in table 25a are the result of this analysis. 41 small RNAs were selected from the list of differentially expressed small RNAs. The combination of these 41 small RNAs is able to distinguish adenomas from adenocarcinomas in a highly predictive manner with a 72% accuracy (overall error rate 0.283, Table 25b). This is exemplified by the fact that the accuracy rate decreases to 66% (overall error rate 0.34) when these 41 small RNAs are not included in the small RNA population used to classify tissue, demonstrating that these 41 contain good classifiers, to accurately predict the type of tissue analyzed. The above described PAM analysis resulted in a classification rule that may be used in a diagnostic application. Such an application makes use of the small RNA content and expression profiles of an unknown sample which will be compared to the above identified combination of small RNAs using advanced algorithms. This calculates whether the final value is below or above a certain threshold that determines the consequent diagnosis. The threshold depends on the required specificity and sensitivity of the final diagnostic test.

To improve the predictive value of such classifiers as described above, a number of strategies can be followed. The first strategy could be to increase the sample set to ensure the correct selection of predictive small RNAs. This strategy could in some cases increase the accuracy of prediction and decrease the error rate. However, in other cases the predictive value of a diagnostic test has already reached its limit and increasing the sample set will not result in a more accurate predictive set. Therefore, a second strategy to improve the predictive value of the diagnostic test may be to combine the dataset based on the microarray data with other data sets. For example, a diagnostic test may combine data based on the small RNA expression levels with array CGH data obtained from the same samples. This could result in a more accurate prediction of disease state. A third option may be to use combined diagnostic tests in a step-wise procedure, where the first diagnostic test will have the best predictive value. For patients that fall within a category for which no clarity as to diagnosis can be given, a second diagnostic test will follow that will ultimately result in a diagnosis of the disease state. The second test on its own would not have given a clear answer, but in combination with the first test, this resulted in a defined and reliable diagnosis. Importantly, of these 41 classifier small RNAs, a portion of them can be detected in faeces (Table 34) or blood (Table 35). As mentioned, both blood and faeces obtained from suspected colorectal patients are suitable samples for use in diagnostic small RNA based microarray tests. The presence of small RNAs identified as good classifiers in faeces and stool suggests that the classifier can be used as a diagnostic test using faeces or blood as a source for small RNAs derived from colorectal adenomas or adenocarcinomas.

Example 3

MATERIALS AND METHODS

For materials and methods for the cluster analysis, represented in Fig IV, we refer to the materials and methods as presented under example 1.

RESULTS

From the 384 small RNAs that were found to be most significantly differentially expressed between adenomas and adenocarcinomas (Fig IHc, d and table 26), 91 were selected and believed to be highly predictive for classification of adenoma vs adenocarcinoma (Table 27). This was reiterated by the fact that, when cluster analysis (Euclidian) was performed using the 91 small RNAs, two distinct clusters are formed (Fig IVa). Moreover, statistical tests showed (Chi-square test) that the clustering based on the 91 selected small RNAs is highly significant (P<0.0001) (Fig IVb).

Example 4

MATERIALS AND METHODS

Patient samples

Fresh colorectal tissue samples from 58 patients with colorectal tumors were collected prospectively at the department of pathology of the VU - University medical center (VUmc), Amsterdam, the Netherlands. In total 27 adenomas and 31 adenocarcinomas, of which 12 adenomas and 12 carcinomas were also analyzed by small RNA based microarray (see example 1). Of all samples, total RNA was isolated using TRIzol (Invitrogen) following the manufacturer's guidelines with some modifications

(http://www.vumc.nl/microarrava/index.html). Total RNA quantity was determined with a Nanodrop NU-1000 ssectrophotometer (Isogen, Hackensack, NJ, USA) and quality was assessed in a 1% agarose gel, stained with ethiduira bromide. The study was earned out in accordance with the ethical guidelines of our institution concerning the use of patient material.

TaqMan PCR Quantification of the left arm of hsa-miR-24-2 (hsa-miR-24-2-]) expression levels was done by real-time RT-PCT using Taqmani® microRNA assays (Applied Biosysteras, Foster City, CA, USA) directed to hsa-mir-24 (ABI4 373072) and an endogenous reference, the KNU48 gene (ABI 4373383). Reactions were performed following the manufacture's protocol using IOng of total RNA as input material. All reactions were carried out in duplo in a 7300 Real-time PCK, System (Applied Biosystems. Foster City. CA, USA). Statistical analysis

Expression levels of the hsa-miR-24-2-1 were calculated from the obtained Ct values using the delta Ct method as previously described. Box and scatter plots were used to appreciate the descriptive statistics of the data (SPSS 14.0 for Windows, SPSS Inc. Chicago, IL, USA). Significance of differences in expression levels between adenomas and carcinomas were computed by the Mann- Whitney U non-parametric test for independent samples (SPSS 14.0 for Windows, SPSS Inc. Chicago, IL, USA).

RESULTS

To validate the microarray expression data as presented in Figs 1-3, the expression levels of mir-24-2-1, for which primers were commercially available, were determined by real-time RT-PCR in 58 colorectal tumors (27 adenomas and 31 adenocarcinomas). Expression levels of hsa-miR-24-2-1 showed 1.4 fold increased expression in the adenomas (mean expression 13.8) compared to the carcinomas (mean expression 12.2) (p = 0.4) (Figure 5A). This observation was in concordance with the results from the microarray expression experiment, where the expression levels of the hsa-mir-24-2-1 were higher in group of adenomas (mean expression 1.4) compared to carcinomas (mean expression 1.0) (p = 0.01) (Figure 5B).

Example 5

Colorectal cancer (CRC) results from the accumulation of DNA copy number gains and losses, promoter methylation changes, mutations and alterations in microRNAs (miRNAs) expression. It is well documented that 85% of the colorectal tumours show genetic instability through specific chromosomal gains and losses of small or large portions or whole chromosomes. These tumours are known as chromosomal instable (CIN) tumours. The biological consequences of the described DNA copy number changes that characterize CRC have not been fully established since the genes or miRNAs with tumour suppressor or oncogenic function, which are located in those regions have not been fully identified. In the last years, small RNA molecules have shown to play an important role in the pathogenesis of human cancers as oncogenes and tumours suppressor genes. Small RNAs contribute to the pathogenesis of human cancers due to their altered expression. The cause of their altered expression has only been partially characterized. It is known that DNA copy number changes, epigenetic changes and transcription factors involved in human carcinogenesis lead to increase or decrease expression of small RNAs during cancer initiation and progression. Therefore, small RNAs located in loss and gain regions characteristic of CRC as well as small RNAs which expression is associated to DNA copy number changes, may play a role as causative oncogenes or tumour suppressor genes in CRC. Identification of the small RNAs that participate as causative oncogenes and tumour suppressor genes in DNA copy number gain and loss regions will lead to a better understanding of the molecular mechanisms underlying CRC pathogenesis and may both serve as highly specific biomarkers for CRC or as possible targets for pharmaceutical intervention with the development of CRC.

MATERIALS AND METHODS

Materials

38 colorectal carcinomas with array CGH data and micros atellite instability status available were collected at the Zaans Hospital, Zaandam, the Netherlands and Leeds University, UK. The study was carried out in accordance with the ethical guidelines of our institution concerning the use of patient material. DNA isolation

DNA from healthy mucosa and tumor DNA of each patient was isolated using the QIAmp microkit (Qiagen, Westburg, Leusden, the Netherlands) as previously described. (Weiss MM, Hermsen MA, Meijer GA, et al. Comparative genomic hybridisation. MoI Pathol 1999;52:243-51. Buffart TE, Carvalho B, Hopmans E, et al. Gastric cancers in young and elderly patients show different genomic profiles. J Pathol 2007;211:45-51).

Microsatellite Instability Analysis Microsatellite Instability analysis was determined by using the MSI Analysis System, MSI Multiplex System Version 1.2 (Promega, Madison, WI, USA) containing five monomorphic markers (BAT-25, BAT-26, NR-21, NR-24, MONO-27). Reactions were performed following the manufacturer's instructions. The obtained PCR products were separated on a ABI 3130 DNA sequencer (Applied Biosystems, Foster City, CA, USA) and analyzed by

GeneScan 3100 (Applied Biosystems, Foster City, CA, USA). An internal lane size standard was added to the PCR samples for accurate sizing of alleles and to adjust for run-to run variations. Tumours were considered as microsatellite instable (MSI) when two or more markers ((MSI-H) showed length changes (instability). Tumours showing none or only one instable marker (MSI-L) were considered as Microsatellite stable (MSS).

Array Comparative Genomic Hybridization

Array CGH was performed on 3OK oligonucleotide arrays as described before (Snijders AM, Nowak N, Segraves R, et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet 2001;29:263-4. Van den Ijssel P, Tijssen M, Chin SF, et al. Human and mouse oligonucleotide- based array CGH. Nucleic Acids Res 2005;33:el92). Briefly, 600 ng of tumour and normal DNA were differentially labelled by random priming (Bioprime DNA Labeling System, Invitrogen, Breda, the Netherlands). Unincorporated nucleotides were removed with Sephadex columns (ProbeQuant G-50 Micro Columns, Amersham Biosciences) and 50 μl of tumour and normal DNA were combined with 10 μg Cot-1 DNA and precipitated by adding 2.5 volumes of ice- cold 100% ethanol and 0.1 volume of 3M sodium acetate (pH 5.2). The DNA was collected by centrifugation at 14000 rpm for 30 minutes at 4 °C. The pellet was dissolved in 130 μl hybridization solution and incubated at 73°C for 10 minutes to denature the DNA, followed by 60-120 minute incubation at 37°C. Next, the hybridization mixture was added to the array in a hybridization station (HybArrayl2TM, Perkin Elmer Life Sciences, Zaventum, Belgium) and incubated for 38 hours at 37°C. After hybridization the slides were washed in six washing steps and dried by centrifugation for 3 minutes at 1000 g.

Image acquisition and data analysis

Images of the arrays were acquired by scanning (Agilent DNA Microarray scanner, Agilent Technologies, Palo Alto, USA) and Bluefuse software version

3.4 (BlueGnome, Cambridge, UK) was used for automatic feature extraction.

Spots were excluded when the quality flag was below 1 or the confidence value was below 0.1. Log2 tumour to normal ratio was calculated for each spot and normalized against the mode of the ratios of all autosomes. For determining copy number gains and losses, the R package CGH call was used (van de Wiel

MA, Kim KI, Vosse SJ, et al. CGHcall: calling aberrations for array CGH tumor profiles. Bioinformatics 2007;23:892-4).

Statistical analysis ACE-it (Array CGH Expression integration tool) was applied to statistically test whether gene dosage affects microRNA expression (van Wieringen et al., 2006). This tool was applied to the whole genome data. We used a cut-off value 0.15 for gains and losses, a default group value of 9 and an FDR for significance of 0.10. RESULTS

Localization of small RNAs in microdeletion or microgain regions in colorectal carcinoma Eight microdeleted regions, smaller than 3 megabases, were observed in at least two of the 38 colorectal carcinomas. To determine whether the changes in small RNA expression in colorectal carcinomas may be a consecuence of their location in the previously mentioned microdeletions or microgains (smaller than 3 Mb), the localization of small RNAs in such regions detected by array CGH was ascertained. A significant amount of small RNAs appear to be located in these eight deleted regions (table 28a). Out of this list of small RNAs, 6 small RNAs were shown to be differentially expressed between adenomas and carcinomas (table 28b). Due to the location of the small RNA in these specific regions, these small RNAs could therefore contribute causally to colorectal carcinogenesis as tumor suppressor genes or oncogenes and form targets for therapeutic intervention or be used as highly specific biomarkers. Reintroduction of such, previously deleted, small RNAs may benefit the patient by affecting tumor progression or response to therapy and therefore clinical outcome. Moreover, they could be used as biomarkers for early diagnosis, therapy response or clinical outcome of colorectal carcinomas.

Five micro-gain regions, smaller than 3 megabases, were observed in at least two of the 38 colorectal carcinomas. In these 5 regions, 22 small RNAs are located (Table 29a), one of which has been shown to be differentially expressed between adenomas and carcinomas (Table 29b). Gain of these small RNAs may be causatively involved in the initiation and maintenance of colorectal tumours. As such, inhibition of these small RNAs could result in the opposite effect and provide a novel therapeutic strategy for the treatment of colorectal carcinomas. In addition, these microRNAs could be used as biomarkers for molecular diagnosis or tumor classification regarding therapy response, therapeutical intervention or clinical outcome. Localization of small RNAs in microdeletion or microgain regions in colorectal microsatellite stable carcinomas

Within the population of colorectal carcinomas, two groups can be distinguished. One group that has stable microsatellites, the other group is defined by instable microsatellites. The microsatellite instability is often a result of DNA mismatch repair deficiencies and therefore, the status of stability of the microsatellites determines the sensitivity of these tumors for the accumulation of mutations or epigenetic changes. To determine whether microdeletions or gains can be found specifically in one group or the other, array CGH data was used to determine such changes in these two groups. In at least two out of 26 microsatellite stable carcinomas, two micro- deletions, smaller than 3 megabases, were observed. Four small RNAs are located in these regions (table 30). Three micro-gain regions, smaller than 3 megabases, were observed in at least two of the 26 microsatellite stable colorectal carcinomas. In these regions, 10 small RNAs are localized (table 31a), of which 1 is differentially expressed in adenomas compared to carcinomas (table 31b). It is known that MSI and MSS have different clinical outcome and respond differently to the current chemotherapy regimens. On this basis, small RNAs located in microdeleted or microgained chromosomal regions that are most frequently present in MSS tumours, might be responsible for the different clinical behaviour seen in the MSS colorectal tumors. Therefore, small RNAs that are located in these gain and loss regions are highly suitable for use as biomarkers to distinguish microsatellite stable from microsatellite instable carcinomas, for early diagnosis of these tumors or tumor classification regarding therapy response, to dispense the most suitable therapeutical regimen for the patients or predict clinical outcome. Localization of small RNAs in microdeletion or microgain regions in colorectal microsatellite instable carcinoma

, Eight micro-deletions, smaller than 3 megabases, were observed in at least two of the 12 microsatellite instable colorectal carcinomas. In these deleted regions, 41 small RNAs are localized (table 32a), of which 4 are differentially expressed between adenomas and carcinomas (table 32b). No microgains could be detected in this group of colorectal carcinomas. These 41 small RNAs that are localized in deleted regions, and in particular the 4 that are differentially expressed, may contribute to the maintenance of the tumor phenotype. Therefore, they could be suitable for therapeutic approaches, where reintroduction of these small RNAs may intervene with tumor growth or other tumor specific characteristics. Moreover, these small RNAs may serve as highly specific biomarkers since it is known that MSI and MSS have different clinical outcome and respond differently to the current chuemotherapy regimens. On this basis, small RNAs located in microdeleted chromosomal regions that are most frequently present in MSI tumours, might be responsible for the different clinical behaviour seen in the MSI colorectal tumors. Therefore, small RNAs that are located in these microdeleted regions are highly suitable for use as biomarkers to distinguish microsatellite stable from microsatellite instable carcinomas, for early diagnosis of these tumors or tumor classification regarding therapy response, to dispense the most suitable therapeutical regimen for the patients or predict clinical outcome.

Integration of small RNAs expression and array Comparative Hybridization data.

BAC array CGH data were related to small RNA expression array data as presented in Example 1, independently of adenoma or carcinoma status. Therefore, a dedicated integration tool called ACE-it was applied (van Wieringen et al., 2006). We obtained a list of five small RNAs for which DNA dosage affected expression levels (FDR <0.1) (Table 33). The expression of these five small RNAs is associated to DNA copy number changes, located on chromosomal regions implicated in colorectal pathogenesis (Beatriz Carvalho, Cindy Postma, Sandra Mongera, Erik Hopmans, Sharon Diskin, Mark A. van de Wiel, Wim van Criekinge, Olivier Thas, Anja Matthai, Miguel A. Cuesta, Jochim S. Terhaar sive Droste, Mikael Edward Craanen, Evelin Schrόck, Bauke Ylstra, and Gerrit A. Meijer. Multiple putative oncogenes at the chromosome 2Oq amplicon contribute to colorectal adenoma to carcinoma progression (in press)). This indicates that these 5 small RNAs may be involved and causal in colorectal carcinogenesis. Small RNAs which expression is associated to DNA copy number changes may contribute causally to colorectal carcinogenesis as tumor suppressor genes or oncogenes and form targets for therapeutic intervention or be used as highly specific biomarkers. Moreover, they could be used as therapeutical targets or be used as biomarkers for early diagnosis, therapy response or clinical outcome of colorectal carcinomas.

Brief description of the tables

Brief description of the tables

Tables

1. Differentially expressed small RNAs in colorectal samples vs reference pool.

For every probe, samples with minimal and maximal values of Iog2(sample/reference) were selected and amplitude of differential expression was calculated by subtracting minimal value from maximal. Probes with the amplitude above 4 were considered as differentially expressed.

2. Differentially expressed small RNAs in colorectal adenoma vs control

A. Small RNAs that are differentially expressed between control (brush sample of resected colorectal margins) and adenoma. A wilcoxon analysis was performed adjusting the p values with a Benjamini — Hochberg correction. Small RNAs are differentially expressed when the adjusted p value is below 0.2

B. Up- or downregulated small RNAs adenoma compared to control

C. List of small RNAs upregulated in adenoma compared to control. A small RNA is considered upregulated when the ratio is above 1

D. List of small RNAs downregulated in adenoma compared to control. A small RNA is considered downregulated when the ratio is below 1. 3. Differentially expressed small RNAs in colorectal adenocarcinoma vs control

A. Small RNAs that are differentially expressed between control (brush sample of resected colorectal margins) and adenocarcinoma. A wilcoxon analysis was performed adjusting the p values with a Benjamini — Hochberg correction. Small RNAs are differentially expressed when the adjusted p value is below 0.2 B. Up- or downregulated small RNAs adenocarcinoma compared to control

C. List of small RNAs upregulated in adenocarcinoma compared to control. A small RNA is considered upregulated when the ratio is above 1 D. List of small RNAs downregulated in adenocarcinoma compared to control. A small RNA is considered downregulated when the ratio is below 1

4. Differentially expressed small RNAs in adenoma vs adenocarcinoma

A. Small RNAs that are differentially expressed between adenoma and adenocarcinoma. A wilcoxon analysis was performed adjusting the p values with a Benjamini -Hochberg correction. Small RNAs are differentially expressed when the adjusted p value is below 0.2

B. Up- or downregulated small RNAs adenocarcinoma compared to adenoma

C. List of small RNAs upregulated in adenocarcinoma compared to adenoma. A small RNA is considered upregulated when the ratio is above 1 D. List of small RNAs downregulated in adenocarcinoma compared to adenoma. A small RNA is considered downregulated when the ratio is below 1

5. Classification on the basis of predictive small RNA subset for distinction between normal tissue and adenoma

A. List of small RNAs that are selected by PAM as good classifiers to distinguish control from adenoma tissue B. Confusion tables before and after exclusion of the selected set of small RNAs

6. Classification on the basis of predictive small RNA subset for distinction between normal tissue and adenocarcinoma A. List of small RNAs that are selected by PAM as good classifiers to distinguish control from adenocarcinoma tissue

B. Confusion tables before and after exclusion of the selected set of small RNAs

7. Classification on the basis of predictive small RNA subset for distinction between adenoma and adenocarcinoma

A. List of small RNAs that are selected by PAM as good classifiers to distinguish adenoma from adenocarcinoma tissue

B. Confusion tables before and after exclusion of the selected set of small RNAs

8. Recovered small RNAs in faeces. For every probe, ratio of processed signal above background, as determined by FeatureExtraction software, was calculated, and probes with the ratio above 2 were considered as positively detected in the sample. 9. Small RNAs recovered from faeces and differentially expressed in adenoma vs control tissue

This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenoma compared to control and are detectable in faeces (signal/background >2) were listed.

A. Small RNA hairpin arm that shows highest expression with signal/background>2

B. Small RNA hairpin arm that shows lowest expression with signal/background>2

10. Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs normal tissue

This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenocarcinoma compared to control and are detectable in faeces (signal/background >2) were listed.

A. Small RNA hairpin arm that shows highest expression with signal/background>2

B. Small RNA hairpin arm that shows lowest expression with signal/background>2

11. Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs adenoma This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenocarcinoma compared to adenoma and are detectable in faeces (signal/background >2) were listed.

A. Small RNA hairpin arm that shows highest expression with signal/background>2 B. Small RNA hairpin arm that shows lowest expression with signal/background>2

12. Presence of classifiers in faeces This table includes small RNAs that were selected as good classifiers in tables 5-7 and could be detected in faeces

A. Classifiers for adenoma vs control detectable in faeces

B. Classifiers for adenocarcioma vs control detectable in faeces

C. Classifiers for adenoma vs adenocarcinoma detectable in faeces

13. Recovered small RNAs in blood. For every probe, ratio of processed signal above background, as determined by FeatureExtraction software, was calculated, and probes with the ratio above 2 were considered as positively detected in the sample.

14. Small RNAs recovered from blood and differentially expressed in adenoma vs normal tissue

This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenoma compared to control and are detectable in blood (signal/background >2) were listed.

A. Small RNA hairpin arm that shows highest expression with signal/background>2

B. Small RNA hairpin arm that shows lowest expression with signal/background>2

15. Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs normal tissue

This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenocarcinoma compared to control and are detectable in blood (signal/background >2) were listed. A. Small RNA hairpin arm that shows highest expression with signal/background>2

B. Small RNA hairpin arm that shows lowest expression with signal/background>2

16. Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs adenoma

This table includes small RNAs that were expressed differentially in a significant manner (p value <0.2) in adenocarcinoma compared to adenoma and are detectable in blood (signal/background >2) were listed.

A. Small RNA hairpin arm that shows highest expression with signal/background>2

B. Small RNA hairpin arm that shows lowest expression with signal/background>2

17. Summary of results shown in Tables 8-16

18. Presence of classifiers in blood

This table includes small RNAs that were selected as good classifiers in tables 5-7 and could be detected in blood

A. Classifiers for adenoma vs control detectable in blood

B. Classifiers for adenocarcinoma vs control detectable in blood

C. Classifiers for adenoma vs adenocarcinoma detectable in blood

19. Correlation of expressed small RNAs with chromosomal aberrations in adenoma and adenocarcinoma samples

A. Small RNAs correlated with a loss of chromosome 8p. No correlation could be detected between these small RNAs and loss of chromosome 17p or gain of 13q (see table) or gain of 15q, 18q or 2Oq (data not shown). B. Small RNAs correlated with a loss of chromosome 17p. No correlation could be detected between these small RNAs and loss of chromosome 8p or gain of 13q (see table) or gain of 15q, 18q or 2Oq (data not shown). C. List of small RNAs correlated with loss of X8p

D. List of small RNAs correlated with loss of X17p

20. List of 23 best predictive small RNAs in adenoma vs control

21. Sequences of microarray probe inserts for small RNA detection

22. Sample IDs of patient material

23. Small RNA mature and star strand sequences

A. Small RNA sequences derived from PCT/NL2007/000012

B. Small RNAs sequences derived from public miRNA database miRBase

24. Small RNA precursor sequences

A. Small RNA precursor sequences derived from PCT/NL2007/000012

B. Small RNAs precursor sequences derived from public miRNA database miRBase

25. Classification on the basis of predictive small RNA subset for distinction between adenoma and adenocarcinoma

A. List of small RNAs that are selected by PAM as good classifiers to distinguish colorectal adenoma from adenocarcinoma tissue B. Confusion tables before and after exclusion of the selected set of small RNAs

Most significantly differentially expressed small RNAs between adenomas and adenocarcinomas

List of small RNAs (N=384) that are differentially expressed according to stringent statistical criteria (p<0.1 ). All of these small RNAs are downregulated in adenocarcinomas compared to adenomas (see also Fig. IHc and IHd).

Selection of predictive small RNAs for classification of adenomas vs adenocarcinomas

A selection of 91 small RNAs was made that can cluster adenomas or adenocarcinomas highly predictable (p<0.0001) (see also Fig IVa and

IVb)

Small RNAs located on micro-deletions present in colorectal carcinomas Microdeletions of smaller than 3 megabases were determined in colorectal carcinomas using array CGH data.

A, Small RNAs located in the detemined deleted regions are listed.

B, Differentially expressed small RNAs (adenoma vs carcinoma) localized in the deleted regions are listed

Small RNAs located on micro-gains present in colorectal carcinomas Microgains of smaller than 3 megabases were determined in colorectal carcinomas using array CGH data.

A, Small RNAs located in the detemined microgain regions are listed. B, Differentially expressed small RNAs (adenoma vs carcinoma) localized in the gained regions are listed

Small RNAs located on micro-deletion present in microsatellite stable colorectal carcinomas

Microdeletions of smaller than 3 megabases were determined in colorectal microsatellite stable carcinomas using array CGH data. Small RNAs located in the detemined deleted regions are listed.

Small RNAs located on micro-gains present in microsatellite stable colorectal carcinomas

Microgains of smaller than 3 megabases were determined in colorectal microsatellite stable carcinomas using array CGH data. A, Small RNAs located in the detemined microgain regions are listed. B, Differentially expressed small RNAs (adenoma vs adenocarcinoma) localized in the gained regions are listed

Small RNAs located on micro-deletions present in microsatellite instable colorectal carcinomas Microdeletions of smaller than 3 megabases were determined in colorectal microsatellite instable carcinomas using array CGH data.

A, Small RNAs located in the detemined deleted regions are listed.

B, Differentially expressed small RNAs (adenoma vs adenocarcinoma) localized in the deleted regions are listed

Five small RNAs showed associated expression and DNA copy number levels in colorectal cancer.

The software program ACE-it integrated small RNA based microarray data with array CGH data, determining whether differences in expression of small RNAs is a consequence of DNA copy number changes. Results show that expression of 5 small RNAs is associated with DNA copy number changes.

34 Presence of classifiers distinguishing adenomas from adenocarcinomas in faeces

This table includes small RNAs that were selected as good classifiers in tables 25 and could be detected in faeces

35 Presence of classifiers distinguishing adenomas from adenocarcinomas in blood

This table includes small RNAs that were selected as good classifiers in tables 25 and could be detected in blood

The sequence of the small RNAs listed by name in the tables 1-35 is given in table 23. The sequence of associated precursors is given in table 24. The sequence of a collection of probes for the small RNAs of table 23 is given in table 21.

Brief description of the drawings

Figure 1. a. Hierarchical cluster analysis of 36 colorectal adenoma samples and ten normal colorectal epithelium controls. Cluster analysis with expression data of 1554 small RNAs yields one cluster (cluster 1) containing six out of ten controls and a second cluster (cluster 2) containing 27 colorectal adenoma samples. Each column represents a colorectal (adenoma or control) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. Only a fraction of the complete heat chart is shown, indicating the clusters, b. Cross table adenomas and control samples versus cluster membership. Cluster 1 contains six controls and nine adenoma tumours and cluster 2 includes four control samples and 27 colorectal adenoma tumours, c and d. The same hierarchical clustering was performed on the basis of 852 small RNAs, that were differentially expressed with a p value <0.1 including a cross table, e and f . The same hierarchical clustering was performed on the basis of 359 small RNAs, that were differentially expressed with a p value <0.05 including a cross table, g. The same hierarchical clustering was performed on the basis of 230 small RNAs, that were differentially expressed with a p value <0.025. h. The same hierarchical clustering was performed on the basis of the best 23 predictive small RNAs.

Figure 2. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and ten normal colorectal epithelium controls. Cluster analysis with expression data of 105 small RNAs yields one cluster (cluster 1) containing all ten control samples and a second cluster (cluster 2), including 26 colorectal carcinoma samples. Each column represents a colorectal (carcinoma or control) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. b. Cross table carcinomas and control samples versus cluster membership. Cluster 1 contains all ten control samples and five carcinoma tumours and cluster 2 includes 26 colorectal carcinomas, c and d. The same hierarchical clustering was performed on the basis of 44 small RNAs, that were differentially expressed with a p value <0.1 including a cross table.

Figure 3. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and 36 colorectal adenomas. Cluster analysis with expression data of 1080 small RNAs yields one cluster (cluster 1) that includes 20 colorectal adenoma tumours and a second cluster (cluster 2), which comprises 24 of the colorectal carcinoma tumours. Each column represents a colorectal (carcinoma or adenoma) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up- regulation. b. Cross table carcinomas and adenomas tumours samples versus cluster membership. Cluster 1 contains 20 colorectal adenoma tumours and seven colorectal carcinomas and cluster 2 contains 24 colorectal carcinomas and 16 colorectal adenoma samples, c and d. The same hierarchical clustering was performed on the basis of 384 small RNAs, that were differentially expressed with a p value <0.1 including a cross table.

Figure 4. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and 36 colorectal adenomas. Cluster analysis with expression data of small RNAs yields one cluster (cluster 1) that includes 23 colorectal adenocarcinoma tumours and a second cluster (cluster 2), which comprises 28 of the colorectal adenoma tumours. Each column represents a colorectal (adenocarcinoma or adenoma) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up- regulation. b. Cross table carcinomas and adenomas tumours samples versus cluster membership. Cluster 1 contains 8 colorectal adenoma tumours and 23 colorectal adenocarcinomas and cluster 2 contains 8 colorectal adenocarcinomas and 28 colorectal adenoma samples. The clustering is highly significant: pO.0001.

Figure 5. RT-PCR analysis of hsa-mir-24-2-1. RNA was isolated from 27 colorectal adenomas and 31 adenocarcinomas and Taqman PCR was performed, a, The expression levels of hsa-mir-24-2-1 RNA were detected and compared between the two groups, b, RT-PCR results were compared with expression level results for has-hir-24-2-1 as detected by microarray.

Table 1 Differentially expressed small RNAs in colorectal samples vs reference pool

MAX Iog2 MIN Iog2

Systematic Name (Sample/REF) (Sample/REF) Iog2 range1

Hsd_1_l 2.088695405 -1.912512559 4.001207964

HS_from_MM_216_l 3.039107456 -0.964247181 4.003354637

Hsd_95_r 3.436602675 -0.567767452 4.004370127 hsa-mir-519b_r 1.808824422 -2.195595466 4.004419888

HS_from_MQbrain_387_l 3.011798091 -0.99318349 4.004981581

HS_from_MQbrain_1453_l 3.18109327 -0.826023558 4.007116828

HS_146_I 1.925545312 -2.081708119 4.007253431

Hsd_108_r 1.995591703 -2.013406769 4.008998471

Hsd_33_r 2.141519065 -1.86783118 4.009350246

HS_from_MQbrain_1851_r 1.953336363 -2.057525604 4.010861967

HS_from_MQbrain_832_l 3.446216492 -0.566661909 4.012878401

HSbrain_695_l 1.63064494 -2.383156365 4.013801306

HS_from_MQbrain_285_r 1.034414575 -2.980175248 4.014589823

HSbrain_741_r 1.543845894 -2.470976079 4.014821974

HSbrain_421_l 2.072907825 -1.942291385 4.01519921

HSbrain_649_r 3.326270271 -0.688997381 4.015267653

Hsd_64_l 1.408247542 -2.608890571 4.017138113 hsa-mir-526a-2_l 2.708372776 -1.309295741 4.017668517

HS_from_MQbrain_782_l 1.743725561 -2.274212896 4.017938457

HS_155_r 2.837291129 -1.181419902 4.018711031

Hsd_61_l 2.219038295 -1.801406885 4.02044518

HS_70_l 2.52640836 -1.494414894 4.020823253

HSbrain_444_l 1.582704817 -2.438311287 4.021016104

HS_from_MQbrain_1024_r 3.014769503 -1.007329753 4.022099256

HSbrain_194_l 2.348967735 -1.673488376 4.022456112

HS_from_PT_48_r 2.631303094 -1.39222147 4.023524564

Hsd_from_Mmd_468_r 2.454803712 -1.568889086 4.023692798

HSbrain_273_l 1.831392763 -2.192600976 4.023993739

HS_74_I 3.265905838 -0.758224149 4.024129986

HSbrain_524_l 3.180726782 -0.843561389 4.024288171

HS_from_MM_299_r 2.292740527 -1.731689095 4.024429622

HS_from_MQbrain_689_r 2.222938714 -1.802712043 4.025650757

HS_from_MQbrain_1873_r 2.237532145 -1.788151021 4.025683166

Hsd_from_Mmd_383_l 3.448975628 -0.577051179 4.026026807

HS_from_MQbrain_222_l 2.584403955 -1.441772057 4.026176012

Hsd_from_Mmd_237_r 2.204167698 -1.822293249 4.026460947

HS_from_MQbrain_1332_r 1.428609239 -2.598212413 4.026821651 hsa-mir-190_l 0.962332185 -3.064623649 4.026955834

HS_from_MQbrain_345_l 2.472953718 -1.554177129 4.027130847

Hsd_from_Mmd_306_r 3.114214478 -0.913664866 4.027879344

HSbrain_1336_r 1.98318273 -2.044872431 4.028055161 hsa-mir-590_r 1.480590433 -2.547657779 4.028248213

Hsd_60_r 2.714183878 -1.314177354 4.028361232 hsa-mir-527_l 3.274510245 -0.75478888 4.029299126 hsa-mir-125b-1_l 1.669667452 -2.36030098 4.029968432

HS_from_MM_208_l 3.113520569 -0.918925647 4.032446216

Hsd_from_M md_42_r 1.788514504 -2.244615379 4.033129883

HS_from_MQbrain_779_r 3.074553118 -0.95948886 4.034041979

Hsd_97_l 3.120215279 -0.91479182 4.035007099

HS from MQbrain 717 I 3.336120523 -0.700043063 4.036163585 HS_from_MQbrain_995_l 1.923042913 -2.113284502 4.036327415

HSbrain_379_l 3.395930199 -0.640690918 4.036621116

HSbrain_360_r 1.399949752 -2.63714983 4.037099583

HSbrain_23_r 2.78275896 -1.254450749 4.037209709

HSbrain_46_r 2.613865567 -1.423787971 4.037653539 hsa-mir-450-2_l 0.985889776 -3.051941859 4.037831636 hsa-mir-299_r 2.867791219 -1.171901952 4.039693171

Hsd_from_M md_41 J 2.481504187 -1.558977032 4.040481219

HS_from_MQbrain_1734J 3.746423731 -0.295131716 4.041555446

HS_from_MQbrain_1182_r 3.139834681 -0.902030206 4.041864887

HSbrain_665_r 1.487643319 -2.557027009 4.044670329

HSbrain_563_l 2.360039309 -1.684782813 4.044822122

HS_from_PT_292_l 1.685434947 -2.359996291 4.045431238

HSbrain_182_l 1.794410839 -2.252022992 4.046433831

HS_from_MQbrain_1 197_l 3.110590697 -0.936448606 4.047039303

Hsd_from_M md_49_r 2.579386826 -1.468504049 4.047890874 hsa-mir-583_l 2.230582983 -1.820568126 4.051151108

HS_298_r 2.975580603 -1.077341264 4.052921867

HS_210_l 3.005408513 -1.049259575 4.054668089

HS_from_MQbrain_1216_l 2.724796118 -1.330579318 4.055375436

HS_from_MQbrain_1108_r 2.862237119 -1.193744151 4.05598127

HSbrain_579_r 1.40925375 -2.647444316 4.056698066

HS_from_MM_6_r 3.124595142 -0.933246204 4.057841346

Hsd_from_Mmd_180_l 1.610394113 -2.447473763 4.057867876

HS_from_MQbrain_1214_l 2.82335625 -1.23529739 4.05865364

HS_from_MQbrain_1757J 3.146647396 -0.912182423 4.058829818

HS_from_MQbrain_984_r 3.299222196 -0.761264239 4.060486435

Hsd_68_l 3.407872364 -0.652984039 4.060856403

Hsd_from_Mmd_167_l 3.307979739 -0.755409571 4.06338931

HS_from_PT_210_l 1.555223227 -2.508438651 4.063661879 hsa-mir-29c_l 2.251504167 -1.812858532 4.064362698

HS_from_MQbrain_946_l 2.987652722 -1.081392757 4.069045479

Hsd_from_Mmd_336_l 2.685058565 -1.384237172 4.069295737

HSbrain_11_l 1.50304215 -2.566901844 4.069943994

HS_210_r 2.548656471 -1.521791374 4.070447845

HS_from_MQbrain_766_r 1.495004303 -2.575468452 4.070472755

HS_from_MQbrain_1504J 1.928779508 -2.143286333 4.072065841

HS_from_PT_221_l 3.113947553 -0.958652008 4.072599561

HS_241_r 2.727132873 -1.345845446 4.072978319 hsa-mir-450-1_l 0.967359793 -3.107519985 4.074879778

HSbrain_2_r 1.714101263 -2.364273227 4.07837449

HS_from_MM_112_r 2.766784429 -1.31191063 4.078695059 hsa-mir-429_r 3.270712052 -0.808687162 4.079399213

Hsd_from_Mmd_272_r 2.686690588 -1.39497378 4.081664368

HSbrain_294_r 1.93035153 -2.156250764 4.086602294 hsa-mir-525_r 3.499359361 -0.59153303 4.090892391 hsa-mir-32_r 1.511270971 -2.580050206 4.091321177 hsa-mir-194-2_l 1.877987368 -2.213953242 4.091940609

HSbrain_601_l 1.447126351 -2.645387932 4.092514283 hsa-mir-146b_l 1.231334378 -2.862293453 4.093627831

Hsd_from_Mmd_518_r 2.983229897 -1.110549566 4.093779463

HS_from_MQbrain_744_l 1.996266499 -2.099304092 4.095570591

HS_from_MQbrain_613_r 3.331023916 -0.764672498 4.095696414

HS_from_MQbrain_1663_r 1.446639428 -2.649696845 4.096336273

HSbrain_750_l 2.08655999 -2.011722123 4.098282113 hsa-mir-194-1 I 1.930819662 -2.168480826 4.099300489 HS_from_MQbrain_740_l 2.298572839 -1.801408165 4.099981003

HS_232_r 1.212775317 -2.888763224 4.10153854

Hsd_from_Mmd_413_l 3.254011952 -0.847828032 4.101839983

HS_242_I 3.281061296 -0.821383269 4.102444565 hsa-mir-302d_r 1.134037131 -2.969490448 4.103527579

HS_13_r 3.325827789 -0.778265765 4.104093555

HSbrain_33_r 2.646811644 -1.458438688 4.105250333

Hsd_66_l 2.387342505 -1.717921714 4.10526422 hsa-mir-639_r 3.362748936 -0.742532587 4.105281523

HS_from_MQbrain_1048_r 3.368346417 -0.736954975 4.105301392 hsa-mir-630_l 0.934157367 -3.172776941 4.106934308

HS_from_MQbrain_21_l 1.739970275 -2.367317237 4.107287512

HSbrain_127_r 0.842157726 -3.267834226 4.109991953

Hsd_from_Mmd_69_l 3.35164685 -0.758839345 4.110486195

HS_from_MQbrain_198_l 3.019877358 -1.090753169 4.110630528

HS_from_MQbrain_198_l 2.446960973 -1.66685195 4.113812923

HS_from_MQbrain_663_l 1.257822727 -2.857700652 4.115523379

HSbrain_1387_l 2.551619155 -1.564398693 4.116017848 hsa-mir-486_r 2.253616104 -1.862596947 4.116213052 hsa-mir-424_l 1.874062513 -2.242250797 4.116313311

HSbrain_566_r 3.063293636 -1.053635725 4.116929361

HSbrain_1392_l 2.525149812 -1.591990324 4.117140135

HSbrain_100_r 3.126583282 -0.990797952 4.117381235

HS_from_PT_108_l 3.792884876 -0.325020225 4.117905101

HS_from_MQbrain_261_r 2.72514481 -1.394675248 4.119820057

HS_from_MQbrain_549_r 2.403950881 -1.716060047 4.120010928

HSbrain_668_r 3.09183027 -1.028865429 4.120695699

HSbrain_125_l 1.812802385 -2.308656215 4.1214586

HSbrain_815_l 1.494998806 -2.627703969 4.122702775

HS_from_MQbrain_366_l 1.873826288 -2.249669571 4.123495859

HS_from_MQbrain_1306J 3.481994339 -0.642164797 4.124159135

HS_from_MQbrain_637_l 3.269301702 -0.855197558 4.12449926

HS_from_MQbrain_1055J 3.826461999 -0.298321824 4.124783823 hsa-mir-182_l 3.043662609 -1.082124344 4.125786953

HS_from_PT_134_r 1.677604376 -2.448920174 4.12652455

HS_from_MQbrain_283_l 1.511361471 -2.615228726 4.126590197

HSbrain_421_r 2.294092029 -1.833066173 4.127158202 hsa-mir-606_r 1.673921879 -2.454731269 4.128653148

HS_from_MM_123_r 2.41352431 -1.71625623 4.12978054

HSbrain_670_l 2.568284445 -1.56212134 4.130405785

HS_from_MQbrain_1 112_l 2.498183737 -1.634144642 4.13232838

Hsd_56_l 2.102749876 -2.030606037 4.133355913

HS_from_MQbrain_1682_r 2.090005371 -2.044755865 4.134761237

HS_from_MQbrain_663_r 2.865084367 -1.269689425 4.134773792

HS_269_r 3.826634218 -0.309441006 4.136075224

HSbrain_341_r 1.858468781 -2.279907256 4.138376036

HS_from_MQbrain_1779J 2.793138989 -1.346080788 4.139219777

HSbrain_491_l 1.302048165 -2.837651231 4.139699395 hsa-mir-98_l 0.966572026 -3.173625248 4.140197274

HS_from_PT_70_l 1.059894906 -3.082005806 4.141900712

HS_from_MQbrain_1656_r 2.347722084 -1.797177196 4.14489928

HS_from_MQbrain_141 OJ 2.1604767 -1.984558858 4.145035557

HS_203_r 1.993454149 -2.15178467 4.14523882

HSbrain_274_r 2.551357842 -1.595269122 4.146626965

HSbrain_848_l 2.826198231 -1.320514298 4.146712528

Hsd from Mmd 326 r 2.412744392 -1.735454736 4.148199128 HSbrain_561_r 4.051652073 -0.099717017 4.151369091

HS_from_MQbrain_1235J 3.416522189 -0.735166181 4.15168837

HSbrain_439_l 1.289303857 -2.862525771 4.151829629

HS_from_MQbrain_1711_l 3.497043706 -0.655263539 4.152307245 hsa-mir-653_r 0.98182448 -3.171621167 4.153445647

HS_from_MM_44_r 2.804739701 -1.349347414 4.154087115

HSbrain_595_l 1.463193402 -2.694308006 4.157501407

HS_from_MQbrain_545_l 3.22663762 -0.931256531 4.15789415

HS_249_r 1.514697456 -2.644437886 4.159135342

HSbrain_64_r 1.971703045 -2.187896901 4.159599947

HS_from_MQbrain_952_l 3.446889258 -0.718850097 4.165739355

HSbrain_486_r 1.897118787 -2.268757685 4.165876473 hsa-mir-675_l 3.115834412 -1.051639823 4.167474235

HS_from_MM_339_l 1.597557716 -2.571789523 4.169347238

HSbrain_344_r 1.467181102 -2.703440434 4.170621536

HS_from_MQbrain_1525_r 2.789776074 -1.381436483 4.171212557

HS_from_MQbrain_1880_l 3.193429908 -0.978119046 4.171548954

HSbrain_259_l 3.182274869 -0.989342132 4.171617001

HS_36_I 2.048680384 -2.124225689 4.172906073

HSbrain_1398_l 2.411483784 -1.761492961 4.172976745 hsa-mir-504_l 3.725684236 -0.449577893 4.175262129

HSbrain_490_r 2.474326459 -1.702004657 4.176331116 hsa-mir-518a-1_l 3.217992148 -0.958678037 4.176670184 hsa-mir-502_r 3.042089261 -1.135977424 4.178066684

HS_from_MQbrain_1760J 2.670972591 -1.508208772 4.179181363

HS_from_MQbrain_1685_r 2.747861927 -1.433994718 4.181856645

HS_51_r 0.981611798 -3.202059726 4.183671524

HS_from_MQbrain_638_l 1.253620613 -2.931319081 4.184939694

Hsd_68_l 2.193173751 -1.991888607 4.185062359 hsa-mir-34b_r 1.448020386 -2.737588019 4.185608405 hsa-mir-575_l 3.249553651 -0.937042648 4.186596299

HSbrain_645_r 2.889118823 -1.29773156 4.186850383

HS_80_r 3.559275497 -0.627597731 4.186873227 hsa-mir-1 -2_r 1.726687457 -2.460219642 4.186907098

HSbrain_240_r 1.808684952 -2.378448037 4.187132989

HS_from_MQbrain_1261 J 0.989075555 -3.198383282 4.187458837

HSbrain_209_r 2.441264501 -1.746557031 4.187821532

Hsd_from_M md_54_r 2.481322129 -1.707213145 4.188535274

HS_from_MQbrain_31_l 3.528457094 -0.660289124 4.188746218

HS_248_r 1.565168322 -2.624393107 4.189561428

HSbrain_88_r 2.495129206 -1.695239284 4.19036849

HS_from_MQbrain_297_l 1.937994705 -2.252672464 4.190667169

HSbrain_682_r 1.410233792 -2.780493784 4.190727576

HS_from_MQbrain_1474_r 2.129160072 -2.063207402 4.192367474

Hsd_from_Mmd_184_r 1.692567998 -2.499800673 4.192368671 hsa-mir-148a_r 2.381580191 -1.811256667 4.192836858

HS_from_MQbrain_1325_r 3.40225604 -0.79135648 4.19361252

HSbrain_414_l 1.257763203 -2.937220384 4.194983586

HS_from_MM_236_l 3.202704643 -0.99362294 4.196327582

HS_from_MQbrain_634_l 1.69303102 -2.504197611 4.197228631

HS_from_MQbrain_572_l 1.50074111 -2.701387364 4.202128474 hsa-mir-99a_l 1.502009642 -2.700136694 4.202146337

HS_from_PT_157_l 2.462685253 -1.740216562 4.202901815

HSbrain_1391_l 2.671096297 -1.532233245 4.203329541

HS_from_MQbrain_1778_r 2.934787151 -1.26895031 4.203737461

HS 161 I 1.674576671 -2.530254246 4.204830917 HS_from_MQbrain_1985J 3.558937263 -0.646414954 4.205352217

HSbrain_354_r 3.215840235 -0.989522007 4.205362242

HSbrain_358_l 3.050110083 -1.156063694 4.206173777

HSbrain_1408_l 1.59049657 -2.616103125 4.206599695

HS_from_MQbrain_135_r 2.52167077 -1.686270916 4.207941686

HS_from_MQbrain_1_l 2.618807889 -1.590013898 4.208821787

HSbrain_280_l 2.400542218 -1.811399359 4.211941577

HSbrain_810_r 1.526197944 -2.687063483 4.213261427

HS_from_MQbrain_1217_l 2.951744954 -1.261942862 4.213687816

HS_from_MM_178_l 2.777706709 -1.437120908 4.214827616

HSbrain_737_r 2.512564121 -1.704063393 4.216627514

HSbrain_552_l 2.860555433 -1.356572784 4.217128217

HS_from_MQbrain_820_r 1.545176254 -2.672133591 4.217309845

Hsd_from_Mmd_81_l 2.472179995 -1.74637033 4.218550325

HS_from_MQbrain_1756_r 1.681853948 -2.536721437 4.218575385

HS_from_MQbrain_1195_r 1.885039255 -2.333704713 4.218743968

HS_from_MM_194_r 3.005858693 -1.213331908 4.219190601

Hsd_from_Mmd_326_l 1.716092716 -2.503314163 4.219406879

HS_from_MQbrain_63_r 1.519160307 -2.702599207 4.221759513

HS_from_MQbrain_1849J 3.839096883 -0.382995879 4.222092763

HS_from_PT_294_l 2.934016726 -1.289998538 4.224015264 hsa-mir-635_r 0.928797317 -3.296314912 4.225112229

HSbrain_736_r 2.710837276 -1.514896277 4.225733554

Hsd_from_Mmd_266_l 1.401547647 -2.825134496 4.226682143

HSbrain_172_l 3.029809819 -1.196882004 4.226691823

Hsd_from_M md_461 _r 3.638050804 -0.589232538 4.227283342

HS_from_MQbrain_450_l 1.868517764 -2.35909134 4.227609104

HSbrain_436_r 2.923867369 -1.303801843 4.227669212

Hsd_from_M md_464_l 2.308890741 -1.920451642 4.229342384 hsa-mir-205_l 3.176538808 -1.057279883 4.233818691

HS_from_MQbrain_484_l 2.916214688 -1.317725066 4.233939754

Hsd_from_Mmd_225_r 2.907514253 -1.327273348 4.234787601

HSbrain_616_l 3.607147454 -0.628332803 4.235480257

HSbrain_680_r 1.472380281 -2.763715095 4.236095376

Hsd_39_r 3.060942071 -1.175793781 4.236735853

HSbrain_612_r 3.328984449 -0.908882357 4.237866806

HS_from_MM_294_l 2.811442111 -1.426899879 4.238341991

HS_80_l 3.517733101 -0.725042388 4.242775489

HS_from_MM_310_r 2.782446733 -1.460597803 4.243044536

HS_from_PT_176_r 3.245762647 -1.000908258 4.246670905

HS_from_MQbrain_799_l 3.595960369 -0.651540194 4.247500563

HS_86_I 2.379766914 -1.868806993 4.248573906

HS_from_MQbrain_1885J 1.245427632 -3.005778939 4.251206571

HSbrain_76_r 1.50817019 -2.746517086 4.254687277

HS_from_MQbrain_1396J 2.443623064 -1.812361766 4.25598483

HS_from_MQbrain_869_r 3.610900505 -0.645668315 4.256568821 hsa-mir-302a_r 1.230869052 -3.027608594 4.258477647

HS_from_MQbrain_1300J 3.768112955 -0.490898468 4.259011423

HSbrain_537_l 2.13090412 -2.128153839 4.259057958

HS_from_MQbrain_1856J 3.301347997 -0.958010544 4.25935854

HSbrain_674_l 2.805619786 -1.455808413 4.261428199

Hsd_109_l 2.223976209 -2.039753844 4.263730053

HS_from_MQbrain_1489J 3.112857587 -1.150941421 4.263799007

HS_from_MQbrain_579_l 3.413818624 -0.850427918 4.264246542

HS_303_l 1.686349724 -2.579990869 4.266340593

HS from MQbrain 150 r 1.317629296 -2.949323637 4.266952934 HSbrain_485_l 2.718807568 -1.548574948 4.267382515

HS_from_MQbrain_68_r 2.204805375 -2.063481157 4.268286531 hsa-mir-199a-2_r 1.898521955 -2.371665771 4.270187726

HSbrain_629_r 1.551897427 -2.718549113 4.27044654

Hsd_from_M md_263_r 2.9987514 -1.273122535 4.271873935

HS_from_MQbrain_1387J 2.950511517 -1.323862732 4.274374249 hsa-mir-518a-2_l 3.541635836 -0.737015883 4.278651719

HS_156_r 2.35772661 -1.922889953 4.280616563

HS_from_MQbrain_1322_r 2.965520841 -1.317796304 4.283317145

HSbrain_37_r 1.417208531 -2.868417211 4.285625742

Hsd_78_l 2.638054745 -1.64824861 4.286303355

HS_207_r 3.680232978 -0.60794586 4.288178838

Hsd_from_M md_23_r 1.292673035 -2.996174822 4.288847858

HS_from_MQbrain_106_l 1.942789396 -2.34615461 4.288944006

HS_from_MQbrain_1345J 2.59664488 -1.693143144 4.289788024

HSbrain_684_r 1.465370969 -2.82459941 4.289970379

HS_from_PT_118_r 3.968735645 -0.321653838 4.290389483

HSbrain_120_l 3.00499768 -1.287502149 4.292499829

HSbrain_315_r 1.472305455 -2.821264784 4.293570239

HSbrain_287_r 2.849961269 -1.444781236 4.294742505 hsa-mir-107_r 1.993410686 -2.3019042 4.295314886

Hsd_35_r 3.230763888 -1.065574345 4.296338233

HS_247_r 1.560942652 -2.735473232 4.296415884

HS_from_MQbrain_1746J 3.111397024 -1.185339352 4.296736376

HS_from_MQbrain_578_l 2.764554074 -1.532398648 4.296952723

HS_from_PT_301_r 2.180273215 -2.1170404 4.297313615

HS_from_MQbrain_836_l 2.785167893 -1.514221257 4.29938915

HSbrain_869_l 1.687597965 -2.61309708 4.300695045

HSbrain_209_l 3.548747368 -0.755661606 4.304408974

HS_from_PT_211_l 2.902527183 -1.403507999 4.306035182

HS_from_MQbrain_451_r 1.019967237 -3.286548425 4.306515662

HSbrain_1331_r 3.579692118 -0.727316755 4.307008873

Hsd_59_l 2.691558346 -1.616238627 4.307796973

HS_from_MQbrain_339_l 3.305410559 -1.003192418 4.308602977

HS_from_MQbrain_1522J 2.800381489 -1.510695647 4.311077135

HS_from_MQbrain_385_l 3.237637453 -1.073728609 4.311366062

HS_55_I 1.722065182 -2.590618285 4.312683467

HS_from_MQbrain_635_l 1.658237403 -2.656390086 4.314627489 hsa-mir-320_r 2.706082085 -1.609750237 4.315832323

HSbrain_673_r 1.501956895 -2.814291249 4.316248144

HS_from_MQbrain_91_l 2.363727935 -1.952949293 4.316677228

HS_from_MQbrain_80_l 2.864297039 -1.453562797 4.317859836

HS_from_MQbrain_281_r 1.76433421 -2.554908026 4.319242236

HS_from_MQbrain_932_l 1.614404263 -2.704963908 4.319368171

HS_from_MQbrain_778_r 3.243268583 -1.076769934 4.320038517

Hsd_from_Mmd_293_l 1.530646274 -2.789430607 4.320076881

HSbrain_492_r 3.37112138 -0.950022151 4.321143531

HS_from_MQbrain_904_r 3.01547216 -1.306889582 4.322361741

HSbrain_134_l 2.913704299 -1.410680816 4.324385114

HS_from_PT_55_r 1.702808701 -2.621922146 4.324730846

HSbrain_630_r 1.437649162 -2.88773263 4.325381792

Hsd_from_Mmd_382_r 4.061472311 -0.265165071 4.326637382

HS_from_MQbrain_398_l 3.327522246 -0.999576342 4.327098587 hsa-mir-574_l 1.800159605 -2.527710871 4.327870476

HS_from_MM_334_l 2.441453922 -1.886565596 4.328019518

HS 246 r 1.645801886 -2.683296681 4.329098567 Hsd_from_Mmd_515_r 3.418010274 -0.912720525 4.3307308 hsa-mir-145_r 2.776275383 -1.554693859 4.330969242

HS_from_MQbrain_244_l 2.847057079 -1.487503511 4.33456059

HS_from_MQbrain_1327_r 3.716135032 -0.620138116 4.336273147 hsa-mir-146a_l 1.751434667 -2.585843672 4.337278339

HS_from_MQbrain_284_l 3.546036194 -0.793745822 4.339782016

HS_from_MQbrain_1553J 1.638201508 -2.702270891 4.340472399

HSbrain_620_r 2.145542525 -2.19517459 4.340717115 hsa-mir-30a_l 1.356214192 -2.984587855 4.340802047 hsa-mir-302b_l 2.93276614 -1.411032981 4.343799121

HSbrain_688_r 3.114665698 -1.230112179 4.344777877

HSbrain_363_r 2.121405211 -2.225401911 4.346807122

HSbrain_666_l 2.562979559 -1.784301651 4.34728121

HS_from_MQbrain_922_r 2.658152261 -1.689314118 4.347466378

Hsd_79_r 3.259391947 -1.089850572 4.349242518

HS_from_MQbrain_954_r 1.630346726 -2.723582546 4.353929272

HSbrain_677_r 1.495676583 -2.859143772 4.354820355

HS_from_MQbrain_1670_r 2.754544435 -1.600565308 4.355109743

HSbrain_669_r 1.430328027 -2.925989464 4.356317492 hsa-mir-520d_r 2.847548728 -1.509966377 4.357515105

HSbrain_519_l 3.691255539 -0.666768683 4.358024222

HSbrain_1388_l 2.716374763 -1.643334542 4.359709305

HS_from_PT_95_l 1.73042541 -2.630740693 4.361166103

HS_179_r 1.614599929 -2.748003316 4.362603246 hsa-mir-451_l 2.184012027 -2.178954894 4.362966922

HS_from_MQbrain_741_l 1.394403683 -2.968605749 4.363009431

HS_from_MQbrain_1424_r 1.578189632 -2.786536503 4.364726135

Hsd_111_l 2.177414337 -2.187565567 4.364979904

HSbrain_477_l 3.356586104 -1.00848162 4.365067723

HS_277_r 1.616373868 -2.756902974 4.373276842

HSbrain_198_l 1.514081575 -2.864075011 4.378156586

HS_from_MQbrain_54_r 2.069520645 -2.310045271 4.379565915

HS_from_MM_299_l 1.877993675 -2.503341883 4.381335558

Hsd_from_Mmd_181_l 4.044579996 -0.339367355 4.383947351

HS_from_MQbrain_1721_r 3.267494953 -1.11686394 4.384358893

HS_17_r 2.958938895 -1.431731886 4.390670781

HSbrain_357_r 1.88320241 -2.508549736 4.391752146

HS_from_MQbrain_1815_l 1.863856722 -2.528287591 4.392144313

HS_from_MQbrain_115_l 1.73172028 -2.660450811 4.39217109

HS_from_MM_264_l 3.187804117 -1.204639433 4.39244355

HS_from_PT_99_l 4.187204332 -0.207565199 4.39476953

HS_from_MQbrain_499_r 2.915614281 -1.479420493 4.395034773

HS_from_MQbrain_476_r 3.652782317 -0.743903218 4.396685535 hsa-mir-15b_l 1.171609006 -3.225080876 4.396689881

HSbrain_592_r 3.12628873 -1.27307126 4.39935999

Hsd_56_l 3.329760494 -1.072669427 4.402429922

HS_from_MQbrain_1322J 2.298050317 -2.105139368 4.403189685

HSbrain_656_l 2.995302493 -1.408744426 4.404046919

Hsd_from_Mmd_435_r 1.965877521 -2.438930551 4.404808071

HS_14_r 2.279108528 -2.127372705 4.406481233

HS_from_MM_70_l 1.470797877 -2.93634624 4.407144117

HS_from_MQbrain_1 13_l 3.305005418 -1.10233229 4.407337709

HSbrain_65_l 2.857530515 -1.550065162 4.407595677

Hsd_from_Mmd_262_l 3.349068609 -1.059783835 4.408852444

HSbrain_678_l 2.702675258 -1.706371763 4.409047021 hsa-mir-142 r 0.446226699 -3.963478719 4.409705419 HS_from_MQbrain_1286J 3.236714118 -1.176377798 4.413091916

HS_from_MQbrain_536_l 1.766898397 -2.649369834 4.416268231

HSbrain_61_l 1.751028569 -2.665635932 4.4166645

HSbrain_687_r 1.53020899 -2.886588647 4.416797637

HSbrainJJ 2.110848824 -2.308051191 4.418900016

HSbrain_308_l 3.658177289 -0.760843683 4.419020972 hsa-mir-139_r 3.346487837 -1.072811228 4.419299065

HSbrain_550_l 1.974672856 -2.447238634 4.42191149

HS_from_PT_305_l 3.254701005 -1.168910361 4.423611366

Hsd_from_Mmd_468_l 3.370104224 -1.053626532 4.423730757

HS_from_MM_172_l 1.169829365 -3.256401768 4.426231133

HS_from_MM_283_r 3.179469573 -1.247560791 4.427030364 hsa-mir-372_l 3.260736336 -1.167100664 4.427837

HS_from_MQbrain_1585_r 1.655543967 -2.776140391 4.431684358

HS_1_I 2.833567324 -1.599596683 4.433164007 hsa-mir-23b_l 3.011159748 -1.422148221 4.433307969

HS_282_I 3.513870872 -0.920969256 4.434840128

HS_from_MQbrain_738_l 2.929959668 -1.505719088 4.435678756

HSbrain_449_r 1.730175496 -2.709151333 4.439326829

HS_from_MQbrain_1279_r 2.440884923 -2.000568538 4.441453461

HS_from_MQbrain_99_l 2.627467917 -1.814476687 4.441944603

HSbrain_325_r 1.930462567 -2.512357187 4.442819754

HSbrain_210_r 1.917791002 -2.529124663 4.446915666

HS_from_MQbrain_1 12_r 2.944931331 -1.503200661 4.448131992 hsa-mir-769_l 3.23305404 -1.218437305 4.451491345

HSbrain_667_l 2.847266892 -1.604802788 4.45206968

HSbrain_683_l 2.821294245 -1.631661787 4.452956032

HSbrain_45_l 2.101526263 -2.351898115 4.453424377

Hsd_from_Mmd_294_l 2.456098611 -1.998348032 4.454446643

HS_from_MQbrain_2689_r 3.324416377 -1.131968296 4.456384674

HSbrain_427_l 3.816463754 -0.645996005 4.462459759

Hsd_from_Mmd_437_r 2.587319388 -1.875230042 4.462549431

HSbrain_427_r 3.274557686 -1.189431959 4.463989645 hsa-mir-519c_r 1.411687272 -3.055395521 4.467082793

HS_from_MM_292_l 1.330865479 -3.138464895 4.469330374

HS_from_MQbrain_458_r 2.762590489 -1.708300044 4.470890533

HS_from_MQbrain_270_l 2.427057688 -2.044857075 4.471914763

HS_from_MQbrain_1112_r 2.836725338 -1.636028691 4.472754029

HS_from_MQbrain_1546_r 2.026857743 -2.446318376 4.473176119

Hsd_51_r 3.268384618 -1.205432003 4.473816621

HS_from_PT_3_l 2.862514315 -1.611509863 4.474024179

HS_from_PT_155_r 3.146539722 -1.328212909 4.474752632

HS_from_MQbrain_1792J 3.694645407 -0.780305388 4.474950795

HS_from_MQbrain_366_r 2.699618632 -1.776038681 4.475657313

HS_from_MQbrain_883_l 3.69681464 -0.779545386 4.476360026

HS_from_MM_105_l 1.711052783 -2.767859192 4.478911975 hsa-let-7a-2_l 1.283354756 -3.199923534 4.48327829

HSbrain_356_r 2.144223548 -2.340345355 4.484568903

HS_from_MQbrain_350_r 3.208448604 -1.27992208 4.488370684

HS_266_r 2.936367584 -1.552977041 4.489344625

HS_255_I 3.054441067 -1.436439891 4.490880957

Hsd_52_l 2.877644595 -1.615144472 4.492789067

HS_from_MQbrain_1 18_r 3.603659469 -0.890473388 4.494132857

HSbrain_580_l 1.496287112 -2.998426375 4.494713487

HS_270_l 3.593561927 -0.906035898 4.499597825

HS from MQbrain 1092 I 1.899448204 -2.601928834 4.501377038 Hsd_from_Mmd_226_l 1.31223755 -3.192258052 4.504495602

HSbrain_387_l 2.87116755 -1.633510028 4.504677579

HSbrain_449_l 2.600768007 -1.907137901 4.507905908

HSbrain_137_r 3.092871639 -1.415834041 4.508705681

Hsd_from_M md_69_r 1.332468024 -3.17780478 4.510272804

HSbrain_1305_l 3.070453573 -1.439904175 4.510357748

HSbrain_559_r 1.311678919 -3.200744976 4.512423895 hsa-mir-522_r 2.464862857 -2.048022208 4.512885065

HS_from_MQbrain_1782_r 1.639263872 -2.87373984 4.513003712

HS_from_MQbrain_1507_r 3.842852849 -0.670182731 4.51303558

HS_from_MQbrain_1552J 3.85137131 -0.662960439 4.51433175

HS_215_r 3.47796408 -1.037817097 4.515781178

HS_from_MQbrain_471_l 2.580477757 -1.935713839 4.516191596

HS_from_MQbrain_1558J 3.698728559 -0.818218931 4.516947491

HSbrain_314_r 3.203836216 -1.314579638 4.518415854

HS_from_MQbrain_1620_r 2.297687402 -2.22075291 4.518440312

HSbrain_248_r 2.625010945 -1.894332557 4.519343501

HS_from_MM_120_l 3.088821529 -1.430865824 4.519687353 hsa-mir-153-2_l 1.040941445 -3.481560724 4.522502169

HS_from_MQbrain_1034_r 3.127449244 -1.396056107 4.523505351

HS_from_PT_26_r 2.941680303 -1.583530072 4.525210374

Hsd_from_Mmd_197_r 2.725489619 -1.800780811 4.52627043

HSbrain_223_r 3.480320951 -1.046593962 4.526914914

HS_from_MQbrain_709_r 1.922231476 -2.605796413 4.528027889

HS_303_l 1.884663028 -2.649317147 4.533980175

HS_from_MQbrain_346_r 2.619417953 -1.916393902 4.535811855

HSbrain_525_r 1.903359782 -2.63259443 4.535954212

HS_from_MQbrain_14_l 3.160424873 -1.379272393 4.539697267

H S_from_M Qbra i n_72_l 3.8663402 -0.674416791 4.540756991

HS_from_MQbrain_131_l 3.577445645 -0.964918599 4.542364244

HS_293_r 3.726624217 -0.816128471 4.542752689

HSbrain_198_r 3.254203304 -1.28980211 4.544005414

Hsd_69_l 2.893291378 -1.650766011 4.54405739

HS_239_r 3.393133156 -1.152324612 4.545457769

HS_243_I 2.925307082 -1.623932342 4.549239424

HS_from_MM_103_r 2.703439033 -1.845835577 4.549274609

HSbrain_110J 1.645810531 -2.903885229 4.54969576

HS_from_MQbrain_1 18_l 3.283241084 -1.266561381 4.549802464

HS_from_MM_283_l 2.767294378 -1.785355658 4.552650036

HSbrain_170_l 3.52711995 -1.025868775 4.552988725

HSbrain_608_r 2.871169843 -1.682701268 4.553871111

HS_from_MQbrain_1612_r 2.042791017 -2.511168193 4.55395921

HS_from_MQbrain_594_l 3.046755258 -1.509472285 4.556227542

HS_from_MQbrain_484_r 2.761435223 -1.799275478 4.560710701 hsa-mir-7-3_l 2.956272869 -1.604442698 4.560715567

HSbrain_806_l 2.576344432 -1.985092208 4.561436641 hsa-mir-644_l 2.139841722 -2.422250025 4.562091746

HS_from_MM_153_r 3.176592499 -1.387208126 4.563800625

HS_from_PT_40_l 2.29564242 -2.271794708 4.567437128

Hsd_from_Mmd_353_r 2.908039613 -1.664269151 4.572308764

HS_from_MQbrain_478_l 3.87424015 -0.698209618 4.572449768

Hsd_from_Mmd_494_l 2.062189458 -2.511111728 4.573301186

HS_from_MQbrain_76_r 3.463870673 -1.109572924 4.573443598

HSbrain_712_r 2.210055746 -2.3651778 4.575233545 hsa-mir-615_r 2.872152528 -1.70512199 4.577274517

HS from MQbrain 325 r 2.013062823 -2.564421029 4.577483852 HSbrain_136_l 3.262845735 -1.317027782 4.579873517

HSbrain_1437_r 2.641918297 -1.938728227 4.580646525

HS_from_MQbrain_436_r 1.338217093 -3.243051772 4.581268865

HS_from_MQbrain_465_l 3.494207424 -1.087087336 4.58129476

HS_38_r 1.930212885 -2.657422927 4.587635811

HS_143_I 2.688590054 -1.899072336 4.58766239

HS_269_I 3.59985888 -0.987989834 4.587848713 hsa-mir-16-1_l 1.713130507 -2.877698901 4.590829408

HSbrain_297_r 1.857831981 -2.737274685 4.595106666

HS_from_MQbrain_1723J 3.16533212 -1.430651344 4.595983464

HSbrain_725_l 2.603417138 -1.993933701 4.597350839

HS_291_r 2.657557971 -1.940041489 4.597599459

HSbrain_27_l 1.1841553 -3.415107586 4.599262886 hsa-mir-15a_l 1.311847976 -3.289656486 4.601504462

HS_from_MQbrain_1325J 3.274854262 -1.327730524 4.602584786 hsa-mir-559_l 1.74049034 -2.863272859 4.603763199

HS_296_r 3.670682358 -0.934935245 4.605617603

HS_from_MQbrain_1463_r 3.023733191 -1.582584711 4.606317903 hsa-mir-10b_l 2.441199589 -2.165609909 4.606809498

HS_from_MM_40_r 3.816348891 -0.79143766 4.607786551

HS_from_MQbrain_656_l 3.320716895 -1.287500265 4.608217159

HS_from_MQbrain_1584_r 1.583737691 -3.024762003 4.608499694 hsa-mir-221_l 3.188155557 -1.423138768 4.611294325

HS_from_MQbrain_1958J 3.640767565 -0.97169984 4.612467406

HS_from_MQbrain_343_r 3.352393225 -1.2610524 4.613445626 hsa-mir-184_l 1.923843766 -2.691092784 4.614936551

HS_224_I 3.493750704 -1.123113155 4.61686386

Hsd_49_l 1.631949419 -2.985919283 4.617868703

HS_from_MM_305_r 1.966746456 -2.651920635 4.618667091

Hsd_from_M md_412_r 1.409505326 -3.20932782 4.618833146

HSbrain_203_r 3.519377561 -1.099634942 4.619012503 hsa-mir-7-2_l 3.014182935 -1.606124546 4.620307481

HSbrain_116_r 1.382934557 -3.24282889 4.625763448

HS_from_MQbrain_151_l 3.212830892 -1.413130286 4.625961178 hsa-mir-129-1_r 3.465041908 -1.161114235 4.626156143 hsa-mir-127_l 4.034286121 -0.593971364 4.628257485

HS_from_MQbrain_211_l 2.75908417 -1.873385059 4.632469229

HSbrain_170_r 2.472068757 -2.162096701 4.634165457

HSbrain_178_r 3.482942501 -1.151768997 4.634711497

HS_from_MM_155_l 1.38167318 -3.253679639 4.635352819

HSbrain_389_l 3.225268717 -1.41225515 4.637523867

HS_from_MQbrain_1503_r 3.942616983 -0.697998271 4.640615253

Hsd_from_Mmd_461_l 4.389062425 -0.252921143 4.641983569

HSbrain_454_r 3.63277761 -1.010458004 4.643235614

HS_from_MQbrain_1795_r 3.225071288 -1.420381056 4.645452344

HS_from_PT_206_r 1.224782289 -3.420691168 4.645473457

HS_from_MQbrain_1439J 3.860235729 -0.789688181 4.64992391

HSbrain_284_l 1.934599805 -2.718177339 4.652777144

HSJ 93J 2.258310122 -2.394683737 4.652993859 hsa-let-7a-1_l 1.260886496 -3.393741485 4.654627981

HSbrain_505_r 4.222171738 -0.433219031 4.655390769

HS_from_PT_251_l 3.538833617 -1.116582673 4.655416291

HS_from_MM_20_r 2.703859402 -1.951881337 4.655740739 hsa-mir-203_r 3.294573295 -1.361989825 4.65656312

HSbrain_697_l 3.814563494 -0.842836292 4.657399785

HS from MQbrain 1323 I 3.526017505 -1.132277159 4.658294664 HS_from_MM_163_l 1.614626536 -3.044691758 4.659318293

HS_from_MQbrain_1378J 4.142050526 -0.517476259 4.659526785

Hsd_60_l 4.155701156 -0.503883924 4.65958508 hsa-mir-421_r 2.871695273 -1.788332271 4.660027544

HSbrain_892_l 1.838090774 -2.823450887 4.661541661

HS_from_MQbrain_1087_r 3.6055718 -1.057505619 4.663077419

HS_from_MQbrain_825_l 2.849639526 -1.816395137 4.666034664

HSbrain_672_l 2.852249215 -1.814168504 4.666417719

HS_from_MQbrain_1145_r 2.155166385 -2.511643096 4.666809481

HS_295_I 3.611931466 -1.056759345 4.668690811

HS_from_MQbrain_915_r 3.122038749 -1.550797092 4.672835841 hsa-mir-381_r 4.065989059 -0.607318147 4.673307206

HS_from_MM_191_r 1.85244859 -2.821037944 4.673486534

HS_from_PT_218_l 1.615608436 -3.058489618 4.674098054

HS_from_MQbrain_801_r 3.017891127 -1.65979213 4.677683257

HS_from_MQbrain_16_l 4.599967046 -0.078619751 4.678586798 hsa-mir-650_l 2.937629839 -1.745153308 4.682783147 hsa-mir-192_l 2.527501562 -2.15582679 4.683328352

Hsd_from_Mmd_376_l 3.879796479 -0.803578775 4.683375254

Hsd_from_Mmd_328_l 3.472263136 -1.212889518 4.685152653

HS_from_MQbrain_1290_r 3.510149512 -1.176216936 4.686366448

HSbrain_542_r 4.274225607 -0.412195881 4.686421489

HS_from_MQbrain_284_r 3.667030032 -1.02136734 4.688397372

HSbrain_821_l 1.84549341 -2.843343708 4.688837118

HSbrain_219_l 3.232284116 -1.457514192 4.689798308 hsa-mir-210_r 3.775218629 -0.914635749 4.689854378

HSbrain_1286_l 3.83059884 -0.860230199 4.690829039

HSbrain_1386_l 2.98072241 -1.711947185 4.692669595

HS_from_MQbrain_1514J 3.704802336 -0.989467433 4.694269769

HS_294_I 3.739276109 -0.956345183 4.695621293

HS_from_MQbrain_787_l 3.540784146 -1.1561351 4.696919246

HS_230_l 3.579499332 -1.119718794 4.699218125

HS_from_MQbrain_1180_r 3.461732885 -1.240753943 4.702486828

HS_from_MQbrain_1 14_l 1.642277041 -3.060349557 4.702626598

HS_245_r 2.530846625 -2.172124697 4.702971322

HSbrain_624_r 1.722472157 -2.980985395 4.703457552

HS_from_MM_187_r 3.765531037 -0.938377757 4.703908794 hsa-mir-196a-1_r 2.744883754 -1.961319163 4.706202917

HS_227_I 3.55500649 -1.152895607 4.707902097

HS_from_MQbrain_787_r 1.558863027 -3.149529499 4.708392526 hsa-mir-181d_r 2.987972963 -1.723753302 4.711726264

HS_94_I 1.969693174 -2.745533312 4.715226487 hsa-mir-302b_r 1.691313911 -3.025743438 4.717057348

HSbrain_393_r 2.74572076 -1.97184178 4.717562541 hsa-mir-552_l 1.641371363 -3.077124298 4.718495662

HS_from_MQbrain_701_l 1.860679784 -2.858977215 4.719656999

HS_from_PT_121_l 3.514910587 -1.205511603 4.72042219

HSbrain_685_r 2.94857295 -1.777872924 4.726445874 hsa-mir-602_r 3.540750869 -1.186860327 4.727611196

HS_from_PT_1 13_r 3.13333352 -1.595510169 4.728843689 hsa-mir-24-1_r 2.798304346 -1.93259045 4.730894796

Hsd_from_M md_40_l 4.029351576 -0.704252338 4.733603914

HS_from_PT_203_r 1.613246274 -3.124432272 4.737678546

HSbrain_279_l 3.384031798 -1.353831919 4.737863717

HS_from_PT_194_l 0.924714762 -3.813857839 4.738572601

HSbrain 304 I 3.070625303 -1.671021556 4.741646859 HSbrain_270_l 3.051575508 -1.69024559 4.741821098

HS_187_r 4.181054383 -0.563707635 4.744762018

HS_from_MQbrain_1734J 4.25369456 -0.491487493 4.745182053

HS_from_MQbrain_1343_r 2.106607573 -2.641191028 4.747798601

HS_from_MQbrain_353_r 3.224065244 -1.524931275 4.748996519

HS_from_MQbrain_1238_r 3.797414496 -0.95218608 4.749600576 hsa-let-7a-3_l 1.313035955 -3.439225691 4.752261645

HSbrain_121_r 3.274067942 -1.47858121 4.752649152

Hsd_from_Mmd_228_l 1.364401048 -3.391566948 4.755967996

HS_from_MQbrain_181 OJ 2.464713896 -2.291639748 4.756353645 hsa-mir-22_r 2.327475186 -2.431711551 4.759186737

HS_from_MQbrain_931_r 3.337852904 -1.42441839 4.762271294

Hsd_36_l 1.792951533 -2.96936417 4.762315703

HSbrain_398_l 2.684490701 -2.078898807 4.763389509

HS_from_MQbrain_1551 J 3.884000425 -0.880841465 4.76484189

HS_from_MQbrain_315_l 3.782987997 -0.985110598 4.768098595

HSbrain_655_r 3.738631397 -1.031243068 4.769874465

Hsd_from_Mmd_276_l 4.297154523 -0.475301178 4.772455702

HS_from_MQbrain_792_l 2.864158787 -1.911891394 4.776050181

Hsd_54_l 3.286974174 -1.491907307 4.778881481 hsa-mir-193b_l 2.727217972 -2.056913463 4.784131435 hsa-mir-614_l 3.463898896 -1.322148739 4.786047634

HS_from_MQbrain_476_l 3.995342346 -0.791737922 4.787080269 hsa-mir-500_r 3.658269534 -1.128950477 4.787220011

HS_57_r 3.895038619 -0.89282786 4.787866479

HSbrain_771_r 1.712937445 -3.075072903 4.788010348

HS_from_MQbrain_1728_r 3.313868672 -1.477206863 4.791075535

HS_from_MQbrain_234_l 4.453471636 -0.338793312 4.792264948

HSbrain_486_l 3.965014616 -0.829489353 4.794503969 hsa-mir-16-2_l 2.037765015 -2.758194516 4.795959531

HS_from_MQbrain_1048J 4.009645727 -0.787303704 4.79694943

HS_from_MQbrain_637_l 3.498843713 -1.299597114 4.798440828

HS_from_MQbrain_297_r 3.448132327 -1.354086506 4.802218833

HS_from_PT_44_r 3.263050978 -1.539848565 4.802899542

HS_from_MM_13_r 3.263480901 -1.540007607 4.803488508 hsa-mir-768_r 2.589938983 -2.216918992 4.806857975

HS_from_MQbrain_960_l 2.606113508 -2.203471342 4.80958485

HS_31_I 3.22456319 -1.585254746 4.809817936

HS_from_MM_96_l 2.855031474 -1.954884854 4.809916329

HS_from_PT_7_l 3.346007287 -1.464276638 4.810283925

HS_from_PT_258_r 2.241699745 -2.569827569 4.811527314

Hsd_from_Mmd_274_l 3.091015535 -1.722379515 4.81339505

HS_from_MQbrain_751_l 3.347608177 -1.466031951 4.813640127

HS_from_MQbrain_31_r 4.073436603 -0.740794212 4.814230815

HSbrain_333_r 3.313933938 -1.50150797 4.815441908

HSbrain_278_l 3.014590423 -1.802503646 4.817094069

HSbrain_536_l 3.392835933 -1.427196124 4.820032057

HSbrain_342_l 2.719428812 -2.102932954 4.822361766

HSbrain_496_l 3.009231766 -1.818080955 4.82731272

HSbrain_362_r 2.710368961 -2.121158851 4.831527812

HS_234_I 3.673093797 -1.158581679 4.831675476

HS_from_MM_290_l 1.931507501 -2.904133218 4.83564072 hsa-mir-135a-2_l 1.443761332 -3.393789375 4.837550707

HS_from_MQbrain_1246_r 3.167779633 -1.670405213 4.838184845

HS_271_r 3.688454263 -1.150107795 4.838562058 hsa-mir-195 I 1.315266951 -3.526131828 4.841398779 HSbrain_218_l 1.933765045 -2.909864581 4.843629626

HS_from_MQbrain_870_r 3.780725549 -1.065328564 4.846054112

HS_from_MQbrain_1901J 1.567447504 -3.279664791 4.847112294

Hsd_87_l 2.715380529 -2.133080693 4.848461222

HSbrain_202_r 2.894163056 -1.956817817 4.850980873

HSbrain_288_r 3.627702358 -1.224190854 4.851893213 hsa-mir-221_r 2.243776712 -2.60842676 4.852203472

Hsd_83_r 2.312030239 -2.540245962 4.8522762

HSbrain_638_r 4.263737826 -0.591230463 4.854968289

HSbrain_156_r 3.832628684 -1.025783562 4.858412246

Hsd_from_Mmd_190_l 2.96540259 -1.894736437 4.860139027 hsa-mir-7-1_l 3.254137311 -1.607608592 4.861745902

HSbrain_603_l 3.378028895 -1.484260577 4.862289472 hsa-mir-498_l 2.857356323 -2.006366908 4.863723231

HS_298_I 3.245727352 -1.618515418 4.86424277

HS_from_MQbrain_1082J 3.038041153 -1.828692848 4.866734001

HS_from_MQbrain_1212_r 1.726440526 -3.140455926 4.866896452

HSbrain_539_r 4.254297153 -0.61404578 4.868342934

HS_from_MQbrain_319_l 1.271264614 -3.599037252 4.870301866

HS_270_r 3.807800171 -1.063485635 4.871285805

HSbrain_83_l 4.757960986 -0.113347793 4.871308779

HS_242_r 2.943246653 -1.929069135 4.872315788

HS_238_I 3.778030931 -1.096875033 4.874905964

HS_from_MQbrain_399_l 2.300484061 -2.575422631 4.875906693

HS_236_I 3.868926399 -1.007140666 4.876067065 hsa-mir-150_r 4.007829804 -0.868328259 4.876158063

HS_from_MM_82_r 4.04313532 -0.83522739 4.878362709

HS_from_MM_359_r 2.887847105 -1.991716996 4.879564102

HSbrain_631_r 2.878955855 -2.001762682 4.880718537

Hsd_from_M md_26_r 1.582237121 -3.299428257 4.881665378 hsa-let-7b_r 2.255968183 -2.62716493 4.883133114

HS_from_MQbrain_441_l 3.163026535 -1.72251182 4.885538355

HS_from_MQbrain_2700_r 2.72330886 -2.162562338 4.885871198

Hsd_from_Mmd_80_l 1.626004464 -3.260603521 4.886607985

HSbrain_650_r 4.051139114 -0.837554055 4.888693169

HS_from_MM_192_l 1.500793799 -3.390697473 4.891491271

HS_293_I 3.736043938 -1.156903247 4.892947185 hsa-mir-611_r 4.127661712 -0.765879211 4.893540923 hsa-mir-18b_l 3.366454205 -1.531598877 4.898053082

HS_from_MQbrain_1180_l 2.86662064 -2.031634669 4.898255309 hsa-mir-99b_l 3.220612794 -1.677890004 4.898502798

HSbrain_718_r 1.879461783 -3.019233792 4.898695575 hsa-mir-517a_r 3.323648272 -1.575175801 4.898824073

HS_from_MQbrain_238_r 3.888716774 -1.010966178 4.899682951

HS_from_MQbrain_593_l 4.095851317 -0.80414063 4.899991947

HS_from_MQbrain_694_l 3.545397631 -1.360080526 4.905478156 hsa-mir-503_l 3.294641284 -1.611368203 4.906009487

HSbrain_395_r 3.211007963 -1.697550148 4.90855811

HS_from_MQbrain_215_l 3.06264762 -1.847586802 4.910234422

HS_from_MQbrain_1636J 3.627089647 -1.283917526 4.911007173

HS_from_MQbrain_478_r 3.361299201 -1.550505901 4.911805101

HS_from_MQbrain_659_l 3.747111102 -1.165383071 4.912494173

HS_from_MQbrain_1672J 2.154788884 -2.757967795 4.912756679

HSbrain_733_l 2.368226164 -2.544612556 4.912838719

HS_from_MQbrain_954_l 2.257530912 -2.658631141 4.916162054

HS from MQbrain 402 r 2.522419295 -2.396131891 4.918551186 HS_from_MQbrain_1334_r 1.60360394 -3.316561509 4.92016545 hsa-mir-100_l 1.936797577 -2.986252743 4.923050321

HSbrain_567_r 4.168866772 -0.755661684 4.924528456

HSbrain_1390_l 2.883536151 -2.04232685 4.925863001

HS_from_MQbrain_1353J 1.831945649 -3.097732139 4.929677789

HS_297_I 3.658138951 -1.272758506 4.930897457 hsa-mir-451_l 2.860114507 -2.079355672 4.93947018

HS_from_MQbrain_687_l 3.520203571 -1.422585034 4.942788605

HS_from_MQbrain_920_l 3.643544221 -1.300173672 4.943717893

HS_from_MQbrain_864_l 3.495420383 -1.44897999 4.944400374

HS_from_MQbrain_708_r 3.760727675 -1.18697574 4.947703415

HSbrain_1_r 3.779079405 -1.169504771 4.948584176

HS_from_MM_40_l 4.541405432 -0.410590356 4.951995787

HS_from_MQbrain_693_l 3.671566694 -1.28293922 4.954505913

HS_from_MQbrain_295_l 3.542603651 -1.415423739 4.958027391

HS_from_MQbrain_349_r 3.40314322 -1.562680299 4.96582352 hsa-mir-7-2_r 2.308679799 -2.657442201 4.966122

HS_from_MQbrain_1551_r 3.278055161 -1.692740815 4.970795976

HS_44_r 1.672788352 -3.298341886 4.971130238

HS_from_MQbrain_1671_r 3.387447413 -1.583907189 4.971354602

HS_from_PT_303_l 3.609655813 -1.364530153 4.974185966

HS_226_I 3.413696096 -1.560559144 4.97425524

HSbrain_149_l 3.40164818 -1.574699619 4.976347799

HSJ 92J 3.463427645 -1.513330625 4.976758269 hsa-mir-10a_l 2.764589881 -2.215232301 4.979822182

HS_from_MQbrain_110_r 4.47883335 -0.520780129 4.999613479

HS_from_MQbrain_1832_r 1.664160694 -3.337085827 5.001246521

HS_from_MQbrain_1209_r 4.121755836 -0.879515257 5.001271093

HS_28_r 2.506035722 -2.497749025 5.003784746

Hsd_from_Mmd_149_l 3.042130919 -1.962241796 5.004372716

HS_147_I 3.847931471 -1.162487129 5.0104186

Hsd_50_r 3.891133142 -1.123087161 5.014220303

HSbrain_321_l 4.222442609 -0.793746716 5.016189325

Hsd_from_M md_91 J 1.75725669 -3.25953709 5.016793781

HSbrain_422_r 4.616518979 -0.409413813 5.025932792

HS_from_MQbrain_374_r 3.088425979 -1.945101148 5.033527127

HS_296_I 3.691753934 -1.342843015 5.03459695

Hsd_from_Mmd_343_l 3.153669719 -1.881983743 5.035653463

HSbrain_553_r 3.023799224 -2.014682079 5.038481303

HS_from_MQbrain_240_r 3.559428342 -1.486398141 5.045826483

HS_from_MQbrain_1318_r 3.842538771 -1.203331739 5.04587051

HS_221_I 3.666584393 -1.382013375 5.048597768

HSbrain_57_l 4.384467535 -0.664284292 5.048751827 hsa-mir-565_r 2.606965747 -2.44387871 5.050844458

HSbrain_239_l 3.543168484 -1.514224544 5.057393029

Hsd_from_Mmd_411_l 4.050389674 -1.009209988 5.059599662

HS_174_I 2.798895904 -2.263723875 5.062619779

HS_from_MQbrain_1147_r 2.005031358 -3.057860126 5.062891484

HS_from_MQbrain_575_r 2.969253009 -2.094812156 5.064065166

HS_from_MQbrain_973_r 3.283047874 -1.781131015 5.064178888

HSbrain_426_l 1.956473761 -3.108397502 5.064871263

HS_from_MQbrain_1863J 0.639055626 -4.426586344 5.06564197

HS_from_MQbrain_1552_r 3.420250449 -1.646229571 5.06648002

HSbrain_429_l 3.774359349 -1.297650721 5.07201007 hsa-mir-135a-1_l 1.499107172 -3.573907366 5.073014539 hsa-mir-181a-1 I 1.793713318 -3.283917125 5.077630443 HS_from_MQbrain_1 175_l 4.296965999 -0.782331004 5.079297003

HS_from_MM_145_l 4.10808325 -0.972938521 5.081021771 hsa-mir-181a-2_l 1.588474029 -3.494881079 5.083355108

HS_from_MQbrain_599_r 3.257923847 -1.827189852 5.085113699

HS_from_MQbrain_192_l 3.426958595 -1.65937693 5.086335524

HSbrain_563_r 2.031249955 -3.056601747 5.087851701

HS_from_MQbrain_1560J 2.467180549 -2.625032361 5.09221291

Hsd_from_M md_284_r 2.655380318 -2.437192118 5.092572436

HS_205_l 4.497520544 -0.595149237 5.092669781

HSbrain_789_r 4.560892088 -0.533678481 5.094570569

HS_from_MQbrain_1606_r 3.757884262 -1.338282135 5.096166397

HSbrain_159_r 4.915227951 -0.1863132 5.101541151

HS_from_PT_195_l 4.0936569 -1.008393271 5.102050171 hsa-mir-602_l 4.073233665 -1.034079832 5.107313496 hsa-mir-24-2_r 3.043402392 -2.065397837 5.108800229

HS_93_I 4.032506399 -1.078035098 5.110541497

HS_from_MQbrain_986_r 2.686570455 -2.424099698 5.110670153 hsa-mir-801_l 4.38259069 -0.730479368 5.113070057

HS_from_MQbrain_771_r 2.40206001 -2.711446095 5.113506104

HS_from_MQbrain_1432_l 3.27618405 -1.839114824 5.115298873 hsa-mir-326_l 2.940648196 -2.182634073 5.123282268

HS_65_r 1.996145069 -3.130828915 5.126973984

HSJ 80J 2.983951957 -2.144700078 5.128652035 hsa-mir-18b_r 1.979463641 -3.151317755 5.130781396

HS_43_r 3.478491086 -1.652974563 5.131465649 hsa-mir-27b_r 1.106946065 -4.025174898 5.132120964 hsa-mir-373_l 3.400782096 -1.733979786 5.134761882

HS_from_MQbrain_778_l 3.849723243 -1.290768764 5.140492008

HS_from_MQbrain_708_l 4.727897848 -0.412642135 5.140539984

Hsd_from_Mmd_187_r 2.417885525 -2.726246624 5.144132149

HS_from_MQbrain_1601_r 3.518530966 -1.627291134 5.1458221

HSbrain_805_l 2.8792199 -2.268912216 5.148132116

HSbrain_223_l 3.773237758 -1.37527471 5.148512468

HS_from_MQbrain_241_l 4.409019063 -0.740818822 5.149837885

HS_from_MQbrain_516_l 3.731961903 -1.421300713 5.153262616

HS_103_r 3.181156033 -1.974743918 5.155899951

Hsd_from_Mmd_529_r 2.622526108 -2.537313848 5.159839956 hsa-mir-380_l 4.598642438 -0.561416269 5.160058708

HS_from_MM_93_l 3.552677807 -1.610726515 5.163404322

HS_271_I 3.690765734 -1.477208823 5.167974557

HS_from_MQbrain_1010_r 3.808974254 -1.36161643 5.170590685

HS_from_MQbrain_640_r 4.128384546 -1.044972488 5.173357034

HS_from_MQbrain_713_l 3.970101877 -1.205755763 5.17585764

Hsd_from_M md_45_l 4.255208484 -0.923202105 5.178410589

HS_from_MQbrain_687_r 4.929705256 -0.250929378 5.180634634

HS_from_MQbrain_272_r 3.991791748 -1.19109437 5.182886118

HSbrain_64_l 3.947334812 -1.238110975 5.185445787

H S_from_M Qbra i n_557_l 3.54559829 -1.640039969 5.185638259

H S_from_M Qbra i n_52_l 3.78705098 -1.402264784 5.189315765

HS_from_MM_210_r 2.484073079 -2.707049953 5.191123032

HS_from_MQbrain_497_r 4.104385799 -1.089926272 5.194312071

HS_from_PT_216_r 4.251217878 -0.947559321 5.198777199

HS_228_I 3.733842855 -1.465213159 5.199056015

HSbrain_1404_l 4.666209621 -0.535452732 5.201662353

HS_from_MM_268_l 2.974107426 -2.228999851 5.203107277

HS from MQbrain 874 r 2.161736137 -3.043846435 5.205582573 HSbrain_285_l 4.114220627 -1.094451712 5.208672338

HS_from_PT_35_r 4.183001303 -1.026084249 5.209085553

HS_from_MQbrain_827_l 4.109900073 -1.103162754 5.213062827 hsa-mir-615_l 3.74521244 -1.469688886 5.214901325 hsa-mir-519a-1_r 2.816289364 -2.399292953 5.215582317

HS_253_r 4.206055431 -1.011509985 5.217565415

HS_from_MQbrain_535_r 3.322904452 -1.895704159 5.218608611

HS_from_MQbrain_1625J 3.862343093 -1.357111315 5.219454408

HS_from_MQbrain_827_r 3.304620914 -1.914980744 5.219601658

HS_from_MQbrain_1820_r 4.193120277 -1.031492467 5.224612743

HSbrain_11_r 4.423014918 -0.802072 5.225086918

HS_from_MQbrain_280_l 3.312828284 -1.922504255 5.235332539

HS_from_MQbrain_734_r 4.261730669 -0.977035212 5.238765882

HSbrain_281_r 3.433530801 -1.806335569 5.23986637

HS_from_MQbrain_666_r 3.203599212 -2.040637249 5.244236461 hsa-let-7i_l 1.79628002 -3.448940058 5.245220079

HS_from_MQbrain_1082J 1.671121361 -3.580483686 5.251605047

HSbrain_1168_l 3.438385288 -1.814179309 5.252564597

HS_203_l 2.853775347 -2.398893509 5.252668856

HS_from_MQbrain_1020_r 4.230939895 -1.023262488 5.254202383

HS_from_MQbrain_298_l 1.991021091 -3.266047475 5.257068566

HS_from_MQbrain_1689J 3.098496199 -2.16035018 5.258846379 hsa-mir-194-2_l 4.512111515 -0.747268618 5.259380133

HS_from_PT_156_l 3.47565461 -1.7855137 5.261168311

HS_from_MQbrain_797_l 3.86534469 -1.397104049 5.26244874

HSbrain_406_r 4.454702816 -0.81003235 5.264735165

HS_from_MQbrain_238_l 3.087539957 -2.178610623 5.266150579

HS_from_MQbrain_811_r 3.066374781 -2.202835994 5.269210776

HS_250_r 4.062466414 -1.207232039 5.269698453

HS_222_I 3.700771895 -1.571023484 5.271795379

HSbrain_418_l 4.561662378 -0.713760039 5.275422417

HSbrain_186_l 3.995222297 -1.280916841 5.276139138

Hsd_from_M md_343_r 3.74915385 -1.528358566 5.277512415

HSbrain_164_l 4.018503935 -1.261726538 5.280230473

HS_from_PT_66_l 3.637998024 -1.64939961 5.287397634

HS_from_MQbrain_816_l 4.848657421 -0.43894031 5.287597731 hsa-mir-542_l 3.341049921 -1.947022915 5.288072837

HS_from_MQbrain_542_l 3.709550896 -1.579371536 5.288922431

HSbrain_445_r 4.35680089 -0.932516703 5.289317593

HS_from_MQbrain_628_l 3.529917584 -1.760032633 5.289950216

HS_from_MM_176_r 2.733425405 -2.557008216 5.290433622

HS_272_I 3.786459783 -1.513513457 5.29997324

HS_from_MQbrain_1493J 3.831014826 -1.469908707 5.300923533

HSbrain_379_r 3.23587819 -2.071753506 5.307631696 hsa-mir-93_l 1.882604466 -3.426522329 5.309126795

HS_from_MQbrain_645_l 2.498506817 -2.812854101 5.311360919

HS_from_PT_301_l 3.917612364 -1.39468483 5.312297194

HS_from_MQbrain_1381J 4.379678458 -0.93461924 5.314297697

HSbrain_582_l 1.432690413 -3.886262822 5.318953235

HSbrain_724_l 1.988490494 -3.331175949 5.319666443

HS_from_MQbrain_829_l 4.50954359 -0.819501435 5.329045025

HS_from_MM_304_l 4.325762714 -1.004234861 5.329997575 hsa-mir-574_r 2.85838056 -2.473509603 5.331890163

HS_from_MQbrain_1550_r 4.04701921 -1.286517289 5.333536499

HS_188_r 2.600205622 -2.733838356 5.334043977

HS from MQbrain 314 r 4.789345003 -0.549127536 5.338472538 HS_36_r 4.612352422 -0.728545264 5.340897687 hsa-let-7f-1_l 1.588019082 -3.763964322 5.351983404

Hsd_from_Mmd_291_l 4.361840207 -0.992699443 5.35453965

HS_from_MQbrain_1558_r 4.035543346 -1.323253464 5.358796811

HS_91_r 3.819488244 -1.542548961 5.362037205

HS_2_I 3.458196989 -1.903902242 5.362099231

HSbrain_368_r 4.433887145 -0.929879117 5.363766263

HSbrain_616_r 3.002236638 -2.362695746 5.364932384

HSbrainJ OOJ 3.570227349 -1.79471515 5.3649425

HS_from_MQbrain_1215_r 4.925531911 -0.450970567 5.376502478

HS_from_MQbrain_1879_r 4.228976536 -1.1529606 5.381937136

HS_284_I 2.666555812 -2.71628398 5.382839792

HSbrain_68_l 3.874118734 -1.511493305 5.385612039

HS_from_PT_193_l 4.186127732 -1.204004669 5.390132401

HSbrain_558_r 4.119685364 -1.272218165 5.391903529

HSbrain_81_l 4.673459962 -0.721409572 5.394869535

HS_233_I 3.742243209 -1.656301561 5.39854477

HS_from_MQbrain_296_r 3.304003275 -2.095052299 5.399055573

HSbrain_163_r 4.382358889 -1.022213096 5.404571986

HSbrain_691_l 3.473723841 -1.94134288 5.415066721

HS_from_PT_332_l 3.767926637 -1.650173792 5.41810043

HSbrain_397_r 3.218220646 -2.200206295 5.418426941 hsa-mir-17_r 4.940072682 -0.485631302 5.425703984 hsa-mir-519a-2_r 2.97948479 -2.449215663 5.428700453

HSbrain_222_l 3.403657332 -2.029974787 5.433632119

HS_from_MM_66_r 4.371687398 -1.063556189 5.435243587

HS_from_MM_66_l 4.438051051 -0.998643315 5.436694367

HS_from_MQbrain_1238_l 3.98451293 -1.453005517 5.437518447

HS_from_MQbrain_1638J 3.418178988 -2.02094608 5.439125068

Hsd_76_l 3.490670938 -1.951881927 5.442552865

HS_from_MQbrain_545_r 3.955126899 -1.490012408 5.445139307

Hsd_from_Mmd_41 1_r 4.332224304 -1.116578962 5.448803266 hsa-mir-92b_r 2.748668498 -2.702394176 5.451062674

HS_from_MQbrain_564_r 3.294902232 -2.156804516 5.451706748

HSbrain_628_l 3.082499121 -2.376106514 5.458605635

HSbrain_656_r 2.982458237 -2.477502715 5.459960952

Hsd_14_l 3.689163499 -1.771700139 5.460863639

HS_from_MQbrain_1454_r 4.577495936 -0.887402432 5.464898368

HS_from_MQbrain_855_r 3.825345577 -1.640085564 5.465431141

HS_from_MQbrain_599_l 3.412798886 -2.055944156 5.468743042

Hsd_from_Mmd_226_r 1.291227061 -4.183190395 5.474417456

HS_from_MQbrain_123_r 3.479302649 -1.995817976 5.475120624

HS_301_l 4.627077308 -0.850607121 5.47768443

HS_from_PT_139_l 4.073422524 -1.409405185 5.482827709

Hsd_109_l 3.72673689 -1.759885872 5.486622762 hsa-mir-330_r 3.714449537 -1.773773894 5.488223431

Hsd_65_r 3.748646304 -1.742543071 5.491189375

HS_152_I 3.102277233 -2.393380365 5.495657598

HSbrain_660_l 3.466157655 -2.029987544 5.496145198

HS_from_MQbrain_1382_r 3.13793393 -2.363726857 5.501660787

HS_181_r 4.419469122 -1.082251591 5.501720713

HSbrain_805_l 4.074433503 -1.429676402 5.504109905

Hsd_from_Mmd_516_l 3.412475113 -2.095033896 5.507509009

Hsd_from_Mmd_245_l 3.780690306 -1.727121945 5.507812252

HS_from_MQbrain_578_r 4.166135797 -1.350306755 5.516442553

HSbrain 591 r 4.391529413 -1.12924627 5.520775683 HSbrain_648_r 3.194624354 -2.333467448 5.528091801

HS_from_PT_176_l 3.956699706 -1.576116801 5.532816508

Hsd_7_l 3.22704522 -2.306215626 5.533260846

HS_104_l 3.942124617 -1.592915077 5.535039694

HSbrain_190_l 4.758036339 -0.780199851 5.53823619

HS_from_MM_33_l 3.840554748 -1.69933794 5.539892688 hsa-mir-19a_r 1.9628064 -3.57807505 5.540881449

HSbrain_377_l 2.436684747 -3.106433448 5.543118196

Hsd_from_M md_372_r 4.246402876 -1.299267958 5.545670834

HS_from_MQbrain_1326J 3.976713406 -1.572423915 5.549137321

HSbrain_715_r 3.453512886 -2.09921914 5.552732026 hsa-mir-26b_l 1.764835795 -3.788243571 5.553079366

HS_from_MQbrain_594_r 4.355831166 -1.197465154 5.55329632

HSbrain_653_r 3.322388663 -2.234544302 5.556932965 hsa-mir-801_l 4.017543096 -1.544979742 5.562522838

HS_from_MM_172_r 1.397454629 -4.169510735 5.566965364 hsa-mir-124a-3_r 4.617726819 -0.952351832 5.57007865

HSbrain_29_r 4.260687702 -1.309423869 5.570111571

HS_from_MQbrain_1357_r 4.306226408 -1.270483357 5.576709765

HSbrain_20_l 3.751601424 -1.849028269 5.600629694

HS_from_PT_220_r 4.281748809 -1.320114272 5.601863081 hsa-let-7f-2_l 1.76029603 -3.845246655 5.605542685

HS_from_MQbrain_618_l 3.445454811 -2.164340001 5.609794812

HSbrain_1405_l 4.679472115 -0.934087199 5.613559314

Hsd_14_r 5.086071816 -0.528975621 5.615047436

HSbrain_54_r 4.294762627 -1.32100822 5.615770847

HSbrain_610_l 3.599846841 -2.015963198 5.615810039

HS_from_MQbrain_1405J 3.775686066 -1.842781398 5.618467464

HS_21_I 3.418371497 -2.205431424 5.623802922

HS_from_PT_219_r 4.403612245 -1.228598506 5.632210751

HS_from_MQbrain_354_l 4.735786231 -0.899065708 5.63485194

HS_from_MQbrain_918_r 4.702403782 -0.933235667 5.63563945

HS_from_MQbrain_1061_r 4.062583748 -1.573537454 5.636121203 hsa-mir-23a_r 2.510329712 -3.127381226 5.637710938

Hsd_from_Mmd_266_r 2.805780405 -2.834756512 5.640536917

HSbrain_411_r 2.613717186 -3.042395943 5.656113129

HS_from_MQbrain_1646J 4.15001229 -1.523739312 5.673751602

HSbrain_317_r 3.162439297 -2.516972317 5.679411615 hsa-mir-31_l 3.922440913 -1.765548382 5.687989296

HS_90_l 4.227924969 -1.461704043 5.689629012

HSJ 83J 3.456161799 -2.234645299 5.690807098

HSbrain_99_l 3.920364938 -1.770561757 5.690926695

HS_from_MM_47_r 3.671346828 -2.024788693 5.696135521 hsa-mir-572_r 4.971923816 -0.727695707 5.699619523

Hsd_from_Mmd_115_l 4.853790974 -0.852245434 5.706036407

HS_from_MQbrain_796_r 4.415678039 -1.29112765 5.706805689

HS_from_MQbrain_433_r 4.108677086 -1.600787572 5.709464658 hsa-mir-181 c_l 2.138737177 -3.573048009 5.711785186

Hsd_from_Mmd_154_r 3.762836127 -1.949146778 5.711982905

Hsd_33_l 3.343345301 -2.369363954 5.712709255

HSbrain_499_l 3.469097037 -2.246893498 5.715990535

HS_from_MQbrain_1362_r 4.28548566 -1.435541542 5.721027201

HS_from_MM_210_l 4.10523656 -1.617132807 5.722369367 hsa-mir-519e_r 3.116430575 -2.612911942 5.729342517

HS_72_I 4.268290644 -1.463946628 5.732237271

HS from PT 125 I 4.702104541 -1.033066802 5.735171343 HSbrain_1389_l 3.024112414 -2.711581946 5.735694359

HS_from_MQbrain_273_r 4.632780656 -1.124780689 5.757561345 hsa-mir-124a-2_r 4.828261068 -0.933932683 5.762193751

HSbrain_327_r 4.660529086 -1.10899521 5.769524296

HSbrain_482_l 4.199508553 -1.575202359 5.774710912

Hsd_from_M md_35_r 4.487620932 -1.295421708 5.78304264

HSbrain_40_l 4.019944325 -1.773412253 5.793356578

HSbrain_533_r 4.196700156 -1.619525068 5.816225224

HS_from_MQbrain_1858_r 4.483323757 -1.335052328 5.818376085 hsa-let-7g_l 1.806582222 -4.012710072 5.819292294

HS_from_MM_35_r 4.703256578 -1.11746028 5.820716859

HSbrain_112_l 3.235279252 -2.586285347 5.821564599

Hsd_from_M md_246_r 2.780871742 -3.043528889 5.824400631

HSbrain_28_r 5.48605974 -0.346305969 5.832365709 hsa-mir-566_l 3.429280027 -2.403734308 5.833014335

HS_from_MQbrain_924_r 3.811192391 -2.037005336 5.848197727

HS_from_MQbrain_575_l 4.830160754 -1.01981064 5.849971394

Hsd_72_l 3.836626412 -2.014491701 5.851118113

HSbrain_377_r 2.907687708 -2.947146756 5.854834465

HSbrain_657_r 4.303051294 -1.556854409 5.859905704

HSbrain_26_r 4.236057005 -1.63051195 5.866568955 hsa-mir-200c_r 2.576005313 -3.290828708 5.866834021

HS_from_MM_296_l 4.744357804 -1.129429551 5.873787355

HS_267_r 3.354881307 -2.520776419 5.875657726

HS_from_MQbrain_732_l 5.596275896 -0.283871028 5.880146923

HSbrain_418_r 4.272110494 -1.60831359 5.880424085

HS_from_MQbrain_2633_l 3.794994035 -2.096595326 5.891589361

HSbrain_278_r 3.805184267 -2.089225652 5.894409919

HSbrain_558_l 4.291784938 -1.602898464 5.894683402

HS_143_r 3.012115136 -2.894275789 5.906390924

HS_from_MQbrain_792_r 3.643333503 -2.281909887 5.92524339

HS_14_I 4.709045762 -1.218830057 5.927875819

HSJ 18J 3.878595746 -2.054769168 5.933364914

HS_from_MQbrain_8_r 3.772568617 -2.162192464 5.934761082 hsa-mir-23b_r 2.780138092 -3.160150843 5.940288935

HS_from_PT_7_r 4.737928104 -1.206096838 5.944024942

Hsd_from_Mmd_260_l 4.790164575 -1.156684188 5.946848763

HSbrain_654_l 4.975188549 -0.97202554 5.947214089

HSbrain_15_l 4.679770369 -1.269776956 5.949547325

HS_from_MM_234_l 4.240768704 -1.717054897 5.957823601 hsa-mir-143_r 4.421696799 -1.538445702 5.960142501

HS_from_MQbrain_760_r 5.809892718 -0.155311287 5.965204005 hsa-mir-542_r 4.473592048 -1.497936368 5.971528416 hsa-mir-124a-1_r 5.075346959 -0.896800495 5.972147454

HS_from_MM_29_l 4.117736752 -1.854487591 5.972224343

HS_192_r 4.989345344 -0.993611356 5.9829567

HS_254_r 4.114536249 -1.868510953 5.983047203

HS_from_MQbrain_843_l 4.352681523 -1.63782679 5.990508313

HSJ 93J 4.75212295 -1.239024261 5.99114721

HS_from_PT_130_r 3.148538054 -2.856593123 6.005131177

HSbrain_765_r 4.882015038 -1.128191572 6.01020661

HS_from_MQbrain_1421_r 3.888984872 -2.124894931 6.013879803

HSbrain_436_l 4.30323071 -1.715247803 6.018478513

HS_287_r 4.495264347 -1.534503365 6.029767713

HSbrain_499_r 4.098369288 -1.932646304 6.031015592 hsa-mir-564 r 4.909851444 -1.123461194 6.033312638 HSbrain_208_r 3.212598106 -2.830561144 6.043159249

HS_from_MQbrain_807_l 4.661135153 -1.382077972 6.043213126

Hsd_from_M md_222_r 3.32302302 -2.721408253 6.044431273

HSbrain_1360_r 4.547229214 -1.500155717 6.047384931

Hsd_from_M md_271 _r 3.42090646 -2.633339035 6.054245494 hsa-mir-636_l 4.586138795 -1.480297143 6.066435938

HSbrain_83_r 5.045353177 -1.02436812 6.069721297

HS_from_MQbrain_452_l 3.931878227 -2.142948942 6.07482717

HS_from_MQbrain_661_l 3.309819773 -2.767618454 6.077438227

HSbrain_11 1_l 4.478063253 -1.601864592 6.079927845

HS_from_MQbrain_1205_r 3.798533287 -2.287026649 6.085559937

HS_from_PT_123_r 4.699877455 -1.393673208 6.093550663

HS_from_MQbrain_1803J 3.990717912 -2.104101824 6.094819736 hsa-mir-208_l 4.498924031 -1.604037691 6.102961722

HSbrain_238_l 4.522924806 -1.581116125 6.104040931

HS_from_MQbrain_137_l 5.249572176 -0.855933068 6.105505244

HSbrairM 363_r 4.690028685 -1.419093516 6.109122201

HS_from_MM_260_r 3.447152671 -2.667288315 6.114440986 hsa-mir-30e_l 3.0644184 -3.050098809 6.11451721

HSbrain_16_l 4.573890866 -1.550435178 6.124326044

HSbrain_122_r 4.320735556 -1.818946269 6.139681825 hsa-mir-551a_r 4.680313939 -1.465502125 6.145816064 hsa-mir-520f_l 5.79689907 -0.350966934 6.147866004

HSbrain_394_l 4.573621055 -1.590725756 6.164346812

HSbrain_375_l 4.170862628 -1.99497765 6.165840277

HS_from_MQbrain_287_r 4.390750308 -1.775092716 6.165843023

Hsd_26_r 4.528037162 -1.646247286 6.174284449

HSbrain_131_r 4.642917681 -1.531943569 6.17486125

HS_from_MQbrain_1502J 4.306880119 -1.872571169 6.179451288

HSJ 17J 3.914149118 -2.266893911 6.181043029

HS_from_MQbrain_374_l 4.048069346 -2.135713316 6.183782662

HSbrain_366_r 4.695428359 -1.500832349 6.196260708

HS_11_r 4.359066265 -1.840949358 6.200015623

HSbrain_766_r 4.292091907 -1.907936735 6.200028642

Hsd_from_Mmd_433_l 4.189641245 -2.014185933 6.203827179

HS_288_r 4.613651482 -1.601155032 6.214806514

Hsd_92_l 4.453319016 -1.772517608 6.225836624

HS_from_MQbrain_1295J 4.467230834 -1.769790663 6.237021496 hsa-mir-498_r 4.742805113 -1.497579431 6.240384544

HS_from_MQbrain_1312J 3.945332299 -2.307158367 6.252490666

HS_from_MQbrain_521_r 4.250672499 -2.008401215 6.259073714

HSJ 14J 4.014399822 -2.260096796 6.274496618

HSbrain_383_l 2.848711871 -3.430707313 6.279419184

HSbrain_653_l 3.553247415 -2.727155834 6.280403249

HS_from_MQbrain_1765J 4.776879998 -1.506865206 6.283745204 hsa-mir-363_l 4.650693847 -1.643106855 6.293800702

HS_from_MQbrain_1065J 4.432098881 -1.863369953 6.295468834

HSbrain_706_l 4.714094744 -1.583427201 6.297521946

Hsd_from_M md_59_r 4.939409317 -1.365011536 6.304420853

HS_205_r 4.953281694 -1.358308462 6.311590155

HS_206_l 3.947577057 -2.36586125 6.313438307 hsa-mir-106b_l 2.230048384 -4.084607376 6.314655761 hsa-mir-375_r 3.404471243 -2.913526702 6.317997945 hsa-mir-612_r 4.153701447 -2.164532199 6.318233646

Hsd_from_Mmd_227_r 4.969514785 -1.350466056 6.319980841

HS from MQbrain 525 I 4.325248296 -2.001844685 6.327092981 HS_284_r 4.382098264 -1.948138028 6.330236293 hsa-mir-27a_r 1.963166985 -4.378793384 6.341960369

HSbrain_42_r 3.597747739 -2.746338563 6.344086302

HSbrain_118_l 5.091238684 -1.260477419 6.351716103

HS_from_MQbrain_1110_r 4.905874678 -1.456293927 6.362168605

HS_from_PT_63_l 4.729838898 -1.633775996 6.363614894

HSbrain_484_l 3.495467707 -2.874483359 6.369951066

HS_from_MQbrain_820_l 5.400175183 -0.969934259 6.370109442

HS_from_MQbrain_601_l 4.33308059 -2.041207019 6.374287609

HS_from_MQbrain_1570_r 5.826121312 -0.554136646 6.380257959

HS_212_r 2.969552561 -3.426937067 6.396489629 hsa-mir-551 b_r 5.02160857 -1.381305208 6.402913778 hsa-mir-517a_l 4.530169487 -1.873171691 6.403341178

HSbrain_214_l 4.736730898 -1.66726547 6.403996368

HS_302_l 4.597912524 -1.826783726 6.42469625

HS_from_MQbrain_630_l 4.231929713 -2.193260438 6.425190151

HSbrain_20_r 5.062760753 -1.364215928 6.426976681

HS_from_PT_104_r 5.278512668 -1.162086911 6.440599579 hsa-mir-200b_r 2.909157847 -3.54818764 6.457345488

HS_from_MQbrain_967_l 4.266510532 -2.202403708 6.46891424

HS_257_r 5.232858698 -1.254197891 6.48705659

Hsd_from_Mmd_137_r 4.206897564 -2.282544453 6.489442017

HS_82_r 4.799299574 -1.691810282 6.491109856

HSbrain_566_l 4.66772169 -1.83147388 6.499195571

HS_from_MQbrain_1793J 4.095637227 -2.40403094 6.499668167

HS_273_I 4.833637268 -1.671078137 6.504715405

HSJ OOJ 3.193876747 -3.31976598 6.513642727 hsa-mir-29a_r 2.028711838 -4.495005517 6.523717354

HS_from_PT_155_l 5.059131261 -1.466536807 6.525668067

HS_from_PT_104_l 4.4602838 -2.066362192 6.526645992

HSbrain_28_l 5.393049923 -1.139202058 6.532251981

HS_from_PT_221_r 4.355040962 -2.180277912 6.535318874

HSbrainJ 362_r 4.944687989 -1.59084435 6.535532339

HS_from_MQbrain_1777_r 5.150932182 -1.387694907 6.538627089 hsa-mir-19b-2_r 1.989061638 -4.549799434 6.538861071

HS_from_MQbrain_144_l 4.038471969 -2.503355258 6.541827227

HS_from_MQbrain_1 144J 3.758683069 -2.80260379 6.56128686 hsa-mir-484_r 5.579400105 -0.985905105 6.56530521

HS_from_MQbrain_537_l 4.746677785 -1.819698903 6.566376688

HS_from_PT_180_r 4.902484378 -1.667109583 6.569593961

HS_from_MM_83_l 4.066456218 -2.51897756 6.585433779

HS_289_r 5.108709649 -1.481421146 6.590130794

H S_from_M Qbra i n_462_l 4.64779877 -1.957301099 6.605099869 hsa-mir-106a_l 2.12180599 -4.487431834 6.609237824

HSbrain_526_l 4.573914512 -2.037321142 6.611235653 hsa-mir-20b_l 2.021731933 -4.59922435 6.620956283

HSbrain_806_r 4.240528032 -2.384542882 6.625070914

HS_from_MM_323_r 5.480266936 -1.14677998 6.627046915

Hsd_11_r 5.249599651 -1.383955949 6.6335556 hsa-mir-141_r 3.847321923 -2.789655843 6.636977766

HS_from_MQbrain_207_r 4.838454137 -1.807132718 6.645586855

HS_from_MQbrain_1175_r 4.195815982 -2.452473053 6.648289034

HS_from_MQbrain_1712J 4.569203391 -2.079799264 6.649002655 hsa-mir-517c_l 4.491318049 -2.1589711 6.650289149

HS_from_PT_269_l 4.12142642 -2.531640317 6.653066737

HSbrain 638 I 4.928462908 -1.742445994 6.670908902 HS_from_MQbrain_477_l 4.941037179 -1.737334585 6.678371764

HSbrain_644_l 5.690934417 -0.990262022 6.681196439

HS_from_MQbrain_109 OJ 4.563380193 -2.118979823 6.682360015

HS Jrom_MQbrain_1571_r 5.33383266 -1.354822809 6.688655469 hsa-mir-26a-1 J 2.86738772 -3.823840736 6.691228456

HSJrom_MQbrain_506J 4.997959927 -1.694546909 6.692506836 hsa-mir-19b-1_r 2.111928811 -4.594002685 6.705931496

HSbrain_137J 4.893237752 -1.816706861 6.709944614 hsa-mir-517bj 4.566645976 -2.145699396 6.712345372

HS Jrom_MQbrain_140_r 3.986572678 -2.726394722 6.7129674

HS Jrom_MQbrain_16_r 5.566280457 -1.148896248 6.715176705

HS _from_MQbrain_1539J 4.876671232 -1.847412856 6.724084088

HSJrom_MQbrain_552_r 5.017813786 -1.716953375 6.734767161

HS_290_r 5.182365159 -1.562217353 6.744582512 hsa-mir-20aJ 2.062165027 -4.684878044 6.747043071 hsa-mir-17J 2.126869394 -4.625109005 6.751978399

HSbrain_750_r 4.066569697 -2.700350055 6.766919752

HSJrom_MQbrain_340_r 4.435814155 -2.341736847 6.777551002 hsa-mir-26a-2J 3.040722248 -3.737428702 6.77815095

HS Jrom_MQbrain_17_r 4.479251469 -2.303997472 6.783248941

HSbrain_332J 5.213396221 -1.578722089 6.79211831

HsdJrom_Mmd_483_r 5.315092406 -1.483685329 6.798777735

HS _from_MQbrain_1728J 4.985635056 -1.822843757 6.808478813

HSJrom_MQbrain_340J 3.895756709 -2.917362468 6.813119177

HSJrom_MQbrain_279J 5.214245442 -1.60627643 6.820521872

HSbrain_438J 4.738087688 -2.085318354 6.823406042

HS_from_MM_129J 4.874406145 -1.951318632 6.825724776

HS _from_MQbrain_1201 J 4.276418531 -2.551107134 6.827525665

HS_from_MQbrain_1497_r 4.97080598 -1.859203898 6.830009878 hsa-mir-200a_r 3.963877308 -2.86637397 6.830251278

HS _from_MQbrain_1320_r 5.103524221 -1.729838067 6.833362287

Hsd_55J 4.531891327 -2.302100667 6.833991994

HSbrain_660J 5.513419211 -1.330781278 6.844200489

HSbrain_1364_r 5.366606756 -1.485438789 6.852045545 hsa-mir-593J 4.932339535 -1.925441211 6.857780746

HSJ231J 4.686130131 -2.174007413 6.860137544 hsa-mir-29c_r 2.178692982 -4.681702494 6.860395475

HSbrain_437J 4.762473053 -2.124418959 6.886892012

HS_250J 4.137454636 -2.750116172 6.887570808

HS Jrom_MQbrain_153J 5.873972902 -1.014588707 6.888561609 hsa-mir-557J 5.733681079 -1.162104113 6.895785191

HSbrain_758J 5.103685318 -1.794979992 6.898665311

HSJrom_MQbrain_453J 4.787359609 -2.13175075 6.919110359

HSJrom_PT_292J 4.552921488 -2.386407281 6.93932877 hsa-mir-560J 4.394413378 -2.551856773 6.946270152 hsa-mir-345_r 4.273594511 -2.678761116 6.952355627

HSJrom_MQbrain_279_r 4.939079839 -2.042983141 6.98206298

HSJrom_MQbrainJ309J 4.985103282 -2.011053263 6.996156544

HS_from_MM_147J 3.743097086 -3.261243741 7.004340828

HS _from_MQbrain_1843J 5.965959445 -1.052555568 7.018515013

HSJrom_MQbrain_622J 4.376171362 -2.645175527 7.021346889

HSJrom_MQbrain_606_r 4.756545126 -2.283771606 7.040316732

HSbrainJ582_r 3.689488954 -3.354690718 7.044179672

HS _from_MQbrain_1463J 4.880859335 -2.164240124 7.045099459

HSbrain_136_r 5.079441797 -1.971376246 7.050818042

HS from MQbrain 2630 I 4.398935251 -2.674677908 7.073613159 HSbrain_72_r 6.017630146 -1.069678172 7.087308318

HSbrain_587_l 5.1299973 -1.964544846 7.094542146

HS_from_MQbrain_973_l 4.943200444 -2.172290006 7.11549045

HS_from_MQbrain_1168J 4.97862079 -2.137842327 7.116463118

Hsd_from_Mmd_426_l 3.747335182 -3.370219535 7.117554717 hsa-mir-663_l 5.011240432 -2.159387436 7.170627867 hsa-mir-517c_r 4.480986651 -2.69422913 7.175215781

HSbrain_237_r 4.675472342 -2.51110095 7.186573292

HS_from_MQbrain_1404_l 4.05761419 -3.139556758 7.197170948

Hsd_from_Mmd_74_l 4.339313831 -2.867371228 7.206685059

HS_from_MQbrain_170_l 6.138058127 -1.080821964 7.218880091

HS_from_MM_329_r 5.712011478 -1.521907738 7.233919216

HS_from_MQbrain_1497J 6.073170949 -1.174094228 7.247265177

HS_from_MQbrain_1810_r 6.122979468 -1.126623894 7.249603362

HS_from_MQbrain_808_l 4.947162374 -2.309157784 7.256320158

Hsd_from_Mmd_286_r 4.226672233 -3.037609517 7.26428175

HS_from_MQbrain_671_l 5.534101291 -1.744414628 7.278515919

HS_from_MQbrain_1 195_l 5.519733146 -1.778822251 7.298555397

HS_from_MQbrain_137_r 4.292665749 -3.02271647 7.315382219

HS_from_MQbrain_453_r 5.096022508 -2.234501088 7.330523596

HSbrain_620_l 4.619780262 -2.722968038 7.3427483

HS_from_MQbrain_800_l 4.99053162 -2.358874546 7.349406166 hsa-mir-29b-1_r 2.507736393 -4.843123724 7.350860117 hsa-mir-565_l 4.149892881 -3.206795324 7.356688205

HSbrain_468_l 3.80362517 -3.563185747 7.366810918 hsa-mir-29b-2_r 2.563842324 -4.826456007 7.390298331

HSbrain_534_l 4.500081575 -2.894021126 7.394102701

HS_from_MQbrain_1 109_l 4.029606516 -3.382276204 7.41188272

HSJ 30J 6.21383474 -1.223177365 7.437012105

HS_213_r 3.448098231 -4.004380141 7.452478372

HS_from_MQbrain_1784_r 5.458060554 -2.008655821 7.466716375 hsa-mir-92-1_r 3.953740575 -3.523815432 7.477556007

HS_from_MQbrain_681_r 4.86756847 -2.655295001 7.522863471

HS_from_MQbrain_1030_r 5.482419864 -2.050160962 7.532580827

HSbrain_1337_r 3.552234375 -3.996126137 7.548360511

HS_from_MQbrain_386_r 4.667495409 -2.88737231 7.554867719

HSbrain_609_r 5.007422508 -2.616095825 7.623518334 hsa-mir-92-2_r 3.874690749 -3.760803493 7.635494241 hsa-mir-663_r 5.467271847 -2.171521464 7.638793311

HS_from_MQbrain_485_l 4.276180188 -3.36267375 7.638853938

HS_from_MQbrain_530_l 4.530899577 -3.136538969 7.667438546

HS_from_MQbrain_1590_r 5.618889763 -2.063583825 7.682473587

HSbrain_412_l 4.076386045 -3.674915919 7.751301964 hsa-mir-9-2_r 4.593661545 -3.177024616 7.770686161

HS_from_MQbrain_666_l 5.485658527 -2.32972148 7.815380007

HS_from_MQbrain_1490_l 5.64200061 -2.257253419 7.899254029 hsa-mir-9-1_r 4.700973627 -3.281093675 7.982067302 hsa-mir-9-3_r 4.729775968 -3.255497845 7.985273812

HS_from_PT_114_l 3.583990998 -4.407945806 7.991936804

HS_from_MQbrain_868_l 4.38199392 -3.612346682 7.994340602

HS_from_MQbrain_750_l 4.24585762 -3.788058659 8.033916279

HSbrain_225_l 5.102922553 -3.13165277 8.234575323

HS_from_PT_114_r 3.967307291 -4.292042281 8.259349572

HS_68_I 4.385354801 -3.937554066 8.322908867 hsa-mir-520g_l 4.943810712 -3.467378187 8.4111889

HS from MM 303 r 4.847876578 -3.649650041 8.497526619 HS_306_l 5.653094519 -2.863407345 8.516501864

Hsd_from_Mmd_383_r 4.846843191 -3.732116805 8.578959996

HS_306_l 5.556294478 -3.05973905 8.616033528 hsa-mir-145_l 5.644247849 -3.038892211 8.683140061

Hsd_from_M md_94_l 4.90141117 -3.801059753 8.702470924

Hsd_13_l 5.772543113 -2.933788243 8.706331355

HS_from_MQbrain_817_l 5.668999177 -3.046828158 8.715827335

HS_from_PT_206_l 4.727701851 -4.018056539 8.74575839 hsa-mir-520h_l 5.131084114 -3.655170271 8.786254385 hsa-mir-671_l 5.767779447 -3.053619735 8.821399182 hsa-mir-21_l 1.609681489 -7.236732615 8.846414105

HS_from_PT_313_l 5.481942633 -3.408145534 8.890088167

HS_from_MQbrain_722_r 5.410709411 -3.573201166 8.983910577

HSbrain 126 r 5.454802988 -3.86635451 9.321157497 Cut off Iog2 range>4

Table 2a Small RNAs that are differentially expressed between control and adenoma adenoma vs HS_from_MQbrain_1485_r 0.008946182

Systematic Name control adj p1 HS_from_MQbrain_1522_r 0.008946182

HS_from_MM_118_r 0.000489293 HS_from_PT_101_r 0.008946182

HS_from_MM_169_r 0.000489293 Hsd_from_Mmd_298_r 0.008946182

HSbrain_106_r 0.000489293 HSJ41J 0.009734613

HSbrain_801_r 0.000489293 HS_71_I 0.009734613

Hsd_from_Mmd_485_r 0.000489293 HSbrain_411_r 0.009734613

Hsd_from_Mmd_452_l 0.000704567 Hsd_from_Mmd_117_r 0.009734613 hsa-mir-130a_r 0.001129352 HS_291_r 0.01044887

HSbrain_731_r 0.001129352 HS_from_MQbrain_1462J 0.01044887

HS_from_MQbrain_131 1_r 0.001446314 hsa-mir-325_l 0.01044887 hsa-mir-655_l 0.001446314 HSbrain_483_l 0.01044887

HS_from_MQbrain_1297J 0.001647426 HSbrain_754_r 0.01044887

HSbrain_458_r 0.001883183 HS_215_r 0.010727702

HS_from_MQbrain_1292_r 0.003939952 HS_from_MQbrain_1056J 0.010727702

HS_from_MQbrain_1657_r 0.003939952 HS_from_MQbrain_655_l 0.010727702

HS_from_MQbrain_839_r 0.003939952 HS_from_MQbrain_671_r 0.010727702

HS_from_PT_36_l 0.003939952 hsa-let-7a-3_l 0.010727702

HS_79_I 0.004006907 hsa-mir-135a-2_r 0.010727702

HS_from_MQbrain_100_l 0.004006907 hsa-mir-516-3_l 0.010727702

HS_from_MQbrain_1 183_l 0.004006907 hsa-mir-659_l 0.010727702

HS_from_MQbrain_1363J 0.004006907 hsa-mir-768_r 0.010727702

HS_from_MQbrain_1628_r 0.004006907 hsa-mir-98_l 0.010727702

HS_from_MQbrain_1823_r 0.004006907 HSbrain_253_l 0.010727702 hsa-mir-633_l 0.004006907 HSbrain_268_r 0.010727702

HS_from_MQbrain_288_r 0.004431894 HSbrain_337_l 0.010727702

HSbrain_377_l 0.004431894 HSbrain_398_r 0.010727702

HS_from_MQbrain_131_r 0.004575487 HSbrain_472_l 0.010727702

HS_from_MQbrain_20_r 0.004575487 HSbrain_485_r 0.010727702

HS_from_MQbrain_212_r 0.004575487 HSbrain_583_l 0.010727702 hsa-mir-125a_r 0.004575487 HSbrain_727_l 0.010727702 hsa-mir-196a-2_r 0.004799641 HSbrain_794_r 0.010727702 hsa-mir-302d_l 0.004799641 HSbrain_811_r 0.010727702 hsa-mir-497_r 0.004799641 HS_232_I 0.011699489

HSbrain_629_l 0.004799641 HS_from_MQbrain_629_l 0.011699489

HS_from_MQbrain_1070_r 0.004957702 HSbrain_359_r 0.011699489

HS_from_MQbrain_2380_r 0.004957702 HSbrain_709_l 0.011699489 hsa-mir-616_r 0.004957702 HSbrain_916_l 0.011699489

HSbrain_52_r 0.004957702 HSJ69J 0.012506309

Hsd_from_Mmd_480_l 0.004957702 HS_from_MQbrain_194_l 0.012506309 hsa-mir-421_r 0.006601644 HS_from_MQbrain_330_r 0.012506309

HSbrain_224_r 0.006601644 HSbrain_1437_r 0.012506309

HS_from_MM_339_r 0.00676609 HSbrain_722_l 0.012506309

H SJ ro m_M Qbra i n_566_l 0.00676609 Hsd_from_Mmd_155_l 0.012506309 hsa-mir-554_l 0.00676609 Hsd_from_Mmd_219_r 0.012506309 hsa-mir-573_l 0.00676609 HS_from_MQbrain_1687J 0.013034759

HSbrain_1076_r 0.00676609 HS_from_MQbrain_71_r 0.013034759

HSbrain_426_r 0.00676609 HS_from_MQbrain_843_r 0.013034759

HSbrain_102_r 0.007781761 hsa-let-7f-1_l 0.013034759

HS_from_MQbrain_441_l 0.008573112 hsa-let-7g_l 0.013034759

HSbrain_231_l 0.008573112 hsa-mir-126_r 0.013034759

Hsd_49_r 0.008573112 hsa-mir-516-4_l 0.013034759

HS_217_I 0.008946182 HSbrain_399_l 0.013034759

HS from MM 295 I 0.008946182 HSbrain 617 I 0.013034759 Hsd_107_l 0.013034759 HSbrain_636_l 0.018600058

HS_from_MQbrain_1444J 0.014035635 HSbrain_703_r 0.018600058

HS_from_MQbrain_79_r 0.014035635 Hsd_from_Mmd_533_l 0.018600058

HSbrain_2_l 0.014035635 Hsd_from_M md_92_r 0.018600058

HSbrain_377_r 0.014035635 HS_262_I 0.019454312

HSbrain_446_l 0.014035635 HS_from_MM_309_r 0.019454312

HSbrain_75_l 0.014035635 HS_from_MQbrain_1 103_l 0.019454312

Hsd_70_l 0.014035635 HS_from_MQbrain_917_r 0.019454312

HS_9_r 0.015394932 HS_from_PT_146_r 0.019454312

HS_from_MQbrain_1485J 0.015394932 HS_from_PT_40_r 0.019454312

HS_from_MQbrain_349_l 0.015394932 hsa-mir-299_l 0.019454312

HSbrain_1305_l 0.015394932 hsa-mir-568_r 0.019454312

HSbrain_540_r 0.015394932 hsa-mir-92-2_r 0.019454312

HS_21_r 0.015739043 HSbrain_1377_l 0.019454312

HS_from_MQbrain_1624J 0.015739043 HSbrain_1413_l 0.019454312

HS_from_MQbrain_1792_r 0.015739043 HSbrain_321_r 0.019454312

HS_from_MQbrain_191 1 0.015739043 HSbrain_714_l 0.019454312

HS_from_MQbrain_2700_r 0.015739043 HSbrain_723_l 0.019454312

HS_from_MQbrain_375_l 0.015739043 HS_291_r 0.021088597

HS_from_MQbrain_619_r 0.015739043 HS_from_MM_63_l 0.021088597

HS_from_MQbrain_940_r 0.015739043 HS_from_MQbrain_1260_r 0.021088597 hsa-mir-133a-2_r 0.015739043 HS_from_PT_201_r 0.021088597 hsa-mir-181a-1_l 0.015739043 HS_from_PT_237_r 0.021088597 hsa-mir-591_r 0.015739043 hsa-mir-125a_l 0.021088597

HSbrain_12_l 0.015739043 Hsd_46_l 0.021088597

HSbrain_753_r 0.015739043 Hsd_from_Mmd_527_r 0.021088597

Hsd_from_Mmd_473_l 0.015739043 HS_from_MM_178_r 0.022745616

HS_281_r 0.016464393 HS_from_MM_18_l 0.022745616

HS_from_MM_264_l 0.016464393 HS_from_MQbrain_207_l 0.022745616

HS_from_MQbrain_350_l 0.016464393 HS_from_MQbrain_549_l 0.022745616

HS_from_MQbrain_825_r 0.016464393 hsa-mir-27a_r 0.022745616

HS_from_MQbrain_854_r 0.016464393 hsa-mir-383_r 0.022745616

HS_from_PT_114_r 0.016464393 HSbrain_500_r 0.022745616 hsa-let-7a-1_l 0.016464393 HSbrain_597_r 0.022745616 hsa-let-7a-2_l 0.016464393 HSbrain_74_r 0.022745616

HSbrainJJ 0.016464393 HS_218_r 0.023736962

HSbrain_158_l 0.016464393 HS_from_MM_241_l 0.023736962

HSbrain_171_l 0.016464393 HS_from_MM_319_l 0.023736962

HSbrain_420_r 0.016464393 HS_from_MQbrain_1317_r 0.023736962

HS_from_MQbrain_1 100_l 0.017198956 HS_from_MQbrain_1456J 0.023736962

HS_from_MQbrain_1 128J 0.017198956 HS_from_MQbrain_1632_r 0.023736962

HS_from_MQbrain_1393_r 0.017198956 HS_from_MQbrain_1884_r 0.023736962

HS_from_MQbrain_1630J 0.017198956 HS_from_PT_114_l 0.023736962

HS_from_MQbrain_965_l 0.017198956 HS_from_PT_257_r 0.023736962

HS_from_PT_190_r 0.017198956 HS_from_PT_26_r 0.023736962 hsa-mir-181 c_l 0.017198956 HS_from_PT_32_r 0.023736962 hsa-mir-296_l 0.017198956 hsa-mir-29a_r 0.023736962

HSbrain_148_r 0.017198956 HSbrain_243_l 0.023736962

HSbrain_225_r 0.017198956 HSbrain_527_r 0.023736962

HSbrain_713_r 0.017198956 HSbrain_8_r 0.023736962

Hsd_18_l 0.017198956 Hsd_26_l 0.023736962

Hsd_from_Mmd_519_l 0.017198956 HS_255_I 0.024762366

HS_from_MM_39_l 0.018600058 HS_from_MM_334_l 0.024762366

HS_from_MQbrain_1625_r 0.018600058 HS_from_MQbrain_1043_r 0.024762366 hsa-mir-454_r 0.018600058 HS_from_MQbrain_1085J 0.024762366

HSbrain 398 I 0.018600058 HS from MQbrain 1300 r 0.024762366 HS_from_MQbrain_1761_r 0.024762366 HS_from_MQbrain_1863J 0.03224042

HS_from_MQbrain_1808_r 0.024762366 HS_from_PT_103_l 0.03224042

H S_from_M Qbra i n_55_l 0.024762366 hsa-mir-106b_r 0.03224042 hsa-mir-197_l 0.024762366 hsa-mir-145_l 0.03224042 hsa-mir-323_l 0.024762366 Hsd_105_l 0.03224042 hsa-mir-92-1_r 0.024762366 Hsd_17_r 0.03224042

HSbrainJ 384_r 0.024762366 HS_231_r 0.03374871

HSbrain_362_r 0.024762366 HS_from_MM_359_l 0.03374871

HSbrain_503_r 0.024762366 HS_from_MQbrain_1690J 0.03374871

HSbrain_6_r 0.024762366 HS_from_MQbrain_435_l 0.03374871

HSbrain_778_r 0.024762366 HS_from_MQbrain_482_l 0.03374871

Hsd_from_Mmd_387_l 0.024762366 HS_from_MQbrain_800_r 0.03374871

HS_from_MM_121_l 0.026800941 HS_from_MQbrain_969_l 0.03374871

HS_from_MM_131_l 0.026800941 hsa-mir-133a-1_r 0.03374871

HS_from_MQbrain_1684J 0.026800941 hsa-mir-640_l 0.03374871

HS_from_MQbrain_444_r 0.026800941 hsa-mir-668_r 0.03374871

HS_from_MQbrain_509_r 0.026800941 HSbrainJ 65_l 0.03374871

HS_from_MQbrain_734_l 0.026800941 HSbrain_316_l 0.03374871 hsa-mir-598_l 0.026800941 HSbrain_41_l 0.03374871 hsa-mir-647_r 0.026800941 HSbrain_458_l 0.03374871

HSbrain_359_l 0.026800941 HSbrain_500_l 0.03374871

HS_262_r 0.028655448 HSbrain_760_l 0.03374871

HS_from_MQbrain_391_r 0.028655448 HSbrain_792_r 0.03374871

HS_from_MQbrain_74_r 0.028655448 Hsd_from_Mmd_487_r 0.03374871

HS_from_PT_139_l 0.028655448 Hsd_from_M md_81 J 0.03374871 hsa-let-7d_l 0.028655448 HS_97_r 0.036099692 hsa-mir-373_r 0.028655448 HS_from_MQbrain_1340J 0.036099692 hsa-mir-378_r 0.028655448 HS_from_MQbrain_1513_r 0.036099692 hsa-mir-500_l 0.028655448 HS_from_PT_295_r 0.036099692

HSbrain_318_l 0.028655448 HS_from_PT_299_r 0.036099692

HSbrain_50_r 0.028655448 hsa-mir-26b_l 0.036099692

HSbrain_545_r 0.028655448 hsa-mir-30c-1_l 0.036099692

Hsd_from_Mmd_302_r 0.028655448 hsa-mir-423_r 0.036099692

HSJ 06J 0.02997784 HSbrain_272_l 0.036099692

HS_from_MQbrain_1 169J 0.02997784 Hsd_102_l 0.036099692

HS_from_MQbrain_1832J 0.02997784 Hsd_from_M md_23_l 0.036099692

HS_from_MQbrain_1985J 0.02997784 Hsd_from_Mmd_410_r 0.036099692

HS_from_MQbrain_918_l 0.02997784 Hsd_from_Mmd_97_l 0.036099692

HS_from_PT_299_l 0.02997784 HS_292_I 0.038273758 hsa-let-7f-2_l 0.02997784 HS_33_I 0.038273758 hsa-mir-134_r 0.02997784 HS_from_MM_354_r 0.038273758 hsa-mir-146a_l 0.02997784 HS_from_MQbrain_1087J 0.038273758 hsa-mir-331_r 0.02997784 HS_from_MQbrain_1315_l 0.038273758 hsa-mir-453_l 0.02997784 HS_from_MQbrain_1420J 0.038273758 hsa-mir-95_r 0.02997784 HS_from_MQbrain_282_l 0.038273758

HSbrain_114_r 0.02997784 HS_from_MQbrain_498_r 0.038273758

HSbrain_259_r 0.02997784 HS_from_MQbrain_883_l 0.038273758

HSbrain_296_l 0.02997784 hsa-mir-140_l 0.038273758

HSbrain_546_r 0.02997784 hsa-mir-550-2_r 0.038273758

HSbrain_696_r 0.02997784 HSbrain_261_l 0.038273758

HSbrain_713_l 0.02997784 HSbrain_266_r 0.038273758

HSJ 18J 0.03224042 HSbrain_543_r 0.038273758

HS_from_MQbrain_1392_r 0.03224042 HSbrain_580_r 0.038273758

HS_from_MQbrain_1443_r 0.03224042 HSbrain_700_r 0.038273758

HS_from_MQbrain_1445J 0.03224042 HSJ89J 0.040151024

HS from MQbrain 1469 r 0.03224042 HS 191 I 0.040151024 HS_56_r 0.040151024 HS_from_MQbrain_539_r 0.048378078

HS_from_MM_276_l 0.040151024 H S_from_M Qbra i n_92_l 0.048378078

HS_from_MQbrain_1080_l 0.040151024 hsa-mir-200c_r 0.048378078

HS_from_MQbrain_1379_r 0.040151024 hsa-mir-92b_r 0.048378078

HS_from_MQbrain_1561_r 0.040151024 HSbrain_1362_l 0.048378078

HS_from_MQbrain_1703_r 0.040151024 HSbrain_25_r 0.048378078

HS_from_MQbrain_1747_r 0.040151024 HSbrain_48_r 0.048378078

HS_from_MQbrain_470_l 0.040151024 HSbrain_703_l 0.048378078

HS_from_MQbrain_951_l 0.040151024 Hsd_from_M md_49_l 0.048378078

HS_from_PT_43_l 0.040151024 HS_171_r 0.050130838 hsa-let-7a-2_r 0.040151024 HS_215_I 0.050130838 hsa-let-7c_r 0.040151024 HS_93_r 0.050130838 hsa-mir-181a-2_l 0.040151024 HS_from_MQbrain_1042_r 0.050130838 hsa-mir-329-2_r 0.040151024 HS_from_MQbrain_1283J 0.050130838

HSbrain_109_l 0.040151024 HS_from_MQbrain_1610_r 0.050130838

HSbrain_92_l 0.040151024 HS_from_MQbrain_1642J 0.050130838

Hsd_from_M md_436_r 0.040151024 HS_from_MQbrain_1686_l 0.050130838

Hsd_from_Mmd_527_l 0.040151024 HS_from_MQbrain_1771J 0.050130838

HS_15_I 0.042549287 HS_from_MQbrain_209_r 0.050130838

HSJ 77J 0.042549287 HS_from_MQbrain_315_l 0.050130838

HS_261_r 0.042549287 HS_from_MQbrain_343_l 0.050130838

HS_from_MM_289_l 0.042549287 HS_from_MQbrain_542_r 0.050130838

HS_from_MQbrain_1227J 0.042549287 HS_from_MQbrain_572_l 0.050130838

HS_from_MQbrain_1246J 0.042549287 HS_from_MQbrain_691_l 0.050130838

HS_from_MQbrain_1388J 0.042549287 HS_from_MQbrain_774_r 0.050130838

HS_from_MQbrain_1844_r 0.042549287 H S_from_M Qbra i n_842_l 0.050130838

HS_from_MQbrain_67_r 0.042549287 HS_from_MQbrain_901_l 0.050130838

HS_from_MQbrain_782_r 0.042549287 HS_from_PT_136_l 0.050130838

HS_from_PT_63_r 0.042549287 hsa-mir-141_r 0.050130838

HS_from_PT_91_r 0.042549287 hsa-mir-584_r 0.050130838 hsa-mir-148a_r 0.042549287 hsa-mir-668_l 0.050130838

HSbrain_1410_l 0.042549287 hsa-mir-767_r 0.050130838

HSbrain_752_r 0.042549287 HSbrain_585_l 0.050130838

Hsd_42_r 0.042549287 HSbrain_652_l 0.050130838

Hsd_from_Mmd_261_l 0.042549287 HSbrain_84_l 0.050130838

HS_266_r 0.045725655 Hsd_65_l 0.050130838

HS_from_MQbrain_1143_r 0.045725655 HS_131_r 0.053159859

HS_from_MQbrain_1717_r 0.045725655 HS_from_MQbrain_1239J 0.053159859

HS_from_MQbrain_951_l 0.045725655 HS_from_MQbrain_1334_r 0.053159859

HS_from_PT_21_r 0.045725655 HS_from_MQbrain_1395_r 0.053159859

HS_from_PT_70_r 0.045725655 HS_from_MQbrain_1484J 0.053159859 hsa-mir-148a_l 0.045725655 HS_from_MQbrain_1794J 0.053159859 hsa-mir-653_l 0.045725655 HS_from_MQbrain_1958J 0.053159859

HSbrain_284_l 0.045725655 HS_from_MQbrain_723_l 0.053159859

Hsd_63_r 0.045725655 HS_from_MQbrain_873_r 0.053159859

Hsd_from_M md_34_r 0.045725655 hsa-mir-520b_r 0.053159859

Hsd_from_Mmd_422_l 0.045725655 HSbrain_374_r 0.053159859

HSJ 14J 0.048378078 HSbrain_442_r 0.053159859

HS_212_I 0.048378078 HSbrain_711_l 0.053159859

HS_from_MM_1_r 0.048378078 Hsd_18_r 0.053159859

HS_from_MM_32_r 0.048378078 Hsd_37_l 0.053159859

HS_from_MQbrain_1006_l 0.048378078 Hsd_6_l 0.053159859

HS_from_MQbrain_1075J 0.048378078 Hsd_76_r 0.053159859

HS_from_MQbrain_1752J 0.048378078 Hsd_from_Mmd_535_r 0.053159859

HS_from_MQbrain_1773J 0.048378078 HS_59_I 0.05566524

HS from MQbrain 472 r 0.048378078 HS 62 I 0.05566524 HS_from_MM_115_l 0.05566524 HS_from_MQbrain_1862J 0.061046963

HS_from_MM_49_l 0.05566524 HS_from_MQbrain_420_l 0.061046963

HS_from_MM_72_r 0.05566524 HS_from_MQbrain_43_l 0.061046963

HS_from_MQbrain_1620J 0.05566524 HS_from_MQbrain_70_l 0.061046963

HS_from_MQbrain_1674J 0.05566524 HS_from_MQbrain_991_r 0.061046963

HS_from_MQbrain_1700_r 0.05566524 HS_from_PT_242_l 0.061046963

HS_from_MQbrain_38_r 0.05566524 HS_from_PT_340_l 0.061046963

HS_from_MQbrain_56_l 0.05566524 hsa-mir-299_r 0.061046963

HS_from_MQbrain_579_l 0.05566524 hsa-mir-412_r 0.061046963

H S_f ro m_M Qbra i n_664_l 0.05566524 hsa-mir-628_r 0.061046963

HS_from_PT_321_r 0.05566524 HSbrain_214_l 0.061046963 hsa-mir-372_r 0.05566524 HSbrain_408_r 0.061046963 hsa-mir-521-1_r 0.05566524 HSbrain_409_r 0.061046963 hsa-mir-652_l 0.05566524 HSbrain_663_l 0.061046963

HSbrain_239_l 0.05566524 Hsd_from_Mmd_284_l 0.061046963

HSbrain_419_l 0.05566524 Hsd_from_Mmd_439_l 0.061046963

HSbrain_671_r 0.05566524 HS_180_r 0.064770288

HSbrain_704_l 0.05566524 HS_from_MM_6_r 0.064770288

HSbrain_719_l 0.05566524 HS_from_MQbrain_1235J 0.064770288

HSbrain_85_l 0.05566524 HS_from_MQbrain_1446J 0.064770288

HSbrain_916_r 0.05566524 HS_from_MQbrain_1450_r 0.064770288

Hsd_from_Mmd_500_r 0.05566524 HS_from_MQbrain_1696J 0.064770288

HS_109_r 0.058253679 HS_from_MQbrain_435_r 0.064770288

HS_156_I 0.058253679 HS_from_MQbrain_750_r 0.064770288

HSJ 90J 0.058253679 HS_from_PT_308_l 0.064770288

HS_from_MQbrain_1099_r 0.058253679 HS_from_PT_41_r 0.064770288

HS_from_MQbrain_1 119_l 0.058253679 hsa-mir-29c_r 0.064770288

HS_from_MQbrain_1300J 0.058253679 HSbrain_116_l 0.064770288

HS_from_MQbrain_1374J 0.058253679 HSbrain_1338_r 0.064770288

HS_from_MQbrain_796_l 0.058253679 HSbrain_157_l 0.064770288

HS_from_MQbrain_81 OJ 0.058253679 HSbrain_506_l 0.064770288

HS_from_MQbrain_883_r 0.058253679 HSbrain_598_l 0.064770288

HS_from_MQbrain_974_l 0.058253679 HSbrain_755_l 0.064770288

HS_from_PT_121_r 0.058253679 HSbrain_776_l 0.064770288

HS_from_PT_187_r 0.058253679 Hsd_81_r 0.064770288 hsa-mir-148b_r 0.058253679 HS_203_r 0.067503134 hsa-mir-20b_l 0.058253679 HS_from_MM_342_r 0.067503134 hsa-mir-514-1_r 0.058253679 HS_from_MM_47_l 0.067503134 hsa-mir-646_r 0.058253679 HS_from_MQbrain_1 164J 0.067503134

HSbrain_123_l 0.058253679 HS_from_MQbrain_1323J 0.067503134

HSbrain_300_l 0.058253679 HS_from_MQbrain_1427J 0.067503134

HSbrain_304_r 0.058253679 HS_from_MQbrain_1877J 0.067503134

HSbrain_35_r 0.058253679 HS_from_MQbrain_239_r 0.067503134

Hsd_19_r 0.058253679 HS_from_MQbrain_468_r 0.067503134

Hsd_7_r 0.058253679 HS_from_MQbrain_549_r 0.067503134

Hsd_from_Mmd_166_l 0.058253679 HS_from_MQbrain_745_r 0.067503134

Hsd_from_Mmd_70_l 0.058253679 HS_from_PT_112_l 0.067503134

HSJ 50J 0.061046963 HS_from_PT_339_l 0.067503134

HS_281_r 0.061046963 hsa-mir-137_l 0.067503134

HS_304_r 0.061046963 hsa-mir-329-1_r 0.067503134

HS_36_I 0.061046963 hsa-mir-518f_r 0.067503134

HS_from_MQbrain_128_r 0.061046963 hsa-mir-524_l 0.067503134

HS_from_MQbrain_1354J 0.061046963 HSbrain_139_l 0.067503134

HS_from_MQbrain_1404_r 0.061046963 HSbrain_212_l 0.067503134

HS_from_MQbrain_1412_l 0.061046963 HSbrain_330_l 0.067503134

HS from MQbrain 1500 I 0.061046963 HSbrain 431 r 0.067503134 HSbrain_469_l 0.067503134 HSJrom_MQbrain_253_r 0.072349461

HSbrain_572_r 0.067503134 HSJrom_MQbrain_433J 0.072349461

Hsd_42_l 0.067503134 HS_from_MQbrain_991J 0.072349461

Hsd_62_l 0.067503134 HSJrom_PT_170J 0.072349461

Hsd_from_Mmd_311_l 0.067503134 hsa-mir-199a-2_r 0.072349461

Hsd_from_Mmd_370_r 0.067503134 hsa-mir-200b_r 0.072349461

Hsd_from_Mmd_436_l 0.067503134 hsa-mir-204_r 0.072349461

Hsd_from_M md_524_r 0.067503134 hsa-mir-219-1_r 0.072349461

HS_from_MM_1_l 0.069749265 hsa-mir-224J 0.072349461

HS_from_MQbrain_1215_l 0.069749265 hsa-mir-363J 0.072349461

HS_from_MQbrain_1376J 0.069749265 hsa-mir-449b_r 0.072349461

HS_from_MQbrain_1771_r 0.069749265 HSbrain_1363J 0.072349461

HS_from_MQbrain_1841_r 0.069749265 HSbrain_1364J 0.072349461

HS_from_MQbrain_251_r 0.069749265 HSbrain_250_r 0.072349461

HS_from_MQbrain_29_r 0.069749265 HSbrain_301J 0.072349461

HS_from_MQbrain_366_r 0.069749265 HSbrain_480_r 0.072349461

HS_from_MQbrain_37_r 0.069749265 HSbrain_507J 0.072349461

HS_from_MQbrain_641_r 0.069749265 HSbrain_635J 0.072349461

HS_from_MQbrain_723_r 0.069749265 HSbrain_747J 0.072349461

HS_from_MQbrain_739_l 0.069749265 HSbrain_749_r 0.072349461

HS_from_MQbrain_997_l 0.069749265 HsdJrom_Mmd_333_r 0.072349461

HS_from_PT_187_l 0.069749265 HS_166_r 0.076797167

HS_from_PT_201_l 0.069749265 HS_66_r 0.076797167

HS_from_PT_235_l 0.069749265 HSJrom_MM_219J 0.076797167 hsa-mir-124a-3_r 0.069749265 HS_from_MMJ353J 0.076797167 hsa-mir-193a_l 0.069749265 HSJrom_MQbrain_1414_r 0.076797167 hsa-mir-30b_l 0.069749265 HSJrom_MQbrain_224J 0.076797167 hsa-mir-331_l 0.069749265 HSJrom_MQbrain_590J 0.076797167 hsa-mir-506_l 0.069749265 HSJrom_MQbrain_634J 0.076797167 hsa-mir-616_l 0.069749265 HSJrom_MQbrain_687_r 0.076797167 hsa-mir-619_l 0.069749265 HSJrom_MQbrain_698_r 0.076797167 hsa-mir-644_r 0.069749265 HSJromJVIQbrain_930_r 0.076797167 hsa-mir-9-3_r 0.069749265 HSJrom_PT_73J 0.076797167

HSbrain_155_r 0.069749265 hsa-mir-124a-2_r 0.076797167

HSbrain_245_r 0.069749265 hsa-mir-379J 0.076797167

HSbrain_371_r 0.069749265 HSbrain_271J 0.076797167

HSbrain_610_r 0.069749265 HSbrain_344J 0.076797167

HSbrain_657_l 0.069749265 HSbrain_43_r 0.076797167

HSbrain_721_r 0.069749265 HSbrain_767_r 0.076797167

HSbrain_728_l 0.069749265 HSbrain_788J 0.076797167

HSbrain_777_r 0.069749265 HsdJ38_r 0.076797167

Hsd_50_l 0.069749265 HSJ 19J 0.079954597

Hsd_from_Mmd_330_l 0.069749265 HSJ213J 0.079954597

HS_49_r 0.072349461 HS_215_r 0.079954597

HS_81_r 0.072349461 HS_223J 0.079954597

HS_98_I 0.072349461 HS Jrom_MQbrain_1520_r 0.079954597

HS_from_MM_289_r 0.072349461 HSJrom_MQbrain_1637_r 0.079954597

HS_from_MM_295_r 0.072349461 HS Jrom_MQbrain_1665_r 0.079954597

HS_from_MQbrain_1082J 0.072349461 HS_from_MQbrain_1700J 0.079954597

HS_from_MQbrain_1219_l 0.072349461 HS_from_MQbrain_1706J 0.079954597

HS_from_MQbrain_1268J 0.072349461 HS Jrom_MQbrain_1745_r 0.079954597

HS_from_MQbrain_128 OJ 0.072349461 HS_from_MQbrain_1777J 0.079954597

HS _from_MQbrain_1561 J 0.072349461 H S _f rom_M Qbra i n J576 J 0.079954597

HS Jrom_MQbrain_1565_r 0.072349461 HSJrom_MQbrainJ304_r 0.079954597

HS Jrom_MQbrain_1658_r 0.072349461 HSJrom_PT_102J 0.079954597

HS from MQbrain 1748 r 0.072349461 HS from PT 148 I 0.079954597 hsa-mir-124a-1_r 0.079954597 HS_from_MQbrain_291_l 0.088143181 hsa-mir-199a-1_r 0.079954597 HS_from_MQbrain_686_r 0.088143181 hsa-mir-641_l 0.079954597 HS_from_MQbrain_806_l 0.088143181 hsa-mir-9-1_r 0.079954597 HS_from_MQbrain_848_l 0.088143181

HSbrain_1337_l 0.079954597 HS_from_MQbrain_948_r 0.088143181

HSbrain_1406_l 0.079954597 HS_from_PT_126_l 0.088143181

HSbrain_1423_l 0.079954597 HS_from_PT_254_r 0.088143181

HSbrain_1425_r 0.079954597 hsa-mir-20a_l 0.088143181

HSbrain_172_l 0.079954597 hsa-mir-375_l 0.088143181

HSbrain_317_l 0.079954597 hsa-mir-521-2_r 0.088143181

HSbrain_455_r 0.079954597 hsa-mir-617_l 0.088143181

HSbrain_661_l 0.079954597 hsa-mir-648_l 0.088143181

HSbrain_797_r 0.079954597 HSbrain_122_l 0.088143181

Hsd_101_l 0.079954597 HSbrain_124_l 0.088143181

Hsd_11_l 0.079954597 HSbrain_170_r 0.088143181

Hsd_33_l 0.079954597 HSbrain_276_l 0.088143181

Hsd_from_Mmd_204_l 0.079954597 HSbrain_530_l 0.088143181

Hsd_from_Mmd_215_r 0.079954597 HSbrain_590_r 0.088143181

HS_57_I 0.083930001 HS_4_r 0.09152926

HS_from_MM_195_r 0.083930001 HS_from_MM_184_r 0.09152926

HS_from_MM_202_l 0.083930001 HS_from_MQbrain_1031J 0.09152926

HS_from_MQbrain_1 102_l 0.083930001 HS_from_MQbrain_1037_r 0.09152926

HS_from_MQbrain_1 13_r 0.083930001 HS_from_MQbrain_1227J 0.09152926

HS_from_MQbrain_1253_r 0.083930001 HS_from_MQbrain_1314J 0.09152926

HS_from_MQbrain_1325_r 0.083930001 HS_from_MQbrain_1417_l 0.09152926

HS_from_MQbrain_154_l 0.083930001 HS_from_MQbrain_1437J 0.09152926

HS_from_MQbrain_1593_r 0.083930001 HS_from_MQbrain_1494J 0.09152926

HS_from_MQbrain_384_r 0.083930001 HS_from_MQbrain_1592J 0.09152926

HS_from_MQbrain_48_r 0.083930001 HS_from_MQbrain_1602J 0.09152926

HS_from_MQbrain_597_r 0.083930001 HS_from_MQbrain_1658J 0.09152926

HS_from_MQbrain_669_r 0.083930001 HS_from_MQbrain_1678_r 0.09152926

HS_from_MQbrain_675_r 0.083930001 HS_from_MQbrain_1684_r 0.09152926

HS_from_MQbrain_715_l 0.083930001 HS_from_MQbrain_1726J 0.09152926

HS_from_MQbrain_769_r 0.083930001 HS_from_MQbrain_1758_r 0.09152926

HS_from_MQbrain_814_l 0.083930001 HS_from_MQbrain_1781J 0.09152926

HS_from_PT_20_r 0.083930001 HS_from_MQbrain_1885_r 0.09152926

HS_from_PT_313_r 0.083930001 HS_from_MQbrain_487_l 0.09152926 hsa-mir-635_l 0.083930001 H S_from_M Qbra i n_550_l 0.09152926

HSbrain_286_l 0.083930001 HS_from_MQbrain_770_r 0.09152926

HSbrain_389_l 0.083930001 HS_from_MQbrain_779_l 0.09152926

HSbrain_437_r 0.083930001 HS_from_PT_95_r 0.09152926

HSbrain_463_r 0.083930001 hsa-let-7f-1_r 0.09152926

HSbrain_548_l 0.083930001 hsa-mir-502_l 0.09152926

HSbrain_56_l 0.083930001 hsa-mir-506_r 0.09152926

HSbrain_711_r 0.083930001 HSbrain_1360_l 0.09152926

Hsd_from_Mmd_501_r 0.083930001 HSbrain_19_l 0.09152926

HSJ 02J 0.088143181 HSbrain_237_r 0.09152926

HS_11_I 0.088143181 HSbrain_619_r 0.09152926

HS_71_r 0.088143181 HSbrain_637_l 0.09152926

HS_80_l 0.088143181 HSbrain_642_r 0.09152926

HS_from_MM_165_l 0.088143181 Hsd_from_Mmd_120_r 0.09152926

HS_from_MM_229_r 0.088143181 Hsd_from_Mmd_161_l 0.09152926

HS_from_MM_347_l 0.088143181 Hsd_from_Mmd_371_r 0.09152926

HS_from_MQbrain_1064_r 0.088143181 Hsd_from_Mmd_378_l 0.09152926

HS_from_MQbrain_1267_r 0.088143181 Hsd_from_Mmd_93_r 0.09152926

HS from MQbrain 1626 r 0.088143181 HS 129 I 0.095394629 HSJ 73J 0.095394629 hsa-mir-630_r 0.098921026

HS_288_I 0.095394629 hsa-mir-661_r 0.098921026

HS_61_I 0.095394629 HSbrain_1425_l 0.098921026

HS_from_MM_150_r 0.095394629 HSbrain_240_l 0.098921026

HS_from_MQbrain_1201_r 0.095394629 HSbrain_305_r 0.098921026

HS_from_MQbrain_1228_r 0.095394629 HSbrain_415_l 0.098921026

HS_from_MQbrain_1241_r 0.095394629 HSbrain_540_l 0.098921026

HS_from_MQbrain_1545_r 0.095394629 HSbrain_680_r 0.098921026

HS_from_MQbrain_163_l 0.095394629 HSbrain_720_l 0.098921026

HS_from_MQbrain_1648_r 0.095394629 HSbrain_722_r 0.098921026

HS_from_MQbrain_255_l 0.095394629 HSbrain_769_r 0.098921026

HS_from_MQbrain_458_l 0.095394629 HSbrain_86_r 0.098921026

HS_from_MQbrain_755_l 0.095394629 Hsd_20_r 0.098921026

HS_from_MQbrain_932_l 0.095394629 Hsd_from_Mmd_176_l 0.098921026

HS_from_PT_339_r 0.095394629 Hsd_from_Mmd_318_l 0.098921026

HS_from_PT_50_r 0.095394629 Hsd_from_Mmd_325_l 0.098921026

HS_from_PT_74_r 0.095394629 Hsd_from_Mmd_344_l 0.098921026 hsa-mir-625_r 0.095394629 Hsd_from_Mmd_480_r 0.098921026

HSbrain_113_r 0.095394629 HS_172_r 0.103393572

HSbrain_209_l 0.095394629 HS_68_I 0.103393572

HSbrain_453_r 0.095394629 HS_from_MM_346_r 0.103393572

HSbrain_473_l 0.095394629 HS_from_MQbrain_1355_r 0.103393572

HSbrain_481_r 0.095394629 HS_from_MQbrain_1442J 0.103393572

HSbrain_557_r 0.095394629 HS_from_MQbrain_1459J 0.103393572

HSbrain_570_r 0.095394629 HS_from_MQbrain_1633_r 0.103393572

HSbrain_691_l 0.095394629 HS_from_MQbrain_1744_r 0.103393572

HSbrain_708_l 0.095394629 HS_from_MQbrain_1784_r 0.103393572

HSbrain_717_l 0.095394629 HS_from_MQbrain_412_l 0.103393572

Hsd_79_l 0.095394629 HS_from_MQbrain_609_l 0.103393572

Hsd_from_Mmd_166_r 0.095394629 HS_from_MQbrain_751_l 0.103393572

Hsd_from_Mmd_223_r 0.095394629 HS_from_MQbrain_882_l 0.103393572

Hsd_from_Mmd_298_l 0.095394629 HS_from_MQbrain_906_r 0.103393572

Hsd_from_Mmd_324_l 0.095394629 HS_from_MQbrain_943_l 0.103393572

Hsd_from_Mmd_519_r 0.095394629 HS_from_PT_22_l 0.103393572

HSJ 57J 0.098921026 HS_from_PT_27_l 0.103393572

HS_306_r 0.098921026 hsa-mir-10a_r 0.103393572

HS_38_r 0.098921026 hsa-mir-155_l 0.103393572

HS_from_MM_103_l 0.098921026 hsa-mir-296_r 0.103393572

HS_from_MM_237_l 0.098921026 hsa-mir-324_r 0.103393572

HS_from_MM_313_l 0.098921026 hsa-mir-99a_r 0.103393572

HS_from_MM_34_l 0.098921026 HSbrain_319_l 0.103393572

HS_from_MM_92_r 0.098921026 HSbrain_343_l 0.103393572

HS_from_MQbrain_1139_r 0.098921026 HSbrain_482_l 0.103393572

HS_from_MQbrain_1213_l 0.098921026 HSbrain_504_r 0.103393572

HS_from_MQbrain_1382J 0.098921026 HSbrain_596_r 0.103393572

HS_from_MQbrain_1410_l 0.098921026 HSbrain_673_r 0.103393572

HS_from_MQbrain_1753_r 0.098921026 HSbrain_677_l 0.103393572

HS_from_MQbrain_2670_r 0.098921026 HSbrain_684_r 0.103393572

HS_from_MQbrain_574_l 0.098921026 HSbrain_94_l 0.103393572

HS_from_MQbrain_868_l 0.098921026 Hsd_111_r 0.103393572 hsa-let-7c_l 0.098921026 Hsd_63_l 0.103393572 hsa-mir-30d_l 0.098921026 Hsd_from_Mmd_78_r 0.103393572 hsa-mir-507_l 0.098921026 HSJ 01J 0.108118292 hsa-mir-513-1_l 0.098921026 HSJ64J 0.108118292 hsa-mir-518b_r 0.098921026 HS_from_MM_124_l 0.108118292 hsa-mir-532 I 0.098921026 HS from MQbrain 114 r 0.108118292 HS_from_MQbrain_1366J 0.108118292 HSbrain_412_l 0.113099484

HS_from_MQbrain_1627J 0.108118292 HSbrain_47_r 0.113099484

HS_from_MQbrain_1637J 0.108118292 HSbrain_495_r 0.113099484

HS_from_MQbrain_1840J 0.108118292 HSbrain_509_l 0.113099484

HS_from_MQbrain_374_r 0.108118292 HSbrain_520_l 0.113099484

HS_from_MQbrain_437_l 0.108118292 HSbrain_568_r 0.113099484

HS_from_MQbrain_546_l 0.108118292 HSbrain_764_r 0.113099484

HS_from_MQbrain_567_r 0.108118292 Hsd_from_Mmd_391_l 0.113099484

HS_from_MQbrain_594_r 0.108118292 HS_106_r 0.11858389

HS_from_MQbrain_80_l 0.108118292 HS_289_I 0.11858389

HS_from_MQbrain_88_l 0.108118292 HS_from_MQbrain_1051_r 0.11858389

HS_from_PT_220_l 0.108118292 HS_from_MQbrain_1487_r 0.11858389

HS_from_PT_7_r 0.108118292 HS_from_MQbrain_1590J 0.11858389

HS_from_PT_95_l 0.108118292 HS_from_MQbrain_1750_r 0.11858389 hsa-mir-125b-1_r 0.108118292 HS_from_MQbrain_1834_r 0.11858389 hsa-mir-129-1_r 0.108118292 HS_from_MQbrain_1889J 0.11858389 hsa-mir-185_r 0.108118292 HS_from_MQbrain_301_l 0.11858389 hsa-mir-211_r 0.108118292 HS_from_MQbrain_502_r 0.11858389 hsa-mir-483_l 0.108118292 HS_from_MQbrain_560_r 0.11858389 hsa-mir-526b_r 0.108118292 H S_from_M Qbra i n_592_l 0.11858389

HSbrain_280_l 0.108118292 HS_from_MQbrain_897_l 0.11858389

HSbrain_299_r 0.108118292 HS_from_MQbrain_999_l 0.11858389

HSbrain_384_l 0.108118292 hsa-mir-409_r 0.11858389

HSbrain_506_r 0.108118292 hsa-mir-633_r 0.11858389

HSbrain_536_r 0.108118292 hsa-mir-634_l 0.11858389

HSbrain_643_l 0.108118292 HSbrain_1_r 0.11858389

HSbrain_691_l 0.108118292 HSbrain_135_l 0.11858389

Hsd_from_Mmd_249_r 0.108118292 HSbrain_145_l 0.11858389

Hsd_from_M md_291 _r 0.108118292 HSbrain_220_r 0.11858389

Hsd_from_Mmd_478_l 0.108118292 HSbrain_383_l 0.11858389

HS_204_l 0.113099484 HSbrain_452_l 0.11858389

HS_73_r 0.113099484 HSbrain_664_r 0.11858389

HS_98_I 0.113099484 Hsd_60_r 0.11858389

HS_from_MM_251_r 0.1 13099484 Hsd_82_r 0.11858389

HS_from_MM_57_r 0.113099484 Hsd_from_Mmd_217_r 0.11858389

HS_from_MQbrain_105_l 0.1 13099484 Hsd_from_Mmd_31 1_r 0.11858389

HS_from_MQbrain_1478J 0.1 13099484 Hsd_from_Mmd_372_l 0.11858389

HS_from_MQbrain_1502J 0.1 13099484 Hsd_from_Mmd_499_r 0.11858389

HS_from_MQbrain_1695J 0.1 13099484 Hsd_from_Mmd_518_r 0.11858389

HS_from_MQbrain_241_l 0.1 13099484 Hsd_from_Mmd_93_l 0.11858389

HS_from_MQbrain_354_r 0.113099484 HSJ 35J 0.12422104

HS_from_MQbrain_604_l 0.1 13099484 HS_25_r 0.12422104

HS_from_MQbrain_824_l 0.1 13099484 HS_287_I 0.12422104

HS_from_MQbrain_828_r 0.113099484 HS_98_r 0.12422104

HS_from_MQbrain_921_l 0.1 13099484 HS_from_MM_174_l 0.12422104 hsa-mir-224_r 0.113099484 HS_from_MM_298_r 0.12422104 hsa-mir-377_l 0.113099484 HS_from_MM_79_l 0.12422104 hsa-mir-571_r 0.113099484 HS_from_MM_87_l 0.12422104 hsa-mir-770_r 0.113099484 HS_from_MQbrain_1 109_l 0.12422104

HSbrain_159_l 0.113099484 HS_from_MQbrain_1184_r 0.12422104

HSbrain_216_l 0.113099484 HS_from_MQbrain_1304_r 0.12422104

HSbrain_227_r 0.113099484 HS_from_MQbrain_1384_r 0.12422104

HSbrain_267_l 0.113099484 HS_from_MQbrain_161_r 0.12422104

HSbrain_328_l 0.113099484 HS_from_MQbrain_406_l 0.12422104

HSbrain_390_l 0.113099484 HS_from_MQbrain_485_l 0.12422104

HSbrain 4 I 0.1 13099484 HS from MQbrain 490 r 0.12422104 HS_from_MQbrain_789_l 0.12422104 HS_189_r 0.134970683

HS_from_PT_237_l 0.12422104 HS_214_r 0.134970683

HS_from_PT_283_r 0.12422104 HS_261_I 0.134970683 hsa-mir-513-2_l 0.12422104 HS_51_r 0.134970683 hsa-mir-622_l 0.12422104 HS_from_MM_119_r 0.134970683

HSbrain_1076_l 0.12422104 HS_from_MM_185_r 0.134970683

HSbrain_131_l 0.12422104 HS_from_MQbrain_1081_r 0.134970683

HSbrain_396_r 0.12422104 HS_from_MQbrain_1097_r 0.134970683

HSbrain_478_r 0.12422104 HS_from_MQbrain_1318_l 0.134970683

HSbrain_50_l 0.12422104 HS_from_MQbrain_1376_r 0.134970683

HSbrain_543_l 0.12422104 HS_from_MQbrain_1523_r 0.134970683

HSbrain_570_l 0.12422104 HS_from_MQbrain_1640J 0.134970683

Hsd_17_l 0.12422104 HS_from_MQbrain_1692J 0.134970683

Hsd_from_Mmd_183_r 0.12422104 HS_from_MQbrain_1804_r 0.134970683

Hsd_from_Mmd_237_l 0.12422104 HS_from_MQbrain_1806_l 0.134970683

Hsd_from_Mmd_328_r 0.12422104 HS_from_MQbrain_234_r 0.134970683

Hsd_from_Mmd_489_r 0.12422104 HS_from_MQbrain_461_l 0.134970683

HSJ 09J 0.129399391 HS_from_MQbrain_540_l 0.134970683

HS_22_r 0.129399391 HS_from_MQbrain_684_r 0.134970683

HS_85_I 0.129399391 HS_from_MQbrain_89_l 0.134970683

HS_from_MM_145_r 0.129399391 HS_from_MQbrain_968_l 0.134970683

HS_from_MM_157_l 0.129399391 HS_from_MQbrain_99_r 0.134970683

HS_from_MM_304_r 0.129399391 HS_from_PT_194_r 0.134970683

HS_from_MQbrain_129_r 0.129399391 HS_from_PT_250_r 0.134970683

HS_from_MQbrain_137_r 0.129399391 hsa-mir-181a-1_r 0.134970683

HS_from_MQbrain_1377_r 0.129399391 hsa-mir-31_r 0.134970683

HS_from_MQbrain_1574J 0.129399391 hsa-mir-550-1_r 0.134970683

HS_from_MQbrain_1712_r 0.129399391 hsa-mir-588_r 0.134970683

HS_from_MQbrain_1722J 0.129399391 hsa-mir-609_r 0.134970683

HS_from_MQbrain_1776J 0.129399391 HSbrain_496_r 0.134970683

HS_from_MQbrain_1794_r 0.129399391 HSbrain_687_r 0.134970683

HS_from_MQbrain_1839J 0.129399391 HSbrain_715_l 0.134970683

HS_from_MQbrain_36_r 0.129399391 Hsd_62_l 0.134970683

HS_from_MQbrain_382_l 0.129399391 Hsd_74_r 0.134970683

HS_from_MQbrain_466_l 0.129399391 Hsd_from_Mmd_101_r 0.134970683

HS_from_MQbrain_555_r 0.129399391 Hsd_from_Mmd_291_l 0.134970683

HS_from_MQbrain_597_l 0.129399391 Hsd_from_Mmd_388_l 0.134970683

HS_from_MQbrain_967_l 0.129399391 Hsd_from_Mmd_524_l 0.134970683

HS_from_PT_207_l 0.129399391 HSJ 11J 0.140323812

HS_from_PT_38_l 0.129399391 HS_121_r 0.140323812 hsa-mir-412_l 0.129399391 HS_157_r 0.140323812 hsa-mir-525_l 0.129399391 HS_161_r 0.140323812 hsa-mir-622_r 0.129399391 HS_168_r 0.140323812 hsa-mir-9-2_r 0.129399391 HSJ 75J 0.140323812

HSbrain_152_l 0.129399391 HS_219_I 0.140323812

HSbrain_204_r 0.129399391 HS_241_r 0.140323812

HSbrain_244_l 0.129399391 HS_41_r 0.140323812

HSbrain_267_r 0.129399391 HS_53_r 0.140323812

HSbrain_347_r 0.129399391 HS_from_MM_109_l 0.140323812

HSbrain_448_l 0.129399391 HS_from_MM_84_r 0.140323812

HSbrain_695_l 0.129399391 HS_from_MQbrain_1 110J 0.140323812

HSbrain_72_l 0.129399391 HS_from_MQbrain_15_r 0.140323812

HSbrain_970_r 0.129399391 HS_from_MQbrain_1855J 0.140323812

Hsd_from_Mmd_128_l 0.129399391 H S_from_M Qbra i n_22_r 0.140323812

Hsd_from_Mmd_363_l 0.129399391 HS_from_MQbrain_221_r 0.140323812

Hsd from Mmd 431 I 0.129399391 HS from MQbrain 235 r 0.140323812 HS_from_MQbrain_266_r 0.140323812 Hsd_77_r 0.146822481

HS_from_MQbrain_467_l 0.140323812 Hsd_96_r 0.146822481

HS_from_MQbrain_56_r 0.140323812 Hsd Jrom_M md_316_r 0.146822481

HS_from_MQbrain_664_r 0.140323812 HS_115_r 0.152858542

HS_from_PT_170_r 0.140323812 HSJ76J 0.152858542

HS_from_PT_178_l 0.140323812 HS_from_MM_89J 0.152858542

HS_from_PT_250_l 0.140323812 HS Jrom_MQbrain_1072_r 0.152858542 hsa-mir-135a-1_r 0.140323812 HSJrom_MQbrain_1127_r 0.152858542 hsa-mir-23a_l 0.140323812 HS Jrom_MQbrain_153J 0.152858542 hsa-mir-26a-1_l 0.140323812 HS Jrom_MQbrain_154_r 0.152858542 hsa-mir-27b_r 0.140323812 HS _from_MQbrain_1817 J 0.152858542 hsa-mir-570_l 0.140323812 HS Jrom_MQbrain_1896_r 0.152858542 hsa-mir-599_r 0.140323812 HSJrom_MQbrain_338J 0.152858542

HSbrain_108_l 0.140323812 HSJrom_MQbrain_340J 0.152858542

HSbrain_126_r 0.140323812 HSJrom_MQbrain_355_r 0.152858542

HSbrain_144_r 0.140323812 H S Jrom_M Qbra i n_6_r 0.152858542

HSbrain_361_l 0.140323812 HSJrom_MQbrain_689J 0.152858542

HSbrain_425_l 0.140323812 HSJrom_MQbrain_693_r 0.152858542

HSbrain_522_r 0.140323812 HSJrom_MQbrain_707J 0.152858542

HSbrain_541_r 0.140323812 HSJromJVIQbrain_969_r 0.152858542

HSbrain_716_l 0.140323812 HSJrom_PT_238J 0.152858542

HSbrain_737_r 0.140323812 HSJrom_PT_92J 0.152858542

Hsd_from_Mmd_123_l 0.140323812 hsa-mir-17J 0.152858542

Hsd_from_Mmd_523_l 0.140323812 hsa-mir-188J 0.152858542

HS_268_I 0.146822481 hsa-mir-641_r 0.152858542

HS_76_r 0.146822481 HSbrain_130_r 0.152858542

HS_from_MQbrain_103 OJ 0.146822481 HSbrainJ 325_r 0.152858542

HS Jrom_MQbrain_1036_r 0.146822481 HSbrain_171J 0.152858542

HS Jrom_MQbrain_1222_r 0.146822481 HSbrain_22J 0.152858542

HS Jrom_MQbrain_1250_r 0.146822481 HSbrain_222_r 0.152858542

HSJrom_MQbrain_1381_r 0.146822481 HSbrain_266J 0.152858542

HSJrom_MQbrain_1462_r 0.146822481 HSbrain_306_r 0.152858542

HSJrom_MQbrain_1493_r 0.146822481 HSbrain_32_r 0.152858542

HS Jrom_MQbrain_1675_r 0.146822481 HSbrain_483_r 0.152858542

HS Jrom_MQbrain_1695_r 0.146822481 HSbrain_604_r 0.152858542

HS _from_MQbrain_1759J 0.146822481 HSbrain_641_r 0.152858542

HS _from_MQbrain_1807J 0.146822481 HSbrain_656J 0.152858542

HSJrom_MQbrain_260_r 0.146822481 HSbrain_695_r 0.152858542

HSJrom_MQbrain_283_r 0.146822481 HSbrain_717_r 0.152858542

HSJrom_MQbrain_600J 0.146822481 HSbrain_752J 0.152858542

HSJrom_MQbrain_67J 0.146822481 HSbrain_811 J 0.152858542

HSJrom_MQbrain_697J 0.146822481 Hsd_38_r 0.152858542

HSJromJVIQbrain_97_r 0.146822481 HsdJrom_Mmd_280J 0.152858542

HSJrom_PT_219J 0.146822481 Hsd_from_MmdJ346J 0.152858542

HSJrom_PT_271J 0.146822481 HSJ28J 0.158799149

HSJrom_PT_284_r 0.146822481 HSJ8J 0.158799149 hsa-mir-1-1J 0.146822481 HS_95_r 0.158799149 hsa-mir-521-1J 0.146822481 HS_from_MM_118J 0.158799149

HSbrain_107_r 0.146822481 HS_from_MM_135J 0.158799149

HSbrain_1298_r 0.146822481 HS_from_MM_35J 0.158799149

HSbrain_130J 0.146822481 HS _from_MQbrain_1018 J 0.158799149

HSbrain_139_r 0.146822481 HS Jrom_MQbrain_1204_r 0.158799149

HSbrainJ599_r 0.146822481 HSJrom_MQbrain_140J 0.158799149

HSbrain_624J 0.146822481 HS Jrom_MQbrain_1501_r 0.158799149

HSbrain_663_r 0.146822481 HS Jrom_MQbrain_155J 0.158799149

HSbrain 705 r 0.146822481 HS from MQbrain 1831 r 0.158799149 HS_from_MQbrain_2699_l 0.158799149 HS_from_MQbrain_941_r 0.163891418

HS_from_MQbrain_281_r 0.158799149 HS_from_MQbrain_996_l 0.163891418

HS_from_MQbrain_382_r 0.158799149 HS_from_PT_155_l 0.163891418

HS_from_MQbrain_414_l 0.158799149 HS_from_PT_196_r 0.163891418

HS_from_MQbrain_6_l 0.158799149 HS_from_PT_234_l 0.163891418

HS_from_MQbrain_625_l 0.158799149 HS_from_PT_280_l 0.163891418

HS_from_MQbrain_631_l 0.158799149 hsa-mir-124a-1_l 0.163891418

HS_from_MQbrain_675_l 0.158799149 hsa-mir-30c-2_l 0.163891418

HS_from_MQbrain_68_r 0.158799149 hsa-mir-33b_l 0.163891418

HS_from_MQbrain_900_r 0.158799149 hsa-mir-652_r 0.163891418

HS_from_MQbrain_912_l 0.158799149 HSbrain_275_r 0.163891418

HS_from_PT_158_l 0.158799149 HSbrain_304_l 0.163891418

HS_from_PT_255_l 0.158799149 HSbrain_305_l 0.163891418 hsa-mir-151_l 0.158799149 HSbrain_376_l 0.163891418 hsa-mir-16-2_l 0.158799149 HSbrain_402_l 0.163891418 hsa-mir-422a_l 0.158799149 HSbrain_438_r 0.163891418 hsa-mir-518c_l 0.158799149 HSbrain_446_r 0.163891418 hsa-mir-98_r 0.158799149 HSbrain_578_l 0.163891418

HSbrain_121_l 0.158799149 HSbrain_598_r 0.163891418

HSbrain_248_l 0.158799149 HSbrain_680_l 0.163891418

HSbrain_320_l 0.158799149 HSbrain_784_r 0.163891418

HSbrain_347_l 0.158799149 HSbrain_804_l 0.163891418

HSbrain_413_l 0.158799149 HSbrain_95_l 0.163891418

HSbrain_55_l 0.158799149 Hsd_108_r 0.163891418

HSbrain_653_l 0.158799149 Hsd_84_r 0.163891418

HSbrain_669_r 0.158799149 Hsd_from_Mmd_19_l 0.163891418

HSbrain_673_l 0.158799149 Hsd_from_Mmd_455_l 0.163891418

HSbrain_768_l 0.158799149 Hsd_from_M md_52_r 0.163891418

HSbrain_783_l 0.158799149 Hsd_from_Mmd_94_l 0.163891418

Hsd_67_r 0.158799149 HS_128_r 0.170271053

Hsd_from_M md_334_r 0.158799149 HS_151_r 0.170271053

Hsd_from_M md_44_r 0.158799149 HS_192_r 0.170271053

HSJ 81J 0.163891418 HS_197_r 0.170271053

HS_286_r 0.163891418 HS_212_r 0.170271053

HS_74_r 0.163891418 HS_223_r 0.170271053

HS_from_MM_218_l 0.163891418 HS_264_r 0.170271053

HS_from_MM_340_r 0.163891418 HS_78_r 0.170271053

HS_from_MQbrain_1028J 0.163891418 HS_83_r 0.170271053

HS_from_MQbrain_1090_r 0.163891418 HS_from_MM_163_l 0.170271053

HS_from_MQbrain_1 119_l 0.163891418 HS_from_MM_232_r 0.170271053

HS_from_MQbrain_1212_l 0.163891418 HS_from_MM_304_l 0.170271053

HS_from_MQbrain_1223J 0.163891418 HS_from_MQbrain_1 199_l 0.170271053

HS_from_MQbrain_1426J 0.163891418 HS_from_MQbrain_1377J 0.170271053

HS_from_MQbrain_1520J 0.163891418 HS_from_MQbrain_1846_r 0.170271053

HS_from_MQbrain_1535_r 0.163891418 HS_from_MQbrain_1893_r 0.170271053

HS_from_MQbrain_1721J 0.163891418 HS_from_MQbrain_281_l 0.170271053

HS_from_MQbrain_1724J 0.163891418 HS_from_MQbrain_392_r 0.170271053

HS_from_MQbrain_365_r 0.163891418 HS_from_MQbrain_468_l 0.170271053

HS_from_MQbrain_449_l 0.163891418 HS_from_MQbrain_603_r 0.170271053

HS_from_MQbrain_529_r 0.163891418 HS_from_MQbrain_841_l 0.170271053

HS_from_MQbrain_566_r 0.163891418 HS_from_MQbrain_97_l 0.170271053

HS_from_MQbrain_596_r 0.163891418 hsa-mir-192_r 0.170271053

HS_from_MQbrain_629_r 0.163891418 hsa-mir-196b_r 0.170271053

HS_from_MQbrain_650_r 0.163891418 hsa-mir-765_r 0.170271053

HS_from_MQbrain_824_r 0.163891418 HSbrain_143_l 0.170271053

HS from MQbrain 936 r 0.163891418 HSbrain 177 I 0.170271053 HSbrain_216_r 0.170271053 HSbrain_626_l 0.176183859

HSbrain_364_r 0.170271053 HSbrain_707_r 0.176183859

HSbrain_41_r 0.170271053 HSbrain_771_l 0.176183859

HSbrain_467_l 0.170271053 Hsd_27_r 0.176183859

HSbrain_53_l 0.170271053 Hsd_65_r 0.176183859

HSbrain_701_l 0.170271053 Hsd_from_Mmd_123_r 0.176183859

HSbrain_724_l 0.170271053 Hsd_from_M md_212_r 0.176183859

HSbrain_726_l 0.170271053 Hsd_from_Mmd_296_l 0.176183859

HSbrain_745_l 0.170271053 Hsd_from_Mmd_328_l 0.176183859

HSbrain_755_r 0.170271053 Hsd_from_M md_344_r 0.176183859

HSbrain_780_l 0.170271053 Hsd_from_Mmd_391_r 0.176183859

HSbrain_80_l 0.170271053 Hsd_from_M md_412_r 0.176183859

Hsd_47_r 0.170271053 Hsd_from_M md_92_l 0.176183859

Hsd_from_Mmd_235_r 0.170271053 HSJ 32J 0.182758186

Hsd_from_Mmd_306_l 0.170271053 HSJ67J 0.182758186

Hsd_from_M md_35_l 0.170271053 HS_307_r 0.182758186

Hsd_from_Mmd_367_l 0.170271053 HS_from_MM_124_r 0.182758186

Hsd_from_Mmd_410_l 0.170271053 HS_from_MM_149_r 0.182758186

HSJ 30J 0.176183859 HS_from_MM_160_l 0.182758186

HS_145_r 0.176183859 HS_from_MM_342_l 0.182758186

HS_186_r 0.176183859 HS_from_MM_6_l 0.182758186

HS_204_r 0.176183859 HS_from_MQbrain_1 137_l 0.182758186

HS_220_l 0.176183859 HS_from_MQbrain_1219_r 0.182758186

HS_from_MM_123_l 0.176183859 HS_from_MQbrain_1349J 0.182758186

HS_from_MM_84_l 0.176183859 HS_from_MQbrain_1380_r 0.182758186

HS_from_MQbrain_1 126J 0.176183859 HS_from_MQbrain_147_l 0.182758186

HS_from_MQbrain_1204J 0.176183859 HS_from_MQbrain_1509_r 0.182758186

HS_from_MQbrain_1245J 0.176183859 HS_from_MQbrain_1576_r 0.182758186

HS_from_MQbrain_135_l 0.176183859 HS_from_MQbrain_162_r 0.182758186

HS_from_MQbrain_1444J 0.176183859 HS_from_MQbrain_1793J 0.182758186

HS_from_MQbrain_1497J 0.176183859 HS_from_MQbrain_1883J 0.182758186

HS_from_MQbrain_1565J 0.176183859 HS_from_MQbrain_361_l 0.182758186

HS_from_MQbrain_1566_r 0.176183859 HS_from_MQbrain_559_r 0.182758186

HS_from_MQbrain_1773J 0.176183859 HS_from_MQbrain_635_l 0.182758186

HS_from_MQbrain_1832_r 0.176183859 HS_from_MQbrain_676_r 0.182758186

HS_from_MQbrain_2087_r 0.176183859 HS_from_MQbrain_694_r 0.182758186

HS_from_MQbrain_314_l 0.176183859 HS_from_MQbrain_732_r 0.182758186

HS_from_MQbrain_365_l 0.176183859 HS_from_MQbrain_736_r 0.182758186

HS_from_MQbrain_520_l 0.176183859 HS_from_MQbrain_850_l 0.182758186

HS_from_MQbrain_628_l 0.176183859 HS_from_MQbrain_881_l 0.182758186

HS_from_MQbrain_855_r 0.176183859 HS_from_PT_104_l 0.182758186

HS_from_MQbrain_984_l 0.176183859 HS_from_PT_161_l 0.182758186

HS_from_PT_27_r 0.176183859 HS_from_PT_188_l 0.182758186 hsa-mir-101-1_r 0.176183859 hsa-mir-1 -2_l 0.182758186 hsa-mir-144_r 0.176183859 hsa-mir-190_r 0.182758186 hsa-mir-16-1_l 0.176183859 hsa-mir-26a-2_l 0.182758186 hsa-mir-432_l 0.176183859 hsa-mir-383_l 0.182758186 hsa-mir-526a-1_r 0.176183859 hsa-mir-432_r 0.182758186 hsa-mir-92-1_l 0.176183859 hsa-mir-514-3_r 0.182758186

HSbrain_120_r 0.176183859 hsa-mir-520f_r 0.182758186

HSbrain_1418_r 0.176183859 hsa-mir-624_l 0.182758186

HSbrain_151_r 0.176183859 hsa-mir-93_l 0.182758186

HSbrain_32_l 0.176183859 HSbrain_388_r 0.182758186

HSbrain_334_r 0.176183859 HSbrain_456_r 0.182758186

HSbrain_491_l 0.176183859 HSbrain_706_l 0.182758186

HSbrain 590 I 0.176183859 Hsd from Mmd 187 r 0.182758186 Hsd_from_Mmd_190_r 0.182758186 Hsd_from_Mmd_274_r 0.188867139

Hsd_from_Mmd_208_r 0.182758186 Hsd_from_M md_314_r 0.188867139

Hsd_from_Mmd_232_r 0.182758186 Hsd_from_Mmd_325_r 0.188867139

Hsd_from_Mmd_333_l 0.182758186 HSJ24J 0.19639408

Hsd_from_M md_68_l 0.182758186 HSJ 98J 0.19639408

HS_190_r 0.188867139 HS_203_l 0.19639408

HS_77_I 0.188867139 HS_265_I 0.19639408

HS_from_MM_182_r 0.188867139 HS_77_r 0.19639408

HS_from_MM_298_l 0.188867139 HS_from_MM_194_l 0.19639408

HS_from_MM_331_r 0.188867139 HS_from_MQbrain_1402_r 0.19639408

HS_from_MM_48_l 0.188867139 HS_from_MQbrain_1424_r 0.19639408

HS_from_MM_86_l 0.188867139 HS_from_MQbrain_1671J 0.19639408

HS_from_MQbrain_105_l 0.188867139 HS_from_MQbrain_1783_r 0.19639408

HS_from_MQbrain_1073_r 0.188867139 HS_from_MQbrain_188_l 0.19639408

HS_from_MQbrain_120_l 0.188867139 HS_from_MQbrain_1883_r 0.19639408

HS_from_MQbrain_1208J 0.188867139 HS_from_MQbrain_383_l 0.19639408

HS_from_MQbrain_1224_r 0.188867139 HS_from_MQbrain_389_l 0.19639408

HS_from_MQbrain_1234J 0.188867139 HS_from_MQbrain_406_r 0.19639408

HS_from_MQbrain_1353J 0.188867139 HS_from_MQbrain_648_l 0.19639408

HS_from_MQbrain_1596_r 0.188867139 H S_from_M Qbra i n_84_r 0.19639408

HS_from_MQbrain_1734J 0.188867139 HS_from_MQbrain_901_r 0.19639408

HS_from_MQbrain_1760_r 0.188867139 HS_from_PT_130_r 0.19639408

HS_from_MQbrain_178_r 0.188867139 HS_from_PT_196_l 0.19639408

HS_from_MQbrain_436_r 0.188867139 HS_from_PT_204_r 0.19639408

HS_from_MQbrain_487_r 0.188867139 HS_from_PT_48_l 0.19639408

HS_from_MQbrain_524_l 0.188867139 hsa-mir-139_l 0.19639408

HS_from_MQbrain_65_l 0.188867139 hsa-mir-324_l 0.19639408

HS_from_MQbrain_768_l 0.188867139 hsa-mir-454_l 0.19639408

HS_from_MQbrain_791_r 0.188867139 hsa-mir-662_l 0.19639408

HS_from_MQbrain_999_r 0.188867139 HSbrain_143_r 0.19639408

HS_from_PT_22_l 0.188867139 HSbrain_180_l 0.19639408

HS_from_PT_247_l 0.188867139 HSbrain_237_l 0.19639408

HS_from_PT_271_r 0.188867139 HSbrain_295_r 0.19639408

HS_from_PT_3_l 0.188867139 HSbrain_325_r 0.19639408

HS_from_PT_328_l 0.188867139 HSbrain_433_r 0.19639408

HS_from_PT_99_r 0.188867139 HSbrain_476_r 0.19639408 hsa-mir-183_r 0.188867139 HSbrain_615_l 0.19639408 hsa-mir-203_r 0.188867139 HSbrain_616_r 0.19639408 hsa-mir-21_l 0.188867139 HSbrain_658_l 0.19639408 hsa-mir-587_r 0.188867139 HSbrain_690_r 0.19639408 hsa-mir-604_l 0.188867139 HSbrain_70_r 0.19639408

HSbrain_153_r 0.188867139 HSbrain_810_l 0.19639408

HSbrain_156_l 0.188867139 Hsd_19_l 0.19639408

HSbrain_198_l 0.188867139 Hsd_25_l 0.19639408

HSbrain_210_l 0.188867139 Hsd_from_Mmd_197_l 0.19639408

HSbrain_242_l 0.188867139 Hsd_from_Mmd_259_r 0.19639408

HSbrain_270_l 0.188867139 Hsd_from_Mmd_326_l 0.19639408

HSbrain_370_r 0.188867139 Hsd from Mmd 399 r 0.19639408

HSbrain_403_l 0.188867139

HSbrain_471_r 0.188867139 Wilcoxon analysis: cut offadj. p value<0.2

HSbrain_553_l 0.188867139

HSbrain_571_l 0.188867139

HSbrain_627_r 0.188867139

Hsd_from_Mmd_120_l 0.188867139

Hsd_from_Mmd_180_r 0.188867139

Hsd from Mmd 253 I 0.188867139 Table 2b Up- or downregulated small RNAs adenoma compared to control adenoma

VS

Systematic Name control adenoma controls adenomas/controls

(adj p)1 (avg expression) (avg expression) (ratio expression)2

HS_from_MQbraιn_485_l 0 124 0 621 1 997 -1 377

HSbraιn_412_l 0 113 0 278 1 614 -1 336

HS_from_MQbraιn_1497_l 0 176 1 843 3 166 -1 323

HS_from_MQbraιn_594_r 0 108 0 859 2 180 -1 321

HS_from_MQbraιn_1109 1 0 124 0 527 1 813 -1 286

HS_from_MQbraιn_967_l 0 129 0 867 2 144 -1 277

HS_from_MQbraιn_137_r 0 129 0 859 2 113 -1 254

HS_from_MQbraιn_1082_l 0 072 -1 727 -0 502 -1 225

HS_from_PT_155_l 0 164 1 326 2 524 -1 198

HS_from_MQbraιn_1334_r 0 053 -1 612 -0 419 -1 192

HSbraιn_724_l 0 170 -1 686 -0 535 -1 151

HS_from_MQbraιn_340_l 0 153 0 732 1 879 -1 146

HSbraιn_126_r 0 140 0 598 1 713 -1 115

HSbraιn_653_l 0 159 0 620 1 725 -1 105

HS_from_PT_104_l 0 183 0 615 1 720 -1 105

HS_from_MQbraιn_1353_l 0 189 -1 557 -0 453 -1 104 hsa-mιr-124a-3_r 0 070 0 106 1 207 -1 101

HS_from_MQbraιn_1793_l 0 183 0 546 1 638 -1 093 hsa-mιr-124a-2_r 0 077 0 186 1 276 -1 090

HS_38_r 0 099 -1 398 -0 321 -1 077

HS_from_MQbraιn_855_r 0 176 1 019 2 091 -1 072

HS_from_MQbraιn_634_l 0 077 -1 384 -0 322 -1 063 hsa-mιr-124a-1 r 0 080 0 236 1 287 -1 051

HS_from_MQbraιn_1832_r 0 176 -1 661 -0 631 -1 030

HS_from_MQbraιn_932_l 0 095 -1 329 -0 301 -1 028

HS_from_MQbraιn_1424_r 0 196 -1 461 -0 448 -1 013

HS_from_MQbraιn_281_r 0 159 -1 396 -0 386 -1 010

Hsd_from_Mmd_94_l 0 164 -0 053 0 946 -0 999

HS_from_MQbraιn_825_r 0 012 -0 915 0 083 -0 998

HS_261_r 0 043 -1 240 -0 249 -0 992

HS_from_MQbraιn_436_r 0 189 -1 739 -0 758 -0 981

HSbraιn_491_l 0 176 -1 399 -0 425 -0 974

HS_from_PT_95_l 0 108 -1 290 -0 327 -0 963

HS_from_MM_163_l 0 170 -1 554 -0 612 -0 942

HS_from_MQbraιn_1268_l 0 072 -1 227 -0 286 -0 941

HS_203_l 0 196 0 658 1 592 -0 934

HSbraιn_680_r 0 099 -1 254 -0 338 -0 916

HS_from_MM_123_l 0 176 -1 163 -0 251 -0 912

HS_from_MQbraιn_635_l 0 183 -1 339 -0 431 -0 908

HS_from_MQbraιn_824_l 0 113 -1 224 -0 329 -0 895

HS_from_PT_130_r 0 196 0 515 1 410 -0 895

HS_71_I 0 004 -0 861 0 033 -0 893

HS_from_MQbraιn_37_r 0 070 -1 191 -0 299 -0 892

Hsd_101_l 0 080 -1 212 -0 322 -0 889

HS_51_r 0 135 -1 387 -0 499 -0 888

Hsd_from_Mmd_326_l 0 196 -1 132 -0 252 -0 881

HS_from_MQbraιn_968_l 0 135 -1 191 -0 319 -0 872

HSbraιn_673_r 0 103 -1 174 -0 303 -0 871

HS_97_r 0 036 0 155 1 026 -0 871

HSbrain 1406 I 0 080 -0 299 0 569 -0 868 HS_262_I 0 001 -0 228 0 636 -0864

HS_203_r 0 068 0 078 0 937 -0859

HSbraιn_458_r 0 020 -0 452 0 407 -0858

HSbraιn_687_r 0 135 -1 259 -0 403 -0855

Hsd_f rom_Mmd_412_r 0 176 -1 668 -0 814 -0855

HSbraιn_270_l 0 189 0 524 1 376 -0852 hsa-mιr-449b r 0 072 -0 894 -0 053 -0841

HSbraιn_684_r 0 103 -1 235 -0 412 -0822

HS_from_MQbraιn_991_l 0 072 0 438 1 259 -0821

HS_from_PT_283_r 0 124 -1 162 -0 351 -0812

HSbraιn_695_l 0 129 -1 139 -0 329 -0810

HS_106_r 0 119 -1 141 -0 333 -0808

HS_from_MM_169_r 0 004 -0 743 0 062 -0804

HS_from_MM_353_l 0 077 0 019 0 823 -0804

HS_from_MQbraιn_1502_l 0 113 -1 097 -0 293 -0804

HSbraιn_198_l 0 189 -1 309 -0 506 -0803

HSbraιn_711_r 0 084 0 379 1 174 -0794

HSbraιn_570_r 0 095 -1 044 -0 258 -0786 hsa-mιr-635_l 0 084 0 520 1 301 -0781

HS_from_MQbraιn_1561_r 0 040 -0 679 0 100 -0779

HS_from_PT_36_l 0 013 -0 741 0 038 -0778 hsa-mιr-524 I 0 068 -0 064 0 713 -0778

Hsd_from_Mmd_372_l 0 119 -0 938 -0 161 -0776

HSbraιn_669_r 0 159 -1 197 -0 432 -0764

HS_from_MQbraιn_1520 I 0 164 -1 097 -0 337 -0760

HS_from_MQbraιn_736_r 0 183 -1 132 -0 374 -0758

HS_128_I 0 159 -0 990 -0 238 -0752

HS_from_MQbraιn_1085_l 0 005 -0 935 -0 185 -0751

Hsd_from_Mmd_452_l 0 025 -0 286 0 462 -0748

HSbraιn_656_l 0 153 0 468 1 216 -0747

HSbraιn_296_l 0 030 0 085 0 828 -0742

HSbraιn_389_l 0 084 -0 915 -0 173 -0742

HS_from_MM_118_r 0 004 -0 556 0 179 -0735

Hsd_from_Mmd_328_l 0 176 0 566 1 299 -0733

HSbraιn_157_l 0 065 -0 837 -0 111 -0726

HS_from_MQbraιn_559_r 0 183 -1 064 -0 346 -0718

HS_from_MQbraιn_48_r 0 084 -0 848 -0 132 -0715

HSbraιn_41_r 0 170 -0 877 -0 162 -0715 hsa-mιr-185 r 0 108 0 201 0 911 -0710

HS_from_MQbraιn_15_r 0 140 -1 076 -0 367 -0709

HS_from_MQbraιn_301_l 0 119 -1 043 -0 336 -0706

HSbraιn_453_r 0 095 -0 857 -0 156 -0701

Hsd_105_l 0 032 -0 841 -0 141 -0700 hsa-mιr-591_r 0 017 0 025 0 724 -0699

HSbraιn_47_r 0 113 -0 986 -0 288 -0699

HS_from_PT_207_l 0 129 -0 921 -0 223 -0697

HS_from_MQbraιn_1087_l 0 038 -0 740 -0 043 -0697

HS_from_MM_118_l 0 159 -0 915 -0 220 -0695

HS_from_MQbraιn_161_r 0 124 0 226 0 920 -0694

HS_from_MQbraιn_354_r 0 113 -0 882 -0 189 -0692

HS_261_I 0 135 0 324 1 016 -0692

HS_from_MQbraιn_1648_r 0 095 0 036 0 726 -0691

HS_from_MQbraιn_1246_l 0 043 0 389 1 078 -0689

HSbraιn_616_r 0 196 0 375 1 064 -0688

HS_98_I 0 072 -1 008 -0 320 -0688

HSbrain 304 r 0 058 -0 783 -0 097 -0687 HS_from_MQbraιn_314_l 0 176 -0 924 -0 243 -0681

HSbraιn_583_l 0 021 -0 586 0 095 -0681

H S_f rom_MQb rai n_629_r 0 164 -0 976 -0 296 -0680

Hsd_from_Mmd_485_r 0 025 -0 553 0 126 -0679

HS_from_PT_3_l 0 189 0 352 1 026 -0675

HS_from_MQbraιn_1500_l 0 061 0 178 0 850 -0672

HS_175_I 0 140 -0 909 -0 238 -0671

HS_from_MQbraιn_1219_r 0 183 -0 953 -0 285 -0668

HSbraιn_172_l 0 080 0 083 0 747 -0664

Hsd from Mmd 117 r 0 025 -0 532 0 129 -0661 hsa-mιr-383_r 0 016 -0 034 0 626 -0660

Hsd_107_l 0 024 -0 573 0 086 -0659

HS_145_r 0 176 -1 153 -0 497 -0657

HSbraιn_690_r 0 196 -0 957 -0 301 -0657

HSbraιn_2_l 0 019 -0 562 0 092 -0654

HS_181_I 0 164 -1 057 -0 406 -0651

HS_176_I 0 153 -0 933 -0 282 -0651

HS_from_MQbraιn_1099_r 0 058 -0 662 -0 013 -0649

HS_9_r 0 004 -0 731 -0 083 -0649 hsa-mιr-619_l 0 070 -0 336 0 309 -0645

HS_from_MQbraιn_694_r 0 183 0 350 0 995 -0645

HS_from_MQbraιn_1081_r 0 135 -0 031 0 613 -0644

HS_241_r 0 140 0 465 1 104 -0639

HS_from_MQbraιn_458_l 0 095 -0 816 -0 178 -0638

HSbraιn_704_l 0 056 0 198 0 830 -0632

HS_from_MQbraιn_1444_l 0 008 -1 059 -0 429 -0630

HSbraιn_159_l 0 113 -1 013 -0 385 -0628

HS_from_MM_135_l 0 159 -0 023 0 604 -0627

HSbraιn_344_l 0 077 -0 642 -0 017 -0624

HS_from_MQbraιn_520_l 0 176 -0 948 -0 325 -0623

HSbraιn_390_l 0 113 -0 817 -0 194 -0622

HSbraιn_657_l 0 070 -0 850 -0 228 -0622

HS_from_MQbraιn_901_r 0 196 0 174 0 796 -0622

HSbraιn_456_r 0 183 -0 828 -0 207 -0621

HSbraιn_120_r 0 176 0 508 1 125 -0617

HS_from_PT_295_r 0 036 -0 497 0 120 -0617

HS_from_MQbraιn_1535_r 0 164 -0 833 -0 216 -0617

HSbraιn_695_r 0 153 0 176 0 791 -0615

HSbraιn_719_l 0 056 0 061 0 674 -0613

HSbraιn_305_l 0 164 -1 071 -0 461 -0610

HS_from_MQbraιn_1773_l 0 048 -0 942 -0 335 -0607

HSbraιn_571_l 0 189 -0 891 -0 291 -0600

HSbraιn_216_l 0 113 -0 857 -0 258 -0599

HSbraιn_107_r 0 147 -0 715 -0 116 -0599 hsa-mιr-661 r 0 099 -0 380 0 217 -0597

HSbraιn_122_l 0 088 -0 799 -0 204 -0595

HS_132_I 0 183 -0 675 -0 082 -0593

HSbraιn_325_r 0 196 -1 053 -0 460 -0592

HS_157_r 0 140 -0 878 -0 286 -0592

HS_from_MQbraιn_560_r 0 119 -0 731 -0 139 -0592

HS_212_r 0 170 -0 314 0 278 -0591

HS_from_PT_284_r 0 147 0 474 1 062 -0589

HS_from_PT_103_l 0 032 -0 507 0 080 -0587

HS_from_MQbraιn_1042_r 0 050 -0 400 0 186 -0586

HS_from_PT_41_r 0 065 -0 324 0 261 -0585

HS from MQbrain 178 r 0 189 -0 684 -0 099 -0584 Hsd_from_Mmd_120_l 0 189 -0 867 -0 285 -0583

HS_from_MQbraιn_1442_l 0 103 0 047 0 630 -0583

HSbraιn_707_r 0 176 -0 556 0 021 -0577

Hsd_from_Mmd_296_l 0 176 -0 110 0 466 -0576

HS_from_MQbraιn_235_r 0 140 -0 811 -0 237 -0575

Hsd_from_Mmd_346_l 0 153 -0 928 -0 355 -0573

HS_from_PT_187_l 0 070 -0 656 -0 086 -0570

HS_204_r 0 176 -0 741 -0 172 -0569

HSbraιn_177_l 0 170 -0 752 -0 183 -0568

HS_173_I 0 095 -0 578 -0 009 -0568

HS_from_MQbraιn_1314_l 0 092 -0 577 -0 009 -0568

HS_from_MQbraιn_755_l 0 095 0 177 0 741 -0564

HS_from_MQbraιn_1753_r 0 099 0 239 0 803 -0564

HS_from_MQbraιn_1376_r 0 135 0 327 0 890 -0563

HSbraιn_530_l 0 088 -0 657 -0 097 -0560

HSbraιn_153_r 0 189 -0 773 -0 214 -0559

HS_from_MQbraιn_1478_l 0 113 -0 834 -0 275 -0559

Hsd_67_r 0 159 -0 803 -0 245 -0558

HS_from_MQbraιn_129_r 0 129 -0 659 -0 101 -0557

Hsd_from_Mmd_370_r 0 068 0 017 0 572 -0555

Hsd_from_Mmd_473_l 0 025 -0 251 0 301 -0553

Hsd_42_l 0 068 -0 650 -0 100 -0550

HS_from_MM_276_l 0 040 -0 253 0 297 -0550

HS_from_MM_39_l 0 005 -0 155 0 394 -0549

HS_from_MQbraιn_574_l 0 099 0 327 0 875 -0548

HSbraιn_777_r 0 070 -0 877 -0 332 -0545

HSbraιn_598_r 0 164 0 144 0 689 -0545

HSbraιn_726_l 0 170 -0 919 -0 375 -0544

HS_98_I 0 072 -0 947 -0 406 -0541

HS_from_MM_218_l 0 164 -0 955 -0 415 -0540

HS_from_PT_201_l 0 070 -0 573 -0 034 -0539

HS_from_MQbraιn_1006_l 0 048 -0 593 -0 055 -0538

HSbraιn_22_l 0 153 -0 159 0 378 -0537

HS_from_MQbraιn_1204_l 0 176 -0 915 -0 381 -0534

HS_from_MQbraιn_65_l 0 189 -0 083 0 451 -0534

HS_from_MQbraιn_1633_r 0 103 -0 635 -0 102 -0533

HS_from_MQbraιn_1783_r 0 196 0 348 0 880 -0532

HS_from_MQbraιn_1402_r 0 196 -0 824 -0 294 -0530

HS_from_MQbraιn_1883_l 0 183 -0 608 -0 081 -0527

HS_231_r 0 034 -0 796 -0 271 -0525

HSbraιn_713_r 0 023 -0 564 -0 041 -0523

HSbraιn_578_l 0 164 -0 619 -0 099 -0520

HSbraιn_442_r 0 053 0 220 0 740 -0519

HS_from_MQbraιn_437_l 0 108 -0 563 -0 049 -0514

HS_from_MQbraιn_1626_r 0 088 0 001 0 509 -0509

Hsd_from_Mmd_324_l 0 095 -0 734 -0 227 -0508

Hsd_from_Mmd_523_l 0 140 0 149 0 654 -0505

HSbraιn_703_r 0 023 -0 500 0 004 -0504

HS_from_MQbraιn_843_r 0 012 -0 512 -0 013 -0499

HSbraιn_347_r 0 129 -0 638 -0 143 -0495

HS_from_MQbraιn_1444_l 0 008 -0 527 -0 034 -0494

HSbraιn_1423_l 0 080 -0 583 -0 092 -0491

HSbraιn_343_l 0 103 -0 579 -0 093 -0486

HSbraιn_86_r 0 099 -0 605 -0 122 -0483

HS_from_MQbraιn_1877_l 0 068 -0 227 0 255 -0482

HS from MQbrain 1103 I 0 005 -0 190 0 290 -0480 HS_from_MQbraιn_1893_r 0 170 0 202 0 682 -0480

HSbraιn_463_r 0 084 -0 222 0 257 -0480

HSbraιn_752_r 0 043 -0 613 -0 135 -0478

HS_from_MQbraιn_1377_r 0 129 0 283 0 761 -0477

HSbraιn_747_l 0 072 -0 034 0 441 -0475

HS_62_I 0 056 -0 564 -0 091 -0473

HS_from_MM_131_l 0 027 -0 261 0 210 -0471 hsa-mιr-640_l 0 034 -0 148 0 322 -0470

HS_from_MQbraιn_487_l 0 092 -0 841 -0 371 -0470

HS_from_MQbraιn_590_l 0 077 -0 280 0 189 -0469

HS_135_I 0 124 -0 144 0 323 -0467 hsa-mιr-196a-2_r 0 015 -0 123 0 342 -0465

HS_from_MQbraιn_597_r 0 084 -0 606 -0 142 -0464

HS_from_MQbraιn_697_l 0 147 -0 518 -0 057 -0462

HS_from_MQbraιn_365_l 0 176 0 235 0 696 -0461

Hsd_f rom_Mmd_212_r 0 176 -0 510 -0 051 -0459

HSbraιn_446_l 0 020 -0 397 0 062 -0459

HSbraιn_32_r 0 153 -0 616 -0 158 -0458

HSbraιn_483_r 0 153 0 145 0 602 -0456

HSbraιn_334_r 0 176 -0 377 0 076 -0452

HS_from_MQbraιn_1137_l 0 183 -0 675 -0 223 -0452

Hsd_27_r 0 176 0 166 0 616 -0450

HS_from_MQbraιn_113_r 0 084 0 052 0 502 -0450 hsa-mιr-324 r 0 103 -0 112 0 337 -0449

HSbraιn_304_l 0 164 0 017 0 465 -0448

HSbraιn_629_l 0 023 -0 646 -0 199 -0447

Hsd_from_Mmd_306_l 0 170 -0 590 -0 145 -0445 hsa-mιr-372 r 0 056 0 185 0 630 -0444

HS_from_MQbraιn_1317_r 0 007 -0 193 0 251 -0444 hsa-mιr-525_l 0 129 0 196 0 638 -0442

HS_from_MQbraιn_1806_l 0 135 -0 081 0 357 -0438

HS_from_MM_298_r 0 124 -0 087 0 350 -0437 hsa-mιr-644_r 0 070 -0 262 0 173 -0435

HS_from_MQbraιn_814_l 0 084 0 092 0 526 -0435

H S_f rom_MQb rai n_906_r 0 103 -0 642 -0 208 -0434

Hsd_from_Mmd_487_r 0 034 -0 529 -0 096 -0433

HS_from_MQbraιn_1208_l 0 189 0 334 0 765 -0431

Hsd_from_Mmd_311_r 0 119 -0 006 0 423 -0429

HS_from_MQbraιn_1771_l 0 050 -0 654 -0 226 -0429

HS_171_r 0 050 -0 274 0 154 -0428

HS_from_MQbraιn_1752_l 0 048 -0 014 0 411 -0425

HS_from_MQbraιn_1840_l 0 108 -0 025 0 399 -0424

HSbraιn_437_r 0 084 -0 052 0 373 -0424

HS_from_MQbraιn_1245_l 0 176 -0 711 -0 287 -0424

HS_71_r 0 088 -0 153 0 270 -0423

Hsd_88_r 0 077 -0 265 0 157 -0422

HS_from_MQbraιn_1437_l 0 092 -0 244 0 177 -0421

HSbraιn_755_l 0 065 -0 427 -0 006 -0421

HS_from_MQbraιn_1817_l 0 153 0 002 0 421 -0420

HSbraιn_151_r 0 176 -0 522 -0 103 -0419

HS_from_MQbraιn_567_r 0 108 -0 378 0 039 -0417

HSbraιn_155_r 0 070 -0 057 0 360 -0417

HSbraιn_43_r 0 077 -0 371 0 046 -0417 hsa-mιr-584 r 0 050 -0 203 0 213 -0416

HS_from_PT_91_r 0 043 -0 068 0 345 -0413

HS from PT 126 I 0 088 -0 052 0 358 -0411 Hsd_from_Mmd_399_r 0 196 -0 367 0 042 -0410

HS_from_MQbraιn_1420_l 0 038 -0 388 0 019 -0407

HSbraιn_12_l 0 017 -0 292 0 112 -0404

HSbraιn_764_r 0 113 -0 045 0 357 -0402

HS_from_MQbraιn_1070_r 0 005 -0 290 0 110 -0400

HS_223_I 0 080 -0 213 0 186 -0399

HS_from_MQbraιn_163_l 0 095 -0 645 -0 248 -0397

HS_from_MQbraιn_1119_l 0 058 -0 111 0 285 -0397

HS_from_MQbraιn_1748_r 0 072 -0 171 0 224 -0394

HSbraιn_319_l 0 103 -0 232 0 161 -0393

HSbraιn_116_l 0 065 -0 732 -0 339 -0393

Hsd_65_l 0 050 -0 128 0 263 -0390

HSbraιn_1325_r 0 153 -0 451 -0 061 -0390

HSbraιn_755_r 0 170 -0 635 -0 246 -0389

HSbraιn_753_r 0 024 -0 232 0 156 -0388

HS_from_PT_242_l 0 061 -0 402 -0 017 -0386

HSbraιn_48_r 0 048 -0 110 0 274 -0384

HS_93_r 0 050 -0 412 -0 030 -0382

Hsd_f rom_Mmd_120_r 0 092 -0 425 -0 048 -0377

HS_from_MQbraιn_1494_l 0 092 0 310 0 687 -0376

HSbraιn_481_r 0 095 -0 825 -0 449 -0376

Hsd_63_l 0 103 -0 283 0 092 -0375

HS_from_MM_219_l 0 077 -0 105 0 265 -0370

HS_from_MQbraιn_912_l 0 159 0 449 0 817 -0369

HS_from_MQbraιn_1073_r 0 189 -0 122 0 246 -0368

HS_81_r 0 072 -0 099 0 269 -0367

HS_from_MQbraιn_842_l 0 050 0 049 0 415 -0366

HS_from_PT_321_r 0 056 -0 070 0 295 -0365

HSbraιn_320_l 0 159 0 052 0 414 -0362

HS_from_MQbraιn_524_l 0 189 -0 475 -0 117 -0358

HSbraιn_135_l 0 119 -0 146 0 211 -0358

HS_from_MQbraιn_991_r 0 061 -0 017 0 337 -0354

HS_from_PT_170_r 0 140 -0 438 -0 084 -0354

HS_from_MQbraιn_1051_r 0 119 0 156 0 509 -0353

HS_from_MQbraιn_391_r 0 029 -0 169 0 183 -0352

HS_from_MQbraιn_140_l 0 159 0 077 0 427 -0350

HSbraιn_438_r 0 164 -0 066 0 282 -0348

HS_from_MQbraιn_804_r 0 080 -0 287 0 061 -0348

Hsd_from_Mmd_391_l 0 113 -0 103 0 245 -0348

HSbraιn_476_r 0 196 0 063 0 410 -0347

HS_from_MQbraιn_745_r 0 068 -0 292 0 053 -0345

HS_from_MQbraιn_1102 1 0 084 -0 516 -0 173 -0343

HS_from_MQbraιn_868_l 0 099 -0 413 -0 071 -0342

HS_from_MQbraιn_984_l 0 176 -0 423 -0 082 -0341

HS_from_MQbraιn_1792_r 0 010 -0 296 0 045 -0341

HS_from_MQbraιn_603_r 0 170 -0 178 0 161 -0339

HS_from_MQbraιn_365_r 0 164 -0 252 0 085 -0337

HS_from_MQbraιn_1075_l 0 048 -0 648 -0 312 -0336

HS_172_r 0 103 0 080 0 416 -0336

HSbraιn_384_l 0 108 -0 164 0 172 -0336

HS_from_MQbraιn_406_l 0 124 -0 273 0 063 -0336

HS_from_PT_339_l 0 068 -0 719 -0 383 -0336

Hsd from Mmd 535 r 0 053 -0 453 -0 118 -0335

Hsd_84_r 0 164 -0 195 0 136 -0332

HS_from_MQbraιn_1565_l 0 176 -0 209 0 123 -0332

HS from MQbrain 420 I 0 061 -0 349 -0 020 -0329 HS_from_PT_201_r 0 013 -0 178 0 150 -0 328

HS_265_I 0 196 0 045 0 372 -0 327

HS_from_MQbraιn_1726 I 0 092 -0 112 0 214 -0 327 hsa-mιr-197 I 0 016 -0 405 -0 080 -0 325

HS_from_MQbraιn_114_r 0 108 -0 679 -0 354 -0 325

HS_from_MQbraιn_355_r 0 153 0 155 0 479 -0 324

HSbraιn_703_l 0 048 -0 443 -0 121 -0 323

Hsd_from_Mmd_155_l 0 025 -0 274 0 048 -0 322

HS_from_MQbraιn_435_r 0 065 -0 103 0 219 -0 322

HS_from_MQbraιn_1043_r 0 005 -0 624 -0 302 -0 322

HSbraιn_1298_r 0 147 -0 271 0 050 -0 321

HS_from_MQbraιn_1690_l 0 034 -0 631 -0 313 -0 318

HS_from_PT_250_l 0 140 0 222 0 539 -0 318 hsa-mιr-377 I 0 113 -0 086 0 229 -0 316

H S_f rom_MQb rai n_686_r 0 088 -0 636 -0 322 -0 314

HSbraιn_691_l 0 095 -0 865 -0 552 -0 313

HSbraιn_370_r 0 189 -0 088 0 225 -0 313

HS_from_MQbraιn_1484_l 0 053 -0 038 0 271 -0 308

HS_from_MQbraιn_89_l 0 135 -0 128 0 179 -0 307

HS_from_MQbraιn_361_l 0 183 0 178 0 484 -0 306

HS_from_MQbraιn_596_r 0 164 -0 114 0 192 -0 306

HS_from_MQbraιn_600_l 0 147 -0 210 0 096 -0 306

HS_from_PT_92_l 0 153 -0 695 -0 390 -0 305

HS_from_MQbraιn_1624_l 0 009 -0 245 0 058 -0 303

HS_from_PT_73_l 0 077 0 058 0 359 -0 301

HS_from_MQbraιn_1374_l 0 058 -0 430 -0 130 -0 299

Hsd_49_r 0 025 -0 276 0 023 -0 299

HS_from_MQbraιn_1596_r 0 189 -0 280 0 018 -0 298

HS_from_MM_174_l 0 124 -0 325 -0 027 -0 298 hsa-mιr-204_r 0 072 -0 384 -0 087 -0 297

HS_from_MQbraιn_1426_l 0 164 -0 698 -0 404 -0 293

HS_220_l 0 176 -0 135 0 158 -0 293

HS_from_MQbraιn_1839_l 0 129 -0 692 -0 400 -0 292

HS_from_MM_346_r 0 103 -0 463 -0 173 -0 290

HS_from_MQbraιn_1119_l 0 058 -0 615 -0 325 -0 290

HSbraιn_1425_l 0 099 -0 622 -0 332 -0 290

Hsd_from_Mmd_363_l 0 129 -0 293 -0 003 -0 289

HS_from_MQbraιn_162_r 0 183 -0 461 -0 172 -0 289

HS_198_I 0 196 -0 603 -0 314 -0 289

HS_from_PT_188_l 0 183 -0 268 0 020 -0 288

Hsd_50_l 0 070 -0 532 -0 244 -0 288

HSbraιn_143_r 0 196 -0 381 -0 093 -0 287

HSbraιn_663_l 0 061 -0 005 0 282 -0 287

HSbraιn_109_l 0 040 -0 582 -0 296 -0 286

HS_from_MQbraιn_382_l 0 129 -0 075 0 210 -0 285

HS_from_MQbraιn_675_l 0 159 -0 628 -0 343 -0 285

HS_from_MQbraιn_1671_l 0 196 -0 314 -0 030 -0 284

H S_f rom_MQb rai n_999_r 0 189 -0 845 -0 563 -0 283 hsa-mιr-148a I 0 046 -0 199 0 082 -0 281

HS_from_MQbraιn_974_l 0 058 -0 613 -0 333 -0 280

HS_from_MQbraιn_1627_l 0 108 -0 614 -0 335 -0 280

HS_from_MM_359_l 0 034 -0 086 0 193 -0 279

HSbraιn_25_r 0 048 -0 147 0 132 -0 279

HSbraιn_568_r 0 113 -0 156 0 122 -0 278

HS_49_r 0 072 0 167 0 445 -0 278

HSbrain 316 I 0 034 -0 303 -0 025 -0 278 Hsd_108_r 0 164 -0 266 0 012 -0 278

HS_from_MQbraιn_1678_r 0 092 -0 080 0 198 -0 277

HS_from_MQbraιn_943_l 0 103 -0 647 -0 370 -0 277

HS_167_I 0 183 -0 391 -0 114 -0 277

HS_from_MQbraιn_1566_r 0 176 -0 302 -0 026 -0 277

HS_from_MQbraιn_466_l 0 129 -0 308 -0 034 -0 275

HS_from_MQbraιn_99_r 0 135 -0 627 -0 352 -0 275

HS_from_PT_271_r 0 189 -0 271 0 002 -0 273

HSbraιn_642_r 0 092 0 356 0 627 -0 271

HS_from_MQbraιn_433_l 0 072 -0 495 -0 225 -0 270 hsa-mιr-622_l 0 124 -0 337 -0 068 -0 269

HSbraιn_717_l 0 095 -0 453 -0 184 -0 269

HS_from_PT_170_l 0 072 -0 362 -0 094 -0 269

HSbraιn_85_l 0 056 0 065 0 333 -0 268 hsa-mιr-483_l 0 108 -0 570 -0 302 -0 267

HS_from_PT_112_l 0 068 -0 217 0 050 -0 267

HS_from_MQbraιn_1758_r 0 092 -0 494 -0 229 -0 264

HSbraιn_139_l 0 068 -0 533 -0 269 -0 264

HSbraιn_32_l 0 176 -0 350 -0 087 -0 263

HS_98_r 0 124 -0 635 -0 373 -0 261

HS_from_MM_342_l 0 183 0 142 0 402 -0 260

HSbraιn_284_l 0 046 -0 589 -0 331 -0 258

HS_157_I 0 099 -0 493 -0 236 -0 257

HS_from_MQbraιn_1777_l 0 080 -0 385 -0 131 -0 253

Hsd_from_Mmd_284_l 0 061 -0 006 0 246 -0 253

HS_102_l 0 088 -0 528 -0 276 -0 252

HS_from_MQbraιn_1127_r 0 153 0 133 0 384 -0 251

HS_from_MQbraιn_1620_l 0 056 -0 368 -0 118 -0 250

HS_from_MQbraιn_734_l 0 027 -0 281 -0 031 -0 250

HSbraιn_664_r 0 119 -0 538 -0 288 -0 250

HS_101_l 0 108 -0 480 -0 231 -0 249

HSbraιn_94_l 0 103 -0 414 -0 165 -0 249

HS_from_MQbraιn_56_r 0 140 0 263 0 512 -0 249

HS_264_r 0 170 -0 277 -0 033 -0 244

HS_from_MQbraιn_1222_r 0 147 -0 456 -0 212 -0 244 hsa-mιr-192_r 0 170 -0 033 0 211 -0 243

HSbraιn_708_l 0 095 -0 485 -0 243 -0 242

HS_from_MM_103_l 0 099 -0 154 0 089 -0 242

HS_from_MM_251_r 0 1 13 -0 289 -0 047 -0 242

HS_168_r 0 140 -0 608 -0 367 -0 240

HS_from_MQbraιn_1832_l 0 030 -0 372 -0 132 -0 240

HSbraιn_433_r 0 196 0 076 0 312 -0 236

HSbraιn_210_l 0 189 -0 350 -0 114 -0 235

HSbraιn_522_r 0 140 -0 057 0 178 -0 235

HS_from_MQbraιn_1574_l 0 129 -0 195 0 040 -0 235

HSbraιn_471_r 0 189 -0 059 0 175 -0 234

HS_128_r 0 170 -0 408 -0 174 -0 234

HS_57_I 0 084 -0 132 0 101 -0 233

Hsd_from_Mmd_261_l 0 043 -0 223 0 009 -0 232

HS_from_PT_308_l 0 065 -0 164 0 067 -0 232

Hsd_from_Mmd_235_r 0 170 0 389 0 621 -0 231

HS_from_MM_339_r 0 005 -0 211 0 019 -0 230

Hsd_from_Mmd_436_l 0 068 0 065 0 294 -0 230 hsa-mιr-765 r 0 170 -0 628 -0 399 -0 229

H S_f rom_MQb rai n_406_r 0 196 -0 588 -0 362 -0 226

HS from MQbrain 1204 r 0 159 -0 475 -0 249 -0 226 hsa-mιr-224_r 0 113 -0 139 0 087 -0226

HS_from_MQbraιn_1883_ r 0 196 -0 343 -0 118 -0225

HS_from_MQbraιn_1630_ I 0 009 -0 228 -0 005 -0223

HS_25_r 0 124 -0 152 0 071 -0223

HSbraιn_152_l 0 129 -0 232 -0 009 -0223

HS_from_PT_238_l 0 153 -0 588 -0 370 -0218

HS_from_MQbraιn_715_l 0 084 -0 218 -0 001 -0217

HS_from_MQbraιn_1834_ r 0 119 -0 402 -0 186 -0216

HSbraιn_266_r 0 038 -0 094 0 121 -0215

Hsd_from_Mmd_237_l 0 124 -0 154 0 061 -0215 hsa-mιr-211 r 0 108 -0 272 -0 058 -0214

Hsd_from_Mmd_371_r 0 092 -0 247 -0 033 -0214

HS_from_MQbraιn_850_l 0 183 -0 340 -0 127 -0214

Hsd_from_Mmd_274_r 0 189 -0 159 0 054 -0213

HS_from_MQbraιn_597_l 0 129 -0 577 -0 364 -0213

HS_from_MQbraιn_1750_ r 0 119 -0 620 -0 408 -0212

HS_83_r 0 170 -0 107 0 103 -0210

Hsd_63_r 0 046 -0 051 0 158 -0209

HS_from_MQbraιn_1349_ J 0 183 -0 464 -0 255 -0209

HSbraιn_402_l 0 164 -0 178 0 030 -0209

Hsd from Mmd 78 r 0 103 -0 437 -0 228 -0208

HSbraιn_452_l 0 119 -0 192 0 016 -0208

HS_from_MQbraιn_70_l 0 061 -0 336 -0 131 -0206

HS_from_MQbraιn_1219_ I 0 072 -0 421 -0 216 -0205

HS_from_MM_115_l 0 056 -0 242 -0 037 -0204

HSbraιn_626_l 0 176 -0 007 0 197 -0204

HS_from_MQbraιn_281_l 0 170 -0 322 -0 118 -0204

HS_from_MQbraιn_628_l 0 176 -0 131 0 071 -0202

HS_from_PT_247_l 0 189 -0 250 -0 049 -0201

HS_119_I 0 080 -0 077 0 124 -0200

HSbraιn_783_l 0 159 -0 235 -0 035 -0200

HS_from_MQbraιn_1355_ r 0 103 -0 064 0 136 -0200

HSbraιn_485_r 0 021 -0 292 -0 093 -0199

HS_129_I 0 095 -0 341 -0 143 -0198

HSbraιn_80_l 0 170 -0 128 0 069 -0198

HS_from_MQbraιn_1110_ J 0 140 -0 055 0 142 -0197

HS_130_l 0 176 -0 004 0 190 -0195

HS_from_MQbraιn_1846_ r 0 170 -0 164 0 030 -0193

HSbraιn_347_l 0 159 -0 392 -0 199 -0193

HSbraιn_548_l 0 084 -0 271 -0 079 -0192

HS_from_MQbraιn_338_l 0 153 0 011 0 202 -0191

Hsd from Mmd 52 r 0 164 -0 717 -0 527 -0191

HSbraιn_328_l 0 113 -0 209 -0 019 -0190

HS_from_MQbraιn_1228_ r 0 095 -0 395 -0 205 -0190

HS_from_MM_124_l 0 108 -0 173 0 017 -0190

HSbraιn_216_r 0 170 -0 228 -0 039 -0189

HS_from_MQbraιn_999_l 0 119 -0 229 -0 040 -0189

HSbraιn_56_l 0 084 -0 150 0 039 -0189

HS_from_MQbraιn_996_l 0 164 -0 341 -0 153 -0188

HS_from_MQbraιn_1509_ r 0 183 -0 579 -0 391 -0188

HS_from_MQbraιn_550_l 0 092 -0 294 -0 106 -0188

HSbraιn_8_r 0 024 -0 390 -0 202 -0188

HS_from_MQbraιn_1036_ r 0 147 -0 463 -0 276 -0187

Hsd_from_Mmd_388_l 0 135 -0 135 0 051 -0186

HS_from_MQbraιn_566_r 0 164 -0 444 -0 258 -0186

HS from MQbrain 941 r 0 164 -0 208 -0 023 -0186 HS_from_MQbraιn_1889 I 0 119 -0 155 0 030 -0185

HS_from_MM_340_r 0 164 -0 442 -0 257 -0185

HS_from_PT_158_l 0 159 -0 475 -0 291 -0185

HS_from_MQbraιn_1241_r 0 095 -0 169 0 014 -0183

HSbraιn_305_r 0 099 -0 303 -0 121 -0182

HS_from_MQbraιn_732_r 0 183 -0 164 0 018 -0182

HS_197_r 0 170 -0 206 -0 025 -0181

HS_from_MQbraιn_1675_r 0 147 -0 400 -0 218 -0181

HS_from_MQbraιn_707_l 0 153 -0 068 0 111 -0179

HSbraιn_222_r 0 153 0 025 0 204 -0179

HS_from_MQbraιn_1380_r 0 183 -0 298 -0 120 -0178

HSbraιn_275_r 0 164 0 068 0 243 -0176

HS_from_MQbraιn_689_l 0 153 -0 177 -0 001 -0175

HS_from_MQbraιn_449_l 0 164 -0 336 -0 161 -0175

HSbraιn_306_r 0 153 -0 241 -0 069 -0172

HSbraιn_810_l 0 196 -0 211 -0 040 -0172

HSbraιn_240_l 0 099 -0 366 -0 195 -0171

HSbraιn_769_r 0 099 -0 129 0 041 -0170

HS_from_MQbraιn_38_r 0 056 0 045 0 213 -0168

HS_from_MQbraιn_546_l 0 108 -0 166 0 000 -0165

HS_18_I 0 159 -0 250 -0 087 -0164

HSbraιn_53_l 0 170 -0 221 -0 058 -0163

HS_from_PT_194_r 0 135 -0 001 0 161 -0162 hsa-mιr-647 r 0 027 -0 154 0 006 -0161

HSbraιn_599_r 0 147 -0 011 0 146 -0157

HSbraιn_4_l 0 113 -0 060 0 095 -0155

HS_from_MQbraιn_1523_r 0 135 -0 166 -0 012 -0154

HSbraιn_70_r 0 196 -0 402 -0 250 -0153

Hsd_from_Mmd_197_l 0 196 -0 075 0 077 -0152

HS_from_MQbraιn_22_r 0 140 -0 252 -0 104 -0148

HS_from_MQbraιn_487_r 0 189 -0 100 0 046 -0146

HS_22_r 0 129 0 023 0 168 -0144

HSbraιn_376_l 0 164 -0 016 0 126 -0142

HSbraιn_701_l 0 170 0 014 0 155 -0141

HS_from_MQbraιn_43_l 0 061 0 036 0 165 -0130

Hsd_from_Mmd_128_l 0 129 0 121 0 249 -0127 hsa-mιr-570_l 0 140 -0 103 0 020 -0123

HS_from_MQbraιn_810_l 0 058 -0 182 -0 062 -0120

HS_from_MQbraιn_1863_l 0 032 0 106 0 224 -0118

HS_from_MQbraιn_1223_l 0 164 -0 156 -0 043 -0113

Hsd_from_Mmd_333_l 0 183 -0 077 0 033 -0110

H S_f rom_MQb rai n_669_r 0 084 -0 015 0 089 -0103

HS_from_MQbraιn_1576_r 0 183 -0 006 0 095 -0100

HS_from_MQbraιn_97_l 0 170 -0 024 0 074 -0098

HSbraιn_541_r 0 140 -0 014 0 084 -0098

HSbraιn_545_r 0 029 -0 056 0 033 -0089

HS_from_MQbraιn_1018_l 0 159 -0 008 0 072 -0081

HSbraιn_469_l 0 068 0 016 0 093 -0077

HSbraιn_727_l 0 024 0 218 0 269 -0051

Hsd_from_Mmd_259_r 0 196 0 066 0 098 -0032

HS_from_MQbraιn_1674_l 0 056 -0 451 -0 426 -0025

HSbraιn_723_l 0 024 0 071 0 049 0022

Hsd_25_l 0 196 0 017 -0 038 0054

HS_from_MQbraιn_1637_l 0 108 0 088 0 027 0061

HSbraιn_244_l 0 129 0 095 0 032 0062 hsa-mιr-507 I 0 099 0 036 -0 035 0071 HS_from_MQbraιn_2087_r 0 176 0 070 -0 006 0075

Hsd_from_Mmd_325_r 0 189 0 061 -0 016 0077 hsa-mιr-454 I 0 196 0 034 -0 044 0078

HS_286_r 0 164 0 019 -0 061 0081

Hsd_from_Mmd_391_r 0 176 0 056 -0 025 0081

HS_from_PT_196_l 0 196 0 046 -0 035 0081 hsa-mιr-568 r 0 017 -0 020 -0 105 0085 hsa-mιr-518b_r 0 099 0 030 -0 056 0086

HS_from_MQbraιn_1379_r 0 040 0 049 -0 038 0086 hsa-mιr-139_l 0 196 -0 062 -0 150 0088

Hsd_from_Mmd_500_r 0 056 0 034 -0 055 0089

HS_from_MQbraιn_897_l 0 119 0 080 -0 008 0089

HS_from_MQbraιn_2699_l 0 159 -0 016 -0 106 0089 hsa-mιr-33b I 0 164 0 024 -0 067 0091

HSbraιn_1076_l 0 124 0 034 -0 059 0093 hsa-mιr-124a-1_l 0 164 0 129 0 036 0094

HS_from_MQbraιn_392_r 0 170 -0 007 -0 104 0097

Hsd_from_Mmd_499_r 0 119 -0 033 -0 131 0098

HS_from_MM_86_l 0 189 -0 144 -0 243 0099

HS_from_MQbraιn_779_l 0 092 0 055 -0 045 0100

Hsd_f rom_Mmd_316_r 0 147 0 057 -0 043 0100

HSbraιn_478_r 0 124 0 052 -0 049 0101

HS_from_MM_109_l 0 140 0 048 -0 057 0104 hsa-mιr-646 r 0 058 0 078 -0 027 0105

HS_from_MQbraιn_1224_r 0 189 -0 013 -0 118 0105

HS_from_MQbraιn_1804_r 0 135 0 061 -0 045 0106

HS_262_r 0 029 0 010 -0 100 0110

HSbraιn_780_l 0 170 0 051 -0 064 0115

HS_from_MQbraιn_1687_l 0 010 -0 002 -0 120 0118

HS_from_MQbraιn_1721_l 0 164 0 118 -0 002 0119

HSbraιn_1418_r 0 176 -0 023 -0 143 0121

HS_from_MQbraιn_221_r 0 140 0 075 -0 051 0125

Hsd_f rom_Mmd_190_r 0 183 0 120 -0 007 0126

HS_from_MM_57_r 0 113 0 069 -0 061 0130

HS_from_MM_150_r 0 095 0 038 -0 094 0131

HSbraιn_590_l 0 176 0 023 -0 109 0132

HS_from_PT_99_r 0 189 0 057 -0 076 0133

HS_from_MQbraιn_1164_l 0 068 0 146 0 012 0134

Hsd_from_Mmd_431_l 0 129 0 039 -0 096 0135

HS_223_r 0 170 0 137 -0 001 0138

HS_from_PT_27_r 0 176 0 155 0 014 0140

Hsd_from_Mmd_253_l 0 189 0 013 -0 128 0141

HS_from_PT_255_l 0 159 0 038 -0 106 0144

HS_from_MQbraιn_1283_l 0 050 0 125 -0 021 0146

HSbraιn_771_l 0 176 0 400 0 252 0147

Hsd_f rom_Mmd_180_r 0 189 0 232 0 084 0148 hsa-mιr-432 r 0 183 0 031 -0 118 0150 hsa-mιr-423 r 0 036 0 179 0 022 0156 hsa-mιr-1-2 I 0 183 -0 180 -0 337 0157

HS_from_MQbraιn_648_l 0 196 0 152 -0 005 0157

HSbraιn_204_r 0 129 0 080 -0 082 0163

HSbraιn_615_l 0 196 0 011 -0 152 0163

HSbraιn_596_r 0 103 -0 097 -0 261 0164

Hsd_from_Mmd_344_l 0 099 0 068 -0 098 0166

HS_from_MQbraιn_1722_l 0 129 0 368 0 201 0167

HS from MQbrain 675 r 0 084 -0 002 -0 170 0168 HS_from_MQbraιn_67_r 0 043 0 127 -0 043 0170

HSbraιn_715_l 0 135 -0 021 -0 191 0170

Hsd_38_r 0 153 0 356 0 185 0171

HS_190_r 0 189 0 206 0 034 0171

HS_219_I 0 140 0 293 0 121 0173 hsa-mιr-331_r 0 030 0 070 -0 103 0173 hsa-mιr-99a r 0 103 0 047 -0 127 0173

HS_from_MQbraιn_1184_r 0 124 0 643 0 464 0179

HSbraιn_403_l 0 189 -0 069 -0 251 0181

HS_77_I 0 189 0 160 -0 022 0182

HSbraιn_714_l 0 023 0 104 -0 078 0182

HSbraιn_792_r 0 034 0 095 -0 088 0182

HS_from_MQbraιn_1382_l 0 099 0 505 0 320 0185

HS_109_l 0 129 0 348 0 162 0186

HS_from_MQbraιn_1561 J 0 072 0 162 -0 026 0187

HS_292_I 0 038 0 093 -0 095 0188

HS_124_I 0 196 -0 062 -0 251 0189

HS_from_PT_21_r 0 046 0 060 -0 130 0191

HS_from_MQbraιn_824_r 0 164 0 234 0 043 0191

HS_from_MQbraιn_188_l 0 196 -0 006 -0 200 0194

HSbraιn_509_l 0 113 0 014 -0 180 0194

HSbraιn_643_l 0 108 0 178 -0 017 0195

HSbraιn_156_l 0 189 0 172 -0 024 0196

HS_from_MM_49_l 0 056 0 366 0 168 0198

HS_from_MQbraιn_1862_l 0 061 0 022 -0 177 0199

HS_from_MM_237_l 0 099 -0 083 -0 283 0200

HSbraιn_540_l 0 099 0 105 -0 097 0202

HS_from_MM_48_l 0 189 0 191 -0 013 0204

HS_from_MM_89_l 0 153 0 102 -0 105 0207

HS_77_r 0 196 0 231 0 024 0208

HS_from_MQbraιn_1794_r 0 129 0 140 -0 069 0209

Hsd_from_Mmd_204_l 0 080 0 324 0 115 0209

HS_from_MQbraιn_921_l 0 113 0 359 0 150 0209

HSbraιn_721_r 0 070 0 103 -0 106 0209

HS_from_MQbraιn_468_l 0 170 0 749 0 539 0210

HSbraιn_220_r 0 119 0 167 -0 044 0211

HS_from_MM_79_l 0 124 0 689 0 478 0211

H S_f rom_MQb rai n_490_r 0 124 0 500 0 288 0212

HS_from_MQbraιn_1215_l 0 070 0 094 -0 118 0212

HS_from_MQbraιn_901_l 0 050 0 289 0 077 0212

Hsd_111_r 0 103 -0 224 -0 436 0212

HSbraιn_717_r 0 153 -0 106 -0 318 0213

HS_from_PT_204_r 0 196 0 033 -0 180 0213

HSbraιn_50_l 0 124 0 286 0 072 0214

HS 191 I 0 040 0 118 -0 096 0214 hsa-mιr-196b r 0 170 -0 001 -0 216 0215

HS_from_PT_63_r 0 043 0 166 -0 050 0216

HS_from_MQbraιn_609_l 0 103 0 669 0 452 0217

HS_from_MQbraιn_461_l 0 135 0 120 -0 099 0219

HS_from_MQbraιn_1366_l 0 108 0 461 0 241 0220

HSbraιn_171_l 0 017 0 169 -0 050 0220 hsa-mιr-224_l 0 072 -0 139 -0 359 0221 hsa-mιr-181a-1 r 0 135 -0 157 -0 378 0221

HSbraιn_804_l 0 164 0 142 -0 079 0221

HS_from_MQbraιn_1896_r 0 153 -0 102 -0 324 0222

HS from MQbrain 383 I 0 196 0 060 -0 163 0223 Hsd_f rom_Mmd_215_r 0 080 0 014 -0 208 0223

HSbraιn_266_l 0 153 0 428 0 205 0223 hsa-mιr-31 r 0 135 -0 060 -0 283 0224

H S_f rom_MQb rai n_266_r 0 140 0 074 -0 150 0224

HS_from_MM_92_r 0 099 0 030 -0 195 0225

HS_from_MQbraιn_1590_l 0 119 0 806 0 578 0228

HS_from_MQbraιn_1724_l 0 164 0 749 0 521 0228

HSbraιn_641_r 0 153 -0 024 -0 254 0230

HSbraιn_553_l 0 189 0 097 -0 133 0230

HSbraιn_248_l 0 159 0 632 0 402 0230

HS_from_MQbraιn_930_r 0 077 0 318 0 087 0230

HSbraιn_419_l 0 056 0 178 -0 053 0230

HS_from_MQbraιn_414_l 0 159 0 803 0 570 0233 hsa-mιr-453 I 0 030 0 185 -0 049 0233

HSbraιn_371_r 0 070 -0 018 -0 252 0234 hsa-mιr-604_l 0 189 0 046 -0 188 0235

HSbraιn_231_l 0 019 0 327 0 092 0235

HS_from_MQbraιn_1318_l 0 135 0 681 0 445 0236

HS_from_PT_148_l 0 080 -0 106 -0 343 0237

Hsd_from_Mmd_232_r 0 183 -0 015 -0 253 0237

HS_from_PT_38_l 0 129 -0 280 -0 518 0238

HS_from_MQbraιn_1030_l 0 147 0 778 0 539 0239

Hsd_62_l 0 068 0 623 0 383 0240

HS_from_PT_313_r 0 084 0 047 -0 193 0240

HS_from_MQbraιn_1592_l 0 092 0 731 0 491 0240

HSbraιn_123_l 0 058 0 178 -0 062 0241

Hsd_from_Mmd_19_l 0 164 0 089 -0 152 0241

HSbraιn_409_r 0 061 0 059 -0 182 0241

Hsd_19_l 0 196 0 891 0 649 0242

HS_76_r 0 147 0 057 -0 185 0242

HS_from_MQbraιn_1280_l 0 072 0 244 0 002 0242

HSbraιn_364_r 0 170 -0 099 -0 341 0242

HS_from_MQbraιn_1712_r 0 129 0 783 0 540 0243

HS_from_MQbraιn_1381_r 0 147 0 154 -0 090 0243

HSbraιn_731_r 0 024 0 232 -0 011 0243

HSbraιn_130_r 0 153 0 137 -0 106 0244

HSbraιn_543_l 0 124 0 114 -0 129 0244

HS_from_MQbraιn_1340_l 0 036 0 326 0 082 0244

HS_from_PT_48_l 0 196 -0 395 -0 640 0245 hsa-mιr-617_l 0 088 -0 106 -0 351 0245

HSbraιn_506_r 0 108 -0 013 -0 258 0245

HS_from_MQbraιn_1487_r 0 119 0 314 0 069 0245

HSbraιn_374_r 0 053 0 005 -0 242 0247

HSbraιn_467_l 0 170 0 226 -0 022 0248

HS_from_MQbraιn_135_l 0 176 0 234 -0 016 0250

HS_from_MQbraιn_936_r 0 164 0 478 0 227 0252

HSbraιn_580_r 0 038 0 029 -0 222 0252

HS_from_MQbraιn_881_l 0 183 0 282 0 030 0252

HS_from_MQbraιn_283_r 0 147 -0 052 -0 303 0252

HS_from_MQbraιn_120_l 0 189 0 210 -0 042 0252

HS_from_PT_22_l 0 103 0 076 -0 176 0253

HSbraιn_745_l 0 170 0 591 0 337 0254 hsa-mιr-324_l 0 196 0 036 -0 219 0255

Hsd_from_Mmd_519_r 0 095 -0 172 -0 428 0256

HS_304_r 0 061 0 774 0 518 0256

HS from MQbrain 1700 I 0 080 0 739 0 482 0257 HS_from_MQbraιn_1212_l 0 164 0 012 -0 245 0257

HS_from_MQbraιn_604_l 0 113 0 592 0 334 0257

HS_from_MM_194_l 0 196 -0 232 -0 489 0258

HS_from_MQbraιn_789_l 0 124 0 489 0 231 0258

HSbraιn_227_r 0 113 0 233 -0 025 0258 hsa-mιr-518c_l 0 159 -0 072 -0 331 0259

HS_189_r 0 135 0 018 -0 241 0260

HS_from_MQbraιn_1443_r 0 032 0 499 0 239 0260

HSbraιn_144_r 0 140 0 402 0 142 0260

HSbraιn_212_l 0 068 0 365 0 105 0260

HS_from_MM_145_r 0 129 0 539 0 278 0261

HS_from_MQbraιn_1412_l 0 061 0 235 -0 027 0261

HSbraιn_480_r 0 072 0 220 -0 041 0262

HS_from_MM_182_r 0 189 0 012 -0 250 0262

HS_from_MQbraιn_29_r 0 070 0 169 -0 093 0262

Hsd_from_Mmd_330_l 0 070 0 724 0 461 0263

HS_from_MM_149_r 0 183 0 014 -0 249 0263

HS_from_MQbraιn_1841_r 0 070 0 453 0 190 0263

Hsd_from_Mmd_378_l 0 092 0 016 -0 248 0264

HSbraιn_496_r 0 135 0 107 -0 158 0265

HS_from_MQbraιn_1637_r 0 080 0 669 0 404 0265

HS_from_PT_299_l 0 030 0 560 0 295 0266

HSbraιn_431_r 0 068 -0 043 -0 310 0266

HS_from_MQbraιn_36_r 0 129 0 707 0 440 0266

HSbraιn_627_r 0 189 -0 199 -0 466 0267

HSbraιn_752_l 0 153 0 618 0 351 0267

HS_from_MQbraιn_1761_r 0 010 0 063 -0 204 0267

HS_from_MQbraιn_1686_l 0 050 0 556 0 287 0268

HS_from_MQbraιn_1593_r 0 084 0 010 -0 259 0269

HSbraιn_527_r 0 021 0 188 -0 082 0270

HSbraιn_680_l 0 164 0 643 0 371 0271

HS_from_MQbraιn_207_l 0 011 0 419 0 146 0273

HS_from_MM_34_l 0 099 0 070 -0 204 0274

HS_from_MQbraιn_1658_l 0 092 -0 003 -0 277 0274 hsa-mιr-588 r 0 135 -0 038 -0 313 0274 hsa-mιr-599_r 0 140 -0 219 -0 494 0275

HS_from_MQbraιn_239_r 0 068 0 200 -0 077 0277

HS_from_MQbraιn_631_l 0 159 0 217 -0 060 0277

HS_41_r 0 140 0 115 -0 163 0277 hsa-mιr-770_r 0 113 0 414 0 136 0278

HS_from_PT_43_l 0 040 0 556 0 277 0279

HS_from_MM_289_r 0 072 -0 112 -0 391 0279

HS_from_MM_184_r 0 092 0 056 -0 224 0280

Hsd_from_Mmd_344_r 0 176 0 401 0 121 0280

HSbraιn_130_l 0 147 -0 089 -0 370 0281

HSbraιn_361_l 0 140 0 500 0 216 0283

HS_from_MQbraιn_770_r 0 092 0 133 -0 150 0283

HS_from_PT_328_l 0 189 0 916 0 633 0283

HS_from_MQbraιn_1090_r 0 164 0 785 0 502 0284

HS_from_MQbraιn_1640_l 0 135 -0 162 -0 446 0284

HSbraιn_113_r 0 095 0 246 -0 038 0284

HSbraιn_706_l 0 183 0 144 -0 140 0284

HS_74_r 0 164 0 022 -0 262 0284

HS_from_MM_229_r 0 088 0 239 -0 047 0286

HSbraιn_661_l 0 080 0 295 0 009 0286

HSbrain 299 r 0 108 0 337 0 051 0286 HS_from_MQbraιn_234_r 0 135 0 095 -0 192 0287

HSbraιn_677_l 0 103 0 580 0 292 0287

HS_306_r 0 099 0 086 -0 201 0288

HS_from_MQbraιn_1642_l 0 050 0 194 -0 094 0289

HS_from_MQbraιn_84_r 0 196 -0 016 -0 306 0290

HSbraιn_139_r 0 147 0 028 -0 263 0290

HS_from_MM_331_r 0 189 0 087 -0 204 0291

HS_from_MQbraιn_540_l 0 135 0 527 0 235 0292

HSbraιn_271_l 0 077 0 277 -0 016 0292

HSbraιn_446_r 0 164 0 229 -0 064 0293 hsa-mιr-133a-2_r 0 015 0 045 -0 248 0293

H S_f rom_MQb rai n_828_r 0 113 -0 077 -0 370 0293

HS_from_MM_165_l 0 088 0 274 -0 019 0293

HS_115_r 0 153 0 076 -0 217 0293

Hsd_from_Mmd_280_l 0 153 0 068 -0 227 0294

HS_from_PT_178_l 0 140 0 365 0 070 0295

HS_from_MQbraιn_1706_l 0 080 0 011 -0 284 0295

HSbraιn_145_l 0 119 0 537 0 241 0296

HS_73_r 0 113 0 093 -0 203 0296

HS_from_MQbraιn_769_r 0 084 -0 227 -0 524 0297

HS_from_MQbraιn_1759_l 0 147 -0 484 -0 781 0297

Hsd_18_l 0 024 0 264 -0 034 0298

HS_from_MQbraιn_951_l 0 040 -0 184 -0 483 0298

HS_from_PT_237_l 0 124 0 091 -0 207 0299

HS_from_MM_1_l 0 070 0 044 -0 255 0299

HS_109_r 0 058 0 140 -0 159 0299

HS_95_r 0 159 0 115 -0 185 0300 hsa-mιr-622_r 0 129 0 125 -0 175 0300 hsa-mιr-550-2_r 0 038 0 054 -0 246 0301

HS_from_MQbraιn_883_r 0 058 0 108 -0 193 0301

HSbraιn_624_l 0 147 0 406 0 105 0301 hsa-mιr-550-1_r 0 135 0 070 -0 231 0301

HSbraιn_811_l 0 153 0 249 -0 053 0301

HS_from_MM_124_r 0 183 0 245 -0 057 0302

Hsd_from_Mmd_97_l 0 036 0 019 -0 283 0302

Hsd_70_l 0 025 0 301 -0 001 0302

HS_from_MM_84_r 0 140 0 278 -0 024 0303

HS_from_MM_119_r 0 135 0 196 -0 107 0303 hsa-mιr-409 r 0 119 -0 062 -0 366 0304

Hsd_77_r 0 147 0 582 0 277 0304

HSbraιn_84_l 0 050 0 033 -0 271 0304

HS_from_MM_232_r 0 170 -0 130 -0 435 0305

HS_66_r 0 077 0 016 -0 289 0305

H S_f rom_MQb rai n_260_r 0 147 0 919 0 614 0305

HS_from_MQbraιn_592_l 0 119 0 560 0 255 0305

HSbraιn_237_l 0 196 0 083 -0 222 0305

HSbraιn_301_l 0 072 -0 048 -0 354 0306

HS_from_MQbraιn_155_l 0 159 0 415 0 109 0306 hsa-mιr-190 r 0 183 -0 207 -0 513 0306

HS_from_MQbraιn_1260_r 0 005 0 078 -0 228 0306

HS_111_I 0 140 0 182 -0 125 0307

HSbraιn_788_l 0 077 -0 018 -0 326 0308

HSbraιn_250_r 0 072 0 183 -0 125 0308

HSbraιn_415_l 0 099 0 852 0 544 0308

HSbraιn_673_l 0 159 0 614 0 306 0309

Hsd 82 r 0 119 0 092 -0 217 0309 HS_from_MQbraιn_1602_l 0 092 0 607 0 298 0309

HS_from_MQbraιn_1459_l 0 103 0 242 -0 068 0311

HS_from_MQbraιn_1771_r 0 070 0 467 0 156 0311

HSbraιn_300_l 0 058 -0 034 -0 345 0312

HSbraιn_728_l 0 070 0 048 -0 265 0313

HSbraιn_495_r 0 113 0 278 -0 036 0314

HS_from_MQbraιn_67_l 0 147 0 278 -0 037 0314

HSbraιn_473_l 0 095 0 066 -0 249 0314

HS_121_r 0 140 -0 247 -0 562 0315

Hsd_from_Mmd_480_r 0 099 0 393 0 078 0315

HS_from_MQbraιn_768_l 0 189 -0 116 -0 431 0315

HS_from_PT_237_r 0 013 0 375 0 060 0315

Hsd_from_Mmd_524_r 0 068 -0 074 -0 391 0317

HSbraιn_1425_r 0 080 0 033 -0 284 0317

HS_281_r 0 001 0 024 -0 293 0317

HS_from_MQbraιn_650_r 0 164 0 647 0 329 0318 hsa-mιr-30d_l 0 099 -0 193 -0 511 0318

HSbraιn_671_r 0 056 0 006 -0 314 0319

HS_from_MQbraιn_1684_r 0 092 0 219 -0 100 0319

HSbraιn_55_l 0 159 0 203 -0 117 0319

HS_from_MQbraιn_739_l 0 070 0 043 -0 276 0319

Hsd_from_Mmd_49_l 0 048 0 374 0 054 0320

HS_from_MQbraιn_291_l 0 088 0 671 0 350 0320

HSbraιn_598_l 0 065 0 319 -0 002 0320 hsa-mιr-133a-1 r 0 034 0 140 -0 180 0321

HSbraιn_408_r 0 061 0 099 -0 223 0322

HS_from_PT_220_l 0 108 0 774 0 452 0322

HS_from_MQbraιn_997_l 0 070 0 705 0 383 0322

HS_from_MQbraιn_502_r 0 119 -0 061 -0 384 0322

HS_from_MQbraιn_882_l 0 103 0 123 -0 200 0323 hsa-mιr-296_l 0 016 0 082 -0 243 0325

HS_from_MQbraιn_1446_l 0 065 0 056 -0 269 0325

Hsd_20_r 0 099 0 121 -0 204 0325

HSbraιn_597_r 0 023 0 707 0 382 0325

HS_from_MQbraιn_1513_r 0 036 -0 284 -0 609 0325

HSbraιn_214_l 0 061 0 195 -0 131 0326

HS_from_MQbraιn_444_r 0 027 0 273 -0 053 0326

HS_from_MQbraιn_1744_r 0 103 0 357 0 031 0326

HSbraιn_722_l 0 024 0 457 0 130 0327

HS_from_MQbraιn_1884_r 0 010 0 365 0 038 0327

HS_289_I 0 119 0 887 0 559 0328

HS_from_MQbraιn_1885_r 0 092 0 295 -0 033 0329

Hsd_from_Mmd_93_r 0 092 0 393 0 064 0329

HSbraιn_716_l 0 140 0 504 0 175 0329

HS_from_PT_161_l 0 183 -0 016 -0 345 0329

Hsd_from_Mmd_298_l 0 095 0 067 -0 263 0330

HS_214_r 0 135 -0 146 -0 475 0330

HS_from_PT_27_l 0 103 0 062 -0 268 0330

HS_from_MM_121_l 0 027 0 010 -0 320 0330

HS_1 1_l 0 088 0 176 -0 154 0330 hsa-mιr-609_r 0 135 0 112 -0 219 0331

HS_from_MQbraιn_684_r 0 135 0 173 -0 159 0332

HS_from_MQbraιn_1427_l 0 068 0 511 0 179 0332

Hsd from Mmd 44 r 0 159 -0 038 -0 370 0333 hsa-mιr-296_r 0 103 0 509 0 177 0333

HSbrain 482 I 0 103 0 381 0 048 0333 HS_from_MQbraιn_1545_r 0 095 -0 248 -0 581 0333

Hsd_f rom_Mmd_410_r 0 036 0 062 -0 272 0335

HSbraιn_1338_r 0 065 0 062 -0 272 0335

HS_from_PT_299_r 0 036 0 123 -0 212 0335

HS_from_MQbraιn_467_l 0 140 0 164 -0 171 0335

Hsd_from_Mmd_527_l 0 040 0 075 -0 261 0335 hsa-mιr-625 r 0 095 0 258 -0 078 0336

HS_from_MQbraιn_1250_r 0 147 0 014 -0 322 0336

HS_from_MQbraιn_723_l 0 053 0 126 -0 211 0336

HSbraιn_95_l 0 164 0 001 -0 336 0337 hsa-mιr-526b r 0 108 -0 393 -0 731 0338

HS_from_PT_70_r 0 046 0 477 0 139 0338

HSbraιn_1410_l 0 043 0 613 0 275 0338

H S_f rom_MQb rai n_698_r 0 077 0 215 -0 124 0338

HSbraιn_784_r 0 164 0 646 0 308 0338 hsa-mιr-767_r 0 050 0 043 -0 296 0339

HSbraιn_696_r 0 030 0 116 -0 223 0340

HS_from_MQbraιn_1445_l 0 032 0 638 0 298 0340

HS_from_MQbraιn_1684_l 0 027 0 214 -0 126 0340 hsa-mιr-323_l 0 016 0 418 0 077 0341

HS_from_MM_295_r 0 072 0 439 0 098 0341

HS_from_MQbraιn_482_l 0 034 0 019 -0 322 0341

Hsd_79_l 0 095 1 169 0 828 0341

HSbraιn_143_l 0 170 0 885 0 543 0342 hsa-mιr-93 I 0 183 -0 474 -0 816 0342

HSbraιn_75_l 0 024 0 433 0 089 0344

HSbraιn_124_l 0 088 0 821 0 477 0345

Hsd_from_Mmd_489_r 0 124 0 044 -0 302 0345 hsa-mιr-554_l 0 017 0 159 -0 187 0346

HS_from_MQbraιn_1776_l 0 129 0 783 0 437 0346

HSbraιn_180_l 0 196 0 131 -0 215 0346

HS_from_MQbraιn_1267_r 0 088 0 024 -0 323 0346

HSbraιn_272_l 0 036 0 028 -0 319 0347

HS_from_MQbraιn_154_r 0 153 0 268 -0 079 0347

HS_from_MQbraιn_1855_l 0 140 0 079 -0 269 0348 hsa-mιr-412_r 0 061 0 236 -0 114 0350

HS_from_MQbraιn_848_l 0 088 0 124 -0 227 0350

HSbraιn_652_l 0 050 0 616 0 265 0350

HS_287_I 0 124 0 889 0 538 0351

HS_from_PT_102_l 0 080 0 854 0 502 0352

Hsd_from_Mmd_101_r 0 135 0 182 -0 170 0352

HSbraιn_637_l 0 092 0 704 0 351 0353

HS_from_PT_196_r 0 164 0 197 -0 157 0353

HSbraιn_92_l 0 040 0 572 0 219 0353

HS_from_MQbraιn_253_r 0 072 0 028 -0 326 0354

HS_from_MQbraιn_664_l 0 056 0 763 0 409 0354 hsa-let-7f-1_r 0 092 -0 042 -0 397 0355

H S_f rom_MQb rai n_900_r 0 159 0 051 -0 304 0355

HS_from_MQbraιn_664_r 0 140 0 304 -0 051 0355

HS_4_r 0 092 0 812 0 456 0356 hsa-mιr-1-1_l 0 147 -0 033 -0 389 0356

HS_from_MQbraιn_1632_r 0 010 0 174 -0 182 0356

HS_from_MQbraιn_282_l 0 038 0 489 0 132 0357 hsa-mιr-506 r 0 092 -0 034 -0 392 0358

HS_from_MQbraιn_1760_r 0 189 0 864 0 504 0359

HS from MQbrain 251 r 0 070 0 860 0 500 0360 hsa-mιr-500_l 0 029 -0 234 -0 594 0360

HS_from_MQbraιn_1745_r 0 080 0 373 0 013 0360

HS_from_MQbraιn_343_l 0 050 0 119 -0 241 0360

Hsd_from_Mmd_161_l 0 092 0 865 0 505 0360

HSbraιn_1337_l 0 080 0 129 -0 232 0361

HSbraιn_242_l 0 189 -0 254 -0 616 0362

Hsd_f rom_Mmd_217_r 0 119 -0 028 -0 390 0362

HS_59_I 0 056 0 579 0 216 0363 hsa-mιr-98_r 0 159 -0 065 -0 429 0364

HS_from_MQbraιn_131_r 0 007 0 219 -0 146 0365 hsa-mιr-628_r 0 061 0 184 -0 181 0365

HS_from_MM_304_r 0 129 0 878 0 512 0366

HS_from_MQbraιn_1253_r 0 084 -0 014 -0 380 0366 hsa-mιr-134 r 0 030 0 237 -0 130 0366 hsa-mιr-148b r 0 058 -0 018 -0 384 0367

Hsd_18_r 0 053 0 102 -0 264 0367

HSbraιn_472_l 0 020 0 126 -0 242 0367

HS_from_MQbraιn_1126 1 0 176 -0 380 -0 748 0368

HS_from_PT_280_l 0 164 0 002 -0 367 0369 hsa-mιr-532_l 0 099 0 005 -0 365 0370 hsa-mιr-521-2_r 0 088 0 301 -0 069 0370 hsa-mιr-106b r 0 032 -0 338 -0 708 0370

HS_from_MQbraιn_1227_l 0 043 0 034 -0 337 0371 hsa-mιr-379_l 0 077 0 882 0 511 0371

Hsd_from_Mmd_291_r 0 108 0 939 0 568 0371

HS_from_MM_32_r 0 048 0 081 -0 291 0371

HSbraιn_722_r 0 099 0 202 -0 170 0372

HSbraιn_388_r 0 183 0 180 -0 192 0372 hsa-mιr-616_l 0 070 0 022 -0 350 0373

HS_from_PT_146_r 0 013 0 243 -0 130 0373

Hsd_102_l 0 036 0 430 0 056 0374 hsa-mιr-641_r 0 153 -0 082 -0 456 0374

HS_from_MQbraιn_74_r 0 029 0 718 0 344 0374

HSbraιn_121_l 0 159 0 626 0 252 0374

HS_from_PT_95_r 0 092 0 960 0 585 0375

HSbraιn_1360_l 0 092 0 947 0 572 0375

HS_from_MQbraιn_1450_r 0 065 0 418 0 042 0376

HS_268_I 0 147 0 175 -0 201 0376

Hsd_17_l 0 124 1 038 0 662 0376

HS_from_PT_50_r 0 095 0 346 -0 031 0376

Hsd_from_Mmd_333_r 0 072 0 268 -0 108 0376

HSbraιn_1363_l 0 072 0 910 0 534 0376

HS_from_MQbraιn_841_l 0 170 0 990 0 613 0377

HSbraιn_720_l 0 099 0 115 -0 262 0377

Hsd_74_r 0 135 0 166 -0 212 0377

HSbraιn_570_l 0 124 0 507 0 129 0378

HSbraιn_396_r 0 124 0 104 -0 275 0379

HS_from_MQbraιn_56_l 0 056 0 687 0 307 0379

HS_from_MQbraιn_549_r 0 068 0 182 -0 198 0380 hsa-mιr-659 I 0 017 0 060 -0 320 0380

HS_from_MQbraιn_128_r 0 061 0 606 0 226 0381

HS_213_I 0 080 0 138 -0 243 0381

HSbraιn_225_r 0 019 0 308 -0 073 0381

HS_from_MM_202_l 0 084 -0 296 -0 677 0381

HSbraιn_1413_l 0 017 0 287 -0 094 0381

HS from PT 235 I 0 070 -0 047 -0 429 0382 HS_from_MQbraιn_1213_l 0 099 0 632 0 250 0382

HS_from_MQbraιn_542_r 0 050 0 330 -0 054 0384

HS_from_MQbraιn_1703_r 0 040 0 010 -0 374 0384

HS_from_MQbraιn_806_l 0 088 -0 347 -0 731 0384 hsa-mιr-151_l 0 159 0 139 -0 245 0384

HSbraιn_114_r 0 030 0 080 -0 305 0385

H S_f rom_MQb rai n_800_r 0 034 0 393 0 007 0386

HS_from_MQbraιn_88_l 0 108 -0 341 -0 727 0386

HS_288_I 0 095 0 923 0 537 0386

HS_from_MQbraιn_1462_r 0 147 -0 133 -0 519 0386

HS_from_MQbraιn_1781 1 0 092 0 038 -0 348 0386

HS_from_MQbraιn_1234_l 0 189 0 323 -0 064 0387

Hsd_from_Mmd_334_r 0 159 0 078 -0 309 0387

HS_from_MM_354_r 0 038 0 226 -0 162 0388

HS_212_I 0 048 0 075 -0 313 0388

Hsd_f rom_Mmd_166_r 0 095 -0 192 -0 581 0389

HS_from_PT_219_l 0 147 0 844 0 455 0389

HSbraιn_359_l 0 027 0 281 -0 108 0389 hsa-mιr-92-1_l 0 176 0 482 0 092 0389

HSbraιn_1364_l 0 072 0 934 0 545 0390

HSbraιn_74_r 0 024 0 209 -0 181 0390

HSbraιn_749_r 0 072 0 610 0 218 0392

HS_from_MQbraιn_796_l 0 058 0 183 -0 209 0393

HSbraιn_504_r 0 103 0 288 -0 105 0393

HS_from_MQbraιn_1831_r 0 159 0 310 -0 083 0393

HS_from_MQbraιn_693_r 0 153 1 457 1 064 0393

HS_from_MM_6_l 0 183 0 197 -0 197 0393

HS_281_r 0 001 0 083 -0 312 0395

HS_from_MQbraιn_1808_r 0 010 0 575 0 180 0395

Hsd_6_l 0 053 0 033 -0 362 0395

HS_from_MQbraιn_55_l 0 011 0 103 -0 292 0395

HS_from_MM_342_r 0 068 0 301 -0 094 0395 hsa-mιr-521-1_l 0 147 0 094 -0 302 0396

HS_from_MQbraιn_509_r 0 027 -0 223 -0 619 0396

HS_from_MQbraιn_641_r 0 070 0 072 -0 325 0397

HSbraιn_711_l 0 053 0 239 -0 158 0397

H S_f rom_MQb rai n_209_r 0 050 0 217 -0 180 0398

HS_from_MQbraιn_1097_r 0 135 0 614 0 217 0398 hsa-mιr-641 I 0 080 -0 273 -0 674 0400 hsa-mιr-624_l 0 183 -0 154 -0 555 0401

HS_164_I 0 108 0 684 0 284 0401 hsa-mιr-23a I 0 140 0 530 0 129 0401

HS_from_MQbraιn_1747_r 0 040 0 184 -0 217 0401

HS_56_r 0 040 0 327 -0 074 0401

Hsd_from_Mmd_328_r 0 124 0 199 -0 202 0401

HS_204_l 0 113 -0 449 -0 850 0401

HS_from_PT_271_l 0 147 0 142 -0 260 0402

HS 1 14 I 0 048 0 800 0 399 0402

HS_from_MQbraιn_154_l 0 084 0 912 0 509 0403

HS_from_MQbraιn_1376_l 0 070 0 643 0 239 0404

HS_from_MQbraιn_555_r 0 129 0 281 -0 123 0404

Hsd_from_Mmd_478_l 0 108 0 326 -0 078 0404 hsa-mιr-513-2_l 0 124 0 153 -0 251 0404

HS_from_PT_20_r 0 084 0 660 0 256 0404

HS_from_PT_187_r 0 058 0 122 -0 283 0405

HSbrain 483 I 0 021 0 160 -0 245 0405 Hsd_from_Mmd_422_l 0 046 0 067 -0 340 0407

HS_from_MQbraιn_1354_l 0 061 0 424 0 016 0408

HSbraιn_330_l 0 068 0 856 0 448 0408

HS_150_l 0 061 0 702 0 294 0409

HS_from_MQbraιn_1493_r 0 147 1 414 1 005 0409 hsa-mιr-634_l 0 119 0 595 0 184 0410

Hsd_from_Mmd_23_l 0 036 -0 045 -0 455 0410

HSbraιn_158_l 0 017 0 272 -0 139 0411

HS_from_MQbraιn_97_r 0 147 0 512 0 101 0411

HSbraιn_425_l 0 140 -0 124 -0 537 0412 hsa-mιr-219-1_r 0 072 -0 224 -0 636 0412

HSbraιn_448_l 0 129 0 690 0 277 0413

HSbraιn_171_l 0 017 0 374 -0 039 0413

HS_from_PT_32_r 0 013 0 064 -0 349 0413

HSbraιn_572_r 0 068 -0 109 -0 523 0414

Hsd_from_Mmd_208_r 0 183 -0 459 -0 874 0415 hsa-let-7a-2_r 0 040 0 127 -0 290 0416

HS_from_MQbraιn_1377_l 0 170 0 499 0 083 0416

HS_from_MM_195_r 0 084 0 990 0 574 0417 hsa-mιr-652_r 0 164 -0 221 -0 638 0418

HSbraιn_50_r 0 029 0 027 -0 391 0418 hsa-mιr-662_l 0 196 1 115 0 697 0419

HSbraιn_619_r 0 092 -0 156 -0 576 0419

HS_from_MQbraιn_1199 1 0 170 1 278 0 858 0420

HS_from_MQbraιn_723_r 0 070 0 837 0 417 0421

Hsd_from_Mmd_325_l 0 099 -0 149 -0 570 0421

Hsd_42_r 0 043 0 390 -0 031 0421

HSbraιn_604_r 0 153 0 110 -0 313 0422

HS_from_PT_101_r 0 013 0 168 -0 255 0423

HS_131_r 0 053 0 774 0 349 0424 hsa-mιr-30c-2_l 0 164 -0 140 -0 564 0424

HS_from_MQbraιn_948_r 0 088 0 369 -0 055 0424

HS_from_MQbraιn_1695_r 0 147 0 274 -0 150 0424

HSbraιn_1362_l 0 048 0 903 0 478 0425

HS_from_PT_121_r 0 058 0 745 0 320 0425

HSbraιn_108_l 0 140 0 073 -0 354 0427

HS_from_MQbraιn_1717_r 0 046 0 133 -0 294 0427

HSbraιn_768_l 0 159 0 729 0 302 0427 hsa-mιr-653_l 0 046 0 091 -0 336 0427

HS_166_r 0 077 0 573 0 145 0428

HS_from_MM_289_l 0 043 0 004 -0 424 0428

HS_from_MQbraιn_782_r 0 043 1 069 0 639 0430

HS_from_MQbraιn_1658_r 0 072 0 047 -0 383 0430

HSbraιn_35_r 0 058 0 689 0 259 0431

HS_186_r 0 176 0 490 0 058 0432

HS_from_MQbraιn_1201_r 0 095 0 803 0 371 0432 hsa-mιr-518f r 0 068 -0 162 -0 595 0433

HS_53_r 0 140 1 218 0 785 0434

HS 118 I 0 032 0 766 0 332 0435

HS_from_MQbraιn_412_l 0 103 -0 533 -0 968 0435

Hsd_62_l 0 068 0 256 -0 179 0435

HSbraιn_1377_l 0 017 0 175 -0 261 0436

HSbraιn_420_r 0 020 0 485 0 049 0436

HS_from_MQbraιn_566_l 0 011 0 175 -0 260 0436

HSbraιn_6_r 0 023 0 587 0 151 0437

HS from MQbrain 1392 r 0 032 0 978 0 541 0437 HS_from_MQbraιn_105_l 0 113 -0 007 -0 443 0437

Hsd_from_Mmd_123_l 0 140 0 183 -0 253 0437

HS_from_MQbraιn_105_l 0 113 0 102 -0 335 0437

HSbraιn_797_r 0 080 0 079 -0 358 0437

HS_from_MQbraιn_940_r 0 013 0 435 -0 002 0437 hsa-mιr-633_r 0 119 -0 150 -0 589 0439

HS_from_MQbraιn_6_r 0 153 0 882 0 443 0439 hsa-mιr-648_l 0 088 0 768 0 328 0439

HS_from_MQbraιn_1700_r 0 056 0 279 -0 160 0440

HS_from_PT_340_l 0 061 0 116 -0 325 0441

HS_61_I 0 095 -0 372 -0 814 0442

HSbraιn_520_l 0 113 1 209 0 767 0442

HSbraιn_658_l 0 196 0 001 -0 442 0443

HS_from_MQbraιn_969_l 0 034 0 265 -0 178 0443

HS_from_MM_157_l 0 129 -0 293 -0 736 0443

HS_from_MQbraιn_1794_l 0 053 0 300 -0 144 0443

HS_from_MQbraιn_1404_r 0 061 0 787 0 343 0444 hsa-mιr-521-1 r 0 056 0 323 -0 121 0444

Hsd_f rom_Mmd_187_r 0 183 0 428 -0 016 0445

HS_from_MQbraιn_1414_r 0 077 0 603 0 158 0445

HSbraιn_713_l 0 030 0 842 0 397 0445

HS_from_MQbraιn_873_r 0 053 1 085 0 639 0445

Hsd_19_r 0 058 0 191 -0 254 0446

HS_from_MQbraιn_1773_l 0 048 0 663 0 217 0446

HS_from_MQbraιn_1807_l 0 147 0 503 0 056 0447 hsa-mιr-30b_l 0 070 0 049 -0 398 0447

HS_from_MQbraιn_315_l 0 050 0 531 0 083 0448

HS_from_MQbraιn_1395_r 0 053 0 783 0 334 0449

HSbraιn_507_l 0 072 0 081 -0 369 0449

HS_from_MQbraιn_1696 I 0 065 -0 575 -1 025 0449

HS_from_MQbraιn_100_l 0 005 0 316 -0 134 0450

Hsd_from_Mmd_92_l 0 176 1 146 0 696 0450

HS_from_MQbraιn_1239_l 0 053 -0 109 -0 560 0451

HS_from_MQbraιn_1388_l 0 043 1 152 0 701 0451 hsa-mιr-630 r 0 099 -0 056 -0 509 0452

HS_190_l 0 058 0 834 0 381 0453 hsa-mιr-375_l 0 088 0 394 -0 059 0453

HS_from_MQbraιn_2380_r 0 011 0 503 0 049 0454

HS_from_PT_339_r 0 095 -0 091 -0 545 0454

Hsd_from_Mmd_70_l 0 058 0 351 -0 104 0455

Hsd_from_Mmd_519_l 0 025 0 065 -0 390 0455

HS_from_MQbraιn_1520_r 0 080 0 629 0 173 0456

HSbraιn_413_l 0 159 -0 215 -0 671 0456

HSbraιn_610_r 0 070 0 783 0 327 0456

HS_from_MQbraιn_676_r 0 183 1 535 1 079 0456

HS_from_MQbraιn_1565_r 0 072 0 564 0 106 0458

HS_from_MM_160_l 0 183 -0 049 -0 507 0458

HS_from_MQbraιn_349_l 0 011 0 160 -0 301 0461

HS_from_PT_250_r 0 135 1 045 0 583 0462

HSbraιn_102_r 0 017 0 677 0 215 0462 hsa-mιr-329-1_r 0 068 -0 013 -0 476 0463 hsa-mιr-135a-2 r 0 015 0 264 -0 199 0463

Hsd_from_Mmd_367_l 0 170 -0 305 -0 769 0464

HS_from_MQbraιn_576_l 0 080 0 570 0 106 0465

HS_from_MQbraιn_917_r 0 013 -0 163 -0 628 0465

HSbrain 794 r 0 024 0 758 0 292 0466 HSbraιn_295_r 0 196 -0 277 -0 743 0466

HSbraιn_280_l 0 108 1 581 1 114 0467

HS_33_I 0 038 0 378 -0 091 0469 hsa-mιr-329-2_r 0 040 0 039 -0 430 0469

HSbraιn_506_l 0 065 0 253 -0 218 0471 hsa-mιr-193a_l 0 070 1 119 0 648 0471

H S_f rom_MQb rai n_498_r 0 038 1 096 0 624 0472

HS_from_MM_319_l 0 004 0 890 0 418 0472

HS_from_MQbraιn_854_r 0 012 0 170 -0 303 0473

HSbraιn_148_r 0 017 0 430 -0 043 0473

HSbraιn_705_r 0 147 1 198 0 724 0474

HS_from_MQbraιn_191_l 0 010 0 502 0 028 0475 hsa-mιr-331_l 0 070 -0 128 -0 603 0475 hsa-let-7c r 0 040 0 146 -0 330 0475

HS_from_MQbraιn_20_r 0 011 -0 133 -0 608 0475

HSbraιn_700_r 0 038 0 218 -0 259 0477

HS_from_MQbraιn_350_l 0 011 0 166 -0 311 0478 hsa-mιr-513-1_l 0 099 0 213 -0 265 0478 hsa-mιr-299_l 0 016 0 126 -0 354 0480

HS_from_MQbraιn_791_r 0 189 -0 470 -0 951 0481 hsa-mιr-144 r 0 176 -0 446 -0 927 0481

HSbraιn_754_r 0 024 0 162 -0 320 0481

HSbraιn_165_l 0 034 1 001 0 519 0482 hsa-mιr-412_l 0 129 0 195 -0 288 0483 hsa-mιr-422a_l 0 159 1 153 0 670 0483

HSbraιn_317_l 0 080 0 542 0 059 0483

HS_from_MQbraιn_529_r 0 164 0 548 0 065 0483

HS_from_MQbraιn_375_l 0 011 0 196 -0 288 0484

HS_from_MM_47_l 0 068 0 020 -0 464 0484

Hsd_from_Mmd_480_l 0 025 0 193 -0 291 0484

HS_189_I 0 040 0 881 0 395 0485

HS_from_MM_72_r 0 056 -0 012 -0 498 0486

Hsd_from_Mmd_527_r 0 025 -0 455 -0 942 0487

HS_from_MQbraιn_224_l 0 077 0 677 0 190 0487

HS_from_MQbraιn_1456_l 0 009 0 744 0 256 0488

HS_from_MQbraιn_655_l 0 011 0 084 -0 404 0489

HS_from_MQbraιn_1363_l 0 007 0 297 -0 192 0490

HSbraιn_1076_r 0 017 0 188 -0 303 0491 hsa-mιr-155 I 0 103 -0 206 -0 697 0491

HS_85_I 0 129 1 342 0 850 0492

HS_from_MM_18_l 0 004 0 221 -0 273 0494

HS_from_MQbraιn_1384_r 0 124 0 458 -0 038 0496

Hsd_46_l 0 025 0 367 -0 129 0496 hsa-let-7c_l 0 099 -0 464 -0 964 0500

H S_f rom_MQb rai n_288_r 0 011 0 196 -0 306 0502

HS_from_MQbraιn_951_l 0 040 0 919 0 416 0503

HS_307_r 0 183 -0 456 -0 959 0503

HSbraιn_557_r 0 095 1 309 0 804 0504 hsa-mιr-516-4_l 0 016 0 429 -0 076 0505 hsa-let-7d_l 0 029 -0 159 -0 664 0505

HS_78_r 0 170 0 725 0 220 0505

Hsd_26_l 0 025 0 212 -0 293 0505

HS_79_I 0 004 0 213 -0 293 0505

HS_from_MQbraιn_1064_r 0 088 0 645 0 139 0506

Hsd_from_Mmd_93_l 0 119 1 178 0 672 0507

HS from MQbrain 1522 r 0 009 0 032 -0 476 0508 H S_f rom_MQb rai n_468_r 0 068 0 332 -0 176 0509

HS_from_MQbraιn_750_r 0 065 0 894 0 385 0509 hsa-mιr-516-3_l 0 016 0 360 -0 151 0511

Hsd_from_Mmd_410_l 0 170 -0 321 -0 832 0511

Hsd_47_r 0 170 1 086 0 574 0512

H S_f rom_MQb rai n_969_r 0 153 0 561 0 048 0512

HS_from_PT_136_l 0 050 1 198 0 686 0513

HSbraιn_709_l 0 023 0 841 0 327 0513

HS_from_MQbraιn_1028_l 0 164 1 570 1 057 0513

HSbraιn_585_l 0 050 0 904 0 390 0514 hsa-mιr-125a r 0 014 0 758 0 243 0515

HS_from_MM_178_r 0 004 0 170 -0 345 0515 hsa-mιr-135a-1 r 0 140 0 615 0 100 0515

Hsd_from_Mmd_176_l 0 099 0 008 -0 508 0516

HS_from_MQbraιn_1844_r 0 043 0 622 0 106 0516

HSbraιn_259_r 0 030 0 708 0 192 0516

HSbraιn_261_l 0 038 0 190 -0 326 0516 hsa-mιr-497 r 0 016 0 312 -0 205 0517

HS_from_MQbraιn_1692_l 0 135 1 678 1 160 0518

HSbraιn_359_r 0 020 0 957 0 437 0520

HS_from_MM_295_l 0 004 0 192 -0 328 0520

Hsd_from_Mmd_302_r 0 029 0 158 -0 363 0521

HS_from_PT_74_r 0 095 1 193 0 672 0521

HS_from_MQbraιn_774_r 0 050 0 494 -0 027 0521 hsa-mιr-587 r 0 189 -0 141 -0 663 0522 hsa-mιr-383_l 0 183 0 011 -0 513 0524

HSbraιn_458_l 0 034 -0 681 -1 206 0525

HSbraιn_321_r 0 019 0 716 0 191 0525 hsa-mιr-125b-1_r 0 108 0 830 0 304 0526

HS_from_MQbraιn_330_r 0 011 0 687 0 161 0526 hsa-mιr-183_r 0 189 1 388 0 861 0526

HS_from_MM_347_l 0 088 1 264 0 738 0527

Hsd_37_l 0 053 1 037 0 510 0528

HS_from_MQbraιn_1485_l 0 009 0 128 -0 400 0528 hsa-mιr-502_l 0 092 -0 266 -0 794 0528

HS_15_I 0 043 1 549 1 020 0529

HSbraιn_72_l 0 129 1 342 0 812 0529 hsa-mιr-10a_r 0 103 0 156 -0 375 0531

HS_106_l 0 030 0 650 0 119 0532 hsa-mιr-514-3_r 0 183 -0 317 -0 849 0532

HSbraιn_691_l 0 095 -0 348 -0 881 0533

HS_from_MQbraιn_1417_l 0 092 0 735 0 199 0536

HSbraιn_318_l 0 029 0 876 0 338 0537

HS_from_MQbraιn_472_r 0 048 0 832 0 294 0538

HS_from_MM_87_l 0 124 -0 292 -0 830 0538

HS_from_MQbraιn_671_r 0 011 1 040 0 502 0538

HS_from_MQbraιn_1072_r 0 153 -0 043 -0 582 0539

HS_217_I 0 001 0 658 0 118 0540

HS_from_PT_234_l 0 164 0 188 -0 352 0540

HS_from_MQbraιn_1304_r 0 124 0 507 -0 034 0542

HS_from_MQbraιn_1393_r 0 007 0 873 0 331 0542

HSbraιn_617_l 0 023 1 098 0 556 0542

HSbraιn_276_l 0 088 0 101 -0 443 0544

HS_161_r 0 140 -0 342 -0 886 0544 hsa-mιr-137_l 0 068 0 471 -0 075 0546

Hsd from Mmd 223 r 0 095 -0 374 -0 922 0548 HS_from_MM_298_l 0 189 -0 268 -0 817 0549

HSbraιn_811_r 0 024 -0 031 -0 580 0549 hsa-mιr-188_l 0 153 0 494 -0 056 0549

Hsd_from_Mmd_439_l 0 061 -0 262 -0 811 0549

HS_from_MM_313_l 0 099 -0 694 -1 245 0551

HS_from_MQbraιn_1139_r 0 099 -0 337 -0 890 0552

Hsd from Mmd 34 r 0 046 0 650 0 095 0555

HS_from_MQbraιn_629_l 0 011 0 906 0 350 0556

HSbraιn_503_r 0 021 0 793 0 236 0557

Hsd_from_Mmd_501_r 0 084 0 618 0 060 0558

HS_from_MQbraιn_147_l 0 183 0 715 0 156 0559 hsa-mιr-598_l 0 027 0 957 0 398 0559

HS_180_r 0 065 0 240 -0 319 0559

HSbraιn_663_r 0 147 -0 320 -0 880 0560

HS_215_I 0 050 1 344 0 784 0560

Hsd_11_l 0 080 0 507 -0 054 0561

Hsd_96_r 0 147 -0 209 -0 772 0563

HS_from_MQbraιn_441_l 0 011 0 246 -0 320 0565

HS_from_MQbraιn_1297_l 0 007 0 454 -0 113 0566

Hsd_f rom_Mmd_219_r 0 025 -0 010 -0 577 0567

HSbraιn_536_r 0 108 -0 351 -0 919 0569

HSbraιn_286_l 0 084 1 278 0 709 0569

Hsd_f rom_Mmd_314_r 0 189 -0 315 -0 885 0569

HS_from_MQbraιn_212_r 0 011 0 049 -0 523 0573

HSbraιn_455_r 0 080 1 623 1 049 0573 hsa-mιr-101-1_r 0 176 -0 476 -1 050 0574

HS_from_MQbraιn_384_r 0 084 -0 235 -0 809 0574

Hsd_from_Mmd_249_r 0 108 0 047 -0 528 0575

HS_from_MQbraιn_6_l 0 159 1 944 1 368 0576

HS_from_MQbraιn_625_l 0 159 0 255 -0 323 0577

HSbraιn_546_r 0 030 0 510 -0 070 0581 hsa-mιr-95_r 0 030 -0 158 -0 739 0581

HSbraιn_131_l 0 124 1 302 0 720 0582

HS_from_MQbraιn_1300_r 0 007 -0 097 -0 680 0583 hsa-mιr-506_l 0 070 -0 318 -0 901 0583 hsa-mιr-203_r 0 189 0 895 0 310 0584 hsa-mιr-668_l 0 050 1 334 0 749 0585

Hsd_from_Mmd_68_l 0 183 -0 614 -1 200 0587 hsa-mιr-432_l 0 176 0 356 -0 232 0588

HS_from_MQbraιn_435_l 0 034 0 566 -0 022 0588

HS_from_MQbraιn_1080_l 0 040 -0 105 -0 694 0589

HS_from_MQbraιn_1501_r 0 159 1 467 0 877 0590

Hsd_from_Mmd_518_r 0 119 0 521 -0 070 0591 hsa-mιr-30c-1_l 0 036 -0 002 -0 594 0592

HS_from_MQbraιn_839_r 0 012 0 055 -0 537 0592

HS_from_MQbraιn_1625_r 0 009 0 910 0 318 0592

HSbraιn_801_r 0 024 0 462 -0 130 0592

HSbraιn_267_r 0 129 0 470 -0 123 0593

HS_from_MQbraιn_2670_r 0 099 0 673 0 079 0594

HS_from_MQbraιn_68_r 0 159 -0 182 -0 776 0594 hsa-mιr-571_r 0 113 -0 086 -0 680 0594 hsa-mιr-616 r 0 017 -0 025 -0 620 0595

HS_from_MQbraιn_1610_r 0 050 1 004 0 409 0595

HS_from_MQbraιn_549_l 0 011 0 234 -0 361 0595

HS_156_I 0 058 -0 022 -0 618 0595

HS from MQbrain 1037 r 0 092 0 808 0 213 0595 HSbraιn_543_r 0 038 0 457 -0 139 0596 hsa-mιr-125a_l 0 014 0 117 -0 480 0597

HSbraιn_268_r 0 019 0 831 0 233 0598

HSbraιn_399_l 0 020 0 270 -0 327 0598

HS_from_MQbraιn_1292_r 0 007 0 078 -0 521 0599

Hsd_from_Mmd_92_r 0 025 0 770 0 168 0602

HS_from_MQbraιn_1300 I 0 058 1 357 0 754 0603

HS_from_MQbraιn_1056_l 0 005 -0 166 -0 771 0605

HS_from_MQbraιn_1695_l 0 113 -0 143 -0 751 0607

HS_from_MQbraιn_1315_l 0 038 1 524 0 913 0611

HS_from_MM_309_r 0 004 0 695 0 083 0612

HS_from_MQbraιn_1469_r 0 032 -0 333 -0 945 0612

HS_from_MQbraιn_1665_r 0 080 0 501 -0 111 0613

Hsd_f rom_Mmd_123_r 0 176 0 949 0 335 0614 hsa-mιr-27b r 0 140 -0 809 -1 423 0614

HS_from_MQbraιn_389_l 0 196 0 842 0 226 0616

HS_from_MQbraιn_1657_r 0 010 0 032 -0 586 0618

HSbraιn_778_r 0 024 -0 435 -1 053 0618

HS_151_r 0 170 -0 548 -1 168 0619

Hsd_76_r 0 053 0 546 -0 074 0620

Hsd_7_r 0 058 0 261 -0 359 0620

HS_from_PT_22_l 0 103 0 699 0 077 0621 hsa-mιr-655_l 0 017 0 099 -0 523 0622 hsa-mιr-302d_l 0 016 -0 382 -1 009 0626

HSbraιn_245_r 0 070 1 023 0 396 0627

Hsd_from_Mmd_311_l 0 068 -0 222 -0 850 0628

HSbraιn_41_l 0 034 0 714 0 086 0628

HSbraιn_635_l 0 072 1 042 0 413 0628

HS_218_r 0 001 0 740 0 110 0630

H S_f rom_MQb rai n_92_l 0 048 1 368 0 731 0637

HS_from_MM_84_l 0 176 -0 246 -0 884 0639 hsa-mιr-514-1_r 0 058 -0 315 -0 954 0639 hsa-mιr-325_l 0 016 0 410 -0 231 0641

Hsd_65_r 0 176 1 939 1 298 0641

HS 141 I 0 001 1 087 0 444 0643

HSbraιn_267_l 0 113 0 441 -0 203 0644 hsa-mιr-652_l 0 056 0 524 -0 122 0646

HS_from_MQbraιn_382_r 0 159 1 932 1 286 0646

Hsd_from_Mmd_318_l 0 099 -0 552 -1 199 0647

HS_from_MM_241_l 0 004 -0 739 -1 386 0648

HSbraιn_767_r 0 077 0 727 0 079 0648

HS_from_MQbraιn_470_l 0 040 1 293 0 645 0648

Hsd_from_Mmd_455_l 0 164 -0 593 -1 248 0655

HSbraιn_776_l 0 065 1 480 0 821 0659 hsa-mιr-526a-1 r 0 176 -0 304 -0 964 0660 hsa-mιr-520b r 0 053 -0 035 -0 696 0661

HSbraιn_243_l 0 019 0 648 -0 014 0661

HS_from_MQbraιn_751_l 0 103 0 570 -0 094 0663

HS_from_MQbraιn_1628_r 0 009 0 216 -0 451 0667

Hsd_from_Mmd_35_l 0 170 1 367 0 700 0667

HS_from_MM_185_r 0 135 0 727 0 059 0668

HS_from_PT_254_r 0 088 1 031 0 363 0668 hsa-mιr-140 I 0 038 -0 345 -1 022 0677

HS_from_MQbraιn_883_l 0 038 0 781 0 099 0683

HSbraιn_540_r 0 021 0 504 -0 178 0683

HS from MQbrain 1485 r 0 009 0 440 -0 243 0683 HS_from_MQbraιn_619_r 0 011 0 807 0 123 0685

HS_from_MQbraιn_1311_r 0 007 0 146 -0 542 0688

Hsd_f rom_Mmd_183_r 0 124 1 219 0 529 0690

HSbraιn_106_r 0 017 0 772 0 081 0691

Hsd_from_Mmd_166_l 0 058 -0 375 -1 071 0696

HS_from_MQbraιn_1031_l 0 092 1 334 0 638 0696 hsa-mιr-573 I 0 017 -0 081 -0 781 0700

HS_from_MQbraιn_539_r 0 048 1 051 0 345 0705

HSbraιn_970_r 0 129 -0 385 -1 091 0706

HS_from_MQbraιn_1143_r 0 046 0 735 0 029 0706

HSbraιn_239_l 0 056 0 875 0 169 0706

HS_from_MQbraιn_71 _r 0 011 1 050 0 341 0708

HS_from_MM_63_l 0 005 0 331 -0 382 0714

HS_232_I 0 001 1 105 0 389 0716

HS_36_I 0 061 0 394 -0 323 0716

HSbraιn_426_r 0 020 0 553 -0 164 0717 hsa-mιr-520f r 0 183 -0 259 -0 981 0721 hsa-mιr-141 r 0 050 0 053 -0 670 0723

HS_from_PT_257_r 0 013 0 313 -0 410 0723

HS_from_MQbraιn_255_l 0 095 0 976 0 251 0725 hsa-mιr-199a-2 r 0 072 -0 373 -1 102 0729

HS_from_PT_190_r 0 013 1 545 0 815 0730

Hsd_17_r 0 032 0 906 0 175 0732

HSbraιn_737_r 0 140 0 684 -0 048 0732

HSbraιn_383_l 0 119 -1 312 -2 045 0732

HS_from_MM_35_l 0 159 1 499 0 757 0743 hsa-mιr-17_l 0 153 -0 669 -1 413 0744

HS_from_MQbraιn_1100 1 0 005 0 617 -0 128 0745

HSbraιn_170_r 0 088 -0 538 -1 284 0746 hsa-mιr-373_r 0 029 0 750 0 003 0748

HS_from_MQbraιn_691_l 0 050 1 657 0 909 0748 hsa-mιr-199a-1_r 0 080 -0 277 -1 025 0748

HS_177_I 0 043 0 069 -0 680 0748

HSbraιn_590_r 0 088 0 695 -0 053 0748 hsa-mιr-378 r 0 029 1 004 0 252 0752 hsa-mιr-299_r 0 061 0 678 -0 075 0753

HS_from_MQbraιn_1410_l 0 099 0 318 -0 438 0755

HS_from_PT_40_r 0 013 0 229 -0 528 0757

Hsd_from_Mmd_436_r 0 040 0 764 0 005 0759 hsa-mιr-98_l 0 017 -0 441 -1 200 0759

HS_215_r 0 001 0 927 0 167 0760

HS_from_MQbraιn_1227_l 0 043 0 258 -0 508 0766 hsa-mιr-668 r 0 034 0 802 0 032 0769 hsa-let-7a-2_l 0 013 -0 333 -1 106 0773

HS_from_MQbraιn_1169 1 0 030 0 600 -0 173 0773 hsa-mιr-16-1 I 0 176 0 361 -0 415 0776

HS_from_MQbraιn_918_l 0 030 1 730 0 948 0782

HS_from_MM_6_r 0 065 0 900 0 115 0785

Hsd_33_l 0 080 0 576 -0 214 0791

HSbraιn_760_l 0 034 0 241 -0 550 0791 hsa-let-7a-3_l 0 014 -0 259 -1 051 0792

HSbraιn_636_l 0 023 1 330 0 534 0796

Hsd_from_Mmd_533_l 0 025 0 327 -0 469 0796

HS_from_MQbraιn_1183 1 0 005 1 249 0 452 0797 hsa-mιr-126_r 0 014 -0 136 -0 937 0802 hsa-let-7a-1 I 0 013 -0 237 -1 039 0802 HS_from_MQbraιn_1325_r 0 084 1 734 0 932 0802

HS_from_MQbraιn_1734_l 0 189 2 197 1 394 0802 hsa-mιr-16-2_l 0 159 0 466 -0 337 0803

HS_from_MQbraιn_1128 1 0 005 0 944 0 140 0804

HS_from_MQbraιn_1823_r 0 010 -0 086 -0 892 0806 hsa-mιr-454_r 0 016 -0 337 -1 148 0811

HS_from_MM_304_l 0 170 1 858 1 046 0812

HS_from_MQbraιn_366_r 0 070 0 788 -0 046 0835

HSbraιn_916_r 0 056 1 228 0 387 0841

HS_from_MQbraιn_80_l 0 108 1 137 0 295 0843

Hsd_from_Mmd_291_l 0 135 1 914 1 066 0848 hsa-mιr-633_l 0 017 0 566 -0 285 0850

HS_291_r 0 002 0 012 -0 838 0851

HS_192_r 0 170 2 486 1 634 0853

HS_21_r 0 001 1 909 1 055 0855

HSbraιn_916_l 0 024 1 825 0 966 0859

HS_from_MQbraιn_374_r 0 108 0 701 -0 162 0863 hsa-mιr-148a r 0 043 0 200 -0 668 0867

HS_from_MQbraιn_965_l 0 013 0 734 -0 138 0872

HS_from_MQbraιn_579_l 0 056 1 113 0 240 0872

Hsd_from_Mmd_524_l 0 135 -0 469 -1 342 0873 hsa-mιr-181a-2_l 0 040 -0 194 -1 074 0880

HSbraιn_1384_r 0 017 0 605 -0 276 0881

HSbraιn_52_r 0 021 0 850 -0 035 0885

Hsd_f rom_M md_81 J 0 034 0 626 -0 266 0892

HS_from_MM_1_r 0 048 -0 144 -1 036 0892

Hsd_60_r 0 119 1 274 0 371 0902 hsa-mιr-130a r 0 014 0 355 -0 547 0903

HSbraιn_224_r 0 019 0 732 -0 170 0903 hsa-mιr-26a-2_l 0 183 0 327 -0 583 0910

HS_from_MQbraιn_194_l 0 011 1 076 0 165 0911 hsa-mιr-92b_r 0 048 0 316 -0 596 0912

HSbraιn_253_l 0 019 1 286 0 372 0914

HS_from_MQbraιn_1462_l 0 009 0 967 0 048 0919 hsa-mιr-129-1_r 0 108 1 280 0 361 0919

Hsd_from_Mmd_298_r 0 025 -0 298 -1 219 0921

HSbrairMJ 0 017 0 936 0 012 0924

HSbraιn_337_l 0 020 0 406 -0 521 0927

HSbraιn_19_l 0 092 1 886 0 952 0934

HS_from_MQbraιn_1958_l 0 053 1 083 0 142 0941

HS_from_MM_334_l 0 004 0 627 -0 324 0951 hsa-mιr-26b_l 0 036 -0 144 -1 099 0955

HS_169_I 0 001 1 737 0 779 0958

HS_80_l 0 088 2 217 1 258 0959

HSbraιn_362_r 0 020 1 193 0 230 0963

HS_255_I 0 001 1 422 0 454 0968

HS_from_MM_264_l 0 004 1 081 0 110 0972

HSbraιn_500_l 0 034 1 101 0 116 0984

Hsd_81_r 0 065 -0 348 -1 336 0989 hsa-let-7g I 0 014 -0 344 -1 333 0989 hsa-mιr-26a-1_l 0 140 0 271 -0 719 0990 hsa-mιr-181a-1 I 0 015 -0 200 -1 192 0992

Hsd_from_Mmd_387_l 0 025 1 078 0 082 0996

HSbrain 500 r 0 021 1 019 0 021 0998

HS_68_I 0 103 -1 388 -2 391 1003

HS from MQbrain 1985 I 0 030 1 111 0 108 1004 hsa-mιr-20a_l 0 088 -0 516 -1 527 1010 hsa-mιr-146a_l 0 030 0 140 -0 872 1012 hsa-mιr-20b_l 0 058 -0 713 -1 732 1019 hsa-let-7f-1_l 0 014 -0 167 -1 192 1025

HS_215_r 0 001 1 669 0 641 1028

HS_from_MQbraιn_572_l 0 050 -0 092 -1 130 1038

HSbraιn_209_l 0 095 1 410 0 371 1039

HS_from_MQbraιn_1784_r 0 103 1 648 0 601 1047

HSbraιn_1305_l 0 017 1 470 0 421 1049 hsa-let-7f-2_l 0 030 -0 121 -1 173 1052

HS_266_r 0 046 1 371 0 315 1056

HSbraιn_398_r 0 020 1 061 0 004 1057 hsa-mιr-200b_r 0 072 1 035 -0 027 1062

HSbraιn_1_r 0 119 1 821 0 740 1081 hsa-mιr-363_l 0 072 1 689 0 587 1102

HS_from_PT_26_r 0 013 1 314 0 210 1104

HS_from_MQbraιn_1235_l 0 065 1 757 0 631 1127 hsa-mιr-200c r 0 048 0 810 -0 339 1149

HS_291_r 0 002 0 965 -0 193 1158

HS_from_MQbraιn_153_l 0 153 3 559 2 394 1165

HS_from_MQbraιn_241_l 0 113 2 115 0 949 1166 hsa-mιr-421 r 0 016 1 426 0 252 1175 hsa-mιr-29c_r 0 065 -0 757 -1 938 1181

HS_from_MQbraιn_79_r 0 012 1 972 0 787 1185 hsa-mιr-181c I 0 015 0 066 -1 122 1188 hsa-mιr-145_l 0 032 0 280 -0 909 1189

HSbraιn_237_r 0 092 1 411 0 214 1197

HS_from_MQbraιn_687_r 0 077 2 596 1 397 1199

HS_from_PT_7_r 0 108 2 612 1 393 1218

HS_from_MQbraιn_1323_l 0 068 1 783 0 539 1244

HSbraιn_1437_r 0 017 1 047 -0 202 1248 hsa-mιr-21_l 0 189 -1 905 -3 155 1249 hsa-mιr-768_r 0 017 1 069 -0 182 1251

HSbraιn_398_l 0 020 0 748 -0 536 1285

HS_from_MQbraιn_2700_r 0 011 1 133 -0 188 1321 hsa-mιr-29a_r 0 016 -0 431 -1 810 1379 hsa-mιr-9-2_r 0 129 1 894 0 500 1393

HS_from_PT_139_l 0 029 2 178 0 775 1403 hsa-mιr-27a r 0 016 -0 620 -2 050 1430 hsa-mιr-9-1_r 0 080 1 925 0 491 1434 hsa-mιr-92-2_r 0 017 0 583 -0 929 1512

HSbraιn_411_r 0 020 0 519 -0 994 1512 hsa-mιr-9-3 r 0 070 1 982 0 460 1522 hsa-mιr-92-1_r 0 017 0 637 -0 942 1579

HSbraιn_377_r 0 020 1 073 -0 614 1687

HS_from_PT_114_l 0 013 0 542 -1 365 1907

HSbraιn_377_l 0 020 0 817 -1 136 1 952

HS from PT 114 r 0 013 0 790 -1 277 2 067

Wilcoxon analysis: cut off adj p value<0.2 " upregulation of small RNA when ratio expression^ downregulation of small RNA when ratio expressions Table 2c Small RNAs that are upregulated in colorectal adenomas compared to control samples

HS_from_MQbrain_1985J HS_from_MQbrain_1235J HSbrain_398_l hsa-mir-20a_l hsa-mir-200c_r HS_from_MQbrain_2700_r hsa-mir-146a_l HS_291_r hsa-mir-29a_r hsa-mir-20b_l HS_from_MQbrain_153_l hsa-mir-9-2_r hsa-let-7f-1_l HS_from_MQbrain_241_l HS_from_PT_139_l

HS_215_r hsa-mir-421_r hsa-mir-27a_r

HS_from_MQbrain_572_l hsa-mir-29c_r hsa-mir-9-1_r

HSbrain_209_l HS_from_MQbrain_79_r hsa-mir-92-2_r

HS_from_MQbrain_1784_r hsa-mir-181 c_l HSbrain_411_r

HSbrain_1305_l hsa-mir-145_l hsa-mir-9-3_r hsa-let-7f-2_l HSbrain_237_r hsa-mir-92-1_r

HS_266_r HS_from_MQbrain_687_r HSbrain_377_r

HSbrain_398_r HS_from_PT_7_r HS_from_PT_114_l hsa-mir-200b_r HS_from_MQbrain_1323J HSbrain_377_l

HSbrain_1_r HSbrain_1437_r HS from PT 114 r hsa-mir-363_l hsa-mir-21_l

HS from PT 26 r hsa-mir-768 r

Table 2d Small RNAs that are downregulated in colorectal adenomas compared to control samples

HSJ01J HSJ67J HS_217_I

HS_102_l HS_168_r HS_218_r

HS_106_l HSJ69J HS_219_I

HS_106_r HS_171_r HS_22_r

HSJ09J HS_172_r HS_220_l

HS_109_r HSJ 73J HS_223_I

HS_11_I HS_175_I HS_223_r

HSJ 11J HS_176_I HS_231_r

HSJ 14J HSJ 77J HS_232_I

HS_115_r HS_18_I HS_241_r

HSJ 18J HS_180_r HS_25_r

HSJ 19J HSJ 81J HS_255_I

HS_121_r HS_186_r HS_261_I

HS_124_I HSJ 89J HS_261_r

HSJ28J HS_189_r HS_262_I

HS_128_r HSJ 90J HS_262_r

HS_129_I HS_190_r HS_264_r

HSJ30J HSJ 91J HS_265_I

HS_131_r HS_192_r HS_268_I

HSJ32J HS_197_r HS_281_r

HS_135_I HSJ 98J HS_281_r

HSJ41J HS_203_l HS_286_r

HS_145_r HS_203_r HS_287_I

HS_15_I HS_204_l HS_288_I

HSJ50J HS_204_r HS_289_I

HS_151_r HS_21_r HS_291_r

HS_156_I HS_212_I HS_292_I

HS_157_I HS_212_r HS_304_r

HS_157_r HS_213_I HS_306_r

HS_161_r HS_214_r HS_307_r

HS_164_I HS_215_I HS_33_I

HS 166 r HS 215 r HS 36 I HS_38_r HS_from_MM_174_l HS_from_MM_84_r

HS_4_r HS_from_MM_178_r HS_from_MM_86_l

HS_41_r HS_from_MM_18_l HS_from_MM_87_l

HS_49_r HS_from_MM_182_r HS_from_MM_89_l

HS_51_r HS_from_MM_184_r HS_from_MM_92_r

HS_53_r HS_from_MM_185_r HS_from_MQbrain_100_l

HS_56_r HS_from_MM_194_l HS_from_MQbrain_1006_l

HS_57_I HS_from_MM_195_r HS_from_MQbrain_1018_l

HS_59_I HS_from_MM_202_l HS_from_MQbrain_1028_l

HS_61_I HS_from_MM_218_l HS_from_MQbrain_1030_l

HS_62_I HS_from_MM_219_l HS_from_MQbrain_1031_l

HS_66_r HS_from_MM_229_r HS_from_MQbrain_1036_r

HS_71_I HS_from_MM_232_r HS_from_MQbrain_1037_r

HS_71_r HS_from_MM_237_l HS_from_MQbrain_1042_r

HS_73_r HS_from_MM_241_l HS_from_MQbrain_1043_r

HS_74_r HS_from_MM_251_r HS_from_MQbrain_105_l

HS_76_r HS_from_MM_264_l HS_from_MQbrain_105_l

HS_77_I HS_from_MM_276_l HS_from_MQbrain_1051_r

HS_77_r HS_from_MM_289_l HS_from_MQbrain_1056_l

HS_78_r HS_from_MM_289_r HS_from_MQbrain_1064_r

HS_79_I HS_from_MM_295_l HS_from_MQbrain_1070_r

HS_80_l HS_from_MM_295_r HS_from_MQbrain_1072_r

HS_81_r HS_from_MM_298_l HS_from_MQbrain_1073_r

HS_83_r HS_from_MM_298_r HS_from_MQbrain_1075_l

HS_85_I HS_from_MM_304_l HS_from_MQbrain_1080_l

HS_9_r HS_from_MM_304_r HS_from_MQbrain_1081_r

HS_93_r HS_from_MM_309_r HS_from_MQbrain_1082_l

HS_95_r HS_from_MM_313_l HS_from_MQbrain_1085_l

HS_97_r HS_from_MM_319_l HS_from_MQbrain_1087_l

HS_98_I HS_from_MM_32_r HS_from_MQbrain_1090_r

HS_98_I HS_from_MM_331_r HS_from_MQbrain_1097_r

HS_98_r HS_from_MM_334_l HS_from_MQbrain_1099_r

HS_from_MM_1_l HS_from_MM_339_r HS_from_MQbrain_1 100_l

HS_from_MM_1_r HS_from_MM_34_l HS_from_MQbrain_1 102_l

HS_from_MM_103_l HS_from_MM_340_r HS_from_MQbrain_1 103_l

HS_from_MM_109_l HS_from_MM_342_l HS_from_MQbrain_1 109_l

HS_from_MM_115_l HS_from_MM_342_r HS_from_MQbrain_1 110J

HS_from_MM_118_l HS_from_MM_346_r HS_from_MQbrain_1 119_l

HS_from_MM_118_r HS_from_MM_347_l HS_from_MQbrain_1 119_l

HS_from_MM_119_r HS_from_MM_35_l HS_from_MQbrain_1 126_l

HS_from_MM_121_l HS_from_MM_353_l HS_from_MQbrain_1127_r

HS_from_MM_123_l HS_from_MM_354_r HS_from_MQbrain_1 128_l

HS_from_MM_124_l HS_from_MM_359_l HS_from_MQbrain_1 13_r

HS_from_MM_124_r HS_from_MM_39_l HS_from_MQbrain_1 137_l

HS_from_MM_131_l HS_from_MM_47_l HS_from_MQbrain_1139_r

HS_from_MM_135_l HS_from_MM_48_l HS_from_MQbrain_1 14_r

HS_from_MM_145_r HS_from_MM_49_l HS_from_MQbrain_1143_r

HS_from_MM_149_r HS_from_MM_57_r HS_from_MQbrain_1 164_l

HS_from_MM_150_r HS_from_MM_6_l HS_from_MQbrain_1 169_l

HS_from_MM_157_l HS_from_MM_6_r HS_from_MQbrain_1 183_l

HS_from_MM_160_l HS_from_MM_63_l HS_from_MQbrain_1184_r

HS_from_MM_163_l HS_from_MM_72_r HS_from_MQbrain_1 199_l

HS_from_MM_165_l HS_from_MM_79_l HS_from_MQbrain_120_l

HS from MM 169 r HS from MM 84 I HS from MQbrain 1201 r HS _from_ _MQbrain_ _1204_ J HS. from _MQbrain_ _1377_ r HS _from_ _MQbrain_ .154 J

HS _from_ _MQbrain_ _1204_ r HS. from _MQbrain_ _1379_ r HS Jrom_ _MQbrain_ .154_r

HS _from_ _MQbrain_ ~1208_ j HS" from _MQbrain_ J380_ r HS Jrom_ _MQbrain_ J545_r

HS _from_ _MQbrain_ _1212_ J HS" from _MQbrain_ _1381_ r HS _from_ _MQbrain_ J55J

HS _from_ _MQbrain_ _1213_ \ HS. from _MQbrain_ J 382_ J HS Jrom_ _MQbrain_ .1561 J

HS _from_ _MQbrain_ _1215_ I HS from _MQbrain_ _1384_ r HS Jrom_ _MQbrain_ _1561_r

HS _from_ _MQbrain_ _1219_ J HS" from _MQbrain_ J 388_ J HS Jrom_ _MQbrain_ .1565J

HS _from_ _MQbrain_ .1219_ r HS. from _MQbrain_ _1392_ r HS Jrom_ _MQbrain_ _1565_r

HS _from_ _MQbrain_ _1222_ r HS from _MQbrain_ _1393_ r HS Jrom_ _MQbrain_ _1566_r

HS _from_ _MQbrain_ _1223_ J HS" from _MQbrain_ _1395_ r HS Jrom_ _MQbrain_ .1574 J

HS _from_ _MQbrain_ _1224_ r HS. from _MQbrain_ .14OJ HS Jrom_ _MQbrain_ _1576_r

HS _from_ _MQbrain_ _1227_ I HS. from _MQbrain_ _1402_ r HS Jrom_ _MQbrain_ .1590J

HS _from_ _MQbrain_ J227_ j HS" from _MQbrain_ J404_ r HS Jrom_ _MQbrain_ j 592 J

HS _from_ _MQbrain_ _1228_ r HS" from _MQbrain_ _1410_ J HS Jrom_ _MQbrain_ _1593_r

HS _from_ _MQbrain_ _1234_ \ HS. from _MQbrain_ _1412_ J HS Jrom_ _MQbrain_ _1596_r

HS _from_ _MQbrain_ _1239_ I HS from _MQbrain_ _1414_ r HS Jrom_ _MQbrain_ .1602J

HS _from_ _MQbrain_ _1241_ r HS" from _MQbrain_ _1417_ J HS Jrom_ _MQbrain_ _161_r

HS _from_ _MQbrain_ _1245_ \ HS from _MQbrain_ _1420_ J HS Jrom_ _MQbrain_ _1610_r

HS _from_ _MQbrain_ _1246_ \ HS. from _MQbrain_ _1424_ r HS Jrom_ _MQbrain_ _162_r

HS _from_ _MQbrain_ _1250_ r HS from _MQbrain_ _1426_ I HS Jrom_ _MQbrain_ .1620J

HS _from_ _MQbrain_ _1253_ r HS" from _MQbrain_ _1427_ J HS Jrom_ _MQbrain_ .1624J

HS _from_ _MQbrain_ _1260_ r HS. from _MQbrain_ _1437_ J HS Jrom_ _MQbrain_ _1625_r

HS _from_ _MQbrain_ _1267_ r HS. from _MQbrain_ _1442_ I HS Jrom_ _MQbrain_ _1626_r

HS _from_ _MQbrain_ J268_ j HS" from _MQbrain_ J443_ r HS Jrom_ _MQbrain_ J627J

HS _from_ _MQbrain_ _128_r HS^ from _MQbrain_ _1444_ J HS Jrom_ _MQbrain_ _1628_r

HS _from_ _MQbrain_ _1280_ I HS. from _MQbrain_ _1444_ I HS Jrom_ _MQbrain_ J 63 J

HS _from_ _MQbrain_ J283_ j HS" from _MQbrain_ J445_ j HS Jrom_ _MQbrain_ J630J

HS _from_ _MQbrain_ _129_r HS" from _MQbrain_ _1446_ J HS Jrom_ _MQbrain_ _1632_r

HS _from_ _MQbrain_ _1292_ r HS. from _MQbrain_ _1450_ r HS Jrom_ _MQbrain_ _1633_r

HS _from_ _MQbrain_ _1297_ I HS. from _MQbrain_ _1456_ I HS Jrom_ _MQbrain_ .1637J

HS _from_ _MQbrain_ j 300_ j HS" from _MQbrain_ J459_ j HS Jrom_ _MQbrain_ J637_r

HS _from_ _MQbrain_ _1300_ r HS^ from _MQbrain_ _1462_ J HS Jrom_ _MQbrain_ .1640J

HS _from_ _MQbrain_ _1304_ r HS. from _MQbrain_ _1462_ r HS Jrom_ _MQbrain_ .1642J

HS _from_ _MQbrain_ J31_r HS^ from _MQbrain_ J469_ r HS Jrom_ _MQbrain_ J648_r

HS _from_ _MQbrain_ J311_ r HS" from _MQbrain_ J47J HS Jrom_ _MQbrain_ J657_r

HS _from_ _MQbrain_ _1314_ J HS^ from _MQbrain_ _1478_ J HS Jrom_ _MQbrain_ .1658J

HS _from_ _MQbrain_ _1315_ I HS. from _MQbrain_ _1484_ I HS Jrom_ _MQbrain_ _1658_r

HS _from_ _MQbrain_ J317_ r HS" from _MQbrain_ J485_ j HS Jrom_ _MQbrain_ J665_r

HS _from_ _MQbrain_ _1318_ J HS" from _MQbrain_ _1485_ r HS Jrom_ _MQbrain_ .1671J

HS _from_ _MQbrain_ _1325_ r HS. from _MQbrain_ _1487_ r HS Jrom_ _MQbrain_ .1674J

HS _from_ _MQbrain_ _1334_ r HS from _MQbrain_ _1493_ r HS Jrom_ _MQbrain_ _1675_r

HS _from_ _MQbrain_ .1340_ J HS" from _MQbrain_ _1494_ J HS Jrom_ _MQbrain_ _1678_r

HS _from_ _MQbrain_ .1349_ \ HS. from _MQbrain_ _1497_ J HS Jrom_ _MQbrain_ .1684J

HS _from_ _MQbrain_ J35J HS. from _MQbrain_ J] 5 _r HS Jrom_ _MQbrain_ _1684_r

HS _from_ _MQbrain_ j 353_ I HS" from _MQbrain_ j 500_ I HS Jrom_ _MQbrain_ J686J

HS _from_ _MQbrain_ .1354_ J HS" from _MQbrain_ _1501_ r HS Jrom_ _MQbrain_ .1687J

HS _from_ _MQbrain_ _1355_ r HS. from _MQbrain_ J 502_ J HS Jrom_ _MQbrain_ .1690J

HS _from_ _MQbrain_ .1363_ I HS from _MQbrain_ _1509_ r HS Jrom_ _MQbrain_ .1692J

HS _from_ _MQbrain_ .1366_ J HS" from _MQbrain_ _1513_ r HS Jrom_ _MQbrain_ .1695J

HS _from_ _MQbrain_ .137_r HS from _MQbrain_ J 520_ J HS Jrom_ _MQbrain_ _1695_r

HS _from_ _MQbrain_ .1374_ J HS. from _MQbrain_ _1520_ r HS Jrom_ _MQbrain_ .1696J

HS _from_ _MQbrain_ .1376_ J HS from _MQbrain_ _1522_ r HS Jrom_ _MQbrain_ .1700J

HS _from_ _MQbrain_ _1376_ r HS from _MQbrain_ _1523_ r HS Jrom_ _MQbrain_ _1700_r

HS from MQbrain 1377 I HS from MQbrain 1535 r HS from MQbrain 1703 r HS _from_ _MQbrain_ .1706_ J HS. from _MQbrain_ J 884 r HS _from_ MQbrain. _382_l

HS _from_ _MQbrain_ _1712_ r HS. from _MQbrain_ J 885 r HS _from_ MQbrain. _382_r

HS _from_ _MQbrain_ J717_ r HS" from _MQbrain_ J 889 j HS _from_ MQbrain. _383_l

HS _from_ _MQbrain_ _1721_ J HS" from _MQbrain_ J 893 r HS _from_ MQbrain. _384_r

HS _from_ _MQbrain_ .1722_ \ HS. from _MQbrain_ J 896 r HS _from_ MQbrain. _389_l

HS _from_ _MQbrain_ .1724_ I HS from _MQbrain_ _191_ I HS _from_ MQbrain. _391_r

HS _from_ _MQbrain_ .1726_ J HS" from _MQbrain_ _194_ I HS _from_ MQbrain. _392_r

HS _from_ _MQbrain_ .1734_ \ HS. from _MQbrain_ J 958 J HS _from_ MQbrain. _406_l

HS _from_ _MQbrain_ _1744_ r HS from _MQbrain_ _20_r HS _from_ MQbrain. _406_r

HS _from_ _MQbrain_ _1745_ r HS" from _MQbrain_ _207_ I HS _from_ MQbrain. _412_l

HS _from_ _MQbrain_ _1747_ r HS. from _MQbrain_ _2087 r HS _from_ MQbrain. _414_l

HS _from_ _MQbrain_ _1748_ r HS. from _MQbrain_ _209_ r HS _from_ MQbrain. _420_l

HS _from_ _MQbrain_ J750_ r HS" from _MQbrain_ -212_ r HS _from_ MQbrain. _43_l

HS _from_ _MQbrain_ .1752_ J HS" from _MQbrain_ .22_r HS _from_ MQbrain. _433_l

HS _from_ _MQbrain_ _1753_ r HS. from _MQbrain_ .221_ r HS _from_ MQbrain. _435_l

HS _from_ _MQbrain_ _1758_ r HS from _MQbrain_ _224_ I HS _from_ MQbrain. _435_r

HS _from_ _MQbrain_ .1759_ J HS" from _MQbrain_ _234_ r HS _from_ MQbrain. _436_r

HS _from_ _MQbrain_ _1760_ r HS from _MQbrain_ _235_ r HS _from_ MQbrain. _437_l

HS _from_ _MQbrain_ _1761_ r HS. from _MQbrain_ _2380 r HS _from_ MQbrain. .441 J

HS _from_ _MQbrain_ _1771_ I HS from _MQbrain_ _239_ r HS _from_ MQbrain. _444_r

HS _from_ _MQbrain_ _1771_ r HS" from _MQbrain_ _251_ r HS _from_ MQbrain. _449_l

HS _from_ _MQbrain_ .1773_ \ HS. from _MQbrain_ _253_ r HS _from_ MQbrain. _458_l

HS _from_ _MQbrain_ .1773_ I HS. from _MQbrain_ _255_ I HS _from_ MQbrain. .461 J

HS _from_ _MQbrain_ j 776_ j HS" from _MQbrain_ !260_ r HS _from_ MQbrain. 366J

HS _from_ _MQbrain_ .1777_ J HS^ from _MQbrain_ _266_ r HS _from_ MQbrain. _467_l

HS _from_ _MQbrain_ .178_r HS. from _MQbrain_ _2670 r HS _from_ MQbrain. _468_l

HS _from_ _MQbrain_ J781_ I HS" from _MQbrain_ [2699 j HS _from_ MQbrain. ^468_r

HS _from_ _MQbrain_ _1783_ r HS" from _MQbrain_ .281_ I HS _from_ MQbrain. _470_l

HS _from_ _MQbrain_ _1792_ r HS. from _MQbrain_ .281_ r HS _from_ MQbrain. _472_r

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hsa-mir-30c-1_l HS_from_ PT_27_r hsa-mir-125b-1_r hsa-mir-30c-2_l HS_from_ PT_271_I hsa-mir-126_r hsa-mir-30d_l HS_from_ PT_271_r hsa-mir-129-1_r hsa-mir-31_r HS_from_ PT_280_l hsa-mir-130a_r hsa-mir-323_l HS_from_ PT_283_r hsa-mir-133a-1_r hsa-mir-324_l HS_from_ PT_284_r hsa-mir-133a-2_r hsa-mir-324_r HS_from_ PT_295_r hsa-mir-134_r hsa-mir-325_l HS_from_ PT_299_I hsa-mir-135a-1_r hsa-mir-329-1_r HS_from_ PT_299_r hsa-mir-135a-2_r hsa-mir-329-2_r HS_from_ PT_3_I hsa-mir-137_l hsa-mir-331_l HS_from_ PT_308_l hsa-mir-139_l hsa-mir-331_r HS_from_ PT_313_r hsa-mir-140_l hsa-mir-33b_l HS_from_ PT_32_r hsa-mir-141_r hsa-mir-372_r HS_from_ PT_321_r hsa-mir-144_r hsa-mir-373_r HS_from_ PT_328_I hsa-mir-148a_l hsa-mir-375_l HS_from_ PT_339_I hsa-mir-148a_r hsa-mir-377_l HS_from_ PT_339_r hsa-mir-148b_r hsa-mir-378_r HS_from_ PT_340_l hsa-mir-151_l hsa-mir-379_l HS_from_ PT_36_I hsa-mir-155_l hsa-mir-383_l HS_from_ PT_38_I hsa-mir-16-1_l hsa-mir-383_r HS_from_ PT_40_r hsa-mir-16-2_l hsa-mir-409_r HS_from_ PT_41_r hsa-mir-17_l hsa-mir-412_l HS_from_ PT_43_I hsa-mir-181 a-1_l hsa-mir-412_r HS_from_ PT_48_I hsa-mir-181a-1_r hsa-mir-422a_l HS_from_ PT_50_r hsa-mir-181 a-2_l hsa-mir-423_r HS_from_ PT_63_r hsa-mir-183_r hsa-mir-432_l HS_from_ PT_70_r hsa-mir-185_r hsa-mir-432_r HS_from_ PT_73_I hsa-mir-188_l hsa-mir-449b_r HS_from_ PT_74_r hsa-mir-190_r hsa-mir-453_l HS_from_ PT_91_r hsa-mir-192_r hsa-mir-454_l HS_from_ PT_92_I hsa-mir-193a_l hsa-mir-454_r HS_from_ PT_95_I hsa-mir-196a-2_r hsa-mir-483_l HS_from_ PT_95_r hsa-mir-196b_r hsa-mir-497_r HS from PT 99 r hsa-mir-197 I hsa-mir-500 I hsa-mir-502_l hsa-mir-641_r HSbrain_ _13771J hsa-mir-506_l hsa-mir-644_r HSbrain_ _1384 _r hsa-mir-506_r hsa-mir-646_r HSbrain_ ~139_ I hsa-mir-507_l hsa-mir-647_r HSbrain_ _139_ r hsa-mir-513-1_l hsa-mir-648_l HSbrain_ _1406 J hsa-mir-513-2_l hsa-mir-652_l HSbrain_ 1410 J hsa-mir-514-1_r hsa-mir-652_r HSbrain_ _1413 J hsa-mir-514-3_r hsa-mir-653_l HSbrain_ _1418 _r hsa-mir-516-3_l hsa-mir-655_l HSbrain_ _1423 J hsa-mir-516-4_l hsa-mir-659_l HSbrain_ _1425 J hsa-mir-518b_r hsa-mir-661_r HSbrain_ _1425 _r hsa-mir-518c_l hsa-mir-662_l HSbrain_ _143_ I hsa-mir-518f_r hsa-mir-668_l HSbrain_ ~143_ r hsa-mir-520b_r hsa-mir-668_r HSbrain_ _144_ r hsa-mir-520f_r hsa-mir-765_r HSbrain_ _145_ I hsa-mir-521 -1_l hsa-mir-767_r HSbrain_ _148_ r hsa-mir-521-1_r hsa-mir-770_r HSbrain_ _151_ r hsa-mir-521-2_r hsa-mir-92-1_l HSbrain_ _152_ I hsa-mir-524_l hsa-mir-92b_r HSbrain_ _153_ r hsa-mir-525_l hsa-mir-93_l HSbrain_ _155_ r hsa-mir-526a-1_r hsa-mir-95_r HSbrain_ _156_ I hsa-mir-526b_r hsa-mir-98_l HSbrain_ J57_ I hsa-mir-532_l hsa-mir-98_r HSbrain_ _158_ I hsa-mir-550-1_r hsa-mir-99a_r HSbrain_ ~159_ I hsa-mir-550-2_r HSbrainJJ HSbrain_ _165_ I hsa-mir-554_l HSbrain_102_r HSbrain_ _170_ r hsa-mir-568_r HSbrain_106_r HSbrain_ J71_ I hsa-mir-570_l HSbrain_107_r HSbrain_ _171_ I hsa-mir-571_r HSbrain_1076_l HSbrain_ _172_ I hsa-mir-573_l HSbrain_1076_r HSbrain_ _177_ I hsa-mir-584_r HSbrain_108_l HSbrain_ ~180_ I hsa-mir-587_r HSbrain_109_l HSbrain_ _19_l hsa-mir-588_r HSbrain_113_r HSbrain_ _198_ I hsa-mir-591_r HSbrain_114_r HSbrain_ ~2J hsa-mir-598_l HSbrain_116_l HSbrain_ J204_ r hsa-mir-599_r HSbrain_12_l HSbrain_ _210_ I hsa-mir-604_l HSbrain_120_r HSbrain_ .212_ I hsa-mir-609_r HSbrain_121_l HSbrain_ _214_ I hsa-mir-616_l HSbrain_122_l HSbrain_ _216_ I hsa-mir-616_r HSbrain_123_l HSbrain_ _216_ r hsa-mir-617_l HSbrain_124_l HSbrain_ 22_l hsa-mir-619_l HSbrain_126_r HSbrain_ _220_ r hsa-mir-622_l HSbrain_1298_r HSbrain_ _222_ r hsa-mir-622_r HSbrain_130_l HSbrain_ _224_ r hsa-mir-624_l HSbrain_130_r HSbrain_ .225_ r hsa-mir-625_r HSbrain_131_l HSbrain_ _227_ r hsa-mir-628_r HSbrain_1325_r HSbrain_ _231_ I hsa-mir-630_r HSbrain_1337_l HSbrain_ _237_ I hsa-mir-633_l HSbrain_1338_r HSbrain_ _239_ I hsa-mir-633_r HSbrain_135_l HSbrain_ _240_ I hsa-mir-634_l HSbrain_1360_l HSbrain_ _242_ I hsa-mir-635_l HSbrain_1362_l HSbrain_ _243_ I hsa-mir-640_l 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HSbrain_ 344_l HSbrain_ 472J HSbrain_ _596_r HSbrain_ 347_l HSbrain_ 473J HSbrain_ ^597_r HSbrain_ _347_r HSbrain_ 476_r HSbrain_ 598J HSbrain_ 35_r HSbrain_ 478_r HSbrain_ _598_r HSbrain_ 359J HSbrain_ 48_r HSbrain_ _599_r HSbrain_ _359_r HSbrain_ 480_r HSbrain_ 6_r HSbrain_ 361 J HSbrain_ 481_r HSbrain_ 604_r HSbrain_ _362_r HSbrain_ 482J HSbrain_ 610_r HSbrain_ _364_r HSbrain_ 483J HSbrain_ 615J HSbrain_ _370_r HSbrain_ 483_r HSbrain_ 616_r HSbrain 371 r HSbrain 485 r HSbrain 617 I HSbrain_ 619_r HSbrain_ 717_r HSbrain_94_l HSbrain_ 624_l HSbrain_ 719J HSbrain_95_l HSbrain_ 626_l HSbrain_ 72_l HSbrain_970_r HSbrain_ 627_r HSbrain_ _720_l Hsd_101_l HSbrain_ 629_l HSbrain_ 721_r Hsd_102_l HSbrain_ 635_l HSbrain_ 722_l Hsd_105_l HSbrain_ 636_l HSbrain_ 722_r Hsd_107_l HSbrain_ 637J HSbrain_ 723_l Hsd_108_r HSbrain_ 641_r HSbrain_ 724_l Hsd_1 1_l HSbrain_ 642_r HSbrain_ 726_l Hsd_111_r HSbrain_ 643_l HSbrain_ 727_l Hsd_17_l HSbrain_ 652_l HSbrain_ 728_l Hsd_17_r HSbrain_ 653_l HSbrain_ 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Hsd. from. Mmd. _232_ r Hsd] _from_ Mmd. ]436_r

Hsd. from. Mmd. _235_ r Hsd. _from_ Mmd. _439_l

Hsd] from. _Mmd_ ]237_ ]l Hsd. _from_ Mmd. _44_r

Hsd. from. Mmd. _249_ r Hsd. _from_ Mmd. _452_l

Hsd. from. Mmd. _253_ I Hsd. _from_ Mmd. _455_l

Hsd] from. Mmd. ]259_ r Hsd. _from_ Mmd. _473_l

Hsd. from. Mmd. .261_ J Hsd. _from_ Mmd. _478_l

Hsd. from. _Mmd_ _274_ r Hsd] _from_ Mmd. ~480_l

Hsd. from. Mmd. _280_ I Hsd. _from_ Mmd. _480_r

Hsd] from. Mmd. ]284_ ]l Hsd. _from_ Mmd. _485_r

Hsd. from. Mmd. .291_ J Hsd. _from_ Mmd. _487_r

Hsd. from. Mmd. _291_ r Hsd. _from_ Mmd. _489_r

Hsd] from. _Mmd_ .296_ ]l Hsd. _from_ Mmd. _49_l

Hsd] from. Mmd. ]298_ ]l Hsd. _from_ Mmd. _499_r

Hsd. from. Mmd. _298_ r Hsd. _from_ Mmd. _500_r

Hsd. from. Mmd. _302_ r Hsd. _from_ Mmd. _501_r

Hsd] from. Mmd. ]306_ ]l Hsd. _from_ Mmd. _518_r

Hsd. from. _Mmd_ _311_ J Hsd. _from_ Mmd. _519_l

Hsd. from. Mmd. _311_ r Hsd] _from_ Mmd. ]519_r

Hsd. from. Mmd. _314_ r Hsd. _from_ Mmd. _52_r

Hsd. from. Mmd. _316_ r Hsd. _from_ Mmd. _523_l

Hsd. from. Mmd. _318_ J Hsd] _from_ Mmd. ~524_l

Hsd. from. _Mmd_ _324_ I Hsd. _from_ Mmd. _524_r

Hsd] from. Mmd. ]325_ ]l Hsd. _from_ Mmd. _527_l

Hsd. from. Mmd. _325_ r Hsd. _from_ Mmd. _527_r

Hsd. from. Mmd. _326_ J Hsd] _from_ Mmd. ~533_l

Hsd. from. Mmd. _328_ I Hsd. _from_ Mmd. _535_r

Hsd. from. _Mmd_ _328_ r Hsd. _from_ Mmd. _68_l

Hsd. from. Mmd. _330_ J Hsd] _from_ Mmd. JOJ

Hsd. from. Mmd. _333_ J Hsd] _from_ Mmd. ]78_r

Hsd. from. Mmd. _333_ r Hsd. _from_ Mmd. _81 J

Hsd. from. Mmd. _334_ r Hsd] _from_ Mmd. ]92_l

Hsd from Mmd 34 r Hsd" from Mmd 92 r Table 3a Small RNAs that are differentially expressed between control and adenocarci noma carcinoma vs HSbraιn_500_r 0 120015634

Systematic Name control adj p1

HS_156_I 0 120015634 hsa-mιr-573_l 0 008895418

HS_from_MM_118_r 0 120843678

HSbraιn_801_r 0 016433541

Hsd_from_Mmd_485_r 0 120843678

HSbraιn_377_l 0 016433541 hsa-mιr-655_l 0 120843678

HSbraιn_426_r 0 016433541

HSbraιn_617_l 0 120843678

HSbraιn_148_r 0 016433541

HS_71_I 0 120843678 hsa-mιr-92b_r 0 019274533 hsa-mιr-20b_l 0 120843678 hsa-mιr-92-1_r 0 019274533

HS_from_MQbraιn_71_r 0 120843678

HS_from_PT_146_r 0 019274533 hsa-mιr-199a-2_r 0 120843678 hsa-mιr-92-2_r 0 022921248 hsa-mιr-500_l 0 120843678

HS_from_MQbraιn_207_l 0 022921248

HSbraιn_411_r 0 120843678

HS_from_PT_114_r 0 027924358

HS_from_MQbraιn_930_r 0 120843678

HS_from_PT_114_l 0 027924358 hsa-mιr-9-3_r 0 120843678

HS_from_MQbraιn_100_l 0 030988376

HS_from_MQbraιn_769_r 0 120843678 hsa-mιr-145_l 0 031989408 hsa-mιr-372_r 0 120843678

HS_from_MQbraιn_350_l 0 031989408 hsa-let-7a-2_l 0 120843678 hsa-mιr-302d_l 0 031989408 hsa-let-7f-1_l 0 120843678

HS_from_MQbraιn_1628_r 0 031989408

HSbraιn_1437_r 0 126655157

HS_from_MQbraιn_349_l 0 031989408 hsa-mιr-9-2_r 0 126655157 hsa-mιr-325_l 0 0342406 hsa-mιr-181c_l 0 126655157

HS_from_MQbraιn_20_r 0 0342406

HS_from_MQbraιn_1696_l 0 126655157

HSbraιn_458_r 0 035303066

HS_from_MQbraιn_572_l 0 126655157

Hsd_102_l 0 035303066 hsa-let-7a-1_l 0 126655157

HSbraιn_377_r 0 035303066

HS_from_MQbraιn_1823_r 0 149145996

HS_from_MQbraιn_2700_r 0 045228199

HS_from_MQbraιn_1485_r 0 149145996

HS_from_MQbraιn_1687_l 0 045228199

HS_from_MQbraιn_1100_l 0 149145996

HS_from_MQbraιn_1311_r 0 067337504

Hsd_18_l 0 149145996

Hsd_from_Mmd_519_l 0 067337504 hsa-mιr-9-1_r 0 149145996

HS_from_MQbraιn_343_l 0 07566513 hsa-mιr-29a_r 0 149145996

HS_from_MQbraιn_1169 1 0 084904114

Hsd_111_r 0 149145996

HS_from_MQbraιn_965_l 0 086503988 hsa-mιr-492_r 0 159103307

HS_from_MM_178_r 0 086503988

HSbraιn_299_r 0 159103307 hsa-mιr-98_l 0 086503988

HSbraιn_598_l 0 159103307

HS_from_MQbraιn_549_l 0 086503988

Hsd_26_l 0 159103307 hsa-mιr-616_r 0 090694253

HSbraιn_261_l 0 159103307

HSbraιn_731_r 0 090694253 hsa-mιr-570_l 0 166408872

Hsd_from_Mmd_328_r 0 090694253 hsa-mιr-363_l 0 166408872 hsa-mιr-768_r 0 090694253 hsa-mιr-126_r 0 166408872

HSbraιn_709_l 0 090694253 hsa-mιr-192_r 0 166408872

HSbraιn_398_r 0 090694253

HS_from_MQbraιn_1459_l 0 166408872

HS_from_PT_340_l 0 090694253

HS_from_MQbraιn_1624_l 0 166408872

HS_from_MQbraιn_1884_r 0 090694253

HSbraιn_458_l 0 166408872 hsa-let-7a-3_l 0 090694253

HS_from_MQbraιn_131_r 0 179914563

HSbraιn_106_r 0 099652833

HSbraιn_629_l 0 179914563

HS_from_MQbraιn_2380_r 0 099652833

HS_304_r 0 179914563

HSbraιn_494_l 0 104922786 hsa-let-7d_l 0 179914563

HSbraιn_177_r 0 104922786

HS_141_I 0 19263196

HSbraιn_321_r 0 104922786

HS_from_MQbraιn_55_l 0 19263196

HS_from_MM_289_l 0 104922786

HSbraιn_230_l 0 19263196

HS_from_MQbraιn_191_l 0 110995143

HSbraιn_782_l 0 19263196

HS_291_r 0 110995143

HS_from_MQbraιn_1513_r 0 19263196

HS_from_MQbraιn_128_r 0 110995143 1WiIcOXOn1 cut off adjusted p hsa-let-7g_l 0 110995143 value <0 2 hsa-mιr-633 I 0 120015634 able 3b Up- or downregulated small RNAs in adenocarcinomas compared to control carcinoma vs control carcinomas controls carcinomas/controls

(avg (avg

Systematic Name (adj p)1 expression) expression) (Ratio expression)'2

HS 71 I 0 3 -0 709677388 0 032756041 -0 742433429

HSbraιn_458_r 0 42 -0 266452891 0 406777661 -0 673230551 hsa-mιr-372_r 0 12 0 060069121 0 629631623 -0 569562502

HS_from_MM_118_r 0 69 -0 237583049 0 179327953 -0 416911001 hsa-mιr-192_r 0 17 -0 201240874 0 210651366 -0 411892241

Hsd_from_Mmd_485_r 0 66 -0 252579592 0 125681597 -0 378261188

HS_from_MQbraιn_1624_l 0 15 -0 246477896 0 058106578 -0 304584474

HSbraιn_629_l 0 09 -0 491364645 -0 198765886 -0 292598759 hsa-mιr-570_l 0 17 -0 130852458 0 019615717 -0 150468175 hsa-mιr-492_r 0 16 -0 011846275 0 099781053 -0 111627327

HSbraιn_731_r 0 35 0 090460773 -0 011239856 0 101700629

HS_from_MQbraιn_1687_l 0 12 -0 015384304 -0 120029361 0 104645056

HS_304_r 0 18 0 725994298 0 518291894 0 207702404

Hsd_18_l 0 16 0 185427251 -0 033505144 0 218932395

HSbraιn_177_r 0 1 -0 187948884 -0 433561411 0 245612527

Hsd_111_r 0 15 -0 186817378 -0 43572008 0 248902702

HS_from_MQbraιn_131_r 0 31 0 122733107 -0 145810795 0 268543902

HS_from_MQbraιn_55_l 0 09 -0 014185779 -0 291616347 0 277430568

HS_from_MQbraιn_207_l 0 36 0 435514985 0 145542632 0 289972354

HS_from_MQbraιn_930_r 0 12 0 389172004 0 087275842 0 301896162 hsa-mιr-500_l 0 12 -0 277848327 -0 593537873 0 315689546

HS_from_MQbraιn_1884_r 0 52 0 356353217 0 037880875 0 318472342

HS_from_MQbraιn_1513_r 0 19 -0 290006166 -0 609064857 0 319058691

HS_from_MQbraιn_1459_l 0 17 0 275771992 -0 068316304 0 344088296

HS_from_MQbraιn_191_l 0 68 0 374600902 0 027587412 0 34701349

HS_from_MQbraιn_2380_r 0 09 0 419048482 0 049240856 0 369807627

HS_from_MQbraιn_769_r 0 12 -0 14336964 -0 523899384 0 380529744

Hsd_102_l 0 04 0 443532 0 055860645 0 387671354

HS_from_MQbraιn_128_r 0 11 0 617596666 0 225747368 0 391849298

HS 141 I 0 12 0 8422647 0 443686813 0 398577887

HSbraιn_709_l 0 12 0 733394659 0 327477824 0 405916836

HSbraιn_321_r 0 42 0 600940185 0 190823509 0 410116675

HSbraιn_617_l 0 02 0 966810264 0 555939869 0 410870395

HS_from_MQbraιn_100_l 0 42 0 278755917 -0 134292565 0 413048482

HSbraιn_299_r 0 16 0 470656977 0 050970084 0 419686894

HSbraιn_782_l 0 19 0 394023714 -0 030111689 0 424135402

HSbraιn_230_l 0 19 0 420548412 -0 007405663 0 427954074

HS_from_MQbraιn_343_l 0 08 0 191928075 -0 240864595 0 432792669 hsa-mιr-616 r 0 65 -0 186021179 -0 619960119 0 43393894

HSbraιn_598_l 0 16 0 432451861 -0 001594407 0 434046268 hsa-let-7d_l 0 18 -0 214090094 -0 663813813 0 449723719

HS_from_MQbraιn_20_r 0 25 -0 154082272 -0 608413911 0 454331639

HS_from_MQbraιn_350_l 0 09 0 146762687 -0 311281719 0 458044406

HSbraιn_494_l 0 1 0 06720096 -0 396374725 0 463575685

HSbraιn_801_r 0 15 0 33891208 -0 13043269 0 46934477 hsa-mιr-655 I 0 13 -0 049016209 -0 523332673 0 474316464

HS_from_PT_146_r 0 41 0 344948777 -0 130022489 0 474971266

Hsd_26_l 0 58 0 185069914 -0 292706346 0 47777626

HS from MQbrain 349 I 0 09 0 181998814 -0 301075838 0 483074652 15ό

HSbraιn_148_r 0 3 0 440551449 -0 043142521 0 48369397

HSbraιn_106_r 0 33 0 575843279 0 080837435 0 495005844 hsa-mιr-633_l 0 03 0 215123255 -0 284566041 0 499689296

HS_from_MM_289_l 0 1 0 092159319 -0 424119594 0 516278912

HS_from_MQbraιn_71_r 0 24 0 86119198 0 341225696 0 519966285

HSbraιn_261_l 0 16 0 200748997 -0 325726286 0 526475284

Hsd_from_Mmd_328_r 0 09 0 336779316 -0 20245187 0 539231186

Hsd_from_Mmd_519_l 0 42 0 156016612 -0 390158334 0 546174946

HS_from_MM_178_r 0 03 0 215653589 -0 344575388 0 560228977

HSbraιn_458_l 0 17 -0 623680905 -1 206064715 0 58238381

HS_from_MQbraιn_1485_r 0 28 0 341195456 -0 243332697 0 584528153

HS_from_MQbraιn_1628_r 0 79 0 139811659 -0 450916985 0 590728644 hsa-mιr-302d_l 0 37 -0 417071628 -1 008783793 0 591712165

HS_156_I 0 12 -0 025280933 -0 617537087 0 592256154

HS_from_MQbraιn_1823_r 0 03 -0 296865659 -0 892007201 0 595141542 hsa-mιr-325_l 0 69 0 363886014 -0 231356523 0 595242537

HS_from_MQbraιn_1696 I 0 13 -0 405403011 -1 024758234 0 619355223

HS_from_MQbraιn_549_l 0 37 0 266837912 -0 360518665 0 627356576

HS_from_MQbraιn_1311_r 0 64 0 085649422 -0 542358185 0 628007606

HS_from_PT_340_l 0 09 0 304986748 -0 325416792 0 630403539

HS_from_MQbraιn_1100 1 0 3 0 502916758 -0 128399246 0 631316004

HSbraιn_426_r 0 37 0 499080863 -0 16430699 0 663387852

HS_from_MQbraιn_965_l 0 75 0 559300427 -0 137794367 0 697094794 hsa-mιr-573 I 0 03 -0 059472954 -0 78119509 0 721722137

HS_from_MQbraιn_1169 1 0 08 0 560023874 -0 172737263 0 732761137 hsa-mιr-126_r 0 42 -0 201075637 -0 937409046 0 736333409 hsa-mιr-98_l 0 86 -0 358721365 -1 199711347 0 840989982 hsa-let-7a-2_l 0 54 -0 252165432 -1 106318992 0 85415356

HSbraιn_398_r 0 74 0 878616993 0 004337368 0 874279624 hsa-let-7a-1_l 0 12 -0 130600434 -1 038969263 0 908368829 hsa-let-7a-3_l 0 73 -0 139853217 -1 051229242 0 911376026

HSbraιn_500_r 0 77 0 944568594 0 020888827 0 923679767 hsa-mιr-199a-2 r 0 12 -0 169461658 -1 102399679 0 932938022 hsa-let-7g I 0 34 -0 324092373 -1 332989933 1 008897559

HS_291_r 0 3 0 833287938 -0 193284833 1 026572771 hsa-mιr-768_r 0 73 0 861619701 -0 182102011 1 043721712

HSbraιn_1437_r 0 79 0 870808091 -0 201624857 1 072432947 hsa-mιr-181c I 0 55 -0 036071696 -1 122096366 1 086024669 hsa-let-7f-1_l 0 3 -0 079122123 -1 192010342 1 112888218

HS_from_MQbraιn_572_l 0 13 0 0201842 -1 13040159 1 15058579

HS_from_MQbraιn_2700_r 0 58 0 98864825 -0 187941077 1 176589327

HSbraιn_411_r 0 02 0 267080657 -0 993945285 1 261025942 hsa-mιr-363_l 0 17 1 940171184 0 587265163 1 352906021 hsa-mιr-92b_r 0 02 0 784118073 -0 596107394 1 380225467 hsa-mιr-20b_l 0 12 -0 302677154 -1 731722022 1 429044868 hsa-mιr-29a_r 0 05 -0 289379384 -1 809571559 1 520192175 hsa-mιr-9-2_r 0 13 2 216369234 0 500287664 1 71608157 hsa-mιr-9-1 r 0 15 2 217636141 0 490685702 1 726950439

HSbraιn_377_r 0 02 1 13757316 -0 614439492 1 752012652 hsa-mιr-9-3_r 0 12 2 225977245 0 459667748 1 766309498 hsa-mιr-145 I 0 03 0 930167523 -0 909054029 1 839221552

HSbraιn_377_l 0 28 0 800203766 -1 135562989 1 935766755 hsa-mιr-92-2_r 0 21 1 186285863 -0 928692902 2 114978765 hsa-mιr-92-1_r 0 73 1 223717878 -0 942146802 2 16586468

HS_from_PT_114_l 0 3 0 966988882 -1 364997051 2 331985933

HS from PT 114 r 0 57 1 256897347 -1 276764924 2 533662271 1WiIcOXOn1 cut off adjusted p value <0 2

2Upregulated small RNAs have a ratio for expression >1 (below line in table) Downregulated small RNAs have a ratio for expression <1 (above line in table)

Table 3c Small RNAs that are upregulated in colorectal adenocarcinomas compared to control samples hsa-let-7g_l HSbrain_411_r hsa-mir-9-3_r

HS_291_r hsa-mir-363_l hsa-mir-145_l hsa-mir-768_r hsa-mir-92b_r HSbrain_377_l

HSbrain_1437_r hsa-mir-20b_l hsa-mir-92-2_r hsa-mir-181 c_l hsa-mir-29a_r hsa-mir-92-1_r hsa-let-7f-1_l hsa-mir-9-2_r HS_from_PT_114_l

HS_from_MQbrain_572_l hsa-mir-9-1_r HS from PT 114 r

HS from MQbrain 2700 r HSbrain 377 r

Table 3d Small RNAs that are downregulated in colorectal adenocarcinomas compared to control samples

HSJ41J HS_from_PT_340_l HSbrain_731_r

HSJ 56J hsa-let-7a-1_l HSbrain_782_l

HS_304_r hsa-let-7a-2_l HSbrain_801_r

HS_71_I hsa-let-7a-3_l Hsd_102_l

HS_from_MM_1 18_r hsa-let-7d_l Hsd_111_r

HS_from_MM_178_r hsa-mir-126_r Hsd_18_l

HS_from_MM_289_l hsa-mir-192_r Hsd_26_l

HS_from_MQbrain_100_l hsa-mir-199a-2_r Hsd_from_Mmd_328_r

HS_from_MQbrain_1 100_l hsa-mir-302d_l Hsd_from_Mmd_485_r

HS_from_MQbrain_1 169J hsa-mir-325_l Hsd from Mmd 519 I

HS_from_MQbrain_128_r hsa-mir-372_r

HS_from_MQbrain_131_r hsa-mir-492_r

HS_from_MQbrain_131 1_r hsa-mir-500_l

HS_from_MQbrain_1459J hsa-mir-570_l

HS_from_MQbrain_1485_r hsa-mir-573_l

HS_from_MQbrain_1513_r hsa-mir-616_r

HS_from_MQbrain_1624J hsa-mir-633_l

HS_from_MQbrain_1628_r hsa-mir-655_l

HS_from_MQbrain_1687J hsa-mir-98_l

HS_from_MQbrain_1696J HSbrain_106_r

HS_from_MQbrain_1823_r HSbrain_148_r

HS_from_MQbrain_1884_r HSbrain_177_r

HS_from_MQbrain_191_l HSbrain_230_l

HS_from_MQbrain_20_r HSbrain_261_l

HS_from_MQbrain_207_l HSbrain_299_r

HS_from_MQbrain_2380_r HSbrain_321_r

HS_from_MQbrain_343_l HSbrain_398_r

HS_from_MQbrain_349_l HSbrain_426_r

HS_from_MQbrain_350_l HSbrain_458_l

HS_from_MQbrain_549_l HSbrain_458_r

H S_from_M Qbra i n_55_l HSbrain_494_l

HS_from_MQbrain_71_r HSbrain_500_r

HS_from_MQbrain_769_r HSbrain_598_l

HS_from_MQbrain_930_r HSbrain_617_l

HS_from_MQbrain_965_l HSbrain_629_l

HS from PT 146 r HSbrain 709 I Table 4a Small RNAs that are differentially expressed between adenoma and adenocarcinoma adenocarcinoma hsa-mir-653_l 0.028202169 vs adenoma HS_from_MQbrain_1485_l 0.029237065

Systematic Name (adj p)1 HS_from_MQbrain_1042_r 0.030313454

HS_from_MQbrain_1426_r 0.00750624 HSbrain_680_r 0.031432755

HS_from_MQbrain_638_l 0.00750624 HS_from_MQbrain_828_l 0.032034428

HS_from_MQbrain_1391J 0.012664553 HSbrain_399_l 0.032034428

HS_from_MQbrain_420_l 0.012664553 HS_from_PT_187_r 0.032679147

HS_from_PT_36_l 0.012664553 hsa-mir-453_l 0.032679147

HSbrain_390_l 0.012664553 hsa-mir-548b_l 0.033913448

HS_from_MM_242_r 0.014169909 HS_from_MQbrain_1204J 0.034662803

HS_136_r 0.014224152 HS_from_MQbrain_1469_l 0.034662803

HS_8_r 0.014224152 hsa-mir-331_l 0.034662803

HS_from_PT_201_l 0.014224152 hsa-mir-523_r 0.034662803

HSbrain_545_r 0.014224152 HSbrain_384_l 0.034662803

HSJ 76J 0.014416465 HSbrain_570_r 0.034662803

HS_71_r 0.014416465 HSbrain_687_r 0.034662803

HS_from_MM_169_r 0.014416465 HSbrain_7_r 0.034662803

HS_from_MM_92_r 0.015226536 Hsd_85_r 0.034662803

HSbrain_293_l 0.015226536 HS_from_MQbrain_1099_r 0.035037528

HS_from_MQbrain_1334_r 0.015599346 hsa-mir-412_l 0.035037528

HS_from_MQbrain_590_l 0.015599346 Hsd_70_r 0.035037528

HS_from_MQbrain_63_r 0.015599346 HS_46_I 0.035941334

HSbrain_334_r 0.015599346 HSbrain_1425_l 0.035941334

HS_299_I 0.016786613 HS_from_MQbrain_1781J 0.036886609

HS_276_I 0.016904198 HS_from_PT_250_l 0.036886609

HS_from_MQbrain_1 137_l 0.016904198 HS_from_MM_174_l 0.037874034

HS_from_MQbrain_377_l 0.016904198 HS_from_MQbrain_1750_r 0.037874034

HS_from_MQbrain_941_r 0.016904198 HS_from_MM_251_r 0.039250091

HS_from_MQbrain_1082J 0.018319912 HS_from_MM_84_r 0.039250091

HS_from_MQbrain_1792_r 0.018494113 HS_from_MQbrain_43_r 0.039250091

HS_from_MQbrain_458_l 0.0184941 13 HS_from_MQbrain_984_l 0.039250091 hsa-mir-24-2_l 0.018494113 hsa-mir-375_r 0.039250091

HS_157_r 0.020545593 hsa-mir-377_l 0.039250091

HS_from_MM_295_l 0.020545593 HSbrain_272_l 0.039250091

HS_from_MQbrain_1297J 0.020545593 HSbrain_276_l 0.039250091

HSbrain_217_r 0.020545593 HSbrain_351_r 0.039250091

HS_from_MQbrain_1072J 0.021132076 Hsd_18_r 0.039250091

HS_from_MQbrain_1350J 0.022396706 HSbrain_1325_r 0.040852758

HS_from_PT_226_l 0.022396706 HS_from_MQbrain_365_r 0.042516991

HS_from_MQbrain_1500J 0.023919533 HS_from_MM_118_r 0.044599949 hsa-mir-346_l 0.023919533 HS_from_MQbrain_603_r 0.044599949 hsa-mir-767_r 0.023919533 HS_from_MQbrain_686_r 0.044599949

HSbrain_306_r 0.023919533 HS_from_MQbrain_854_r 0.044599949 hsa-mir-324_r 0.024694474 HSbrain_669_r 0.044599949

HS_124_r 0.024910624 HS_from_PT_287_r 0.045945376

HS_51_r 0.024910624 Hsd_from_Mmd_452_l 0.045945376

HS_from_MQbrain_1363J 0.02517728 hsa-mir-136_l 0.047341086

HS_from_MQbrain_1620_r 0.02517728 hsa-mir-383_r 0.047341086

HSbrain_81 1_l 0.026045397 HS_from_MQbrain_1985J 0.047394461

HS_from_MQbrain_825_r 0.026388496 HS_from_MQbrain_2669_l 0.047394461

Hsd_from_Mmd_157_r 0.026388496 HSbrain_476_r 0.047394461

HS_from_MQbrain_133_r 0.026776445 HSbrain_77_l 0.047394461

HSbrain_583_l 0.026776445 Hsd_108_l 0.047394461

HSbrain_796_r 0.027740873 HS_281_r 0.04754573

HS from MQbrain 441 I 0.028202169 HS from MQbrain 1253 r 0.04754573 hsa-mir-661_r 0.04754573 HS_261_r 0.068590471

HSbrain_304_r 0.04754573 HS_from_MQbrain_108_r 0.068590471

HSbrain_438_r 0.04754573 HS_from_MQbrain_1134_r 0.068590471

HS_213_I 0.048205391 HS_from_MQbrain_120_l 0.068590471

HS_79_I 0.048205391 hsa-mir-133a-1_r 0.068590471

HS_from_MQbrain_542_r 0.048205391 hsa-mir-155_r 0.068590471

HSbrain_177_l 0.048205391 hsa-mir-604_l 0.068590471

HS_from_MQbrain_1212_l 0.049767746 H S_from_M Qbra i n_664_r 0.070590475

HSbrain_122_l 0.049767746 Hsd_88_r 0.070590475

HS_212_I 0.050135128 Hsd_from_Mmd_391_l 0.070590475

HS_from_MQbrain_1565J 0.050135128 HS_from_MQbrain_1832J 0.071451516

HS_from_MQbrain_163_l 0.050135128 H S_from_M Qbra i n_58_l 0.071451516 hsa-let-7c_r 0.050135128 HS_from_MQbrain_736_r 0.071451516 hsa-mir-591_r 0.050135128 HS_from_MQbrain_93_r 0.071451516

HSbrain_187_r 0.050135128 HSbrain_468_r 0.071451516

HSbrain_226_r 0.050135128 Hsd_from_Mmd_237_l 0.071451516

HSbrain_437_r 0.050135128 HS_from_MM_1_l 0.072275086

HSbrain_780_r 0.050135128 HS_from_MM_39_l 0.072275086

Hsd_from_Mmd_166_l 0.050135128 HS_from_MQbrain_1006J 0.072275086

Hsd_from_Mmd_485_r 0.050135128 HS_from_MQbrain_1958J 0.072275086

HS_from_MQbrain_660_l 0.051819249 H S_from_M Qbra i n_504_r 0.072275086

HS_from_PT_101_r 0.051819249 HS_from_MQbrain_921_r 0.072275086 hsa-mir-148a_l 0.052756328 HS_from_PT_237_r 0.072275086

HSbrain_252_l 0.052756328 HS_from_PT_299_r 0.072275086

HSbrain_673_r 0.052756328 hsa-mir-124a-1_l 0.072275086

HSbrain_684_r 0.052756328 HSbrain_182_r 0.072275086

HS_17_I 0.053747925 HSbrain_518_r 0.072275086

HS_from_MQbrain_1444J 0.053747925 HSbrain_62_r 0.072275086

HSbrain_494_l 0.053747925 HSbrain_93_r 0.072275086

HSbrain_55_l 0.053747925 Hsd_107_l 0.072275086

HS_from_MM_218_l 0.055185029 Hsd_from_Mmd_222_l 0.072275086

HS_from_MQbrain_1263_r 0.055185029 HS_200_r 0.072654718

HSbrain_538_r 0.055185029 HS_from_MM_232_r 0.072654718

HSbrain_803_l 0.057478906 HS_from_MQbrain_1246J 0.072654718

HS_189_r 0.058218978 HS_from_MQbrain_1301_r 0.072654718

HS_from_MQbrain_71_l 0.058218978 HS_from_MQbrain_301_l 0.072654718 hsa-mir-411_r 0.058218978 HS_from_MQbrain_435_r 0.072654718 hsa-mir-497_r 0.058218978 HS_from_MQbrain_869_l 0.072654718

Hsd_from_Mmd_371_r 0.058218978 HSbrain_1406_l 0.072654718

HS_from_MQbrain_1340J 0.058254254 HS_from_MM_339_l 0.074901054

HS_from_PT_308_l 0.058254254 HS_from_MQbrain_74_r 0.074901054 hsa-mir-638_r 0.058254254 HSbrain_419_l 0.074901054

HSbrain_374_r 0.058254254 HS_219_I 0.075028175

HSbrain_420_r 0.058254254 HS_307_r 0.075028175

HSbrain_583_r 0.058254254 HS_from_MM_103_l 0.075028175

Hsd_from_Mmd_49_l 0.058254254 HS_from_MM_32_r 0.075028175

HS_262_I 0.059897432 HS_from_MQbrain_1001_r 0.075028175

HS_from_MQbrain_346_l 0.059897432 HS_from_MQbrain_1740_r 0.075028175

HSbrain_791_l 0.059897432 H S_from_M Qbra i n_266_r 0.075028175

HSbrain_25_r 0.062381992 HS_from_MQbrain_470_l 0.075028175 hsa-mir-301_l 0.06455063 HS_from_MQbrain_969_l 0.075028175

Hsd_from_Mmd_413_r 0.06455063 HS_from_PT_254_l 0.075028175

HS_from_MQbrain_209_r 0.0659723 hsa-mir-1-1_l 0.075028175

HS_from_MQbrain_579_l 0.0659723 hsa-mir-130b_l 0.075028175 hsa-mir-659_l 0.0659723 hsa-mir-365-2_l 0.075028175

HSbrain_1076_r 0.0659723 hsa-mir-98_r 0.075028175

HS_from_MQbrain_65_l 0.068270026 HSbrain_1298_r 0.075028175

HS from MQbrain 932 I 0.068270026 HSbrain 47 r 0.075028175 HSbrain_580_r 0.075028175 HS_from_MQbrain_1675_r 0.084885584

Hsd_from_Mmd_215_r 0.075028175 HS_from_MQbrain_597_r 0.084885584

Hsd_from_Mmd_473_l 0.075028175 HS_from_MQbrain_823_l 0.084885584 hsa-mir-190_r 0.07641095 HS_from_MQbrain_824_l 0.084885584 hsa-mir-619_l 0.07641095 HS_from_MQbrain_901_r 0.084885584

HSbrain_6_r 0.07641095 hsa-mir-146a_r 0.084885584

Hsd_from_Mmd_189_l 0.07641095 hsa-mir-412_r 0.084885584

Hsd_from_Mmd_410_r 0.07641095 hsa-mir-652_r 0.084885584

Hsd_from_Mmd_464_l 0.07641095 HSbrain_1423_l 0.084885584

HSJ 18J 0.07715065 HSbrain_389_l 0.084885584

HSJ 19J 0.07715065 HSbrain_95_l 0.084885584

HS_292_I 0.07715065 Hsd_106_l 0.084885584

HS_from_MM_18_r 0.07715065 Hsd_from_Mmd_261_l 0.084885584

HS_from_MM_275_r 0.07715065 Hsd_from_Mmd_302_r 0.084885584

HS_from_MM_342_r 0.07715065 H sd_f ro m_M m d_44_r 0.084885584

HS_from_MQbrain_1 17_r 0.07715065 HS_208_l 0.085697388

HS_from_MQbrain_154_r 0.07715065 HS_83_r 0.085697388

HS_from_MQbrain_1896_r 0.07715065 HS_from_MQbrain_330_r 0.085697388

HS_from_MQbrain_881_r 0.07715065 HS_from_MQbrain_468_r 0.085697388

HS_from_MQbrain_972_r 0.07715065 HS_from_MQbrain_534_l 0.085697388 hsa-mir-299_l 0.07715065 HS_from_MQbrain_928_r 0.085697388 hsa-mir-433_r 0.07715065 hsa-let-7a-1_r 0.085697388

HSbrain_204_r 0.07715065 hsa-mir-584_r 0.085697388

HSbrain_231_l 0.07715065 HSbrain_764_r 0.085697388

HSbrain_250_r 0.07715065 Hsd_101_l 0.085697388

HSbrain_431_r 0.07715065 HS_49_r 0.088269125

HSbrain_703_r 0.07715065 HS_from_MQbrain_1593_r 0.088269125

Hsd_105_l 0.07715065 HS_from_PT_13_l 0.088269125 hsa-mir-362_r 0.07965977 Hsd_from_Mmd_511_r 0.088269125

HSbrain_319_l 0.07965977 HS_from_MQbrain_1355_r 0.089491072

HSbrain_442_r 0.07965977 HS_from_MQbrain_1481_l 0.089491072

HS_95_r 0.080676612 HS_from_MQbrain_597_l 0.089491072

HS_from_MQbrain_355_l 0.080676612 hsa-mir-624_l 0.089491072

HS_from_PT_196_l 0.080676612 HSbrain_365_l 0.089491072

HS_from_PT_308_l 0.080676612 HSbrain_512_l 0.089491072

HSbrain_236_l 0.080676612 HSbrain_695_l 0.089491072

HSbrain_361_l 0.080676612 HSbrain_705_l 0.089491072

HSbrain_473_l 0.080676612 Hsd_27_r 0.089491072

HSbrain_792_r 0.080676612 HS_145_r 0.091337111

HS_from_MQbrain_1260_r 0.08237725 HS_151_r 0.091337111

HS_from_PT_27_r 0.08237725 HS_from_MM_219_l 0.091337111

HSbrain_1360_r 0.08237725 HS_from_MM_72_r 0.091337111

HSbrain_328_l 0.08237725 HS_from_MQbrain_1771_r 0.091337111

HSbrain_757_r 0.08237725 HS_from_MQbrain_1877J 0.091337111

HSbrain_799_r 0.08237725 HS_from_MQbrain_392_l 0.091337111

HS_67_r 0.083833911 HS_from_MQbrain_631_l 0.091337111

HS_from_MQbrain_1087J 0.083833911 HS_from_MQbrain_72_r 0.091337111

HS_from_MQbrain_1374_r 0.083833911 HS_from_MQbrain_723_l 0.091337111

HS_from_MQbrain_1569J 0.083833911 HS_from_MQbrain_765_l 0.091337111

HS_from_MQbrain_634_r 0.083833911 HS_from_MQbrain_81_l 0.091337111

HSbrain_627_l 0.083833911 HS_from_PT_282_l 0.091337111

Hsd_42_l 0.083833911 HSbrain_359_l 0.091337111

HS_54_r 0.084885584 HSbrain_371_r 0.091337111

HS_from_MM_18_l 0.084885584 HSbrain_472_l 0.091337111

HS_from_MQbrain_1294J 0.084885584 HSbrain_594_l 0.091337111

HS_from_MQbrain_1443_r 0.084885584 HSbrain_717_r 0.091337111

HS_from_MQbrain_1494_r 0.084885584 Hsd_46_l 0.091337111

HS from MQbrain 1623 r 0.084885584 Hsd from Mmd 324 I 0.091337111 Hsd_from_M md_93_r 0.091337111 HS_from_MQbrain_221_r 0.102601153

HS_14_r 0.092780591 HS_from_MQbrain_628_l 0.102601153

HS_from_MQbrain_1264J 0.092780591 HS_from_MQbrain_716_l 0.102601153

HS_from_MQbrain_566_l 0.092780591 HSbrain_507_l 0.102601153

HS_from_MQbrain_634_l 0.092780591 HSbrain_661_l 0.102601153

HSbrain_114_r 0.092780591 Hsd_from_Mmd_117_r 0.102601153

HSbrain_773_r 0.092780591 Hsd_from_Mmd_138_l 0.102601153

Hsd_from_Mmd_225_l 0.092780591 HS_from_MQbrain_1116_r 0.104515233

Hsd_from_Mmd_422_l 0.092780591 HS_from_MQbrain_1374J 0.104515233

Hsd_from_Mmd_491_r 0.092780591 HS_from_MQbrain_433_l 0.104515233

HS_171_r 0.094556199 H S_from_M Qbra i n_62_l 0.104515233

HS_from_MQbrain_1901_r 0.094556199 H S_from_M Qbra i n_722_r 0.104515233

HSbrain_135_l 0.094556199 hsa-mir-633_r 0.104515233

HSbrain_465_l 0.094556199 HSbrain_266_r 0.104515233

HSbrain_591_l 0.094556199 Hsd_37_r 0.104515233

HSbrain_728_l 0.094556199 Hsd_from_Mmd_405_l 0.104515233

HSbrain_754_r 0.094556199 HS_99_r 0.105993846

Hsd_from_Mmd_330_l 0.094556199 HS_from_MQbrain_1127_r 0.105993846

HS_74_r 0.096132958 HS_from_MQbrain_1537_r 0.105993846

HS_from_MM_121_l 0.096132958 HS_from_MQbrain_1545_r 0.105993846

HS_from_MQbrain_1717_r 0.096132958 HS_from_MQbrain_1783_r 0.105993846

HS_from_MQbrain_1793_r 0.096132958 HS_from_MQbrain_22_r 0.105993846 hsa-mir-224_r 0.096132958 H S_from_M Qbra i n_534_r 0.105993846

HSbrain_123_l 0.096132958 HS_from_MQbrain_852_l 0.105993846

HSbrain_532_l 0.096132958 HS_from_MQbrain_900_r 0.105993846

Hsd_30_l 0.096132958 hsa-let-7f-1_r 0.105993846

Hsd_83_l 0.096132958 Hsd_from_Mmd_166_r 0.105993846

HS_from_MQbrain_1771J 0.098301345 HS_from_MQbrain_1541J 0.107794024

HS_from_MQbrain_181_l 0.098301345 HS_from_MQbrain_574_l 0.107794024

HS_from_MQbrain_1893_r 0.098301345 HS_from_MQbrain_921_l 0.107794024

HSbrain_316_l 0.098301345 HS_from_MQbrain_951_l 0.107794024

HSbrain_452_l 0.098301345 HS_from_MQbrain_996_l 0.107794024

HSbrain_52_r 0.098301345 hsa-mir-625_r 0.107794024

HSbrain_553_r 0.098301345 HSbrain_106_r 0.107794024

HS_288_r 0.099488281 HSbrain_184_r 0.107794024

HS_86_r 0.099488281 HSbrain_696_r 0.107794024

HS_from_MM_150_r 0.099488281 Hsd_from_Mmd_255_l 0.107794024

HS_from_MQbrain_1031_r 0.099488281 HS_from_MM_86_l 0.11066006

HS_from_MQbrain_1649_r 0.099488281 HS_from_MQbrain_1339_r 0.11066006

HS_from_MQbrain_1840J 0.099488281 HS_from_MQbrain_2087_r 0.11066006 hsa-mir-193a_l 0.099488281 HSbrain_677_l 0.11066006 hsa-mir-646_r 0.099488281 Hsd_from_M md_266_r 0.11066006

HSbrain_235_l 0.099488281 Hsd_from_Mmd_52_r 0.11066006

HSbrain_719_l 0.099488281 HS_from_MQbrain_1185_l 0.113095726

Hsd_from_Mmd_524_l 0.099488281 HS_from_MQbrain_29_l 0.113095726

HS_from_MM_84_l 0.101009439 HS_from_MQbrain_777_r 0.113095726

HS_from_MQbrain_1085J 0.101009439 HSbrain_1413_l 0.113095726

HS_from_MQbrain_1700_r 0.101009439 HSbrain_440_l 0.113095726

HS_from_MQbrain_1748_r 0.101009439 HSbrain_50_l 0.113095726

HS_from_MQbrain_1806_l 0.101009439 HSbrain_588_l 0.113095726

HS_from_MQbrain_1827J 0.101009439 Hsd_12_r 0.113095726

HS_from_PT_140_l 0.101009439 HSJ 02J 0.114595796

HSbrain_14_r 0.101009439 HS_38_r 0.114595796

HSbrain_703_l 0.101009439 HS_from_MM_276_l 0.114595796

Hsd_from_Mmd_346_l 0.101009439 HS_from_MQbrain_1164_r 0.114595796

HS_287_r 0.102601 153 HS_from_MQbrain_1817_l 0.114595796

HS_from_MQbrain_129_r 0.102601 153 HS_from_MQbrain_184_l 0.114595796

HS from MQbrain 1677 r 0.102601 153 HS from MQbrain 56 I 0.114595796 HS_from_MQbrain_842_l 0.114595796 HSJrom_PT_1 17_r 0.12300785

HSbrain_461_r 0.114595796 hsa-mir-16-1_r 0.12300785

HSbrain_621_r 0.114595796 HSbrain_155_r 0.12300785

HSbrain_677_r 0.114595796 HSbrain_256_r 0.12300785

HSbrain_795_r 0.114595796 HSbrain_402J 0.12300785

HS_from_MM_119_r 0.115928328 HSbrain_50_r 0.12300785

HS_from_MM_331_r 0.115928328 HSbrain_541_r 0.12300785

HS_from_MQbrain_1292_r 0.115928328 Hsd Jrom_M md_314_r 0.12300785

HS_from_MQbrain_1637_r 0.115928328 HS Jrom_MQbrain_1097_r 0.124263194

HS_from_MQbrain_501_l 0.115928328 HSJrom_MQbrain_1633_r 0.124263194

HS_from_MQbrain_609_l 0.115928328 HS Jrom_MQbrain_1806J 0.124263194

HS_from_PT_128_l 0.115928328 HS Jrom_MQbrain_210_r 0.124263194

HS_from_PT_139_r 0.115928328 HSJrom_MQbrain_268_r 0.124263194 hsa-mir-450-2_r 0.115928328 HS Jrom_MQbrain_619 J 0.124263194

HSbrain_1362_r 0.115928328 HSJrom_MQbrain_681J 0.124263194

HSbrain_26_r 0.115928328 HS Jrom_MQbrain _814 J 0.124263194

HSbrain_480_r 0.115928328 hsa-mir-329-1_r 0.124263194

Hsd_from_M md_181 _r 0.115928328 hsa-mir-451 J 0.124263194

HS_246_I 0.117828853 hsa-mir-517cj 0.124263194

HS_76_r 0.117828853 hsa-mir-632J 0.124263194

HS_from_MM_157_l 0.117828853 HSbrain_1338_r 0.124263194

HS_from_MM_208_r 0.117828853 HSbrain_393J 0.124263194

HS_from_MM_260_l 0.117828853 Hsd_from_Mmd_154J 0.124263194

HS_from_MM_34_l 0.117828853 HS_97_r 0.126757752

HS_from_MQbrain_147 OJ 0.117828853 HS_from_MQbrain_1183J 0.126757752

HSJrom_MQbrain_273_r 0.117828853 HS_from_MQbrain_1675J 0.126757752

HSJrom_MQbrain_354_r 0.117828853 HS _from_MQbrain J314 J 0.126757752

HSJrom_MQbrain_791_r 0.117828853 HS_from_MQbrain_822J 0.126757752

HSbrain_720J 0.117828853 HSJrom_MQbrainJ397_r 0.126757752

HS_from_MM_180_r 0.119559457 hsa-mir-299_r 0.126757752

HS_from_MM_184_r 0.119559457 hsa-mir-616J 0.126757752

HS_from_MQbrainJ974J 0.119559457 HSbrain_43_r 0.126757752

HSJrom_PT_60J 0.119559457 HSbrain_771J 0.126757752 hsa-mir-30bJ 0.119559457 HS_290_r 0.129555956 hsa-mir-491_r 0.119559457 HS_77_r 0.129555956

HSbrain_225_r 0.119559457 HSJ38_r 0.129555956

HSbrain_325_r 0.119559457 HS _from_MQbrain_1102J 0.129555956

HSbrain_441_r 0.119559457 HS Jrom_MQbrain_140 J 0.129555956

HSbrain_606J 0.119559457 HS _from_MQbrain_1413 J 0.129555956

HSbrain_708J 0.119559457 HSJrom_MQbrain_453J 0.129555956

Hsd _from_M md_23 J 0.119559457 HSJrom_MQbrain_800J 0.129555956

HS_154_r 0.121604253 HSbrain_393_r 0.129555956

HS Jrom_MQbrain_161_r 0.121604253 HS_50_r 0.130803986

HS _from_MQbrain_1632J 0.121604253 HSJ56J 0.130803986

HS Jrom_MQbrain_1776_r 0.121604253 HS_from_MQbrain_1684_r 0.130803986

HSJrom_MQbrain_648_r 0.121604253 HS _from_MQbrain_1808_r 0.130803986

HSJromJVIQbrain_940_r 0.121604253 HS Jrom_MQbrain_216 J 0.130803986 hsa-mir-548cj 0.121604253 HS_from_MQbrain_37_r 0.130803986 hsa-mir-640J 0.121604253 HS_from_MQbrainJ372J 0.130803986

HSbrain_305_r 0.121604253 HSJrom_MQbrain_722J 0.130803986

HsdJ32_r 0.121604253 HSJrom_PT_313J 0.130803986

Hsd_from_Mmd_136J 0.121604253 hsa-mir-206J 0.130803986

HS _from_MQbrain_1075J 0.12300785 hsa-mir-573_r 0.130803986

HSJrom_MQbrain_1261_r 0.12300785 HSbrain_380_r 0.130803986

HS _from_MQbrain_1412 J 0.12300785 HSbrain_776J 0.130803986

H S Jro m_M Qbra i n_266 J 0.12300785 HSbrain_783J 0.130803986

HSJrom_MQbrain_340_r 0.12300785 HsdJrom_Mmd_503J 0.130803986

HS from MQbrain 760 I 0.12300785 Hsd from Mmd 94 I 0.130803986 HSJ 01J 0.132596379 HS_from_MQbrain_1493_r 0.139019426

HS_from_MM_200_l 0.132596379 HS_from_MQbrain_1657_r 0.139019426

HS_from_MQbrain_1070_r 0.132596379 HS_from_MQbrain_1756J 0.139019426

HS_from_MQbrain_1520J 0.132596379 HS_from_MQbrain_178_r 0.139019426

HS_from_MQbrain_1845J 0.132596379 HS_from_MQbrain_399_l 0.139019426

HS_from_MQbrain_38_r 0.132596379 HS_from_MQbrain_804_r 0.139019426

HS_from_MQbrain_382_l 0.132596379 HS_from_MQbrain_809_l 0.139019426

HS_from_MQbrain_715_l 0.132596379 HS_from_MQbrain_886_r 0.139019426

HS_from_MQbrain_868_l 0.132596379 HS_from_MQbrain_90_r 0.139019426

HSbrain_12_l 0.132596379 HSbrain_1377_l 0.139019426

HSbrain_1364_r 0.132596379 HSbrain_1416_r 0.139019426

HSbrain_691_l 0.132596379 HSbrain_3_l 0.139019426

HSbrain_726_l 0.132596379 HSbrain_337_r 0.139019426

Hsd_from_Mmd_155_l 0.132596379 HSbrain_509_l 0.139019426

HS_62_I 0.134691663 HSbrain_726_r 0.139019426

HS_from_MM_102_r 0.134691663 HSbrain_779_r 0.139019426

HS_from_MQbrain_1420J 0.134691663 Hsd_13_l 0.139019426

HS_from_MQbrain_1549J 0.134691663 Hsd_32_r 0.139019426 hsa-mir-454_r 0.134691663 Hsd_from_Mmd_396_l 0.139019426 hsa-mir-516-1_r 0.134691663 HS_223_r 0.141416815 hsa-mir-520h_l 0.134691663 HS_39_r 0.141416815

HSbrain_220_r 0.134691663 HS_98_r 0.141416815

HSbrain_484_l 0.134691663 HS_from_MQbrain_1331_r 0.141416815

HSbrain_590_l 0.134691663 HS_from_MQbrain_1417_l 0.141416815

HSbrain_636_l 0.134691663 HS_from_MQbrain_332_l 0.141416815

Hsd_42_r 0.134691663 HS_from_MQbrain_812_l 0.141416815

Hsd_7_r 0.134691663 HS_from_MQbrain_845_r 0.141416815

HS_237_r 0.136637202 hsa-mir-328_r 0.141416815

HS_289_r 0.136637202 hsa-mir-488_l 0.141416815

HS_from_MM_48_l 0.136637202 HSbrain_698_r 0.141416815

HS_from_MQbrain_1725J 0.136637202 Hsd_from_Mmd_398_r 0.141416815

HS_from_MQbrain_281_r 0.136637202 Hsd_from_Mmd_487_r 0.141416815

HS_from_MQbrain_348_r 0.136637202 HS_from_MQbrain_1143J 0.14474535

HS_from_MQbrain_600_l 0.136637202 HS_from_MQbrain_770_r 0.14474535

HS_from_PT_44_l 0.136637202 H S_from_M Qbra i n_824_r 0.14474535

HS_from_PT_95_l 0.136637202 HS_from_MQbrain_914_l 0.14474535 hsa-mir-454_l 0.136637202 hsa-mir-204_r 0.14474535 hsa-mir-671_l 0.136637202 hsa-mir-510_r 0.14474535

HSbrain_174_r 0.136637202 HSbrain_369_r 0.14474535

HSbrain_222_r 0.136637202 HSbrain_82_r 0.14474535

HSbrain_970_r 0.136637202 Hsd_from_Mmd_123_r 0.14474535

HS_278_I 0.138217661 HS_175_I 0.145370181

HS_91_I 0.138217661 HS_207_l 0.145370181

HS_from_MQbrain_1525_r 0.138217661 HS_54_I 0.145370181

HS_from_MQbrain_161_l 0.138217661 HS_from_MM_288_l 0.145370181

HS_from_MQbrain_1824J 0.138217661 HS_from_MQbrain_1164J 0.145370181

HS_from_MQbrain_1836J 0.138217661 HS_from_MQbrain_1204_r 0.145370181

HS_from_MQbrain_315_l 0.138217661 HS_from_MQbrain_1227J 0.145370181

HS_from_MQbrain_697_l 0.138217661 HS_from_MQbrain_180_r 0.145370181

HS_from_MQbrain_70_l 0.138217661 HS_from_MQbrain_181 OJ 0.145370181 hsa-mir-196a-2_r 0.138217661 HS_from_MQbrain_535_r 0.145370181 hsa-mir-345_r 0.138217661 H S_from_M Qbra i n_64_l 0.145370181 hsa-mir-369_l 0.138217661 HS_from_PT_283_r 0.145370181 hsa-mir-517a_l 0.138217661 hsa-mir-30b_r 0.145370181

HSbrain_250_l 0.138217661 hsa-mir-517b_l 0.145370181

HSbrain_753_r 0.138217661 HSbrain_117_r 0.145370181

Hsd_69_l 0.138217661 HSbrain_139_r 0.145370181

HS 277 I 0.139019426 HSbrain 214 I 0.145370181 HSbrain_381_l 0.145370181 HSbrain_177_r 0.149149579

HSbrain_620_l 0.145370181 HSbrain_198_l 0.149149579

HSbrain_716_l 0.145370181 HSbrain_313_l 0.149149579

HSbrain_787_l 0.145370181 HSbrain_425_l 0.149149579

Hsd_from_M md_82_r 0.145370181 HSbrain_622_r 0.149149579

HSJ 33J 0.146325218 Hsd_81_r 0.149149579

HS_190_r 0.146325218 Hsd_from_Mmd_516_r 0.149149579

HS_281_r 0.146325218 HS_111_r 0.152177614

HS_306_l 0.146325218 HS_204_r 0.152177614

HS_from_MM_136_l 0.146325218 HS_45_r 0.152177614

HS_from_MM_199_l 0.146325218 HS_from_PT_20_r 0.152177614

HS_from_MQbrain_283_r 0.146325218 hsa-mir-191_r 0.152177614

HS_from_MQbrain_429_l 0.146325218 HSbrain_304_l 0.152177614

HS_from_MQbrain_606_r 0.146325218 HSbrain_41_l 0.152177614

HS_from_MQbrain_906_l 0.146325218 HSbrain_625_l 0.152177614

HS_from_MQbrain_973_l 0.146325218 HSbrain_717_l 0.152177614 hsa-mir-217_r 0.146325218 Hsd_66_l 0.152177614 hsa-mir-368_l 0.146325218 Hsd_from_M md_261 _r 0.152177614 hsa-mir-520g_l 0.146325218 Hsd_from_Mmd_509_l 0.152177614 hsa-mir-647_l 0.146325218 HS_from_MQbrain_1433_r 0.155479351 hsa-mir-655_l 0.146325218 H S_from_M Qbra i n_536_r 0.155479351

HSbrain_307_r 0.146325218 HS_from_MQbrain_629_r 0.155479351

HSbrain_75_l 0.146325218 HS_from_MQbrain_88_l 0.155479351

Hsd_from_M md_246_r 0.146325218 hsa-mir-10b_r 0.155479351

Hsd_from_Mmd_500_l 0.146325218 hsa-mir-31_l 0.155479351

Hsd_from_Mmd_535_r 0.146325218 hsa-mir-338_l 0.155479351

HSJ41J 0.148196723 hsa-mir-579_r 0.155479351

HS_286_r 0.148196723 hsa-mir-616_r 0.155479351

HS_66_r 0.148196723 HSbrain_578_r 0.155479351

HS_from_MM_118_l 0.148196723 Hsd_from_Mmd_424_l 0.155479351

HS_from_MQbrain_1224_r 0.148196723 HSJ 13J 0.15865589

HS_from_MQbrain_1292J 0.148196723 HS_220_l 0.15865589

HS_from_MQbrain_1817_l 0.148196723 HS_from_MQbrain_1168J 0.15865589 hsa-mir-365-2_r 0.148196723 HS_from_MQbrain_1601_r 0.15865589

HSbrain_102_r 0.148196723 HS_from_MQbrain_686_l 0.15865589

HSbrain_244_l 0.148196723 HS_from_MQbrain_936_l 0.15865589

HSbrain_495_r 0.148196723 HSbrain_431_l 0.15865589

HSbrain_624_l 0.148196723 HSbrain_506_r 0.15865589

HSbrain_627_r 0.148196723 HSbrain_652_l 0.15865589

HSbrain_647_r 0.148196723 HSbrain_673_l 0.15865589

HSbrain_794_r 0.148196723 Hsd_from_Mmd_197_l 0.15865589

Hsd_from_Mmd_501_l 0.148196723 Hsd_from_Mmd_58_r 0.15865589

Hsd_from_Mmd_70_l 0.148196723 HS_167_r 0.159708794

HS_110_r 0.149149579 HS_265_I 0.159708794

HSJ 39J 0.149149579 HS_292_r 0.159708794

HS_306_l 0.149149579 HS_from_MQbrain_1110J 0.159708794

HS_58_I 0.149149579 HS_from_MQbrain_1753_r 0.159708794

HS_from_MQbrain_1088J 0.149149579 HS_from_MQbrain_1882_r 0.159708794

HS_from_MQbrain_1419_r 0.149149579 HS_from_MQbrain_529_r 0.159708794

HS_from_MQbrain_1773J 0.149149579 HS_from_MQbrain_604_l 0.159708794

HS_from_MQbrain_666_l 0.149149579 HS_from_MQbrain_833_l 0.159708794

HS_from_MQbrain_817_l 0.149149579 HS_from_PT_254_r 0.159708794

HS_from_PT_134_l 0.149149579 HS_from_PT_91_r 0.159708794

HS_from_PT_188_l 0.149149579 hsa-mir-382_r 0.159708794 hsa-mir-30c-1_l 0.149149579 hsa-mir-516-2_r 0.159708794 hsa-mir-524_r 0.149149579 hsa-mir-622_l 0.159708794

HSbrain_1363_r 0.149149579 HSbrain_158_l 0.159708794

HSbrain 1384 r 0.149149579 HSbrain 202 r 0.159708794 HSbrain_305_l 0.159708794 HS_from_MQbrain_1235J 0.170255758

HSbrain_571_l 0.159708794 HS_from_MQbrain_1627_r 0.170255758

HSbrain_644_r 0.159708794 HS_from_MQbrain_1667_r 0.170255758

HSbrain_692_l 0.159708794 HS_from_MQbrain_1855J 0.170255758

HSbrain_91_r 0.159708794 HS_from_MQbrain_482_l 0.170255758

Hsd_from_Mmd_347_l 0.159708794 HS_from_MQbrain_496_r 0.170255758

Hsd_from_Mmd_480_r 0.159708794 HS_from_MQbrain_710_r 0.170255758

HSJ 81J 0.161647438 hsa-mir-520f_r 0.170255758

HS_288_I 0.161647438 HSbrain_113_r 0.170255758

HS_from_MM_124_l 0.161647438 HSbrain_626_r 0.170255758

HS_from_MQbrain_1215_l 0.161647438 HSbrain_85_r 0.170255758

HS_from_MQbrain_1722J 0.161647438 Hsd_from_Mmd_107_r 0.170255758

HS_from_MQbrain_1839J 0.161647438 Hsd_from_Mmd_176_r 0.170255758

HS_from_MQbrain_1877_r 0.161647438 HS_29_I 0.173467438

HS_from_MQbrain_2441_r 0.161647438 HS_from_MM_6_r 0.173467438

HS_from_MQbrain_587_l 0.161647438 HS_from_MQbrain_560_r 0.173467438

HS_from_MQbrain_635_l 0.161647438 H S_from_M Qbra i n_57_l 0.173467438

HS_from_MQbrain_868_l 0.161647438 hsa-mir-643_r 0.173467438 hsa-mir-588_r 0.161647438 HSbrain_157_l 0.173467438

HSbrain_16_l 0.161647438 HSbrain_336_l 0.173467438

HSbrain_218_l 0.161647438 HSbrain_483_r 0.173467438

HSbrain_408_r 0.161647438 HSbrain_614_l 0.173467438

HSbrain_599_r 0.161647438 HSbrain_777_r 0.173467438

HSbrain_663_l 0.161647438 Hsd_80_r 0.173467438

HSbrain_72_l 0.161647438 Hsd_from_Mmd_35_r 0.173467438

Hsd_106_r 0.161647438 Hsd_from_Mmd_370_r 0.173467438

HSJ 30J 0.16463875 Hsd_from_Mmd_97_l 0.173467438

HS_208_r 0.16463875 HS_191_r 0.175200251

HS_from_MQbrain_1229_r 0.16463875 HS_231_I 0.175200251

HS_from_MQbrain_1645J 0.16463875 HS_from_MQbrain_1091J 0.175200251

HS_from_MQbrain_288_r 0.16463875 HS_from_MQbrain_1463_l 0.175200251

HS_from_MQbrain_444_r 0.16463875 HS_from_MQbrain_1556_r 0.175200251

HS_from_MQbrain_808_l 0.16463875 HS_from_MQbrain_1708J 0.175200251

HS_from_PT_41_l 0.16463875 HS_from_MQbrain_1752J 0.175200251 hsa-mir-296_l 0.16463875 HS_from_MQbrain_1777J 0.175200251

HSbrain_11 1_l 0.16463875 HS_from_MQbrain_437_l 0.175200251

HSbrain_1415_r 0.16463875 H S_from_M Qbra i n_555_r 0.175200251

HSbrain_220_l 0.16463875 HS_from_MQbrain_734_l 0.175200251

HSbrain_366_r 0.16463875 HS_from_MQbrain_85_l 0.175200251

Hsd_from_Mmd_223_r 0.16463875 HS_from_PT_115_r 0.175200251

HS_from_MM_311_l 0.167313007 HS_from_PT_34_r 0.175200251

HS_from_MQbrain_1268J 0.167313007 hsa-mir-770_r 0.175200251

HS_from_MQbrain_1372J 0.167313007 HSbrain_429_l 0.175200251

HS_from_MQbrain_1376_r 0.167313007 HSbrain_540_l 0.175200251

HS_from_MQbrain_1876_r 0.167313007 HSbrain_643_l 0.175200251

HS_from_MQbrain_2670_r 0.167313007 HSbrain_687_l 0.175200251

HS_from_MQbrain_401_l 0.167313007 HSbrain_916_l 0.175200251

HS_from_MQbrain_42_l 0.167313007 HSbrain_970_l 0.175200251

HS_from_MQbrain_699_r 0.167313007 Hsd_from_Mmd_527_l 0.175200251

HS_from_PT_338_l 0.167313007 HS_109_r 0.177405071 hsa-mir-125b-2_l 0.167313007 HS_217_I 0.177405071 hsa-mir-132_l 0.167313007 HS_from_MQbrain_1126J 0.177405071 hsa-mir-190_l 0.167313007 HS_from_MQbrain_1323J 0.177405071

HSbrain_168_l 0.167313007 HS_from_MQbrain_1442_l 0.177405071

HSbrain_513_r 0.167313007 HS_from_MQbrain_1470_r 0.177405071

Hsd_from_Mmd_443_l 0.167313007 HS_from_MQbrain_386_r 0.177405071

HSJ 14J 0.170255758 HS_from_PT_190_r 0.177405071

HS 61 r 0.170255758 HS from PT 211 r 0.177405071 hsa-mir-374_l 0.177405071 HSbrain_166_l 0.185815478

HSbrain_1414_r 0.177405071 HSbrain_32_l 0.185815478

HSbrain_347_l 0.177405071 HSbrain_662_r 0.185815478

HSbrain_568_r 0.177405071 HSbrain_80_l 0.185815478

HSbrain_690_l 0.177405071 Hsd_8_r 0.185815478

HSbrain_692_r 0.177405071 Hsd_from_Mmd_48_r 0.185815478

HSbrain_744_l 0.177405071 HSJ 89J 0.188706417

HSbrain_794_l 0.177405071 HS_241_r 0.188706417

Hsd_from_Mmd_167_r 0.177405071 HS_50_l 0.188706417

Hsd_from_M md_42_r 0.177405071 HS_from_MQbrain_1346_r 0.188706417

Hsd_from_Mmd_480_l 0.177405071 HS_from_MQbrain_194_l 0.188706417

HS_266_r 0.180260145 HS_from_MQbrain_36_r 0.188706417

HS_285_r 0.180260145 HS_from_MQbrain_691_r 0.188706417

HS_292_r 0.180260145 HS_from_MQbrain_745_r 0.188706417

HS_47_I 0.180260145 HS_from_MQbrain_859_l 0.188706417

HS_from_MQbrain_1110_r 0.180260145 HS_from_PT_126_l 0.188706417

HS_from_MQbrain_1631_r 0.180260145 hsa-mir-367_r 0.188706417

HS_from_MQbrain_550_l 0.180260145 hsa-mir-518e_r 0.188706417

HS_from_MQbrain_661_r 0.180260145 HSbrain_141_r 0.188706417

HS_from_MQbrain_991_r 0.180260145 HSbrain_270_r 0.188706417 hsa-mir-365-1_l 0.180260145 HSbrain_497_l 0.188706417

HSbrain_1331_r 0.180260145 HSbrain_570_l 0.188706417

HSbrain_180_l 0.180260145 Hsd_96_r 0.188706417

HSbrain_263_r 0.180260145 Hsd_from_M md_471 _r 0.188706417

HSbrain_593_r 0.180260145 HSJ 05J 0.190550803

HSbrain_689_r 0.180260145 HS_166_I 0.190550803

Hsd_from_Mmd_217_r 0.180260145 HS_from_MM_80_l 0.190550803

Hsd_from_Mmd_286_r 0.180260145 HS_from_MQbrain_1300_r 0.190550803

HSJ 38J 0.184337179 HS_from_MQbrain_1347_r 0.190550803

HSJ 77J 0.184337179 HS_from_MQbrain_1365J 0.190550803

HS_182_r 0.184337179 HS_from_MQbrain_1437_l 0.190550803

HS_243_I 0.184337179 HS_from_MQbrain_397_l 0.190550803

HS_from_MM_131_l 0.184337179 HS_from_MQbrain_405_r 0.190550803

HS_from_MQbrain_1227J 0.184337179 H S_from_M Qbra i n_626_r 0.190550803

HS_from_MQbrain_188_l 0.184337179 HS_from_MQbrain_653_l 0.190550803

HSbrain_621_l 0.184337179 HS_from_MQbrain_675_l 0.190550803

HSbrain_778_l 0.184337179 HS_from_MQbrain_819_r 0.190550803

Hsd_84_r 0.184337179 HS_from_MQbrain_968_r 0.190550803

Hsd_from_Mmd_120_r 0.184337179 HS_from_MQbrain_97_r 0.190550803

HS_142_I 0.185815478 HS_from_PT_238_l 0.190550803

HS_303_r 0.185815478 HS_from_PT_27_l 0.190550803

HS_77_I 0.185815478 hsa-mir-222_r 0.190550803

HS_from_MM_256_r 0.185815478 hsa-mir-502_l 0.190550803

HS_from_MM_310_l 0.185815478 HSbrain_809_r 0.190550803

HS_from_MQbrain_1 11_l 0.185815478 Hsd_62_l 0.190550803

HS_from_MQbrain_1354_r 0.185815478 Hsd_95_l 0.190550803

HS_from_MQbrain_1394J 0.185815478 Hsd_from_Mmd_163_r 0.190550803

HS_from_MQbrain_17_r 0.185815478 Hsd_from_Mmd_253_l 0.190550803

HS_from_MQbrain_1778_r 0.185815478 HS_from_MM_198_r 0.194339793

H S_from_M Qbra i n_22_l 0.185815478 HS_from_MM_35_r 0.194339793

HS_from_MQbrain_272_l 0.185815478 HS_from_MQbrain_1272J 0.194339793

HS_from_MQbrain_453_r 0.185815478 HS_from_MQbrain_1421_l 0.194339793

HS_from_MQbrain_914_l 0.185815478 HS_from_MQbrain_375_l 0.194339793

HS_from_PT_157_r 0.185815478 HS_from_MQbrain_55_l 0.194339793 hsa-mir-135a-2_r 0.185815478 HS_from_PT_149_r 0.194339793 hsa-mir-557_l 0.185815478 hsa-mir-550-2_r 0.194339793 hsa-mir-593_r 0.185815478 hsa-mir-623_r 0.194339793

HSbrain 1364 I 0.185815478 hsa-mir-648 I 0.194339793 HSbrain_259_r 0.194339793 HS_from_MQbrain_121 OJ 0.199721903

HSbrain_755_l 0.194339793 HS_from_MQbrain_1250J 0.199721903

Hsd_from_M md_530_l 0.194339793 HS_from_MQbrain_1357J 0.199721903

Hsd_from_M md_81 _r 0.194339793 HS_from_MQbrain_1405_l 0.199721903

HS_from_MM_190_l 0.197457594 HS_from_MQbrain_1415_r 0.199721903

HS_from_MQbrain_1 159_l 0.197457594 HS_from_MQbrain_1517_r 0.199721903

HS_from_MQbrain_1514_r 0.197457594 HS_from_MQbrain_1747J 0.199721903

HS_from_MQbrain_467_l 0.197457594 HS_from_MQbrain_212_r 0.199721903

HS_from_MQbrain_500_r 0.197457594 HS_from_MQbrain_229_l 0.199721903

HS_from_MQbrain_635_r 0.197457594 HS_from_MQbrain_235_r 0.199721903

HS_from_MQbrain_789_r 0.197457594 HS_from_MQbrain_280_l 0.199721903

HS_from_MQbrain_968_l 0.197457594 hsa-mir-138-2_l 0.199721903 hsa-mir-204_l 0.197457594 hsa-mir-524_l 0.199721903 hsa-mir-219-1_r 0.197457594 hsa-mir-568_l 0.199721903

HSbrain_1337_l 0.197457594 hsa-mir-95_r 0.199721903

HSbrain_190_r 0.197457594 HSbrain_22_l 0.199721903

HSbrain_210_l 0.197457594 HSbrain_388_r 0.199721903

HSbrain_289_r 0.197457594 HSbrain_482_l 0.199721903

HSbrain_479_l 0.197457594 HSbrain_588_r 0.199721903

HSbrain_755_r 0.197457594 HSbrain_651_r 0.199721903

Hsd_24_r 0.197457594 Hsd_41_r 0.199721903

Hsd_from_Mmd_178_l 0.197457594 Hsd from Mmd 478 I 0.199721903

HS from MQbrain 1100 r 0.199721903 Wilcoxon analysis: cut off adjusted p value <0.2

Table 4b Up- or down regulated small RNAs adenocarcinoma compared to adenoma

SystematicName adenoma/carcinoma carcinoma adenoma carcinoma/adenoma

(adj p)1 (avg expression) (avg expression) (ratio expression)2 hsa-mιr-375_r 0 0393 -0 1480 0 8295 -0 9775

HS_from_MQbraιn_1985_l 0 0474 0 3803 1 1112 -0 7308

HS_from_MQbraιn_579_l 0 0660 0 3918 1 1126 -0 7208

HS_from_MQbraιn_1958_l 0 0723 0 3762 1 0830 -0 7067

HS_from_MQbraιn_1235_l 0 1703 1 1233 1 7573 -0 6340

HS_from_MQbraιn_1323 I 0 1774 1 1608 1 7828 -0 6220

HS_from_MQbraιn_1525_r 0 1382 0 3320 0 9272 -0 5951

HS_from_MQbraιn_972_r 0 0772 0 2041 0 7900 -0 5859

HSbraιn_636_l 0 1347 0 8158 1 3298 -0 5141

HS_266_r 0 1803 0 8889 1 3712 -0 4823

HS_from_PT_13_l 0 0883 -0 9932 -0 5123 -0 4809

HS_from_MQbraιn_529_r 0 1597 0 0776 0 5481 -0 4705

HS_from_MQbraιn_470_l 0 0750 0 8272 1 2930 -0 4658 hsa-mιr-10b r 0 1555 -0 0924 0 3721 -0 4645

Hsd_from_Mmd_166_l 0 0501 -0 8357 -0 3751 -0 4607

Hsd_from_Mmd_136_l 0 1216 -1 2261 -0 7690 -0 4571 hsa-mιr-451_l 0 3459 -0 4469 0 0020 -0 4489

Hsd_from_Mmd_524_l 0 0995 -0 9078 -0 4694 -0 4385

HSbraιn_773_r 0 0928 -1 1665 -0 7301 -0 4364

HS_from_MQbraιn_828_l 0 0320 0 2589 0 6920 -0 4331 hsa-mιr-190_l 0 1673 -1 4076 -0 9760 -0 4316

HS_from_MM_6_r 0 1735 0 4691 0 9005 -0 4314 hsa-mιr-573 r 0 1308 -1 2345 -0 8053 -0 4291 hsa-mιr-193a I 0 0995 0 6922 1 1195 -0 4273

HS_from_MM_84_l 0 1010 -0 6664 -0 2459 -0 4205

HS_from_PT_190_r 0 1774 1 1254 1 5446 -0 4192

Hsd_f rom_Mmd_123_r 0 1447 0 5308 0 9486 -0 4178

HS_151_r 0 0913 -0 9626 -0 5484 -0 4141

HSbraιn_1384_r 0 1491 0 1926 0 6048 -0 4122 hsa-mιr-368_l 0 1463 -0 1578 0 2436 -0 4014 hsa-mιr-520f_r 0 1703 -0 6603 -0 2591 -0 4012

HS_from_MQbraιn_1229_r 0 1646 -0 0990 0 3017 -0 4007

HSbraιn_276_l 0 0393 -0 2953 0 1014 -0 3967

HS_from_MQbraιn_1417_l 0 1414 0 3389 0 7346 -0 3957

HSbraιn_220_l 0 1646 -0 2992 0 0905 -0 3897

HS_from_MM_136_l 0 1463 -1 0881 -0 7064 -0 3816 hsa-mιr-450-2_r 0 1159 -0 4279 -0 0493 -0 3785

HSbraιn_916_l 0 1752 1 4491 1 8251 -0 3760 hsa-mιr-516-1_r 0 1347 -0 9059 -0 5366 -0 3693

HS_124_r 0 0249 -0 2279 0 1382 -0 3661

HSbraιn_776_l 0 1308 1 1157 1 4804 -0 3647

Hsd_f rom_Mmd_107_r 0 1703 -1 2270 -0 8628 -0 3643

HS_from_MQbraιn_1771_r 0 0913 0 1028 0 4671 -0 3643 hsa-mιr-367 r 0 1887 -0 2475 0 1160 -0 3636

HSbraιn_52_r 0 0983 0 4883 0 8497 -0 3614

HSbraιn_399_l 0 0320 -0 0904 0 2705 -0 3609

HS from MQbrain 1901 r 0 0946 -0 4682 -0 1080 -0 3602 HSbraιn_259_r 01943 03494 07076 -03581 hsa-mιr-548b_l 00339 -03487 00094 -03581 hsa-mιr-454_r 01347 -06903 -03370 -03534

HSbraιn_570_l 01887 01544 05074 -03530

HS_from_MQbraιn_111_l 01858 -02182 01331 -03513

HS_307_r 00750 -08051 -04560 -03491

HSbraιn_538_r 00552 -00160 03321 -03481

HSbraιn_513_r 01673 -06112 -02644 -03469

Hsd_81_r 01491 -06940 -03476 -03465

HS_from_MQbraιn_1485_l 00292 -02157 01282 -03439 hsa-mιr-648_l 01943 04250 07676 -03427 hsa-mιr-331_l 00347 -04701 -01282 -03419

HS_from_MQbraιn_951_l 01078 05785 09191 -03405

HSbraιn_72_l 01616 10011 13415 -03405

HS_from_MQbraιn_315_l 01382 01929 05309 -03381

HS_from_MM_180_r 01196 -06729 -03357 -03372

HS_from_PT_20_r 01522 03244 06602 -03358

Hsd_from_Mmd_48_r 01858 -03148 00209 -03358 hsa-mιr-433_r 00772 -01074 02280 -03354 hsa-mιr-516-2_r 01597 -08140 -04802 -03337

HS_from_MQbraιn_441_l 04342 -00869 02455 -03324

HSbraιn_117_r 01454 00411 03731 -03321

HS_from_MQbraιn_330_r 00857 03556 06874 -03318 hsa-mιr-299_r 01268 03466 06783 -03317

HS_from_MQbraιn_1493_r 01390 10831 14142 -03310

HS_from_MQbraιn_1413_l 01296 00572 03880 -03308 hsa-mιr-548c_l 01216 -06506 -03199 -03307

HSbraιn_420_r 00583 01546 04847 -03301

HSbraιn_6_r 00764 02574 05872 -03298

HS_from_MM_295_l 00205 -01367 01924 -03291

HS_from_MQbraιn_2670_r 01673 03448 06730 -03282

HSbraιn_716_l 01454 01785 05044 -03260

HS_from_PT_282_l 00913 -00644 02604 -03248

Hsd_f rom_Mmd_314_r 01230 -06381 -03153 -03227

HS_from_MQbraιn_468_r 00857 00111 03325 -03213

HS_from_MQbraιn_501_l 01159 01924 05136 -03212

HSbraιn_369_r 01447 -01235 01952 -03188 hsa-mιr-653_l 00282 -02258 00912 -03170

HS 118J 03927 04518 07665 -03147 hsa-mιr-652_r 00849 -05348 -02206 -03142

HS_from_MM_310_l 01858 -05347 -02217 -03130

HSbraιn_95_l 00849 -03123 00005 -03128

HS_from_MQbraιn_29_l 01131 04126 07253 -03127

HSbraιn_174_r 01366 -07406 -04286 -03120

Hsd_7_r 01347 -00496 02607 -03103 hsa-mιr-524_r 01491 -00033 03055 -03087 hsa-mιr-412_l 00350 -01137 01947 -03085

HS_177_I 01843 -02397 00685 -03082

HS_from_MM_342_r 00772 -00065 03015 -03080

HSbraιn_970_r 01366 -06926 -03850 -03076

HS_from_PT_187_r 00327 -01851 01217 -03068

HS_from_MQbraιn_1227_l 01843 -00475 02585 -03059

HS from MQbrain 97 r 01906 02065 05122 -03058 HS_from_MQbraιn_1756 I 01390 02193 05248 -03055 hsa-let-7c_r 00501 -01593 01458 -03051

Hsd_from_Mmd_82_r 01454 -05385 -02337 -03048 hsa-mιr-624_l 00895 -04583 -01544 -03039

HS_from_MQbraιn_1183_l 01268 09448 12486 -03038

HS_from_MM_72_r 00913 -03145 -00123 -03022 hsa-mιr-497_r 00582 00098 03116 -03018

HS_207_l 01454 -07159 -04144 -03016

HS_from_MQbraιn_1297_l 00205 01527 04538 -03012

HSbraιn_794_r 01482 04585 07581 -02996

HS_from_PT_254_r 01597 07318 10312 -02994

HS_from_MM_256_r 01858 -08368 -05378 -02990

Hsd_from_Mmd_225_l 00928 -05076 -02092 -02984

HS_from_MQbraιn_1363_l 00252 00001 02974 -02973

HS_277_I 01390 -03910 -00947 -02963

HS_from_MQbraιn_1227_l 01843 -02622 00336 -02958

Hsd_96_r 01887 -05046 -02090 -02956

HS_79_I 00482 -00825 02126 -02951

HS_from_MQbraιn_664_r 00706 00091 03041 -02950

HSbraιn_796_r 00277 -01402 01547 -02949

Hsd_18_r 00393 -01922 01024 -02946

HS_292_r 01803 -06801 -03855 -02946

HSbraιn_624_l 01482 01118 04059 -02941

HS_from_MQbraιn_1097_r 01243 03204 06142 -02939 hsa-mιr-190_r 00764 -05001 -02067 -02934

HS_from_MQbraιn_180_r 01454 00609 03529 -02920

HS_189_I 01887 05895 08806 -02911

HSbraιn_381_l 01454 -08145 -05240 -02905

HSbraιn_1076_r 00660 -01027 01878 -02905 hsa-mιr-299_l 00772 -01635 01264 -02899

HSbraιn_388_r 01997 -01095 01800 -02896

HS_from_MQbraιn_1781 1 00369 -02509 00384 -02893

HS_from_MM_232_r 00727 -04188 -01303 -02886

HSbraιn_1331_r 01803 -00587 02288 -02875 hsa-mιr-633_r 01045 -04375 -01504 -02870

HS_246_I 01178 -04272 -01410 -02862

Hsd_42_r 01347 01048 03903 -02855 hsa-mιr-767_r 00239 -02413 00431 -02845

HS_292_r 01803 -06740 -03896 -02844

HS_from_MQbraιn_154_r 00772 -00165 02678 -02844

HS_from_MM_34_l 03286 -02129 00705 -02833

HSbraιn_507_l 01026 -02025 00806 -02831 hsa-mιr-130b_l 00750 -04336 -01518 -02818

HS_from_MQbraιn_1300_r 01906 -03783 -00970 -02812

Hsd_from_Mmd_157_r 00264 -01988 00821 -02808 hsa-mιr-1-1_l 00750 -03136 -00329 -02807

Hsd_from_Mmd_58_r 01587 -08765 -05960 -02805

HS_from_MQbraιn_194_l 01887 07959 10759 -02801

HS_213_I 00482 -01424 01376 -02799

HS_from_MM_32_r 00750 -01992 00806 -02797

HS_from_MQbraιn_74_r 00749 04392 07181 -02789

Hsd_46_l 00913 00904 03671 -02768

HS from PT 41 I 01646 00162 02925 -02764 HS_from_MM_208_r 01178 00831 03590 -02759

HS_212_I 00501 -02004 00752 -02756

HSbraιn_482_l 08056 01051 03806 -02754

HS_166_I 01906 09732 12478 -02746

HS_288_I 01616 06490 09235 -02744

HS_from_MM_157_l 01178 -05670 -02926 -02744 hsa-mιr-206_l 01308 -05186 -02448 -02738

HS_from_PT_101_r 00518 -01057 01677 -02735

Hsd_108_l 00474 -00852 01879 -02730

HSbraιn_532_l 00961 -01027 01698 -02725

HS 1 14 I 04078 05279 08004 -02725

HS_from_MM_18_l 00849 -00504 02213 -02717

HSbraιn_361_l 00807 02281 04996 -02715

HS_from_MQbraιn_1700_r 01010 00114 02793 -02679

HS_from_MQbraιn_1877_r 01616 07927 10605 -02679

HSbraιn_614_l 01735 -00743 01918 -02661

HS_from_MQbraιn_824_r 01447 -00312 02344 -02656 hsa-mιr-616_l 01268 -02425 00224 -02650

H sd_f rom_ M md_44_r 00849 -03018 -00377 -02641

HS_from_MQbraιn_88_l 01555 -06048 -03408 -02639

HS_from_MQbraιn_1717_r 00961 -01303 01329 -02632

HS_29_I 08454 -05409 -02781 -02629

Hsd_from_Mmd_49_l 00583 01113 03738 -02625

HS_from_PT_237_r 00723 01130 03753 -02623

HSbraιn_41_l 01522 04515 07137 -02622

HSbraιn_811_l 00260 -00122 02490 -02611

HS_219_I 00750 00321 02931 -02610

HS_from_MQbraιn_672_l 01308 02914 05518 -02604

HSbraιn_419_l 00749 -00824 01776 -02600

HSbraιn_55_l 00537 -00575 02025 -02600

HS_from_MM_331_r 01159 -01726 00869 -02594

HS_from_MQbraιn_85_l 01752 07506 10100 -02594

HS_from_MQbraιn_900_r 01060 -02078 00506 -02584

HS_from_MQbraιn_854_r 00446 -00875 01696 -02571

HS_from_MQbraιn_210_r 01243 -01029 01535 -02564

Hsd_from_Mmd_422_l 00928 -01881 00673 -02554

HS_from_PT_149_r 01943 -05868 -03316 -02552 hsa-mιr-593_r 01858 -02304 00240 -02545

HS_from_MQbraιn_833_l 01597 -05419 -02877 -02542

Hsd_f rom_Mmd_167_r 01774 01417 03959 -02541

HS_from_MQbraιn_1374_r 00838 -02929 -00392 -02536

HS_from_MQbraιn_791_r 01178 -07234 -04697 -02536

HS_281_r 01463 -01708 00827 -02536

HS_from_MQbraιn_555_r 01752 00272 02808 -02535

HS_from_MQbraιn_1126 1 01774 -06334 -03799 -02535

HS_from_MQbraιn_90_r 01390 -02479 00050 -02529

HS_17_I 00537 -00256 02273 -02529

HS_from_MQbraιn_120_l 00686 -00417 02098 -02515 hsa-mιr-30c-1_l 01491 -02525 -00024 -02500

HS_from_MQbraιn_1159_l 01975 04929 07421 -02491 hsa-mιr-647_l 01463 -00654 01833 -02487

HS_from_MQbraιn_1212_l 00498 -02370 00116 -02486

Hsd from Mmd 166 r 01060 -04404 -01919 -02485 HS_from_MQbraιn_42_l 01673 -01400 01078 -02478 hsa-mιr-382_r 01597 -02563 -00087 -02476

HS_from_MM_184_r 01196 -01915 00560 -02475

Hsd_from_Mmd_478_l 01997 00790 03263 -02474

HSbraιn_1415_r 01646 -07870 -05399 -02471

HS_141_I 01482 08423 10869 -02446

HS_from_MQbraιn_1740_r 00750 01451 03893 -02442 hsa-let-7f-1_r 01060 -02858 -00417 -02440

HSbraιn_180_l 01803 -01130 01309 -02440

HS_from_MQbraιn_609_l 01159 04251 06690 -02439

Hsd_from_Mmd_302_r 00849 -00855 01577 -02432

HSbraιn_1364_l 01858 06922 09342 -02420

HSbraιn_425_l 01491 -03661 -01243 -02418

Hsd_from_Mmd_261_r 01522 -03958 -01542 -02416

HS_from_MQbraιn_1725_l 01366 -02059 00357 -02416

HS_from_MQbraιn_542_r 00482 00882 03297 -02416

Hsd_f rom_Mmd_163_r 01906 00070 02484 -02414 hsa-mιr-98_r 00750 -03063 -00650 -02413

HS_from_MQbraιn_812_l 01414 -07725 -05315 -02410

HS_from_MQbraιn_209_r 00660 -00235 02170 -02406

HSbraιn_250_r 00772 -00569 01834 -02403

Hsd_70_r 00350 -02673 -00273 -02400

HSbraιn_272_l 00393 -02116 00282 -02398

HSbraιn_473_l 00807 -01738 00656 -02394

HS_from_MQbraιn_936_l 01587 -04116 -01725 -02391

HSbraιn_50_r 01230 -02109 00273 -02383

HS_from_MQbraιn_619_l 01243 -01904 00476 -02380 hsa-mιr-502_l 01906 -05042 -02665 -02377

Hsd_from_Mmd_154_l 01243 -01971 00389 -02360

HS_from_MQbraιn_216_l 01308 -01971 00379 -02350

HSbraιn_1377_l 01390 -00599 01746 -02345

HS_95_r 00807 -01187 01150 -02338

HS_from_MQbraιn_631_l 00913 -00162 02174 -02336

Hsd_62_l 09557 00230 02565 -02334

HSbraιn_754_r 00946 -00715 01618 -02334

HS_from_MQbraιn_467_l 01975 -00689 01635 -02324 hsa-let-7a-1_r 00857 -03519 -01201 -02319

HS_from_MM_84_r 00393 00468 02782 -02314

HS_from_PT_254_l 00750 -03623 -01323 -02300

HS_from_MQbraιn_1419_r 01491 01676 03961 -02285

HS_from_MQbraιn_1675_l 01268 -02295 -00011 -02284

HS_from_MQbraιn_117_r 00772 -02392 -00108 -02284 hsa-mιr-95_r 01997 -03852 -01575 -02277 hsa-mιr-204_l 01975 -05553 -03280 -02273 hsa-mιr-362_r 00797 -03608 -01337 -02271

HS_from_MQbraιn_604_l 01597 03646 05916 -02271 hsa-mιr-625_r 01078 00307 02577 -02270

HS_from_MQbraιn_1824_l 01382 00296 02559 -02263 hsa-mιr-329-1_r 01243 -02387 -00133 -02254

HSbraιn_114_r 00928 -01452 00796 -02248

HSbraιn_627_r 01482 -04235 -01994 -02241 hsa-mιr-770_r 01752 01895 04135 -02240

HS from MQbrain 1253 r 00475 -02381 -00141 -02240 Hsd_from_Mmd_480_r 01597 01689 03926 -02237

Hsd_from_Mmd_70_l 01482 01279 03513 -02234

Hsd_83_l 00961 -01407 00815 -02221

HS_from_MQbraιn_1855_l 06805 -01434 00785 -02220

HSbraιn_594_l 00913 04548 06763 -02215

HSbraιn_113_r 01703 00255 02461 -02206

HS_from_PT_60_l 01196 01413 03612 -02199 hsa-mιr-30b_l 01196 -01692 00494 -02186

HS_from_MQbraιn_940_r 01216 02172 04353 -02181

HS_from_MQbraιn_1469_l 00347 00551 02730 -02179

HS_74_r 00961 -01955 00222 -02177 hsa-mιr-412_r 00849 00196 02359 -02163

HS_from_MM_119_r 01159 -00200 01956 -02156

HS_189_r 00582 -01970 00183 -02154

HS_from_MQbraιn_653_l 01906 -06406 -04255 -02150

HSbraιn_652_l 01587 04008 06155 -02147

HSbraιn_720_l 01178 -00996 01151 -02147

HS_86_r 00995 -01634 00513 -02147

HSbraιn_1338_r 01243 -01516 00624 -02140

HSbraιn_687_l 01752 03318 05455 -02138

HS_from_MQbraιn_1433_r 01555 01663 03794 -02131

HS_from_MQbraιn_36_r 01887 04938 07067 -02130 hsa-mιr-604_l 00686 -01664 00462 -02126

Hsd_from_Mmd_330_l 00946 05116 07241 -02125

HS_from_MQbraιn_56_l 01146 04742 06867 -02125

HSbraιn_158_l 01597 00593 02717 -02124

Hsd_from_Mmd_527_l 01752 -01375 00745 -02120

HSbraιn_744_l 01774 -03668 -01557 -02111

Hsd_from_Mmd_23_l 01196 -02557 -00446 -02111

HS_from_MQbraιn_1294_l 05817 -02517 -00407 -02110

HSbraιn_184_r 01078 -01485 00626 -02110 hsa-mιr-659_l 00660 -01505 00602 -02107 hsa-mιr-155_r 00686 -01892 00210 -02102

HSbraιn_673_l 01587 04044 06144 -02100

Hsd_from_Mmd_93_r 00913 01826 03925 -02100

HS_from_PT_27_r 00824 -00549 01546 -02095

HSbraιn_728_l 00946 -01601 00485 -02086

HS_from_MQbraιn_1001_r 00750 -02688 -00603 -02085

HSbraιn_365_l 00895 -00665 01420 -02084

HS_from_MQbraιn_1684_r 01308 00111 02188 -02077

HS_from_MQbraιn_1340 I 00583 01185 03262 -02077

HSbraιn_661_l 01026 00881 02952 -02071

HSbraιn_102_r 01482 04705 06774 -02069

HS_50_l 01887 00232 02298 -02065

HS_from_PT_44_l 01366 -01863 00201 -02064

HSbraιn_85_r 01703 -02468 -00407 -02062

HS_from_MQbraιn_921_l 01078 01529 03587 -02058

Hsd_from_Mmd_223_r 01646 -05801 -03745 -02056

HS_from_MM_92_r 00152 -01753 00302 -02056

HS_285_r 01803 00291 02342 -02051

Hsd_from_Mmd_471_r 01887 -01205 00841 -02046

HS_from_MQbraιn_1637_r 01159 04653 06694 -02041

HSbrain 578 r 01555 -01478 00561 -02039 HS_from_MQbraιn_288_r 01646 -00080 01957 -02038

HS_from_MQbraιn_1292_r 01159 -01252 00783 -02034

HS_from_PT_299_r 00723 -00790 01233 -02022

HS_from_MQbraιn_534_l 00857 -01529 00489 -02018

Hsd_82_r 01216 -01081 00918 -01999

HS_from_MM_198_r 01943 -00866 01132 -01998

HSbraιn_677_l 01107 03804 05796 -01991

HS_77_r 01296 00324 02315 -01991

HSbraιn_480_r 01159 00211 02202 -01991

HS_67_r 00838 -02695 -00706 -01989 hsa-mιr-411_r 00582 -01454 00535 -01989

HS_from_MQbraιn_789_r 01975 01901 03883 -01982 hsa-mιr-219-1_r 01975 -04213 -02238 -01975

HSbraιn_106_r 01078 05758 07719 -01961

HS_from_MM_121_l 00961 -01851 00104 -01954 hsa-mιr-643_r 01735 -02678 -00729 -01949 hsa-mιr-523_r 00347 -00856 01090 -01946

HS_from_MQbraιn_1260_r 00824 -01165 00778 -01943 hsa-mιr-135a-2_r 01858 00702 02640 -01938

HS_303_r 08378 03686 05622 -01936

HS_281_r 01463 -01699 00236 -01935

HS_from_MQbraιn_969_l 00750 00714 02648 -01934

HSbraιn_431_r 00772 -02366 -00434 -01932

HSbraιn_705_l 00895 -00495 01436 -01931

HS_from_MQbraιn_723_l 00913 -00666 01256 -01922

HS_142_I 01858 -00642 01274 -01916

HSbraιn_359_l 00913 00903 02810 -01907

HS_from_MM_1_l 00723 -01459 00441 -01900

HS_99_r 01060 -00002 01891 -01893

HSbraιn_393_l 01243 -04464 -02580 -01883

HSbraιn_204_r 00772 -01078 00804 -01881 hsa-mιr-301_l 00646 -01249 00628 -01877

HS_from_MQbraιn_1292 I 01482 -04554 -02683 -01870

Hsd_from_Mmd_405_l 01045 -02070 -00201 -01869

HSbraιn_408_r 01616 -00881 00988 -01869

HS_from_MQbraιn_770_r 01447 -00536 01332 -01868

HS_from_MQbraιn_429_l 01463 -02247 -00393 -01854

HS_208_r 01646 03023 04876 -01854

HS_from_MQbraιn_133_r 00268 -00861 00992 -01853

HSbraιn_621_r 01146 -02361 -00510 -01851

HSbraιn_225_r 01196 01234 03079 -01844

HS_66_r 01482 -01679 00160 -01839

HSbraιn_371_r 00913 -02014 -00177 -01837

HS_from_MQbraιn_1372_l 01673 -00771 01064 -01835

HS_from_MQbraιn_108_r 00686 -01894 -00065 -01828

HS_from_MQbraιn_1088_l 01491 -02475 -00649 -01827

HS_from_MQbraιn_375_l 01943 00136 01961 -01825

Hsd_from_Mmd_480_l 01774 00106 01927 -01821

HS_91_I 01382 00988 02809 -01821

HS_from_MQbraιn_1657_r 01390 -01499 00316 -01815

HS_from_MQbraιn_1808_r 01308 03936 05746 -01810 hsa-mιr-365-2_r 01482 -05563 -03755 -01808

HSbrain 606 I 01196 01888 03691 -01803 hsa-mιr-453_l 00327 00047 01848 -01802

HS_from_PT_117_r 01230 -00026 01772 -01797

HS_217_I 01774 04782 06578 -01796

HS_from_MQbraιn_1394_l 01858 -06321 -04525 -01796

HSbraιn_374_r 00583 -01743 00053 -01796

HS_from_MQbraιn_635_r 01975 -06176 -04391 -01784

HSbraιn_717_r 00913 -02831 -01057 -01774

Hsd_37_r 01045 -01041 00732 -01773

Hsd_from_Mmd_347_l 01597 -00685 01087 -01771 hsa-mιr-191_r 01522 -02760 -00991 -01769

HS_from_MQbraιn_1649_r 00995 -02685 -00919 -01766

HS_from_MQbraιn_1272_l 09974 -00850 00916 -01766

HSbraιn_123_l 00961 00016 01781 -01765

HSbraιn_689_r 01803 -02996 -01232 -01764

HS_from_PT_139_r 01159 00516 02272 -01756

HSbraιn_16_l 04115 -01118 00634 -01752

HSbraιn_1413_l 01131 01125 02869 -01745

HS_from_MQbraιn_62_l 01045 -02962 -01218 -01744

HS_from_MQbraιn_1896_r 00772 -02758 -01017 -01741

HS_from_MQbraιn_93_r 00715 -01611 00130 -01740

HS_105_l 01906 00160 01900 -01740

HS_from_MQbraιn_283_r 01463 -02255 -00518 -01738

HSbraιn_580_r 00750 -01445 00292 -01737

HS_from_MQbraιn_914_l 01447 -01587 00150 -01737

HS_from_MQbraιn_1545_r 01060 -04218 -02482 -01736

Hsd_f rom_Mmd_410_r 00764 -01101 00625 -01725

HS_from_MQbraιn_268_r 01243 -00744 00978 -01722

HS_76_r 01178 -01154 00566 -01720

HS_from_MQbraιn_1593_r 00883 -01606 00103 -01709

HS_from_MQbraιn_681_l 01243 00405 02111 -01707 hsa-mιr-133a-1_r 00686 -00303 01403 -01706

Hsd_from_Mmd_138_l 01026 -01817 -00111 -01705

HSbraιn_509_l 01390 -01567 00138 -01705

HS_from_MQbraιn_229_l 01997 -03770 -02069 -01701

HSbraιn_1337_l 01975 -00408 01291 -01698

HS_from_MQbraιn_1773_l 01491 04936 06634 -01698

HSbraιn_62_r 00723 00515 02213 -01698

Hsd_f rom_Mmd_215_r 00750 -01552 00144 -01697 hsa-mιr-588_r 01616 -02072 -00385 -01687

HSbraιn_643_l 01752 00096 01777 -01680

Hsd_f rom_Mmd_217_r 01803 -01955 -00280 -01675

HS_from_MQbraιn_1031_r 00995 -03459 -01786 -01673

HSbraιn_468_r 00715 00630 02298 -01669

HS_from_MQbraιn_1556_r 01752 -03436 -01771 -01665

HS_from_MQbraιn_1708_l 01752 00083 01743 -01661

HS_from_MQbraιn_212_r 01997 -01164 00494 -01658

Hsd_from_Mmd_81_r 01943 -02170 -00521 -01649

HS_from_MQbraιn_691_r 01887 -03130 -01483 -01647

HS_from_PT_27_l 01906 -01018 00621 -01639

HS_190_r 01463 00420 02057 -01637

HS_from_MQbraιn_566_l 00928 00128 01755 -01627

HSbraιn_461_r 01146 -01663 -00037 -01626

HS 47 I 01803 -02518 -00898 -01620 HS_from_MQbraιn_332_l 01414 -02211 -00595 -01616

HS_from_MQbraιn_266_r 00750 -00878 00737 -01615

HS_61_r 01703 -05331 -03716 -01615

HS_from_MQbraιn_710_r 01703 01180 02786 -01606 hsa-mιr-616_r 01555 -01860 -00254 -01606

HS_from_MQbraιn_482_l 01703 -01412 00188 -01600

HS_from_MM_80_l 01906 -01170 00431 -01600 hsa-mιr-30b_r 01454 01418 03007 -01589

Hsd_from_Mmd_424_l 01555 -01584 00002 -01586

HS_292_I 04115 -00648 00934 -01582

Hsd_from_Mmd_396_l 01390 -03295 -01716 -01579

HS_from_MQbraιn_1722_l 01616 02108 03684 -01576

HSbraιn_591_l 00946 02730 04305 -01575

HSbraιn_794_l 01774 02067 03638 -01571

HS_from_MM_311_l 01673 -02655 -01088 -01567

Hsd_12_r 01131 -02890 -01328 -01562

HS_from_MQbraιn_1443_r 00849 03428 04988 -01560

HSbraιn_506_r 01587 -01682 -00125 -01557

HSbraιn_472_l 00913 -00300 01255 -01555

HSbraιn_50_l 01131 01314 02857 -01543

HS_from_PT_115_r 01752 -01110 00432 -01542

HSbraιn_696_r 01078 -00376 01164 -01540

HSbraιn_495_r 01482 01239 02778 -01539

HS_50_r 01308 -01876 -00341 -01535

HSbraιn_809_r 01906 02931 04465 -01534

HS_from_MQbraιn_1549_l 01347 -02547 -01022 -01525

HS_77_I 01858 00084 01598 -01514

HS_from_MQbraιn_699_r 01673 01013 02519 -01506

HSbraιn_111_l 05053 -01097 00400 -01497 hsa-mιr-365-2_l 00750 00933 02418 -01484 hsa-mιr-655_l 01463 -00490 00991 -01481

HSbraιn_214_l 04679 00466 01946 -01480

HS_138_I 01843 -01893 -00420 -01474

HSbraιn_139_r 01454 -01193 00278 -01471

Hsd_95_l 01906 -06306 -04846 -01460

HS_from_MQbraιn_397_l 01906 -01741 -00283 -01458

HS_from_MQbraιn_444_r 01646 01288 02734 -01446

HS_from_MM_190_l 01975 -04987 -03542 -01445

HSbraιn_690_l 01774 00326 01771 -01445 hsa-mιr-146a_r 00849 -00432 01010 -01442 hsa-mιr-550-2_r 01943 -00900 00541 -01441 hsa-mιr-296_l 01646 -00608 00819 -01427

HS_182_r 01843 -02247 -00828 -01419

Hsd_from_Mmd_176_r 01703 -00565 00852 -01417

HS_109_r 01774 -00011 01404 -01415

HSbraιn_651_r 01997 02192 03603 -01411

HS_from_MQbraιn_1517_r 01997 01558 02969 -01411

HSbraιn_231_l 00772 01866 03274 -01407

Hsd_from_Mmd_511_r 00883 -02432 -01055 -01378

Hsd_from_Mmd_530_l 01943 -02262 -00894 -01368

HS_from_MQbraιn_1365_l 01906 00966 02333 -01366

HS_from_MQbraιn_886_r 01390 00272 01632 -01360

HSbrain 771 I 01268 02639 03996 -01357 HS_from_MQbraιn_272_l 01858 00712 02065 -01353 hsa-mιr-217_r 01463 -02236 -00892 -01344

HS_from_MQbraιn_1776_r 01216 00480 01819 -01338

HS_54_r 00849 -00037 01294 -01332

HSbraιn_588_r 01997 01444 02767 -01324

Hsd_from_Mmd_501_l 01482 -04092 -02770 -01321

HSbraιn_220_r 01347 00358 01672 -01314 hsa-mιr-374_l 01774 -03352 -02048 -01304

Hsd_from_Mmd_509_l 09380 -01612 -00309 -01303

HS_from_MQbraιn_1215_l 01616 -00358 00941 -01300

HS_from_MQbraιn_968_r 01906 02716 04008 -01292

HSbraιn_75_l 01463 03039 04328 -01289

HSbraιn_593_r 01803 00733 02020 -01286

HS_from_MQbraιn_1677_r 01026 -01597 -00327 -01271 hsa-mιr-579_r 01555 -02613 -01347 -01266

HS_from_MQbraιn_496_r 01703 01682 02947 -01265 hsa-mιr-365-1_l 01803 00808 02059 -01251

Hsd_from_Mmd_500_l 01463 -01701 -00480 -01221

Hsd_from_Mmd_97_l 01735 -01030 00191 -01221

HS_from_MM_86_l 08260 -02663 -01444 -01219

HS_from_MQbraιn_1667_r 01703 -01889 -00693 -01197

HSbraιn_970_l 01752 00116 01296 -01180

HS_from_MQbraιn_55_l 01943 -00142 01033 -01175

HS_from_MM_18_r 00772 -00044 01124 -01168

HS_from_MQbraιn_266_l 01230 -01340 -00176 -01164

HS_from_MQbraιn_626_r 01906 -02955 -01793 -01162

HS_from_MQbraιn_188_l 01843 -01215 -00061 -01154 hsa-mιr-510_r 01447 -01753 -00616 -01137

HS_from_MQbraιn_22_l 01858 -01168 -00031 -01137

HS_from_MQbraιn_405_r 01906 00400 01535 -01135 hsa-mιr-132_l 01673 -01141 -00028 -01113

HS_from_MQbraιn_536_r 01555 00700 01803 -01103

HS_from_MQbraιn_686_l 01587 -01259 -00163 -01096 hsa-mιr-488_l 01414 -00494 00599 -01094

HS_278_I 01382 01250 02333 -01083

HSbraιn_590_l 01347 -00842 00232 -01075

HS_from_MQbraιn_1164_l 01454 00403 01464 -01061

HSbraιn_621_l 01843 -00817 00237 -01054

HS_from_MM_200_l 01326 -01041 00013 -01054

HSbraιn_583_r 00583 -01173 -00120 -01053

HS_from_MQbraιn_1412_l 01230 01293 02345 -01053

HSbraιn_337_r 01390 -00716 00318 -01034 hsa-mιr-568_l 01997 -01221 -00196 -01025 hsa-mιr-518e_r 01887 -01142 -00117 -01025

HS_from_MQbraιn_1346_r 01887 -02318 -01299 -01019

HSbraιn_540_l 01752 00056 01047 -00991

HS_from_MQbraιn_1261_r 01230 -00828 00160 -00988 hsa-mιr-124a-1_l 00723 00336 01293 -00957

HS_from_MQbraιn_1470_l 01178 -00139 00777 -00916

HS_from_MQbraιn_722_l 01308 -00176 00720 -00896

Hsd_from_Mmd_443_l 01673 -00381 00485 -00866

HS_from_MQbraιn_1224_r 01482 -00994 -00129 -00865

Hsd from Mmd 181 r 01159 -00374 00490 -00864 HS_223_r 01414 00531 01369 -00838

Hsd_from_Mmd_503_l 01308 -01190 -00353 -00836

HS_from_MM_288_l 01454 -00096 00740 -00836 hsa-mιr-646_r 00995 -00048 00781 -00829 hsa-mιr-638_r 00583 00812 01608 -00796

HS_56_I 01308 -00116 00680 -00796

HS_from_MQbraιn_221_r 01026 -00042 00746 -00788

Hsd_from_Mmd_253_l 01906 -00633 00133 -00767

HS_from_MQbraιn_1347_r 01906 -00721 00038 -00759 hsa-mιr-454_l 01366 -00405 00339 -00744

HS_from_MM_102_r 01347 -00463 00268 -00731

Hsd_from_Mmd_178_l 01975 -01519 -00804 -00715

HS_from_MQbraιn_1301_r 00727 00246 00959 -00712

HS_from_PT_196_l 00807 -00244 00458 -00702

HS_88_r 01296 00150 00851 -00702

Hsd_30_l 00961 00292 00977 -00685

HSbraιn_792_r 00807 00264 00947 -00683

HS_133_I 01463 -00065 00603 -00668

HS_from_MM_48_l 01366 01246 01911 -00665

HS_from_MM_150_r 00995 -00279 00375 -00654

HSbraιn_698_r 01414 -00004 00647 -00651

HS_from_MQbraιn_355_l 00807 -00045 00599 -00644 hsa-mιr-623_r 01943 -00515 00121 -00636

HS_from_MQbraιn_897_r 01268 -00204 00421 -00626 hsa-mιr-369_l 01382 -00286 00338 -00624

Hsd_8_r 01858 -00038 00586 -00623

HS_237_r 01366 00169 00784 -00616 hsa-mιr-16-1_r 01230 -00390 00196 -00586

HS_from_MQbraιn_161_l 01382 00008 00592 -00584

HS_from_MQbraιn_2087_r 01107 00153 00700 -00547

HS_from_MQbraιn_348_r 01366 -00149 00393 -00543

HSbraιn_244_l 01482 00418 00947 -00529

HS_286_r 01482 -00309 00193 -00502

HSbraιn_791_l 04298 00097 00585 -00488

HS_from_MQbraιn_716_l 01026 00412 00882 -00470

HSbraιn_692_l 01597 00513 00981 -00468

HS_from_MQbraιn_661_r 01803 00243 00554 -00310

HSbraιn_541_r 01230 00318 -00137 00456

HS_45_r 01522 00495 -00050 00546

HS_from_MQbraιn_1569_l 02259 00655 00071 00584

HSbraιn_599_r 01616 00538 -00110 00648

HS_from_MQbraιn_181_l 00983 01268 00570 00698

HS_from_MQbraιn_1263_r 00552 00127 -00594 00720

HSbraιn_222_r 01366 01026 00247 00779

HS_from_MQbraιn_859_l 01887 02026 01234 00791

HS_from_MM_124_l 01616 -00937 -01730 00794

HS_from_MQbraιn_660_l 00518 00998 00085 00913

HSbraιn_166_l 01858 -00447 -01380 00932

Hsd_from_Mmd_398_r 01414 -00587 -01524 00937

HS 113 1 01587 00450 -00512 00962

HS_from_MQbraιn_1100_r 01997 00682 -00296 00979

HSbraιn_80_l 01858 -00297 -01284 00987

HS from MQbrain 1110 I 01597 00443 -00555 00998 HS_from_MQbraιn_1127_r 01060 02349 01325 01024

HS_from_MQbraιn_38_r 01326 01501 00452 01048

HSbraιn_545_r 00142 00498 -00564 01061

HSbraιn_757_r 00824 -00055 -01133 01078

HS_from_PT_211_r 01774 -00027 -01119 01092

HS_from_MQbraιn_1091_l 01752 00075 -01034 01110

HS_from_MQbraιn_1354_r 01858 -00965 -02127 01162

HS_from_PT_91_r 01597 00486 -00679 01164

HS_from_MQbraιn_1421_l 01943 01286 00121 01165

Hsd_from_Mmd_197_l 01587 00412 -00754 01166

HS_130_l 09053 01136 -00044 01180

HSbraιn_266_r 01045 00253 -00941 01194

HS_from_MQbraιn_1845_l 01326 -00250 -01500 01250

HS_from_MQbraιn_734_l 01752 -01549 -02813 01264

HS_from_MQbraιn_1777_l 01752 -02554 -03845 01292

HS_from_MQbraιn_1747_l 01997 01017 -00294 01310

HSbraιn_177_r 01491 -01879 -03196 01316

HS_from_MQbraιn_1632_l 01216 00119 -01227 01346

Hsd_32_r 01390 00226 -01123 01350

HSbraιn_803_l 00575 -00430 -01804 01374

Hsd_from_Mmd_189_l 00764 -01958 -03349 01391

HS_from_MQbraιn_1405_l 01997 05801 04407 01394

HSbraιn_663_l 01616 01353 -00050 01403

HS_from_MQbraιn_1876_r 01673 01051 -00379 01431

HS_from_PT_134_l 01491 -02217 -03658 01441

HS_265_I 01597 01908 00446 01463 hsa-mιr-338_l 01555 -01400 -02904 01503

HS_from_MQbraιn_715_l 01326 -00648 -02180 01532

HS_from_MQbraιn_550_l 01803 -01402 -02938 01536

HSbraιn_270_r 01887 04395 02855 01540

HS_from_MQbraιn_1070_r 01326 -01357 -02898 01541

HSbraιn_32_l 01858 -01929 -03496 01568

HS_from_MQbraιn_1134_r 00686 -00065 -01636 01571

HSbraιn_316_l 03713 -01454 -03027 01573

HS_83_r 00857 00508 -01071 01580 hsa-mιr-204_r 01447 -02259 -03840 01581

HS_from_MQbraιn_57_l 01735 00953 -00629 01582

HSbraιn_305_r 01216 -01436 -03029 01593

HSbraιn_347_l 01774 -02324 -03918 01594

Hsd_24_r 01975 -00114 -01712 01598

HS_from_MQbraιn_991_r 01803 01429 -00174 01603

HS_from_MM_199_l 01463 03322 01697 01625

HSbraιn_307_r 01463 -01357 -02985 01628

HS_from_MQbraιn_70_l 01382 -01727 -03365 01638

HS_from_MQbraιn_675_l 01906 -04637 -06279 01641

Hsd_from_Mmd_155_l 01326 -01095 -02741 01646

HS_from_MQbraιn_58_l 00715 01904 00244 01660

HS_from_MQbraιn_435_r 00727 00635 -01030 01665 hsa-mιr-224_r 00961 00285 -01386 01671

HS_from_MQbraιn_1331_r 01414 -01794 -03465 01671

HS_from_MQbraιn_1793_r 00961 -01079 -02750 01671

HS_from_MQbraιn_500_r 01975 03684 02013 01671 hsa-mιr-622 I 01597 -01693 -03370 01676 hsa-mιr-196a-2_r 01382 00451 -01226 01677

HSbraιn_799_r 00824 02293 00603 01690

HSbraιn_588_l 01131 00224 -01503 01727

HSbraιn_622_r 01491 01098 -00630 01728

HS_from_MQbraιn_382_l 01326 00976 -00752 01728

Hsd_from_Mmd_371_r 00582 -00728 -02467 01739

HSbraιn_440_l 01131 -00596 -02359 01763

HS_from_MQbraιn_600_l 01366 -00334 -02099 01765

HS_from_PT_140_l 01010 02516 00718 01799

HS_from_PT_238_l 01906 -04074 -05879 01805

HSbraιn_717_l 01522 -02717 -04527 01810

HS_167_r 01597 02377 00559 01818

HS_from_PT_34_r 01752 -01093 -02912 01819

HS_from_MQbraιn_1355_r 00895 01201 -00637 01838

HSbraιn_779_r 01390 01375 -00471 01846

HSbraιn_753_r 01382 -00459 -02316 01857

Hsd_from_Mmd_237_l 00715 00317 -01542 01859

HS_from_MQbraιn_974_l 01196 -04263 -06131 01868

HSbraιn_235_l 00995 00495 -01380 01875

HS_from_MQbraιn_1143 1 01447 04623 02739 01884

HS_from_MQbraιn_1836_l 01382 00869 -01029 01899

HS_208_l 00857 01582 -00327 01910

Hsd_from_Mmd_535_r 01463 -02617 -04530 01912

HS_from_MQbraιn_1631_r 01803 -02025 -03937 01913

HSbraιn_402_l 01230 00139 -01784 01923

HSbraιn_483_r 01735 03383 01454 01928

HS_from_MQbraιn_1204_r 01454 -02815 -04745 01930

Hsd_84_r 01843 -00011 -01954 01944

HSbraιn_755_l 01943 -02320 -04270 01950

HS_from_MQbraιn_842_l 01146 02444 00494 01950

HS_from_PT_126_l 01887 01428 -00524 01953

Hsd_85_r 00347 00470 -01495 01964

HS_from_MQbraιn_81_l 00913 -01585 -03556 01971

HS_from_MQbraιn_401_l 01673 -01565 -03546 01981

HS_from_MQbraιn_1752_l 01752 01844 -00138 01982

HS_from_MM_103_l 00750 00450 -01537 01987

HS_from_MQbraιn_1420_l 01347 -01887 -03875 01989

HS_111_r 01522 -02558 -04548 01990

HSbraιn_627_l 00838 -00780 -02773 01993

HSbraιn_1414_r 01774 -02852 -04850 01998

HS 101 I 01326 -02799 -04797 01998

HSbraιn_289_r 01975 04494 02486 02008

HSbraιn_236_l 00807 00995 -01022 02017

Hsd_106_l 00849 -01324 -03348 02025

HS_from_MQbraιn_628_l 08957 00715 -01310 02025 hsa-mιr-148a_l 00528 00097 -01991 02088

HS_from_MM_251_r 00393 -00801 -02890 02089

HS_220_l 01587 00739 -01351 02090

HSbraιn_568_r 01774 00532 -01559 02091

HSbraιn_783_l 01308 -00263 -02354 02091

HS_from_MQbraιn_1748_r 01010 00386 -01705 02092

HS_from_MM_131_l 01843 -00517 -02614 02097

HS from MQbrain 819 r 01906 -03540 -05641 02101 HS_from_MQbraιn_1075_l 01230 -04380 -06483 02102

HS_119_I 00772 01335 -00767 02102

HS_from_MQbraιn_1494_r 00849 -00801 -02906 02105

HS_from_MQbraιn_1832_l 00715 -01609 -03718 02109

Hsd_from_Mmd_261_l 00849 -00120 -02232 02112

HS_39_r 01414 -02181 -04298 02117

HS_from_MQbraιn_1645_l 01646 -00691 -02820 02130

HS_62_I 01347 -03506 -05637 02131

HSbraιn_187_r 00501 00264 -01868 02133

HSbraιn_787_l 01454 04111 01961 02150

HS_from_MQbraιn_1470_r 01774 04504 02350 02154

HS_from_MQbraιn_869_l 00727 -01902 -04057 02155

HSbraιn_780_r 00501 01250 -00914 02164

HSbraιn_755_r 01975 -04185 -06350 02165

HS_58_I 01491 02550 00375 02175

HSbraιn_328_l 00824 00093 -02094 02187

HS_54_I 01454 -00577 -02771 02194

HSbraιn_644_r 01597 03969 01772 02197

HS_from_MQbraιn_72_r 00913 -00812 -03023 02212

HS_102_l 01146 -03072 -05284 02212

HSbraιn_692_r 01774 01442 -00771 02213

HS_from_MQbraιn_1164_r 01146 00905 -01309 02214

HSbraιn_25_r 00624 00766 -01466 02232

HSbraιn_336_l 06371 03315 01075 02240

HSbraιn_708_l 01196 -02608 -04850 02242

Hsd_from_Mmd_487_r 01414 -03042 -05289 02248

HS_49_r 00883 03921 01671 02250

HS_from_MQbraιn_22_r 01060 -00274 -02525 02251

Hsd_from_Mmd_52_r 01107 -04921 -07174 02253

HSbraιn_479_l 01975 03579 01326 02253

HS_from_PT_188_l 01491 -00426 -02680 02255

HS_110_r 01491 -04924 -07179 02255

HS_from_MQbraιn_941_r 00169 00176 -02083 02259

HSbraιn_210_l 01975 -01228 -03499 02270

HSbraιn_452_l 00983 00356 -01920 02276

HSbraιn_647_r 01482 -00282 -02564 02282

HSbraιn_431_l 01587 -03079 -05368 02290

HSbraιn_82_r 01447 02629 00330 02300

HSbraιn_182_r 00723 -01808 -04110 02302

HSbraιn_226_r 00501 01638 -00666 02304

HS_from_MQbraιn_1102 1 01296 -02855 -05159 02305

HS_204_r 01522 -05105 -07412 02306

Hsd_27_r 00895 03963 01656 02307

HSbraιn_12_l 08957 -00603 -02920 02317 hsa-mιr-328_r 01414 -04172 -06491 02319

HS_from_MQbraιn_1437_l 01906 -00115 -02437 02323

HS_from_MQbraιn_745_r 01887 -00589 -02916 02328

HS_191_r 01752 -03362 -05699 02336

Hsd_f rom_Mmd_120_r 01843 -01897 -04250 02353

HSbraιn_155_r 01230 01793 -00573 02366

HS_from_MQbraιn_1339_r 01107 -00438 -02806 02367

HSbraιn_135_l 00946 00917 -01464 02382

HSbrain 476 r 00474 03016 00629 02386 HS_from_MQbraιn_1072_l 00211 02237 -00152 02389

HS_from_MQbraιn_914_l 01447 -05145 -07543 02398

HSbraιn_1298_r 00750 -00314 -02713 02399

HS_from_PT_308_l 00807 00766 -01644 02410

HS_from_MQbraιn_433_l 01045 -02539 -04951 02413

HS_139_I 01491 -01113 -03536 02422 hsa-mιr-138-2_l 01997 00850 -01584 02433

HS_98_r 03012 -03911 -06348 02436

HS_from_MQbraιn_1442_l 01774 02928 00472 02456

HS_from_MQbraιn_1415_r 01997 -03303 -05761 02458

HSbraιn_380_r 01308 -01815 -04274 02459

HS_171_r 00946 -00267 -02742 02476

HSbraιn_726_r 01390 00170 -02306 02476

HS_from_MQbraιn_504_r 00723 -01830 -04323 02493

HS_from_PT_226_l 00224 01161 -01333 02494 hsa-mιr-584_r 00857 00466 -02029 02495

HSbraιn_256_r 01230 08466 05964 02502

HS_from_MQbraιn_1185_l 01131 -04464 -06973 02509

HSbraιn_703_r 00772 -02492 -05002 02510

HSbraιn_91_r 01597 -03890 -06401 02510

HS_from_MQbraιn_852_l 01060 03566 01052 02514

HS_from_MQbraιn_868_l 01616 -01609 -04128 02519

HS_from_PT_157_r 01858 -03869 -06391 02522

HS_97_r 01268 04079 01554 02524 hsa-mιr-640_l 01216 01046 -01481 02527

HS_from_MQbraιn_804_r 01390 -00330 -02871 02541

HS_from_MQbraιn_1116_r 01045 -04187 -06729 02542

Hsd_from_Mmd_491_r 00928 00936 -01626 02562

HSbraιn_3_l 01390 05138 02568 02570

HS_from_MQbraιn_1839_l 01616 -04341 -06922 02581

HS_from_MQbraιn_1357_l 01997 -00965 -03549 02584

HS_from_MQbraιn_1753_r 01597 04978 02387 02590 hsa-mιr-222_r 01906 02426 -00186 02612

HS_from_PT_128_l 01159 -01656 -04278 02622

HSbraιn_441_r 01196 -02577 -05199 02622

HS_from_MM_219_l 00913 01577 -01047 02624

HSbraιn_703_l 01010 -01804 -04430 02627

HS_from_MQbraιn_1893_r 00983 04642 02015 02627

HS_from_MQbraιn_365_r 00425 00118 -02520 02638

HS_from_MQbraιn_1750_r 00379 -03565 -06204 02639

HS_from_MQbraιn_1374_l 01045 -01628 -04296 02668

HSbraιn_141_r 01887 -00643 -03312 02669

HSbraιn_691_l 05142 -05974 -08650 02676

HS_from_MQbraιn_814_l 01243 03611 00916 02695

HS_from_MQbraιn_1426_r 00075 02004 -00691 02695

HS_from_MQbraιn_392_l 00913 01809 -00887 02696

HS_from_MQbraιn_1514_r 01975 -05681 -08383 02703

HS_from_MQbraιn_996_l 01078 -00702 -03413 02712

HS_from_MQbraιn_1882_r 01597 05063 02350 02712

HS_from_MQbraιn_140_l 01296 03493 00774 02719

Hsd_from_Mmd_391_l 00706 01694 -01026 02720

HS_from_MQbraιn_597_l 00895 -03044 -05765 02722

HS from MQbrain 437 I 01752 -02897 -05627 02730 HSbraιn_384_l 00347 01094 -01638 02732

HS_from_MQbraιn_984_l 00393 -01493 -04234 02742

HSbraιn_497_l 01887 -05058 -07804 02746

HSbraιn_1416_r 01390 -05420 -08166 02746

HS_from_MQbraιn_163_l 00501 -03703 -06453 02750

HSbraιn_43_r 01268 -00957 -03712 02755

Hsd_80_r 01735 -06000 -08786 02786

HS_from_PT_287_r 00459 01585 -01203 02788

HS_from_MM_260_l 01178 04785 01992 02793

HSbraιn_626_r 01703 -04710 -07508 02798

HS_from_MQbraιn_1537_r 01060 -02818 -05642 02824

Hsd_f rom_Mmd_413_r 00646 -01419 -04246 02827

Hsd_from_Mmd_370_r 01735 03001 00169 02832

HS_154_r 01216 -04284 -07119 02836

HS_from_MM_276_l 01146 00308 -02531 02839

Hsd_106_r 01616 04018 01163 02855

HSbraιn_22_l 01997 01279 -01588 02867 hsa-mιr-125b-2_l 01673 00719 -02185 02904

Hsd_from_Mmd_473_l 00750 00392 -02513 02905

HS_from_MQbraιn_1376_r 01673 06193 03272 02921

HS_from_MQbraιn_1675_r 00849 -01068 -03996 02929

HS_from_MQbraιn_1565_l 00501 00842 -02086 02929

HS_from_MM_39_l 00723 01386 -01547 02934

HSbraιn_662_r 01858 07747 04809 02938

HS_from_MM_174_l 00379 -00310 -03253 02943

Hsd_from_Mmd_222_l 00723 05247 02299 02947

HSbraιn_494_l 06640 00672 -02279 02951 hsa-mιr-524_l 01997 02315 -00642 02958

HS_from_MQbraιn_1006_l 00723 -02964 -05932 02968

HS_from_MM_275_r 00772 01444 -01526 02969

HS_from_MQbraιn_1444_l 05661 -02300 -05274 02974

HS_from_MQbraιn_597_r 00849 -03089 -06064 02975

HSbraιn_190_r 01975 08006 05006 03001

Hsd_from_Mmd_485_r 00501 -02526 -05532 03006

HSbraιn_250_l 01382 -00881 -03897 03015

HS_from_MQbraιn_697_l 01382 -02157 -05181 03024

HS_from_MQbraιn_560_r 01735 -04285 -07312 03027

HS_from_MQbraιn_629_r 01555 -06726 -09758 03032

HSbraιn_465_l 00946 -02773 -05814 03040

HSbraιn_252_l 00528 -01922 -04989 03067

HS_from_MQbraιn_1817_l 01482 06469 03397 03072

HSbraιn_795_r 01146 -03575 -06648 03072

Hsd_from_Mmd_117_r 01026 -02234 -05320 03086

HSbraιn_1406_l 00727 00109 -02986 03095

HSbraιn_77_l 00474 -00601 -03710 03109

HS_from_MQbraιn_71_l 00582 -03977 -07098 03120

HS_from_MQbraιn_906_l 01463 -00012 -03135 03124

HSbraιn_14_r 01010 02815 -00313 03128

HSbraιn_778_l 01843 00025 -03107 03132

HSbraιn_305_l 01597 -07574 -10710 03136

HSbraιn_726_l 01326 -06046 -09189 03143

HSbraιn_319_l 00797 00842 -02316 03159

HS from MQbrain 178 r 01390 -03678 -06837 03160 HS_from_PT_338_l 01673 -03606 -06772 03166

HSbraιn_438_r 00475 02503 -00664 03167

HSbraιn_764_r 00857 02727 -00448 03176

HS_from_MM_118_r 00446 -02376 -05555 03179

HS_from_MQbraιn_64_l 01454 02943 -00251 03193

HS_175_I 01454 -05896 -09091 03195

HS_from_MQbraιn_1877_l 00913 00926 -02269 03195

HS_200_r 00727 -03033 -06237 03204

HSbraιn_157_l 01735 -05154 -08373 03219

HS_from_MQbraιn_777_r 01131 -01654 -04873 03220

HSbraιn_437_r 00501 02708 -00515 03223

HS_from_MQbraιn_587_l 01616 -04611 -07836 03226

HS_from_MQbraιn_1792_r 00185 00272 -02956 03228

HSbraιn_168_l 01673 -03405 -06643 03238

HS_from_MQbraιn_399_l 01390 02627 -00624 03251

Hsd_42_l 00838 -03226 -06499 03272 hsa-mιr-632_l 01243 03509 00234 03275

HSbraιn_719_l 00995 03897 00612 03285

HS_from_MQbraιn_1623_r 00849 -01231 -04520 03290

HS_from_MQbraιn_1085_l 01010 -06056 -09354 03298

HS_46_I 00359 -00381 -03685 03304

HS_from_MQbraιn_235_r 01997 -04807 -08115 03308

HSbraιn_571_l 01597 -05591 -08905 03314

HS_from_MQbraιn_1633_r 01243 -03035 -06354 03319

HS_from_MQbraιn_760_l 01230 -04651 -07974 03323

Hsd_from_Mmd_324_l 00913 -03968 -07344 03376

Hsd_from_Mmd_516_r 01491 03870 00483 03387

HS_from_MQbraιn_603_r 00446 01619 -01777 03396

Hsd_from_Mmd_452_l 00459 00541 -02865 03406

HS_from_MM_118_l 01482 -05729 -09150 03421

HS_from_MQbraιn_1817_l 01482 03444 00015 03429

HS_243_I 01843 05174 01741 03433

HS 181J 01616 -07137 -10574 03437

HS_from_MQbraιn_648_r 01216 -04144 -07588 03444

HS_71_r 00144 01919 -01534 03452

HSbraιn_1423_l 00849 -02372 -05827 03455

Hsd_66_l 01522 08168 04707 03462

HSbraιn_306_r 00239 01049 -02415 03464

Hsd_88_r 00706 00816 -02651 03466

HS_from_MQbraιn_1350_l 00224 00909 -02567 03476

HSbraιn_1325_r 00409 -01016 -04506 03490

HS_from_PT_250_l 00369 05709 02216 03493

HS_from_MQbraιn_1627_r 01703 -05353 -08861 03508

HSbraιn_512_l 00895 -05385 -08915 03530

Hsd_from_Mmd_464_l 00764 -01277 -04807 03530

HSbraιn_442_r 00797 05744 02202 03542

HSbraιn_1425_l 00359 -02671 -06216 03544

HS_from_MQbraιn_129_r 01026 -03030 -06587 03556

HS_from_MQbraιn_928_r 00857 -01851 -05409 03558

HSbraιn_777_r 01735 -05204 -08772 03567

HS_from_MQbraιn_184_l 01146 07307 03738 03569

HS_262_I 00599 01304 -02281 03584

HS from MQbrain 765 I 00913 -02399 -05992 03593 HS_from_MQbraιn_968_l 01975 -08313 -11911 03598

HS_from_MQbraιn_634_r 00838 05520 01913 03607

HSbraιn_7_r 00347 -02163 -05775 03612

HS_from_MQbraιn_2669_l 00474 -01120 -04735 03615

HS_from_MQbraιn_686_r 00446 -02735 -06359 03624

HS_from_MQbraιn_822_l 01268 05832 02203 03629

HS_from_PT_308_l 00807 -00319 -03958 03639

HSbraιn_393_r 01296 02759 -00882 03642

HS_from_MQbraιn_1827_l 05863 02089 -01554 03643

Hsd_105_l 00772 -04763 -08408 03645

Hsd_from_Mmd_346_l 01010 -05632 -09279 03647

HS_from_MQbraιn_346_l 00599 -01826 -05479 03652

HS_from_MQbraιn_1806_l 01243 06662 03008 03653

HSbraιn_93_r 00723 -00190 -03846 03656

HS_from_MQbraιn_1840_l 00995 03436 -00251 03686

Hsd_107_l 00723 -02032 -05725 03693

HS_from_MQbraιn_181 OJ 01454 01897 -01807 03705

HSbraιn_122_l 00498 -04275 -07990 03715

HS_from_MQbraιn_1806_l 01243 02919 -00815 03734

HS_from_MQbraιn_1264_l 00928 07104 03360 03744

HSbraιn_583_l 00268 -02068 -05861 03793

Hsd_69_l 01382 06284 02466 03819

HS_from_MQbraιn_280_l 01997 05624 01804 03820

HS_from_MQbraιn_314_l 01268 -05418 -09241 03824

HS_from_MQbraιn_574_l 01078 07104 03274 03830

HS_299_I 05233 -00392 -04238 03846

HSbraιn_389_l 00849 -05284 -09148 03864

HS_from_MQbraιn_1250_l 01997 -04297 -08163 03866

HS_from_MQbraιn_823_l 00849 05688 01821 03867 hsa-mιr-591_r 00501 04116 00245 03870

HS_from_MQbraιn_354_r 01178 -04911 -08816 03905

HS_from_PT_283_r 01454 -07717 -11624 03907

HSbraιn_351_r 00393 -02481 -06402 03921

Hsd_from_Mmd_255_l 01078 -02783 -06711 03928

HS_from_MQbraιn_121 OJ 01997 10100 06149 03951

HSJromJ\/IQbraιn_2441_r 01616 07908 03948 03960

HSJromJ\/IQbraιn_37_r 01308 -07936 -11910 03974

HS_from_MQbraιn_1268J 01673 -08281 -12273 03991 hsa-mιr-491_r 01196 -02543 -06566 04023

HSJromJ\/IQbraιn_43_r 00393 -01919 -05962 04043 hsa-mιr-377J 00393 03186 -00863 04049

HS_from_MQbraιn_377J 00169 02996 -01079 04075

HS_from_MM_242_r 00142 -01385 -05463 04078

HSJrom_MQbraιn_1087J 00838 -03314 -07403 04089 hsa-mιr-31J 01555 01679 -02419 04098

HSJromJ\/IQbraιn_845_r 01414 02544 -01576 04120

HSJromJ\/IQbraιn_535_r 01454 12319 08186 04133

HSJrom_MQbraιn_1771J 00983 -02405 -06542 04138

HS_from_MQbraιn_1391J 00127 -01673 -05838 04165

HSbraιnJ304_r 00475 -03663 -07834 04171

HSJromJ\/IQbraιn_534_r 01060 00934 -03256 04191

HSJromJ\/IQbraιn_635J 01616 -09169 -13392 04223

HS from MQbrain 1520 I 01326 -06739 -10973 04233 HS_from_PT_95_l 01366 -08666 -12903 04236

HS_from_MQbraιn_1042_r 00303 00247 -03995 04242

Hsd_from_Mmd_42_r 01774 -07209 -11484 04275

HSbraιn_177_l 00482 -03234 -07516 04282

HS_from_MQbraιn_1481_l 00895 11221 06936 04285

HS_from_MM_218_l 00552 -05267 -09554 04287

HS_from_MQbraιn_301_l 00727 -06137 -10427 04290 hsa-mιr-324_r 00247 03174 -01119 04293

HS_14_r 00928 04778 00470 04308

HS_from_MQbraιn_420_l 00127 00841 -03489 04329

HS_from_MM_169_r 00144 -03087 -07426 04339

HS_from_MQbraιn_1137_l 00169 -02359 -06754 04395

HSbraιn_677_r 01146 -06569 -10979 04410

Hsd_41_r 01997 09793 05380 04413

HS_from_MQbraιn_1500_l 00239 06213 01785 04429

HS_from_MQbraιn_1783_r 01060 07915 03475 04439 hsa-mιr-346_l 00239 00099 -04354 04453

HS_from_MQbraιn_634_l 00928 -09387 -13843 04457

HS_from_MQbraιn_1246_l 00727 08358 03894 04464

HS_from_MQbraιn_901_r 00849 06231 01739 04492

HS_276_I 00169 -00815 -05325 04510

HSbraιn_198_l 01491 -08575 -13085 04511

HSbraιn_202_r 01597 03027 -01517 04544

HS_from_MQbraιn_1778_r 01858 10726 06180 04546

HS_241_r 01887 09239 04646 04593

HSbraιn_695_l 00895 -06791 -11390 04599

HS_from_MQbraιn_590_l 00156 01826 -02798 04624

Hsd_101_l 00857 -07444 -12116 04672

HS_from_MQbraιn_281_r 01366 -09223 -13963 04740

HS_from_MQbraιn_161_r 01216 07005 02259 04747

HS_from_MQbraιn_1541 J 01078 08304 03555 04749

HS_from_MQbraιn_65_l 00683 03926 -00826 04752 hsa-mιr-24-2_l 00185 -00415 -05184 04769

HSbraιn_518_r 00723 03909 -00880 04789 hsa-mιr-661_r 00475 00992 -03802 04793

HS_261_r 00686 -07602 -12402 04800 hsa-mιr-383_r 00473 04476 -00344 04821

HSbraιn_47_r 00750 -05031 -09862 04831

HS_from_MQbraιn_881_r 00772 06213 01375 04839

HSbraιn_293_l 00152 -01832 -06701 04869

HS_from_MQbraιn_825_r 00264 -04284 -09154 04869

HS_157_r 00205 -03871 -08785 04914

HS_from_MQbraιn_1601_r 01587 05820 00892 04928

HSbraιn_313_l 01491 -06644 -11573 04929

HSbraιn_218_l 01616 -09500 -14464 04964

HSbraιn_263_r 01803 04141 -00842 04982

HS_from_MQbraιn_736_r 00715 -06335 -11319 04985

HS_from_MQbraιn_824_l 00849 -07246 -12242 04995

HSbraιn_217_r 00205 -02148 -07164 05017

HSbraιn_625_l 01522 11058 06021 05037

HSbraιn_304_l 01522 05220 00170 05051

HS_136_r 00142 -02220 -07315 05095

HS from PT 36 I 00127 -02277 -07409 05131 HS_from_MQbraιn_340_r 01230 11696 06511 05185

HS_from_PT_201_l 00142 -00537 -05727 05190

HS_from_MQbraιn_1204 I 00347 -03953 -09152 05199

HS_38_r 01146 -08733 -13976 05243

HSbraιn_334_r 00156 01507 -03766 05273

HS_8_r 00142 01320 -04002 05322

HSbraιn_390_l 00127 -02812 -08165 05353 hsa-mιr-619_l 00764 01999 -03361 05360

HS_145_r 00913 -06142 -11533 05391

HS_from_MQbraιn_1099_r 00350 -01187 -06621 05434

HSbraιn_1363_r 01491 11096 05657 05439

HSbraιn_570_r 00347 -04967 -10440 05473

Hsd_from_Mmd_286_r 01803 13502 08009 05494 hsa-mιr-557_l 01858 17522 12007 05515

HS_289_r 01366 10558 05014 05544

HSbraιn_325_r 01196 -04936 -10526 05590

HSbraιn_553_r 00983 06125 00529 05596

HS_288_r 00995 10441 04818 05623

HSbraιn_673_r 00528 -06094 -11736 05642

HSbraιn_669_r 00446 -06296 -11967 05671

HSbraιn_684_r 00528 -06646 -12346 05700

HS_from_MQbraιn_921_r 00723 03348 -02353 05702

HS_290_r 01296 11141 05400 05740

HS_from_MQbraιn_932_l 00683 -07432 -13291 05859

HS_from_MQbraιn_458_l 00185 -02287 -08159 05872 hsa-mιr-136_l 00473 -04760 -10693 05933

HS_176_I 00144 -03321 -09329 06008

HSbraιn_1362_r 01159 10942 04901 06041

HS_from_MM_339_l 00749 -05146 -11191 06046

HSbraιn_1364_r 01326 11234 05126 06108 hsa-mιr-345_r 01382 11389 05259 06130

HS_from_MQbraιn_606_r 01463 15231 09058 06173

HS_from_MQbraιn_386_r 01774 09824 03650 06174

HSbraιn_680_r 00314 -06300 -12537 06237

HS_287_r 01026 10883 04644 06239

HSbraιn_687_r 00347 -06327 -12586 06259

HS_from_MQbraιn_453_r 01858 19060 12728 06332

HS_from_MQbraιn_1463_l 01752 15905 09464 06441

Hsd_from_Mmd_246_r 01463 00400 -06096 06496

HS_from_MQbraιn_17_r 01858 10675 04114 06561

HS_from_MQbraιn_638_l 00075 -03793 -10461 06668

HS_from_MQbraιn_809_l 01390 13436 06759 06676

HS_231_I 01752 19739 13049 06690

HS_from_MQbraιn_1168_l 01587 13948 07208 06740

HSbraιn_429_l 01752 18593 11848 06745

Hsd_from_Mmd_266_r 01107 01541 -05262 06803

HS_from_MQbraιn_63_r 00156 -02442 -09291 06849

HS_from_MQbraιn_973_l 01463 16221 09293 06928

HS_51_r 00249 -06916 -13872 06956

HS_from_MQbraιn_808_l 01646 14040 07031 07008

HS_from_MQbraιn_868_l 01616 06606 -00426 07031 hsa-mιr-517a_l 01382 20127 13048 07079

HSbrain 620 I 01454 12829 05748 07081 HSbraιn_1360_r 00824 11672 04558 07113

HSbraιn_484_l 01347 04330 -02891 07221

HS_from_MM_35_r 01943 22043 14807 07236

Hsd_from_Mmd_35_r 01735 22635 15337 07297

HS_from_MQbraιn_453_l 01296 25221 17765 07455 hsa-mιr-517b_l 01454 21153 13684 07469

HS_from_MQbraιn_800_l 01296 14132 06626 07506

HS_from_MQbraιn_666_l 01491 17216 09704 07511

HS_from_MQbraιn_1110_r 01803 22951 15252 07699

HS_from_MQbraιn_1620_r 00252 -02132 -09994 07862 hsa-mιr-517c_l 01243 21320 13398 07922

HSbraιn_26_r 01159 20135 12097 08037 hsa-mιr-520g_l 01463 14240 06190 08050

HSbraιn_366_r 01646 16560 08440 08120

HS_from_MQbraιn_1334_r 00156 -07830 -16118 08288

Hsd_13_l 01390 18885 10496 08390

HS_306_l 01463 19410 10848 08561

HS_306_l 01463 19702 11069 08633

HS_from_MQbraιn_817_l 01491 17886 09243 08643 hsa-mιr-671_l 01366 19361 10647 08714

HS_from_MQbraιn_1082_l 00183 -08412 -17267 08855

HS_from_PT_313_l 01308 19518 10482 09036 hsa-mιr-520h_l 01347 15659 06398 09261

Hsd_from_Mmd_94_l 01308 08926 -00531 09457

HS from MQbrain 273 r 01178 19679 10064 09615

HS from MQbrain 722 r 0 1045 1 4659 0 4622 1 0037

^Wilcoxon analysis: cut off p value <0.2 Upregulated small RNA expression when ratio>1 (below line) Downregulated small RNA expression when ratio<1 (above line)

Table 4c Small RNAs that are upregulated in colorectal adenocarcinomas compared to adenomas

HS from MQbrain 722 r

Table 4d Small RNAs that are downregulated in colorectal adenocarcinomas compared to adenomas

HS_101_l HS_237_r HS_76_r

HSJ 02J HS_241_r HS_77_I

HSJ 05J HS_243_I HS_77_r

HS_109_r HS_246_I HS_79_I

HS_110_r HS_261_r HS_8_r

HS_11 1_r HS_262_I HS_83_r

HS_113_I HS_265_I HS_86_r

HS_114_I HS_266_r HS_88_r

HS_118_I HS_276_I HS_91_I

HS_119_I HS_277_I HS_95_r

HS_124_r HS_278_I HS_97_r

HS_130_l HS_281_r HS_98_r

HS_133_I HS_281_r HS_99_r

HS_136_r HS_285_r HS_from_MM_1_l

HS_138_I HS_286_r HS_from_MM_102_r

HSJ 39J HS_287_r HS_from_MM_103_l

HS_14_r HS_288_I HS_from_MM_118_l

HS_141_I HS_288_r HS_from_MM_1 18_r

HS_142_I HS_289_r HS_from_MM_1 19_r

HS_145_r HS_29_I HS_from_MM_121_l

HS_151_r HS_290_r HS_from_MM_124_l

HS_154_r HS_292_I HS_from_MM_131_l

HS_157_r HS_292_r HS_from_MM_136_l

HS_166_I HS_292_r HS_from_MM_150_r

HS_167_r HS_299_I HS_from_MM_157_l

HS_17_I HS_303_r HS_from_MM_169_r

HS_171_r HS_306_l HS_from_MM_174_l

HS_175_I HS_306_l HS_from_MM_18_l

HS_176_I HS_307_r HS_from_MM_18_r

HS_177_I HS_38_r HS_from_MM_180_r

HSJ 81J HS_39_r HS_from_MM_184_r

HS_182_r HS_45_r HS_from_MM_190_l

HS_189_I HS_46_I HS_from_MM_198_r

HS_189_r HS_47_I HS_from_MM_199_l

HS_190_r HS_49_r HS_from_MM_200_l

HS_191_r HS_50_l HS_from_MM_208_r

HS_200_r HS_50_r HS_from_MM_218_l

HS_204_r HS_51_r HS_from_MM_219_l

HS_207_l HS_54_I HS_from_MM_232_r

HS_208_l HS_54_r HS_from_MM_242_r

HS_208_r HS_56_I HS_from_MM_251_r

HS_212_I HS_58_I HS_from_MM_256_r

HS_213_I HS_61_r HS_from_MM_260_l

HS_217_I HS_62_I HS_from_MM_275_r

HS_219_I HS_66_r HS_from_MM_276_l

HS_220_l HS_67_r HS_from_MM_288_l

HS_223_r HS_71_r HS_from_MM_295_l

HS 231 I HS 74 r HS from MM 310 I HS. from. _MM_311_ J HS from. MQbrain. _1227_ I HS from. _MQbrain_ _1469_ I

HS. from. _MM_32_r HS" from. MQbrain. _1227_ J HS" from. _MQbrain_ _1470_ J

HS" from. ~MM_331_ r HS. from. MQbrain. _1229_ r HS. from. _MQbrain_ _1470_ r

HS~ from. _MM_339_ J HS from. MQbrain. _1235_ I HS from. _MQbrain_ _1481_ I

HS. from. _MM_34_I HS" from. MQbrain. _1246_ J HS" from. _MQbrain_ _1485_ J

HS~ from. ~MM_342_ r HS from. MQbrain. _1250_ J HS from. _MQbrain_ _1493_ r

HS" from. ~MM_35_r HS. from. MQbrain. _1253_ r HS. from. _MQbrain_ _1494_ r

HS~ from. _MM_39_I HS from. MQbrain. _1260_ r HS from. _MQbrain_ .1500_ I

HS. from. _MM_48_I HS" from. MQbrain. _1261_ r HS" from. _MQbrain_ _1514_ r

HS" from. ~MM_6_r HS. from. MQbrain. _1263_ r HS. from. _MQbrain_ _1517_ r

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HS_from_MQbrain_777_r HSJromJVIQbrainJ996_l hsa-mir-148aj

HS_from_MQbrain_789_r HSJrOmJ3T-101_r hsa-mir-155_r

HS_from_MQbrain_791_r HSJrOmJ3T-115_r hsa-mir-16-1_r

HS_from_MQbrain_800_l HSJrOmJ3T-117_r hsa-mir-190J

HS_from_MQbrain_804_r HSJrOmJ3TJ 26 J hsa-mir-190_r

HS_from_MQbrain_808_l HSJrOmJ3TJ 28 J hsa-mir-191 j"

HS_from_MQbrain_809_l HSJrOmJ3T-I SJ hsa-mir-193aj

HS_from_MQbrain_81_l HSJrOmJ3T-134J hsa-mir-196a-2_r

HS_from_MQbrain_812_l HSJrom_PT_139_r hsa-mir-204J

HS_from_MQbrain_814_l HSJrOmJ3T-MOJ hsa-mir-204_r

HS_from_MQbrain_817_l HS JrOmJ3T J 49_r hsa-mir-206J

HS_from_MQbrain_819_r HSJrOmJ3T-157_r hsa-mir-217_r

H SJ ro m_M Qbra i n_822_l HSJrOmJ3T-187_r hsa-mir-219-1_r

HS_from_MQbrain_823_l HSJrOmJ3T-I SSJ hsa-mir-222_r

H S_f ro m_M Qbra i n_824_l HSJrOmJ3TJ gOj- hsa-mir-224_r

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HS_from_MQbrain_828_l HSJrOmJ3TJ-OIJ hsa-mir-299J

HS_from_MQbrain_833_l HSJrOm-PTJ-Hj- hsa-mir-299_r

H SJ ro m _M Qbra i n J342 J HSJrOmJ3T _226_l hsa-mir-301J

HSJromJVIQbrainJ345_r HSJrOmJ3T _237_r hsa-mir-30bJ

HSJromJVIQbrain_85J HSJrOmJ3TJ-SSJ hsa-mir-30b_r

HSJromJVIQbrain_852J HSJrOmJ3TJ-SOJ hsa-mir-30c-1 J

HSJromJVIQbrainJ354_r HSJrOmJ3T J.54J hsa-mir-31 J

HSJromJVIQbrain_859J HSJrOmJ3T _254_r hsa-mir-324_r

HSJromJVIQbrain_868J HSJrOmJ3T _27J hsa-mir-328_r

HSJromJVIQbrain_868J HSJrOmJ3T _27_r hsa-mir-329-1_r

HSJromJVIQbrain_869J HSJrOmJ3T _282J hsa-mir-331J

HSJromJVIQbrainJ38_l hsa-mir-338J

HSJromJVIQbrainJ381_r HSJrOmJ3T _287_r hsa-mir-345_r

HSJromJVIQbrainJ386_r HSJrOmJ3T _299_r hsa-mir-346J

HSJromJVIQbrainJ397_r HSJrOmJ3T J308J hsa-mir-362_r

HSJromJVIQbrain_90j- HSJrOmJ3T J308J hsa-mir-365-1J

HSJromJVIQbrain_900j- HSJrOmJ3TJSI SJ hsa-mir-365-2J

HSJromJVIQbrainJ901j- HSJrOmJ3T J338J hsa-mir-365-2_r

HSJromJVIQbrain_906J HSJrOmJ3T J34_r hsa-mir-367_r

HSJromJVIQbrain_914J HSJrOmJ3TJSGJ hsa-mir-368J

HSJromJVIQbrain_914J HSJrOmJ3TjHJ hsa-mir-369J

HSJromJVIQbrain_921J HSJromJ3T_44J hsa-mir-374J

HSJromJVIQbrainJ921j- HSJrOmJ3TJoOJ hsa-mir-375_r

HSJromJVIQbrain_928j- hsa-mir-377J

HSJromJVIQbrain_93j- HSJrOmJ3TJJSJ hsa-mir-382_r

HSJromJVIQbrain_932J hsa-let-7a-1_r hsa-mir-383_r

HSJromJVIQbrain_936J hsa-let-7cj" hsa-mir-411_r

HSJromJVIQbrainJ940_r hsa-let-7f-1_r hsa-mir-412J

HSJromJVIQbrainJ941_r hsa-mir-10b_r hsa-mir-412_r

HSJromJVIQbrainJJ51_l hsa-mir-1 -1J hsa-mir-433_r

HSJromJVIQbrainJJ68_l hsa-mir-124a-1 J hsa-mir-450-2_r

HSJromJVIQbrainJ968_r hsa-mir-125b-2J hsa-mir-451J

HSJromJVIQbrainJJ69_l hsa-mir-130bJ hsa-mir-453J

HSJromJVIQbrainJJ7_r hsa-mir-132J hsa-mir-454J

HSJromJVIQbrainJ972_r hsa-mir-133a-1_r hsa-mir-454_r

HSJromJVIQbrainJJ73_l hsa-mir-135a-2_r hsa-mir-488J

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HSbrain_102_r HSbrain_ _220_r HSbrain_ 402J

HSbrain_106_r HSbrain_ .222_r HSbrain_ 408_r

HSbrain_1076_r HSbrain_ _225_r HSbrain_ 41 J

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Hsd] _85_r Hsd. from. Mmd. _261_ J Hsd. from. Mmd. _485 _r

Hsd. _88_r Hsd. from. Mmd. .261_ r Hsd. from. Mmd. _487 _r

Hsd. _95_l Hsd] from. Mmd. ^266_ r Hsd^ from. Mmd. _49_ I

Hsd. _96_r Hsd. from. Mmd. _286_ r Hsd. from. Mmd. _491 _r

Hsd. _from_ Mmd J 07. r Hsd. from. Mmd. _302_ r Hsd. from. Mmd. _500 J

Hsd. _from_ Mmd _1 17. r Hsd] from. Mmd. !S14_ r Hsd] from. Mmd. _501 J

Hsd. _from_ Mmd J 20. r Hsd. from. Mmd. _324_ J Hsd. from. Mmd. _503 J

Hsd] _from_ Mmd _123~ r Hsd. from. Mmd. _330_ \ Hsd. from. Mmd. _509 J

Hsd. _from_ Mmd J 36. J Hsd. from. Mmd. _346_ I Hsd. from. Mmd. 511 _r

Hsd. _from_ Mmd J 38. J Hsd^ from. Mmd. _347_ j Hsd] from. Mmd. _516 _r

Hsd. _from_ Mmd J 54. J Hsd. from. Mmd. _35_r Hsd. from. Mmd. _52_ r

Hsd. _from_ Mmd J 55. J Hsd. from. Mmd. _370_ r Hsd. from. Mmd. _524 J

Hsd. _from_ Mmd J 57. r Hsd^ from. Mmd. !S71_ r Hsd] from. Mmd. _527 J

Hsd. _from_ Mmd J 63. r Hsd^ from. Mmd. _391_ j Hsd] from. Mmd. _530 J

Hsd. _from_ Mmd J 66. J Hsd. from. Mmd. _396_ I Hsd. from. Mmd. _535 _r

Hsd. _from_ Mmd J 66. r Hsd^ from. Mmd. "398_ r Hsd] from. Mmd. _58_ r

Hsd. _from_ Mmd J 67. r Hsd^ from. Mmd. _405_ j Hsd] from. Mmd. _70_ I

Hsd. _from_ Mmd J 76. r Hsd. from. Mmd. _410_ r Hsd. from. Mmd. _81_ r

Hsd. _from_ Mmd J 78. J Hsd. from. Mmd. _413_ r Hsd. from. Mmd. _82_ r

Hsd. _from_ Mmd J 81. r Hsd^ from. Mmd. _42_r Hsd] from. Mmd. _93_ r

Hsd. _from_ Mmd J 89. J Hsd. from. Mmd. _422_ J Hsd. from. Mmd. _94_ I

Hsd] _from_ Mmd _197~ j Hsd. from. Mmd. _424_ \ Hsd from Mmd 97 I

Hsd from Mmd 215 r Hsd from Mmd 44 r

Table 5a List of small RNAs as good classifiers to distinguish colorectal control from adenoma tissue

Systematic name adenoma score control score

[1 ,] HSbraιn_377_l 0 1008 -0 3695

[2,] HS_from_PT_1 14_r 0 0617 -0 2261

[3,] HSbraιn_377_r 0 0606 -0 2224

[4,] hsa-mιr-124a-3_r -0 0447 0 164

[5,] HSbraιn_411_r 0 0443 -0 1624

[6,] HS_from_MM_118_r -0 0416 0 1524

[7,] HSbraιn_398_r 0 0371 -0 1359

[8,] hsa-mιr-421_r 0 0368 -0 1348

[9,] HS_291_r 0 0361 -0 1322

[10,] HS_from_MM_169_r -0 0342 0 1255

[11 ,] hsa-mιr-124a-2_r -0 0332 0 1218

[12,] HSbraιn_458_r -0 033 0 121

[13,] HS_from_PT_114_l 0 0323 -0 1183

[14,] HS_from_MQbraιn_594_r -0 0317 0 1161

[15,] HS_from_PT_36_l -0 0308 0 1131

[16,] hsa-mιr-92-1_r 0 0306 -0 1123

[17,] HSbraιn_1437_r 0 0274 -0 1005

[18,] hsa-mιr-27a_r 0 027 -0 0992

[19,] hsa-mιr-124a-1_r -0 0266 0 0975

[20,] HS_from_MQbraιn_2700_r 0 0245 -0 0897

[21 ,] Hsd_from_Mmd_298_r 0 0242 -0 0887

[22,] hsa-mιr-92-2_r 0 0234 -0 0858

[23,] HSbraιn_52_r 0 0227 -0 0832

[24,] Hsd_from_Mmd_485_r -0 021 0 077

[25,] HSbraιn_1406_l -0 0205 0 0751

[26,] Hsd_from_Mmd_452_l -0 0185 0 0679

[27,] Hsd_from_Mmd_1 17_r -0 0182 0 0666

[28,] HS_97_r -0 0174 0 0639

[29,] HS_from_MQbraιn_79_r 0 0171 -0 0628

[30,] hsa-mιr-635_l -0 0164 0 06

[31 ,] HSbraιn_106_r 0 0147 -0 0538

[32,] HS_262_I -0 0136 0 05

[33,] HS_from_MQbraιn_1311_r 0 0135 -0 0496

[34,] HS_291_r 0 0132 -0 0486

[35,] HS_from_MQbraιn_1462_l 0 013 -0 0477

[36,] hsa-mιr-130a_r 0 0114 -0 042

[37,] HSbraιn_500_r 0 0111 -0 0408

[38,] hsa-mιr-768_r 0 0109 -0 04

[39,] HS_from_MQbraιn_1183_l 0 0108 -0 0396

[40,] HSbraιn_224_r 0 01 -0 0365

[41 ,] hsa-mιr-29a_r 0 0094 -0 0344

[42,] HSbraιn_398_l 0 0078 -0 0285

[43,] HS_71_I -0 0073 0 0267

[44,] HS_169_I 0 0068 -0 025

[45,] hsa-mιr-181c_l 0 0066 -0 0243

[46,] HSbraιn_500_l 0 0038 -0 0139

[47,] HS_from_MQbraιn_825_r -0 0038 0 0138

[48,] hsa-mιr-146a_l 0 0036 -0 0132

[49,] hsa-mιr-454_r 0 0034 -0 0124

[50,] HSbraιn_1_l 0 0025 -0 0091

[51 ,] HS_from_MQbraιn_1823_r 0 0025 -0 009

[52,] hsa-mιr-145_l 0 0014 -0 0052

[53,] HS from MQbrain 194 I 7 00E-04 -0 0024 [54,] hsa-mιr-29c_r 3 00E-04 -0 0012 [55,] HSbraιn_1384_r 1 00E-04 -4 00E-04

CLASSIFICATION COLORECTAL ADENOMA VS CONTROL

> pamr.listgenes(pamr_cgh.class.trained, pamr_cgh. class, threshold = threshold. chosen, genenames=FALSE)

Table 5b Statistical analysis

CLASSIFICATION COLORECTAL ADENOMA VS CONTROL

> pamr.confusion(pamr_cgh.class.cv, threshold = threshold. chosen) prediction tumor type adenoma control Class. Error rate adenoma 27 6 0 181818 control 3 6 0 333333 overall error rate 0.212

AFTER REMOVING THE 55 MIRNAS

> pamr.confusion(pamr_cgh.class.cv, threshold = threshold. chosen) prediction tumor type adenoma control Class. Error rate adenoma 24 9 0 272727 control 6 3 0 666667 overall error rate 0.349

Table 6a List of small RNAs as good classifiers to distinguish colorectal control from adenocarcinoma tissue

CLASSIFICATION COLORECTAL ADENOCARCINOMA VS

CONTROL

> pamr.listgenes(pamr_cgh. class. trained, pamr_cgh. class, threshold

= threshold. chosen, genenames=FALSE) carcinoma control

Systematic name score score

[1 ,] HS_from_PT_114_r 0.1516 -0.5222

[2,] HSbrain_377_l 0.1495 -0.5149

[3,] hsa-mir-92-2_r 0.1355 -0.4668

[4,] hsa-mir-92-1_r 0.1346 -0.4635

[5,] HS_from_PT_1 14_l 0.1 18 -0.4063

[6,] HSbrain_377_r 0.099 -0.341

[7,] hsa-mir-145_l 0.0883 -0.304

[8,] hsa-mir-92b_r 0.0729 -0.2512

[9,] hsa-mir-199a-2_r 0.0619 -0.2134

[10,] hsa-mir-29a_r 0.0599 -0.2064

[11 ,] HSbrain_656_l -0.0536 0.1846

[12,] hsa-mir-124a-2_r -0.0507 0.1746

[13,] hsa-mir-29c_r 0.0503 -0.1734

[14,] hsa-mir-124a-1_r -0.0475 0.1635

[15,] HS_from_PT_155_l -0.0468 0.1613

[16,] HSbrain_411_r 0.0468 -0.1612

[17,] HS_from_MQbrain_991_l -0.0443 0.1525

[18,] HS_291_r 0.0435 -0.1498

[19,] hsa-mir-27a_r 0.0433 -0.1492

[20,] HS_from_MQbrain_2700_r 0.0431 -0.1485

[21 ,] HS_from_MQbrain_2630_l -0.0417 0.1437

[22,] hsa-mir-124a-3_r -0.0417 0.1435

[23,] hsa-mir-635_l -0.0413 0.1423

[24,] hsa-let-7f-1_l 0.0405 -0.1396

[25,] hsa-let-7a-1_l 0.04 -0.1377

[26,] hsa-mir-199a-1_r 0.0393 -0.1353

[27,] hsa-let-7a-2_l 0.0384 -0.1324

[28,] HS_from_MQbrain_1792_l -0.0384 0.1323

[29,] hsa-let-7f-2_l 0.0376 -0.1295

[30,] HS_from_MQbrain_1073J -0.0373 0.1285

[31 ,] hsa-mir-564_r -0.0367 0.1263

[32,] hsa-mir-573_l 0.0355 -0.1223

[33,] HS_from_MQbrain_1320_r -0.0347 0.1197

[34,] hsa-mir-21_l 0.0328 -0.113

[35,] HS_from_MQbrain_594_r -0.0311 0.1073

[36,] hsa-mir-98_l 0.0301 -0.1037

[37,] HSbrain_638_l -0.0291 0.1001

[38,] hsa-mir-20b_l 0.0274 -0.0945

[39,] hsa-mir-768_r 0.0269 -0.0926

[40,] HSbrain_1437_r 0.0267 -0.0918

[41 ,] hsa-mir-181 c_l 0.0265 -0.0913

[42,] HS_from_MQbrain_967_l -0.024 0.0826

[43,] HS_291_r 0.0236 -0.0813

[44,] hsa-let-7a-3_l 0.0233 -0.0803

[45,] HS_from_MQbrain_855_r -0.0231 0.0796

[46,] hsa-mir-20a_l 0.0219 -0.0755 [47,] HSbrain_99_l -0.0206 0.0711

[48,] hsa-mir-181a-1_l 0.0203 -0.07

[49,] HS_from_PT_104_l -0.0201 0.0693

[50,] HSbrain_172_l -0.0199 0.0686

[51 ,] HSbrain_426_r 0.0184 -0.0634

[52,] HSbrain_398_r 0.0181 -0.0623

[53,] HS_from_MQbrain_340_l -0.018 0.0619

[54,] HSbrain_500_r 0.0179 -0.0616

[55,] HSbrain_120_r -0.017 0.0584

[56,] HS_from_MQbrain_1497_l -0.0166 0.0573

[57,] U6_snRNA 0.0156 -0.0538

[58,] hsa-let-7g_l 0.0156 -0.0538

[59,] HS_from_MQbrain_1793J -0.0156 0.0536

[60,] HS_from_MM_353_l -0.0141 0.0486

[61 ,] HSbrainJ OOJ -0.0136 0.0467

[62,] HS_from_MM_210_l -0.0132 0.0453

[63,] HSbrain_704_l -0.0131 0.045

[64,] HS_from_MQbrain_279_l -0.0124 0.0427

[65,] HS_from_MQbrain_485_l -0.0108 0.0372

[66,] Hsd_from_Mmd_328_l -0.0101 0.0348

[67,] hsa-mir-372_r -0.0037 0.0128

[68,] hsa-mir-368_l -0.0034 0.0115

[69,] hsa-mir-17_l 0.0033 -0.0114

[70,] HS_from_MQbrain_1432_l -0.003 0.0104

[71 ,] HS_from_MM_178_l -0.0029 0.0098

[72,] HSbrain_499_l -0.0028 0.0098

[73,] hsa-mir-126_r 0.0026 -0.0089

[74,] HS_from_PT_146_r 0.0025 -0.0086

[75,] hsa-mir-125a_l 0.0018 -0.0062

[76,] HS_from_MQbrain_827_l -0.0015 0.0053

[77,] HS_215_I -8.00E-04 0.0027

[78,] HS_from_MQbrain_755_l -5.00E-04 0.0016

[79,] HS_from_MM_47_r -3.00E-04 0.001

Table 6b Statistical analysis of classifier

CLASSIFICATION COLORECTAL ADENOCARCINOMA VS CONTROL > pamr.confusion(pamr_cgh. class. cv, threshold = threshold. chosen) prediction

Tumor type carcinoma control Class. Error rate carcinoma 25 6 0. 193548 control 2 7 0.222222 overall error rate 0.198

After removing the 79 miRNAs prediction tumor type carcinoma control Class. Error rate carcinoma 24 7 0. 225807 control 8 1 0.888889 overall error rate 0.365 Table 7a List of small RNAs as good classifiers to distinguish colorectal adenoma from adenocarcinoma tissue

CLASSIFICATION OF COLORECTAL ADENOMA VS

ADENOCARCINOMA

> pamr lιstgenes(pamr_cgh class trained, pamr_cgh class, threshold = thresh K)o 00 Olld chosen, genenames=FALSE)

Systematic name Ad-score Care-score

[1.] HS_from_MQbraιn_1082_l -0 0915 0 0974

[2,] HS_51_r -0 0897 0 0955

[3,] HS_from_MQbraιn_1334_r -0 0794 0 0845

[4,] HS_from_MQbraιn_1620_r -0 0596 0 0635

[5,] HS_from_MQbraιn_1099_r -0 0574 0 0611

[6,] HS_from_MQbraιn_63_r -0 0494 0 0526

[7,] HS_176_I -0 0407 0 0433

[8,] HSbraιn_687_r -0 0366 0 039

[9,] hsa-mιr-375 r 0 0342 -0 0364

[10,] HS_from_MQbraιn_458_l -0 0301 0 0321

[11.] HS_from_MQbraιn_638_l -0 03 0 032

[12,] HS_from_MM_339_l -0 0299 0 0318

[13,] HSbraιn_684_r -0 0258 0 0275

[14,] HSbraιn_680_r -0 0236 0 0252

[15,] HS_136_r -0 0233 0 0248

[16,] HS_from_MQbraιn_1204_l -0 0196 0 0209

[17,] hsa-mιr-136_l -0 0177 0 0188

[18,] HS_from_PT_36_l -0 0173 0 0184

[19,] HSbraιn_390_l -0 0168 0 0179

[20,] HSbraιn_570_r -0 0135 0 0143

[21 ,] HSbraιn_669_r -0 0122 0 013

[22,] HS_from_MQbraιn_824_l -0 011 0 0117

[23,] HS_from_MQbraιn_825_r -0 0052 0 0056

[24,] HS_from_PT_201_l -0 0032 0 0034

[25,] HS from MQbrain 1985 I 0 0025 -0 0027

[26,] HS from MQbrain 579 I 0 0022 -0 0023

Table 7b Statistical analysis of classifier

> pamr confusιon(pamr_cgh class cv, threshold = threshold chosen)

CLASSIFICATION OF COLORECTAL ADENOMA VS ADENOCARCINOMA CLASSIFICATION prediction tumor type adenoma carcinoma Class Error rate adenoma 8 0 242424 carcinoma 23 0 258065 overall error rate 0 248

AFTER EXCLUDING THE 26 MIRNAS prediction tumor type adenoma carcinoma Class Error rate adenoma 23 10 0 30303 carcinoma 15 16 0 483871 overall error rate 0 386 Table 8 Recovered small RNAs in faeces signal/backHS_ from _MQbrain J 349_ I 328.4193266

Systematic name ground1 HS_ 31 I 328.1743211

HSJram _MQbrain_ _1596_ r 435.4766611 HSbrain .168J 327.7976202

HSJram _MQbrain_ _610_r 397.2236261 HS_ from _MQbrain _1 15_r 327.5091884

HSJram _MQbrain_ J365_ r 381.7698338 HS_ from _MM_339. _r 327.2871875

HSJram _MQbrain_ J686_ j 381.0649897 HS from _MM_355 J 326.4926227

HSJram _MQbrain_ J 748_ J 379.1642471 HS 249_ J 326.2091382

HSJram _MQbrain_ _397_l 374.0176792 HS_ from _MM_216. _r 326.1851794

HSJram _MQbrain_ J006_ r 373.1830201 HS from _MQbrain _341_l 325.8932327

HSJram _PT_134_ I 371.7744239 HS .123_ J 325.8368333

HSbrain_ _367_r 365.4950355 HS_ from _MQbrain _544_r 325.7380605

HSJram _MQbrain_ _1575_ r 363.8207777 HSbrain _869_r 325.529766

HSJram _MQbrain_ _1245_ r 362.2517824 HS from _MQbrain _731_l 324.8256023

HSbrain_ .154J 356.5198479 HS from _MM_240. _r 324.7437047

Hsd_from_M md_472_r 353.9520892 HS_ from _MQbrain J 339_ I 322.8532283

HSbrain_ _797J 352.8430904 HSbrain .105J 321.4268792

HSJram _MM_315. J 352.564084 HS from _MQbrain 171 1_ r 320.9572229

Hsd_from_Mmd_167_r 352.3358142 HS from _MQbrain _1652_ r 320.4545063

HSJram _MQbrain_ _520_r 352.1386318 HS_ from _MQbrain _1470_ r 320.2896415

HS_148_ r 351.4766543 Hsd _66_ r 320.1767206

HSbrain_ .104J 351.1481239 HS 39_r 320.0335858

HSJram _MM_347. J 350.4004069 HS_ from _MQbrain _1073_ r 319.8894959

HSJram _MQbrain_ _1053_ r 350.2064947 HS_ _156_ r 319.2763913

HSbrain_ 402J 349.5145921 HS_ from _MQbrain J 376_ I 319.0687179

HSbrain_ .75OJ 346.8737514 Hsd_ 39 I 318.8240319

HSJram _MM_73_I 346.8607343 HSbrain 490_r 318.789703

HSbrain_ _783J 345.0006901 HS from _MQbrain _753_l 318.6834937

HSJram _MQbrain_ _1185_ r 344.3922571 HS_ from _MQbrain _928_r 318.1021923

HSJram _MQbrain_ _498_r 342.07876 HS_ from _MQbrain _1210_ I 318.0464645

HSJram _MQbrain_ ~684_r 341.5414126 HSbrain _202_r 317.8857843

Hsd_from_M md_424_r 340.2003175 HS_ from JVIM_351. _r 317.8521227

HS_64_I 340.1621279 HSbrain .323J 317.2801386

HSbrain_ .316 J 339.4367001 HS_ from _PT_101_ I 317.1749629

HSJram _MQbrain_ 747_l 339.3507657 HS_ from _MQbrain _559_l 316.9112294

HSJram _MQbrain_ _301_r 337.8052813 HS from _MQbrain _1 119_ I 316.6560497

HSJram _MQbrain_ J833_ r 336.9120561 HS_ from _PT_185_ r 316.2367142

HSbrain_ _393_r 336.1272016 HS_ from _MQbrain _491_l 315.5363383

HSbrain_ >61_r 335.820625 HSbrain _218_r 315.5273574

HSbrain_ 467J 335.0856427 HS_ from _MQbrain _162_r 314.656125

HSbrain_ ^259_r 334.9867442 HSbrain _802_l 314.4005359

HSJram _MQbrain_ _429_r 334.982389 HS_ 222 r 313.9881647

HSbrain_ 268J 334.6908402 HSbrain 673J 313.971615

HSbrain_ 326_l 334.5936127 HS_ from _MQbrain J 58_r 313.8141203

HSbrain_ ^365_r 333.5124629 HS_ from _MQbrain _76_l 313.7393384

HSJram _MQbrain_ _1846_ r 333.0341838 HSbrain 250J 313.5276305

HSJram _MQbrain_ _1727_ r 332.7123109 HS from _MQbrain _33_l 313.4922139

HSbrain_ _129_r 331.9994753 HS_ from _MQbrain _1237_ I 313.2573889

Hsd_from_Mmd_295_r 331.1451277 HS 25_r 313.2035431

HS_98_r 330.803132 HS from _PT_226_ r 313.0722924

Hsd_from_Mmd_510_l 330.4724501 HS from _MQbrain _1018_ I 312.5603857

HSJram _MQbrain_ _1677_ J 330.4254578 HS_ from _MQbrain _1306_ r 312.3615258

HS_38_I 330.3876378 HSbrain_ 93_l 312.1999205

HSbrain_ _273_r 329.7258072 HSbrain_ _118_r 311.3195051

HSbrain_ 431 J 329.5258621 HSbrain _355_r 310.7457981

HSbrain 668 I 328.9649666 HSbrain_731_l 310.1586585 HS_from_MQbrain_1876_r 294.6889637

HS_from_MQbrain_886_r 310.0903943 HS_from_MQbrain_1605_r 294.5310073

HS_from_PT_231_r 310 HS_19_I 294.2259027

HSbrain_1413_r 309.9504964 HS_from_MQbrain_1367_r 293.8593208

HS_from_MQbrain_1355_r 309.6691714 HS_212_r 293.7948013

HS_279_I 309.5850497 HS_from_MQbrain_198_l 293.4862508

Hsd_from_M md_246_r 309.4213909 HS_from_MQbrain_1446_r 293.2223329

Hsd_from_M md_344_r 309.0726717 HSbrain_410_r 293.1926573

HS_from_MQbrain_1797_r 308.3812108 HSJ 94J 292.9822677

HS_263_r 308.2617369 HS_from_MQbrain_1798_r 292.9376997

HS_from_MQbrain_495_l 307.6030143 Hsd_from_Mmd_198_r 292.8517224

HS_from_MQbrain_1475J 307.3970336 HS_from_MQbrain_280_r 292.4992309

HS_from_MQbrain_1890_r 307.317464 HS_from_MM_200_r 292.4872858

HS_from_MQbrain_1697_r 307.3045602 HS_from_MQbrain_1824J 292.4713609

HS_from_MQbrain_1620J 307.2296305 HS_from_MQbrain_863_r 292.4083724

HSbrain_669_l 307.2172689 HS_from_MQbrain_1344J 292.3514496

HS_from_PT_55_l 307.1963218 Hsd_70_l 292.1907862

HS_206_l 307.0627996 HSJ 71J 291.7377757

Hsd_from_Mmd_237_l 306.9716516 HS_from_MQbrain_1390J 291.6054286

HS_265_r 306.7532262 HSbrain_103_l 291.3575433

HS_from_MM_324_l 306.7520389 HS_from_MQbrain_1845_r 291.144748

HS_from_MQbrain_1701J 306.7083454 HS_from_MQbrain_566_r 291.1249796

HSbrain_166_l 305.2218421 HS_from_MQbrain_1083J 290.7735015

Hsd_from_M md_56_r 305.1038545 HSbrain_550_r 290.7409535

HS_55_I 304.7252967 HS_from_MQbrain_93_r 290.7380082

HSJ 79J 304.5575276 HS_from_MQbrain_1838J 290.6155727

HS_from_MQbrain_1 102_l 303.4601583 HS_from_MQbrain_211_l 290.3053197

HS_from_PT_92_l 303.3056853 HSbrain_92_l 290.3024103

HS_from_MQbrain_996_l 302.9472283 HS_from_MQbrain_604_l 289.730194

HSbrain_47_l 302.9456152 HS_from_MQbrain_1827J 289.495665

HS_from_MQbrain_1 134_l 302.6041466 HS_from_MM_239_l 289.3328779

HSbrain_739_l 302.4299797 HSbrain_549_l 289.1694754

HS_from_MQbrain_1504_r 302.2117858 HS_from_MQbrain_1392_r 288.9210201

HSbrain_728_r 302.1421754 HS_from_PT_237_r 288.8596386

HS_from_MQbrain_1549_r 302.1121702 H S_from_M Qbra i n_546_l 288.7897335

HS_from_PT_305_l 301.2719608 HS_from_MQbrain_850_l 288.5662281

HS_from_MQbrain_1219_l 301.2674923 HS_from_MQbrain_1675_r 288.3970715

HS_from_PT_89_l 301.0441042 HS_from_MQbrain_1601_r 288.3631003

HS_from_MQbrain_1313_l 300.2100934 HSJ29J 287.8783772

HS_197_r 299.8398179 HS_from_MQbrain_183_l 287.7450634

HSJ 39J 299.5699263 HS_from_MQbrain_574_l 287.7017103

HS_from_MQbrain_1412_r 299.4327293 HSbrain_48_l 287.6708455

HS_from_MQbrain_1 14_r 298.9587162 HS_from_MQbrain_1761J 287.6145743

HSbrain_244_r 298.9169907 HS_from_PT_28_l 287.5647925

HS_from_MQbrain_824_r 298.2022039 HS_from_MQbrain_218_l 287.5544126

HSbrain_293_r 298.0504476 HSbrain_679_l 287.4730955

HSbrain_279_r 297.4930175 Hsd_from_Mmd_98_r 286.665116

Hsd_50_l 297.3692697 HSbrain_692_r 285.9738106

HSbrain_508_r 297.2569514 HS_24_r 285.9042671

Hsd_from_Mmd_405_r 296.9247748 Hsd_38_r 285.7326061

HSbrain_39_r 296.7631653 HS_from_MQbrain_1780_r 285.521158

HS_233_r 296.5405897 HS_from_MM_289_r 285.4582707

HSbrain_1247_r 296.4550519 HS_221_r 285.3734928

Hsd_from_M md_28_r 296.3415549 HS_from_MQbrain_70_l 285.3653998

HSbrain_299_l 295.6857933 HS_154_I 285.3397575

HS 86 I 295.4181206 HSbrain 192 I 285.0443884 HS_from_MQbrain_1683J 285.0291226 HSbrain_778_l 276.1268612

HSbrain_290_l 284.9517611 HS_284_I 275.9294255

HSbrain_109_l 284.6354613 HS_21_I 275.8945186

HSbrain_628_r 284.241639 HS_from_MQbrain_737_l 275.8865362

HS_from_MQbrain_1537J 283.6533255 HSbrain_626_l 275.7891397

HSbrain_1425_l 283.5640729 HS_from_MQbrain_1832J 275.5897539

HS_from_MM_202_r 283.5284034 HS_from_MQbrain_709_r 275.3155471

HS_from_MQbrain_1509_r 283.4583708 HSbrain_1426_l 275.2703704

HSbrain_390_r 283.2625881 HS_from_MQbrain_893_l 274.9993461

HSbrain_44_l 283.2059478 HSbrain_810_l 274.8805235

HS_from_MQbrain_1307J 283.1729339 HS_from_MQbrain_736_l 274.8508496

HS_from_MQbrain_1862_r 283.0420705 HSbrain_709_l 274.820351

HS_from_MQbrain_487_r 282.9624273 Hsd_from_Mmd_258_l 274.7024515

HS_from_MQbrain_1272J 282.8549789 Hsd_from_Mmd_517_l 274.4801

HSbrain_584_r 282.7973454 HS_from_MQbrain_152_r 274.3078669

HS_from_MQbrain_1458_r 282.7887074 HSbrain_534_l 274.1093388

HS_from_MQbrain_267_l 282.6850078 Hsd_74_r 274.0203487

HS_from_MQbrain_303_l 282.3294611 HS_7_r 273.8420324

Hsd_1_l 281.9403791 HSbrain_607_l 273.6928046

HS_from_MQbrain_375_r 281.6424907 HSbrain_469_r 273.5380323

HSbrain_372_l 281.6246493 HS_122_I 273.512663

HS_from_MQbrain_1043_r 281.5762963 HS_40_l 273.499248

HSbrain_311_r 281.0626983 Hsd_69_l 273.3125807

HSbrain_404_r 280.8722291 HSbrain_932_r 273.2005064

HSbrain_328_l 280.7719926 HS_from_PT_262_r 273.0777115

HS_from_MQbrain_917_r 280.5140354 HS_124_I 273.022187

Hsd_from_Mmd_483_l 280.4528223 HSbrain_221_l 273.0060427

HS_from_MQbrain_655_r 280.3486118 HS_from_MQbrain_1816_r 272.9813113

HS_from_MQbrain_580_l 280.2794277 HS_50_l 272.9010802

HS_from_MQbrain_1720J 280.052876 HS_from_MQbrain_721_r 272.748855

HSbrain_35_r 279.8399868 HSbrain_745_r 272.6274939

HS_from_PT_43_l 279.7988575 HS_from_MQbrain_734_l 272.5872546

HS_from_MQbrain_461_r 279.2472579 HS_248_I 272.4865373

HS_from_MQbrain_2700_l 279.1948493 HS_from_MQbrain_1523_r 272.3792039

HS_134_r 278.9094666 HS_from_MQbrain_1867J 272.3572417

HSbrain_637_l 278.8901829 HS_from_MQbrain_745_r 271.8779897

HS_188_r 278.645448 Hsd_100_l 271.6852745

HS_from_MQbrain_1747_r 278.4365165 HS_from_MQbrain_1777J 271.5768067

HS_from_MQbrain_1635_r 278.3933949 HSbrain_266_l 271.4320379

HS_from_MQbrain_333_r 278.3594605 HSbrain_1424_l 271.024652

HS_from_PT_94_r 278.3423878 HS_from_MQbrain_1812_r 270.7376586

Hsd_from_Mmd_480_r 278.0451339 HS_from_MQbrain_1421_l 270.6118637

HS_from_MQbrain_1822_r 277.9643504 HS_from_MQbrain_1295_r 270.4897378

HSbrain_141_r 277.8002235 HS_from_MQbrain_1297J 270.3967365

HS_from_MQbrain_436_l 277.7371995 HS_from_MQbrain_106_l 270.3609488

HS_from_MQbrain_3_r 277.7328797 HS_from_MQbrain_325_l 270.247673

HSbrain_101_l 277.3680398 HS_from_MQbrain_1 11_r 270.1965492

HS_from_MQbrain_1394J 277.0531964 HSbrain_484_l 270.1785451

HS_from_MQbrain_496_r 276.9628577 HS_from_MQbrain_102_r 270.159337

HS_from_PT_286_l 276.7057792 HS_from_PT_44_l 269.9446191

HSbrain_729_l 276.5800842 HS_from_MQbrain_620_l 269.779924

HS_from_MQbrain_913_r 276.4621645 HSbrain_588_l 269.5888825

HS_from_MM_117_r 276.4579506 HS_from_MQbrain_1463J 269.5851659

HS_from_MM_195_r 276.4162313 HS_from_MQbrain_18_l 269.5064948

HSbrain_252_r 276.2314589 HS_from_MQbrain_688_l 269.4728687

HS from MQbrain 751 r 276.1913135 HS from MQbrain 387 I 269.3705363 HS_from_MQbrain_1633J 269.2334364 HS_230_r 262.8565928

HSbrain_536_r 269.1404787 HS_from_MQbrain_1860_l 262.7008017

HS_from_MQbrain_738_l 269.1111724 Hsd_from_Mmd_529_l 262.6611279

HSbrain_78_l 268.820699 HSbrain_161_r 262.2125657

HS_from_MQbrain_1416_l 268.5766334 HSbrain_426_r 262.208223

HS_from_MQbrain_540_l 268.4654883 HS_from_MQbrain_1889J 262.029435

Hsd_from_Mmd_141_l 268.0968571 HSbrain_61 1_l 261.8840849

HSbrain_511_r 267.9991684 HSbrain_687_l 261.7764626

HS_from_MQbrain_1 159_l 267.9987738 HS_from_MQbrain_1581J 261.626211

HSbrain_145_l 267.9664391 HS_from_PT_3_r 261.2984224

HS_from_MQbrain_1755J 267.9405008 HS_from_MQbrain_830_l 261.2050408

HSbrain_632_r 267.8498087 HS_from_MQbrain_782_r 261.0759728

HS_from_MQbrain_605_r 267.8150613 HS_from_MQbrain_947_r 261.0750459

HS_from_MQbrain_698_l 267.651359 HSbrain_152_l 261.0331392

HSbrain_43_l 267.5817178 HS_from_MQbrain_867_r 260.9771533

HS_from_MQbrain_1085_r 267.5466978 HS_from_MQbrain_238_l 260.9583211

HSbrain_283_l 267.5118039 HSbrain_315_l 260.8145615

HS_from_MQbrain_1655J 267.3276129 HS_from_MQbrain_458_r 260.7547184

H SJ ro m_M Qbra i n_576_l 267.323134 HS_from_MQbrain_1007J 260.6484254

HS_from_MQbrain_877_l 267.1360371 HSbrain_441_l 260.6089658

HS_from_MQbrain_914_l 266.9248651 HS_from_MQbrain_1709_r 260.5526526

HSbrain_581_r 266.8695989 HS_from_MQbrain_868_l 260.4645119

HSbrain_108_l 266.7753944 Hsd_42_r 260.2142458

HS_from_MQbrain_933_l 266.6934889 HS_89_I 259.9744451

Hsd_from_M md_42_r 266.6423152 HS_from_MQbrain_686_r 259.8101317

HS_111_r 266.2298017 Hsd_56_l 259.7972361

Hsd_from_Mmd_291_r 266.1652183 HS_from_MQbrain_1616_l 259.7668701

HSbrain_794_l 265.9452768 HS_from_MQbrain_1236J 259.6868468

HS_from_MQbrain_1164_r 265.941125 HSbrain_688_l 259.6527506

HS_from_PT_300_l 265.6728802 HSbrain_551_l 259.5465988

HSbrain_241_l 265.4661947 Hsd_from_Mmd_487_l 259.5343392

HS_from_MQbrain_284_r 265.4059563 HS_from_PT_214_r 259.3539306

HS_from_PT_26_l 265.3480358 HSbrain_554_l 259.3095925

HSbrain_160_l 265.1440349 HS_from_MQbrain_1715_l 259.1751881

HS_from_MQbrain_1082J 265.0804535 HSbrain_718_l 259.1468547

HSbrain_1325_l 265.0318212 HS_from_MQbrain_999_l 259.1426385

HS_from_MQbrain_1587_r 264.917603 HS_from_PT_34_r 259.0811135

HS_234_r 264.9059299 HS_from_MQbrain_960_l 258.9661306

HS_from_MQbrain_6_r 264.8578117 HS_from_MQbrain_1075J 258.9475578

HS_from_MM_295_r 264.8300478 HS_from_MQbrain_1299_r 258.8627877

HS_274_I 264.760369 HS_from_MM_83_r 258.6901737

HS_from_MQbrain_2669_r 264.5475927 HS_from_MQbrain_1874_r 258.5072003

HS_from_MM_215_l 264.546988 HSbrain_485_r 258.4877461

HSbrain_85_l 264.5381922 HS_5_I 258.4229952

HS_from_MQbrain_308_l 264.4473766 HS_from_MQbrain_927_l 258.383763

HS_from_MM_234_r 264.3415274 HS_from_MQbrain_1743_r 258.3823305

HSbrain_309_r 264.2249057 HS_87_r 258.2193761

Hsd_from_Mmd_299_l 264.045778 HS_from_MQbrain_477_l 258.0217594

HSbrain_1336_r 263.9717575 HS_from_MQbrain_920_r 257.858748

HS_from_MQbrain_1031_r 263.8971038 HS_291_I 257.3504875

HS_from_MM_153_r 263.8347068 HSbrain_776_r 257.2698457

HSbrain_167_l 263.8194016 HS_from_MQbrain_925_l 257.239961

HS_from_MQbrain_671_r 263.6821505 HS_from_MQbrain_741_r 257.2034813

HS_from_MQbrain_409_l 263.461086 HS_from_MQbrain_1459J 257.1079597

HS_from_MQbrain_1897_r 263.4341793 HSbrain_284_l 257.0803228

HSbrain 744 r 263.2337823 HS from MQbrain 977 r 256.7795957 HSbrain_1262_l 256.5894318 HS_from_MQbrain_1725_r 252.3188281

HS_from_MQbrain_413_r 256.5290041 HSbrain_207_r 252.2600469

HS_from_MQbrain_1500_r 256.5209467 HS_from_MQbrain_345_r 252.2124247

HSbrain_1377_r 256.4853012 HS_from_MQbrain_163_r 252.0716742

HS_from_MQbrain_184_r 256.4572439 HS_from_MM_318_l 252.0703286

HS_from_MQbrain_1399J 256.4469129 HS_from_MQbrain_924_l 252.0474973

HSbrain_115_r 256.2784798 HSbrainJ OJ 251.9975319

Hsd_from_Mmd_120_r 256.1765933 HSbrain_1364_l 251.9113433

HSbrain_303_l 256.101294 HS_from_PT_105_l 251.9105921

HSbrain_684_l 255.9377011 Hsd_from_Mmd_97_r 251.8796136

HSJ 15J 255.8640176 HSbrain_493_l 251.8121263

HS_from_MQbrain_1699J 255.8617681 HSbrain_1421_r 251.7829815

Hsd_17_l 255.7570196 Hsd_from_Mmd_305_l 251.5409922

HSbrain_614_l 255.7168248 HSbrain_425_r 251.4819635

HSbrain_171_l 255.6856718 HS_from_MQbrain_1627J 251.4373669

HS_from_MQbrain_67_l 255.5891945 HS_from_PT_238_l 251.4029293

HS_from_MQbrain_531_r 255.5303715 HS_238_r 251.3418893

HS_28_r 255.3509233 HS_from_MQbrain_801_l 251.3117452

HS_from_MQbrain_1 1_r 255.1937305 Hsd_from_M md_47_r 251.253006

HS_from_MM_111_r 254.8753709 Hsd_from_Mmd_204_l 251.2502954

HS_from_MQbrain_392_l 254.8014108 HSbrain_815_r 251.1910852

HS_from_MQbrain_1664_r 254.7961518 H S_from_M Qbra i n_362_l 251.1148036

HSbrain_371_l 254.7715809 Hsd_109_l 251.0897866

HS_from_MM_293_r 254.6801321 HS_from_MM_121_r 251.0682642

HS_219_I 254.6760586 HSbrain_203_l 250.9770175

HS_from_MQbrain_765_l 254.6466837 HSJ 57J 250.822208

HS_from_MQbrain_716_r 254.6415782 HSbrain_522_l 250.7517293

HS_286_I 254.4260526 HS_from_MQbrain_541_r 250.6783764

HS_from_MQbrain_475_r 254.3932773 HSbrain_49_r 250.6720929

HSbrain_151_l 254.3505933 HS_from_MQbrain_2679_r 250.6148031

HSbrain_629_l 254.3371274 HS_from_MQbrain_38_l 250.553482

HS_from_PT_235_r 254.0382243 Hsd_from_Mmd_448_r 250.5484342

HS_from_MQbrain_52_r 254.0379479 HS_32_I 250.4202101

HSbrain_240_l 253.8771621 HS_57_I 250.390488

HS_from_MQbrain_181_r 253.818416 HS_from_MQbrain_599_l 250.2861907

HS_199_r 253.7948113 HSbrain_257_l 250.1547679

HS_167_r 253.7791765 HS_from_MQbrain_672_l 249.9938404

HS_from_MQbrain_550_l 253.7757692 HS_from_MQbrain_1021J 249.9528181

HSbrain_95_l 253.768018 HS_from_MQbrain_1202J 249.8836584

HSbrain_631_r 253.7613205 HSbrain_693_l 249.866378

HS_from_MQbrain_1380_r 253.5211282 HSbrain_191_l 249.7564415

HSJ49J 253.504048 HS_from_MQbrain_1729_r 249.7095874

HS_from_MQbrain_1263J 253.4875034 Hsd_34_l 249.7070542

Hsd_from_Mmd_128_r 253.41348 HSbrain_319_r 249.6719621

HS_from_MQbrain_660_r 253.3359551 HS_from_MQbrain_1224J 249.5971643

HS_from_MQbrain_524_r 253.3349168 HSbrain_788_l 249.4670383

Hsd_from_Mmd_535_l 253.3218789 HS_224_r 249.4599231

HS_75_I 253.2833704 HSbrain_1298_l 249.2142487

HS_from_MQbrain_1808_r 253.1879056 HSbrain_800_l 249.0877273

HS_from_PT_219_l 253.1829244 HSJ 05J 249.0808996

HS_from_MQbrain_861_l 252.7877399 HS_48_I 248.6727669

Hsd_from_Mmd_303_r 252.716811 HS_from_PT_102_l 248.6580593

HS_from_MQbrain_1357J 252.6330054 Hsd_from_M md_60_r 248.5708006

HS_from_MQbrain_71_r 252.4897985 HS_from_MQbrain_744_l 248.4293356

HS_from_MQbrain_1756J 252.4873393 HSbrain_287_l 248.3731626

HS from MQbrain 1758 r 252.4287529 HSbrain 366 I 248.3201407 HSbrain_559_l 248.2908649 HSbrain_334J 243.7049445

HS_from_MQbrain_1225J 248.1163903 HSJ200J 243.6162631

HS_from_PT_115_l 248.0256549 HS_56_r 243.5447343

HS_from_MQbrain_974_l 247.9593335 H S _f rom_M Qbra i n_266 J 243.4504792

HS_from_MQbrain_1771_r 247.8706875 HSJrom_MQbrain_340_r 243.3848161

HS_from_MQbrain_1211 J 247.8586125 H S Jrom_M Qbra i n_42_r 243.2240866

HS_from_MQbrain_630_l 247.7802526 HSbrain_37J 243.2175482

HS_from_MM_336_r 247.7696355 HS_from_MQbrain_142J 243.1899123

HS_from_MM_340_l 247.7496711 Hsd Jrom JVI md_501 _r 243.1733615

HS_from_MQbrain_1752_r 247.6292267 HSJrom_MQbrainJ397_r 242.9519103

HS_from_MQbrain_338_r 247.601172 HSJrom_MQbrain_48J 242.7495036

HS_from_MQbrain_36_r 247.5789144 HS_from_PT_178J 242.7023061

H S_f ro m_M Qbra i n_866_l 247.563347 HS_from_MQbrain_1 131 J 242.6558541

HS_108_r 247.5356016 H S Jrom _M Qbra i n_59_r 242.5582379

HS_from_MQbrain_1830_r 247.4938017 HSbrain_759_r 242.5194837

HS_from_MQbrain_149_l 247.4259409 HS Jrom _MQbrain_1426J 242.4325995

HSbrain_703_l 247.3420423 HSbrain_685J 242.3863748

HS_268_r 247.3259637 HSbrainJ387_r 242.2536111

HSbrain_53_l 247.0890399 HS_236_r 242.1625453

HS_from_MM_103_l 246.9217731 Hsd_from_Mmd_412J 242.0650219

HS_26_I 246.8184302 HS Jrom_MQbrain_1501_r 242.0224401

HS_from_MQbrain_785_l 246.6323107 HSJrom_MM_208_r 241.9491489

HS_from_MQbrain_1 152_l 246.4764836 H S Jrom _M Qbra i n J562 J 241.9126377

HS_from_MQbrain_331_l 246.4586884 Hsd Jrom JVImd_477_r 241.8020501

HS_from_MQbrain_1673_r 246.4248334 HSJrom_MQbrainJ342_r 241.7880108

HSJ63J 246.3435123 HS _from_MQbrain_1803J 241.674899

HS_from_MQbrain_155_r 246.3195924 HSbrain_107J 241.6141397

HSbrain_428_l 246.1892116 HSbrain_717J 241.5872727

HSbrain_1360_l 246.1741425 HSbrain_291J 241.3015643

HSbrain_701_l 245.9313661 HSJrom_MQbrain_482_r 241.2886123

HS_from_MQbrain_129_l 245.6975055 Hsd_12J 241.2816211

HSbrain_424_l 245.6897519 HS_from_PTJ30J 241.2340994

HS_from_MQbrain_163 OJ 245.6614642 HSJrom_MQbrain_770J 241.0771247

HSbrain_680J 245.548398 HSJrom_MQbrainJ543J 240.9192683

HSJrom_MQbrain_560J 245.4991032 HSJrom_MQbrainJ336J 240.8802238

HSJrom_MQbrainJ362J 245.4814067 HS Jrom_MQbrain_1417_r 240.8593014

HS_from_MM_175J 245.4785201 HSJrom_MQbrainJ902_r 240.8313662

HSJrom_MQbrain_229_r 245.4629526 Hsd Jrom JVI md_44 J 240.8110271

HSJ 90J 245.2188679 HS Jrom_MQbrain_123_r 240.7866904

HSJrom_PT_285J 244.8939459 HSJrom_MQbrain_739_r 240.7727305

HSbrain_6_r 244.8860331 HSJrom_MM_87J 240.7726111

Hsd_36_r 244.879207 HSbrainJ352J 240.7492888

HSJrom_PT_280_r 244.6775996 HSbrain_796J 240.5926111

HSJrom_MQbrainJ352_r 244.6680722 HsdJrom_MmdJ277_r 240.442969

HSJ 8J 244.6303758 HSJ3J 240.4257169

HS Jrom_MQbrain_318J 244.3815927 H S_f rom_M Qbra i n_82_r 240.3655142

HS_from_MM_115J 244.343368 H S_f rom_M Qbra i n_766 J 240.1728548

HS _from_MQbrain_1804J 244.2239598 HS_from_MM_45J 240.1478843

HsdJrom_Mmd_399J 244.1887779 HSbrain_621J 240.1453763

HSbrain_456J 244.1455475 HSJrom_MQbrainJ534_r 240.0925796

HS Jrom_MQbrain_1623_r 244.0389624 HS Jrom_MQbrain_146_r 240.0908888

HS_304_r 244.034349 HS_195_r 240.0699517

HSJrom_MQbrain_1261_r 243.9532889 HSbrain_439_r 240.0466077

HS_from_MQbrain_1227J 243.816199 HSJ35J 240.0227021

HsdJromJVImdJ52_r 243.7569251 HSJrom_MQbrain_412_r 239.9320244

HSbrain 1414 I 243.7148738 HS from MQbrain 590 r 239.9048346 HSJ 98J 239.6726 HS_218_r 235.8613357

HSbrain_41_l 239.6624516 HS_from_PT_91_l 235.8215625

Hsd_from_Mmd_185_l 239.5086227 HSbrain_702_l 235.7253395

HS_from_MQbrain_940_r 239.4870149 HS_168_r 235.6020265

HS_from_MQbrain_635_r 239.4679434 HSbrain_821_r 235.4984573

Hsd_from_Mmd_112_l 239.465298 HS_from_MQbrain_965_l 235.4627068

HS_from_MQbrain_257_l 239.4468171 HS_from_MQbrain_1813_l 235.1182093

Hsd_from_Mmd_266_r 239.3412808 HS_72_r 235.0075281

HS_from_MQbrain_789_l 239.2174834 HSbrain_88_r 234.9973414

HS_from_MQbrain_1028J 239.0895004 HS_from_MQbrain_447_l 234.9547185

HSJ 01J 239.0332153 HSbrain_784_r 234.6735882

HS_from_MQbrain_941_l 238.8667114 HS_from_MQbrain_582_r 234.546672

HS_from_MQbrain_1781_r 238.7683976 HSbrain_66_r 234.5308069

HS_from_PT_158_l 238.7177237 HSbrain_361_l 234.5281831

HS_from_MQbrain_1 163J 238.6802874 HS_from_MQbrain_360_r 234.4085303

HS_from_PT_210_r 238.5965 HS_from_MQbrain_1632J 234.3869839

HS_from_MQbrain_642_r 238.5808146 HS_from_MQbrain_1843_r 234.2751382

Hsd_from_Mmd_78_l 238.3908975 HSbrain_317_l 234.263649

HSbrain_569_l 238.3876463 HS_from_MQbrain_539_r 234.1938897

HSbrain_219_r 238.381585 HSbrain_460_l 234.1480162

HS_58_I 238.3731335 HSbrain_518_l 234.0304825

HS_from_MQbrain_336_l 238.3456325 HS_from_MQbrain_1865_r 233.9908466

HS_from_MQbrain_399_l 238.3085443 HS_246_I 233.9810458

HS_from_MM_227_l 238.2555243 HSJ 19J 233.7784735

HS_from_MQbrain_270_l 238.2332356 HS_285_r 233.586665

HS_from_MQbrain_1855J 238.2044165 HS_from_MQbrain_1331_r 233.5757256

HS_from_MQbrain_1706_r 238.0686643 HS_from_MQbrain_89_r 233.5080048

Hsd_from_Mmd_518_r 238.0578899 HS_from_MQbrain_1672_r 233.4867676

HS_from_MQbrain_1625_r 238.0330045 HS_from_MQbrain_807_r 233.4564439

HSbrain_363_r 237.9427646 Hsd_from_Mmd_215_l 233.3659358

HSbrain_98_l 237.5428289 HS_from_MQbrain_889_r 233.1847619

Hsd_18_l 237.5322474 HSbrain_1408_r 233.1511963

HS_from_MQbrain_398_r 237.4649699 HS_from_MQbrain_404_l 233.1396668

HS_from_MQbrain_1754J 237.3450153 Hsd_107_r 233.060561

Hsd_103_r 237.3131276 HS_from_MQbrain_121_r 232.9199135

HS_from_MQbrain_1 167J 237.3112369 Hsd_21_l 232.8737255

HS_from_MM_67_r 237.2897545 HS_from_MQbrain_1877_r 232.7961089

HSbrain_941_l 237.1641025 HS_from_MQbrain_644_l 232.7594872

HS_from_MQbrain_723_r 237.156234 HSJ OJ 232.7452901

HS_from_MQbrain_750_r 237.0499841 HS_from_MQbrain_1848J 232.6567474

HSbrain_134_l 237.0267014 HSbrain_613_l 232.5256391

HS_from_MQbrain_884_r 236.9294285 HS_from_MQbrain_363_l 232.4863871

Hsd_from_Mmd_301_l 236.8337487 Hsd_from_Mmd_353_l 232.4164195

Hsd_from_Mmd_511_l 236.8080344 HS_from_MQbrain_1260J 232.4018345

HSbrain_292_l 236.7032475 HS_from_MQbrain_69_r 232.3221693

Hsd_from_Mmd_186_l 236.6576528 HS_from_MQbrain_1190_r 232.298263

HS_from_MQbrain_108_l 236.6551839 HS_from_MQbrain_1759_r 232.1142508

HS_from_MQbrain_330_r 236.6286556 HS_275_I 232.0800842

Hsd_from_Mmd_270_l 236.4570545 HSbrain_74_l 231.9729611

HS_from_MQbrain_1574J 236.4214286 HS_from_MQbrain_1873_r 231.9697734

HS_289_I 236.2167396 HSbrain_307_r 231.9591602

HSbrain_520_l 236.1868036 HSbrain_749_r 231.9379385

HS_from_MQbrain_1681J 236.084045 HS_from_MQbrain_386_r 231.6815526

HSbrain_723_l 236.0439796 HS_from_MQbrain_1387J 231.6723487

HS_from_MQbrain_1420_r 235.9747391 HS_from_MQbrain_1661J 231.520072

HS from MM 102 I 235.9016922 HSbrain 440 I 231.4604735 HSbrain_690_l 231.2618802 HSbrain_75_l 227.0689221

HS_from_MQbrain_370_r 231.2423353 HSbrain_220_l 226.9273128

HS_121_r 231.1610876 HSbrain_155_l 226.8778631

HS_from_MQbrain_1447_r 231.1590957 HSJrom_MQbrain_442_r 226.8297266

Hsd_82_l 231.1408694 HSbrain_150_r 226.7664934

HS_from_MQbrain_591_l 230.9251337 HSJrom_MQbrainJ900_l 226.6983928

HS_from_MQbrain_1437_r 230.8888026 HSJrom_MM_273J 226.6169054

Hsd_72_r 230.8138644 HS_227_r 226.5480615

HS_from_MQbrain_951_l 230.432556 HS_173_r 226.5087437

HS_from_PT_295_l 230.1962907 HS Jrom_MQbrain_1719_r 226.4594554

Hsd_from_Mmd_123_l 230.1089517 HSbrain_306_r 226.3244274

HS_from_MQbrain_722_r 230.0329269 HSJrom_MQbrain_1471J 226.2752381

HSbrain_612_l 229.9874033 HS Jrom_MQbrain_1323_r 226.2120415

HS_from_MQbrain_20_r 229.8506554 HSbrain_227_r 226.199823

Hsd_from_Mmd_95_l 229.7701711 HSbrain_359_r 226.1695269

HS_from_MQbrain_973_l 229.669574 HsdJrom_Mmd_147J 226.1156692

HSbrain_70_l 229.5640633 HSbrain_301_l 226.109583

Hsd_111_l 229.5515148 HSbrain_231_l 226.0585846

HS_from_MM_305_l 229.466534 HSJrom_MQbrain_221_l 226.0465685

HS_240_r 229.4510162 HSbrain_45_r 226.0306347

HS_from_MQbrain_840_l 229.3759793 HS Jrom_MQbrain_1768 J 226.0249343

HS_from_MQbrain_1668_l 229.3696849 HS_135_r 225.9650344

HS_from_MQbrain_372_l 229.299134 H S Jrom_M Qbra i n_74_r 225.8922409

HS_from_MQbrain_1542_r 229.2584359 HSbrain_713_l 225.8656496

HSbrain_708_l 229.246264 HSJrom_MQbrain_369_r 225.8273521

HSbrain_808_l 229.1617442 HSbrain_67_l 225.7697699

HS_from_MQbrain_1891J 228.912446 HS Jrom_MQbrain_1239 J 225.7278011

HSbrain_527_r 228.8704808 HSbrain_51 OJ 225.5054446

HS_305_l 228.659446 HSJrom_MQbrain_428_r 225.496121

HSbrain_769_r 228.6374424 HSbrain_188_r 225.4205714

HS_from_MQbrain_911_r 228.6253218 HSbrainJ226_r 225.405043

H SJ ro m_M Qbra i n_553_l 228.565067 HSJrom_MQbrainJ533J 225.4036486

HS_from_PT_325_r 228.4703996 HS Jrom_MQbrain_1215_r 225.3953662

HSbrain_793_r 228.4549548 HSJrom_MM_174_r 225.3789785

HSbrain_457_l 228.4521117 HSJrom_MQbrain_47J 225.3526192

HS_217_I 228.449758 HSJrom_MQbrain_472_r 225.3108408

HSbrain_420_r 228.3614012 HSbrainJ513_r 225.3093848

HS_from_MQbrain_788_r 228.3312808 HS Jrom_MQbrainJ31 OJ 225.1889153

HS_from_MQbrain_845_r 228.2389891 HSJ300J 225.109114

Hsd_from_Mmd_371_l 228.1350664 HSJrom_MQbrain_249J 225.0944779

HS_from_MQbrain_140 OJ 228.1061615 HSbrain_90J 225.0706303

HSbrain_182_r 228.0472357 HSJrom_MQbrain_707J 224.9895326

HSJrom_MM_179J 228.0284987 HS Jrom_MQbrain_1641 J 224.9752825

HS Jrom JVIQbrairM 696_r 227.6895821 HSbrain_1210_r 224.6749935

HS Jrom JVIQbrairM 631_r 227.5696524 HS_34_r 224.6642585

HSbrainJ3_r 227.4862458 HSJrom_MQbrain_612_r 224.6357358

HSJrom_PT_112J 227.4432793 HSbrain_144_r 224.6332678

HS Jrom _MQbrainJ318_r 227.3219021 HS Jrom_MQbrain_1599J 224.6258779

HSJrom_MQbrain_1 120J 227.2890626 HS Jrom_MQbrain_1553_r 224.6151091

HS Jrom_MQbrain_1741 J 227.287559 HSbrainJ54J 224.5049166

HS Jrom_MQbrain_1360J 227.2860027 HSJromJVIQbrain_903_r 224.4989842

HSbrain_514J 227.2074795 HSJrom_MQbrainJ203J 224.3395248

HS Jrom_MQbrain_1794_r 227.1557202 HSbrain_391J 224.3011525

HS Jrom_MQbrain_1869 J 227.1108561 HS Jrom_MQbrain_1084_r 224.2471514

HSbrain_767_r 227.1006295 HSbrainJ212J 224.1025327

Hsd from Mmd 157 I 227.0715861 HSbrain 148 r 224.0526161 HSbrain_183_r 224.0444529 HS_from_MQbrain_1259J 220.6733716

HS_from_MQbrain_1001_r 223.8116976 HS_from_MQbrain_1095_r 220.5708398

HS_from_MM_171_r 223.7805313 HSbrain_610_r 220.5552561

HS_from_MQbrain_1393_r 223.7656716 HS_from_PT_163_r 220.5509774

HSbrain_677_l 223.7296488 HS_from_MQbrain_806_l 220.5421957

HS_from_MQbrain_1608_l 223.6803882 Hsd_83_r 220.5378697

HS_from_MQbrain_1279_r 223.6755379 HS_from_MQbrain_1545J 220.4322592

HS_from_MQbrain_1318_l 223.6306158 HSbrain_1409_r 220.3723662

HS_142_I 223.5805612 HS_from_MQbrain_171_r 220.3354018

HS_from_MQbrain_1398J 223.4944603 HS_from_MQbrain_99_r 220.3197222

HS_from_MQbrain_278_l 223.3803128 HS_from_MQbrain_97_r 220.2493082

HS_from_PT_258_l 223.3578239 HSbrain_483_l 220.2067855

HSbrain_665_l 223.3549301 HS_from_PT_56_r 220.1817978

HSbrain_194_l 223.3237532 HSbrain_738_r 220.0942656

HS_from_MQbrain_828_l 223.2821181 HSbrain_335_l 220.0028261

HS_from_MQbrain_1353_r 223.0961628 HS_44_I 219.9850868

HSbrain_537_r 223.0610428 HSbrain_434_l 219.982723

HS_from_MM_176_r 222.9246348 HSbrain_419_l 219.8793357

HS_from_MQbrain_40_r 222.7083501 HS_from_MQbrain_706_l 219.6839321

HS_from_MQbrain_54_r 222.6947248 HSbrain_305_r 219.5650075

HS_from_MQbrain_219_l 222.5900237 HS_from_MQbrain_297_l 219.3559964

Hsd_29_r 222.5746007 HS_from_MQbrain_1814_r 219.2553574

HSbrain_664_r 222.5408696 HS_from_MQbrain_391_r 219.2029092

HS_from_MQbrain_28_r 222.5267448 HSbrain_479_l 219.1097463

HSbrain_879_r 222.3891398 HS_from_MQbrain_1 160J 219.0375254

HSbrain_110_r 222.3856849 HS_283_r 219.0305275

HS_from_MQbrain_459_l 222.3828955 HS_from_MQbrain_1454_l 218.93675

HSbrain_186_r 222.3706738 HS_256_r 218.9200582

HS_from_MM_335_r 222.293289 HS_from_MQbrain_181 OJ 218.9019542

HSbrain_593_r 222.0517315 HS_from_MQbrain_724_l 218.8401444

HSbrain_18_l 222.0054178 HSbrain_676_l 218.8004656

HSbrain_785_r 221.9470784 HSbrain_386_l 218.7869488

HSbrain_318_l 221.848446 HS_from_MQbrain_427_l 218.7011984

H S_from_M Qbra i n_56_l 221.5946492 Hsd_from_M md_96_l 218.6585211

HS_from_PT_27_r 221.573516 HS_from_MQbrain_650_r 218.5666187

HS_from_PT_121_r 221.5383439 HSbrain_740_r 218.5007167

HSbrain_560_l 221.4874069 HS_from_MQbrain_1 116_l 218.2961635

HS_from_MQbrain_1345J 221.4839913 HS_from_MQbrain_272_l 218.2733075

Hsd_from_Mmd_430_r 221.4427335 HSbrain_210_l 218.1425564

HS_from_MQbrain_1241 J 221.397103 Hsd_from_Mmd_526_r 218.1302929

HS_from_MM_80_l 221.3749747 HS_from_MQbrain_1364J 218.0461843

HS_from_MQbrain_1621_r 221.3394861 HS_from_MQbrain_1379J 217.8911784

HS_166_I 221.2754845 HSbrain_547_r 217.8399451

HS_83_I 221.1440492 HS_from_MQbrain_1750_r 217.7023298

HS_from_MM_338_l 221.1267321 HS_from_MQbrain_421_r 217.599171

Hsd_71_l 221.0863989 HS_165_r 217.5678412

HS_from_PT_64_r 221.0400632 Hsd_from_Mmd_245_r 217.480266

HS_from_MQbrain_448_l 221.0380546 H S_from_M Qbra i n_664_l 217.4766553

HS_from_MQbrain_1807J 220.9858095 HS_from_MQbrain_538_l 217.3956368

HS_170_r 220.9849091 HS_from_MQbrain_626_r 217.3494318

HSbrain_735_l 220.9821714 HS_from_MQbrain_1619_r 217.0923928

Hsd_from_Mmd_100_l 220.9485794 HSbrain_204_r 217.0811451

HSbrain_209_r 220.8283824 HS_from_MQbrain_715_l 216.9853807

HS_from_MQbrain_1645_r 220.7719103 HS_from_MQbrain_1090J 216.9617848

HS_from_MQbrain_919_r 220.7669007 HSbrain_132_r 216.9340307

HS from MQbrain 1027 r 220.7446535 HS from MQbrain 935 r 216.9266428 HSbrain_620_l 216.6725849 HSbrain_288_l 213.7938445

HS_from_MM_14_r 216.6538843 HS_from_MQbrain_449_l 213.7795306

HSbrain_741_l 216.6387437 HS_from_MQbrain_743_l 213.7726216

HS_from_MQbrain_648_r 216.5701764 HS_from_MQbrain_890_l 213.7000098

HSbrain_51_r 216.5598747 HS_from_MQbrain_258_l 213.6672002

HS_137_r 216.3781618 Hsd_37_l 213.5626033

Hsd_from_M md_20_l 216.2744272 HSbrain_388_r 213.3920423

HSbrain_32_l 216.2330231 HS_from_MQbrain_1363_r 213.3710646

HS_from_MQbrain_1382J 216.2287654 HSbrain_181_r 213.2667334

HS_from_MQbrain_87_l 216.1747613 HS_from_MQbrain_609_l 213.1909341

HSbrain_130_l 216.1273018 HSbrain_19_r 213.1745883

HS_161_r 216.0695424 HSbrain_1269_r 213.1586429

HS_from_MQbrain_493_r 215.9987774 HSJ 82J 213.108874

HS_from_MQbrain_466_r 215.8030614 HS_from_MQbrain_654_r 212.9463137

HS_244_I 215.8010509 HS_from_MQbrain_1864_r 212.8955561

HS_from_MQbrain_499_r 215.7448563 HSbrain_724_r 212.8164571

HS_from_MQbrain_1593J 215.6965191 HSbrain_643_l 212.7527559

HSbrain_1362_l 215.6819962 HS_from_MQbrain_1663J 212.7351272

HS_from_MQbrain_1665J 215.5641963 HS_from_MQbrain_872_l 212.7235747

HS_from_MQbrain_1871_r 215.4340318 HSbrain_639_r 212.6705004

HS_from_PT_207_r 215.4230025 HSbrain_472_r 212.582847

HS_from_MQbrain_1854_r 215.3909189 HSbrain_812_r 212.5360978

HS_from_MQbrain_1685J 215.324619 HS_from_MQbrain_532_r 212.5327446

HSbrain_515_r 215.15954 HS_from_MQbrain_968_r 212.4682002

HS_from_MQbrain_645_l 215.060159 HSbrain_30_l 212.4321641

HS_245_r 215.02563 HS_from_MQbrain_1366J 212.34134

HS_3_I 215.0085435 Hsd_from_Mmd_256_l 212.2108757

HS_from_MQbrain_1388J 214.966548 HS_from_MQbrain_561_l 212.1470198

HSbrain_804_r 214.9357091 Hsd_from_M md_92_r 212.1087908

HS_from_MQbrain_343_l 214.8585663 HS_113_r 212.103211

HS_from_MQbrain_1841_r 214.8445757 HSbrain_525_l 212.0061091

Hsd_8_l 214.8202064 HSbrain_176_l 211.9808586

HSbrain_586_r 214.7720002 HS_242_r 211.9082409

HS_from_MQbrain_714_l 214.7487813 HS_from_MM_346_l 211.7235677

HS_from_MQbrain_1455J 214.6991315 HS_243_I 211.6547669

HS_from_MQbrain_319_r 214.6690912 HS_306_l 211.5536628

HS_from_PT_294_l 214.6290251 HS_from_MQbrain_71 OJ 211.5445803

HS_33_r 214.5936716 HSbrain_61_r 211.5356004

HS_from_MQbrain_1766_r 214.5034772 HS_from_MQbrain_708_r 211.4887754

HSbrain_627_r 214.4670798 HSbrain_321_r 211.435012

HS_from_PT_339_l 214.3823639 HSbrain_916_l 211.4233793

HSbrain_33_l 214.3626675 HS_from_PT_229_l 211.3671417

HS_258_I 214.3589815 HS_208_r 211.3635201

HS_from_MQbrain_901_l 214.2516994 HSbrain_364_r 211.3556115

HS_128_r 214.1983377 HS_155_I 211.2855729

HSJ 18J 214.1827525 HS_from_MQbrain_528_l 211.2420518

HS_from_MQbrain_513_l 214.0755624 HS_226_r 211.1840201

HS_from_MQbrain_1222_r 214.0598655 HS_from_MQbrain_1389J 211.1430096

HSbrain_267_l 214.022333 HS_from_MQbrain_452_l 211.1219111

HSbrain_1416_l 214.0180979 HSbrain_347_l 211.107069

HSJ 14J 214.0153294 HSbrain_217_l 211.0589069

HS_from_MM_65_l 213.9686757 HSbrain_57_r 211.0174653

Hsd_90_r 213.9554125 HSbrain_421_r 210.992031

Hsd_from_Mmd_212_l 213.9400439 HSbrain_56_l 210.9521542

HS_from_MQbrain_1198_l 213.821992 Hsd_31_l 210.9485674

HS from MQbrain 260 I 213.7960437 HS from MQbrain 17 r 210.8657734 HSbrain_385_l 210.8123385 HS_from_MQbrain_1055_r 207.0197537

HS_from_MQbrain_504_l 210.6839838 HS_from_MQbrain_160_l 207.0189821

HS_from_MQbrain_120_r 210.6657499 Hsd_from_Mmd_428_r 206.995807

HSbrain_487_r 210.5369083 HSbrain_136_l 206.8622185

HSbrain_656_r 210.503868 HSbrain_746_r 206.8187803

HS_from_MQbrain_712_l 210.3715709 HS_70_l 206.7755591

HS_from_MQbrain_699_r 210.3435386 HSbrain_589_r 206.7062924

HSbrain_743_l 210.3243357 HS_from_MQbrain_268_l 206.6561016

HS_from_MQbrain_180_r 210.3209412 HS_from_MQbrain_873_r 206.5787776

HS_from_PT_18_l 210.1470861 HS_from_MQbrain_1795J 206.4850267

HS_from_MQbrain_85_r 210.1449333 HS_from_MQbrain_1348_r 206.3390148

HS_from_MQbrain_1712J 210.0239788 Hsd_from_Mmd_180_l 206.276727

HS_from_MQbrain_1204_r 209.9240502 HSbrain_400_r 206.2134583

HS_from_MQbrain_145_l 209.7777556 HSbrain_146_r 206.1538175

Hsd_61_l 209.748764 HSbrain_72_l 206.0852876

HS_131_r 209.6414321 HS_159_r 206.0784814

HS_from_MQbrain_1273J 209.6052632 HS_from_MQbrain_1507J 205.841515

HSbrain_260_l 209.5737731 HSJ 02J 205.6195359

HS_from_MQbrain_1689J 209.4623643 HS_from_MQbrain_691_r 205.3284172

HS_from_PT_41_l 209.4264654 HSbrain_396_l 205.3057539

HSbrain_640_r 209.3752287 HS_from_PT_283_l 205.2617999

H S_from_M Qbra i n_84_l 209.3540926 HS_from_MQbrain_1776J 205.2456623

HS_from_MQbrain_1644J 209.32 Hsd_from_Mmd_530_r 205.2141219

HS_from_MQbrain_467_l 209.268142 HS_from_MQbrain_1221_r 205.1595375

HS_77_I 209.1463931 HS_from_MQbrain_313_r 205.1377292

HS_from_MQbrain_527_l 209.0387081 HS_from_MQbrain_234_r 205.0056018

HSbrain_573_l 209.0095416 HSbrain_304_l 204.8368425

Hsd_from_M md_450_r 208.9211404 HS_from_MQbrain_150_l 204.8007622

HSbrain_68_r 208.8873182 HS_from_MQbrain_1266_r 204.7418882

HSbrain_96_l 208.7429867 HS_from_MQbrain_569_r 204.738491

Hsd_78_l 208.7314312 HS_from_MQbrain_1433_r 204.5305106

HSbrain_597_r 208.6310714 HS_from_MQbrain_414_r 204.4830788

HS_from_MQbrain_1184_r 208.6202764 HS_from_MQbrain_802_l 204.4242655

HS_from_MQbrain_1885_r 208.5987571 HS_from_MQbrain_147_r 204.3734082

HS_from_MQbrain_1544_r 208.3981899 HS_from_MQbrain_1413_l 204.3272671

H S_from_M Qbra i n_86_l 208.3164223 HS_from_MQbrain_1695_r 204.2688796

Hsd_62_l 208.0883252 HS_from_MQbrain_210_r 204.1332639

HS_from_MM_182_r 208.0844095 HS_from_MM_321_r 203.9926622

HS_from_MM_309_r 208.0343975 HS_186_r 203.9246728

HS_from_MQbrain_638_r 208.030846 HS_from_MM_306_r 203.8838871

HS_from_MQbrain_450_l 208.0243134 HS_from_MM_44_l 203.8131364

HS_from_PT_146_l 207.9363128 HSbrain_50_l 203.7449536

HS_from_MQbrain_1561J 207.9055923 HS_79_r 203.7167335

HS_from_MQbrain_783_l 207.9026032 HS_from_MM_192_r 203.6417757

HS_from_MQbrain_1046_r 207.8703374 HS_from_MQbrain_1074J 203.636716

HS_from_MQbrain_1402J 207.7391938 HS_from_MQbrain_621_r 203.6320108

HS_from_MQbrain_1557_r 207.6872074 HSbrain_461_l 203.4862371

HSbrain_475_r 207.6303954 HSbrain_123_l 203.4486322

Hsd_from_Mmd_471_l 207.5771736 HSbrain_65_r 203.2999735

HS_from_MQbrain_1493_r 207.5291507 HS_287_I 203.2812692

Hsd_from_Mmd_155_r 207.3532885 HSbrain_516_r 203.206938

HS_from_MQbrain_1552J 207.3050287 HS_from_MQbrain_1036_r 203.1951911

HS_from_MQbrain_1718_r 207.2227537 HS_from_MQbrain_191_l 203.1756555

HS_176_r 207.1975229 HS_from_MQbrain_1193_r 203.1490153

HSbrain_376_r 207.1809373 HS_from_MQbrain_2633_l 203.0852846

HSbrain 772 I 207.1044984 HSbrain 64 r 203.067999 HSbrain_578_r 203.0612339 HS_from_MM_112_r 198.8560904

HSbrain_138_l 202.9635847 HSbrain_116_l 198.8454747

HS_from_MQbrain_9_r 202.9562969 HS_78_I 198.7048825

HS_from_PT_248_l 202.9458098 HS_from_MQbrain_1 183_l 198.4935006

HS_from_MM_319_l 202.6221234 HS_303_r 198.3144581

HS_from_PT_70_r 202.4337957 HSJ 38J 198.1359437

HSbrain_55_r 202.4300733 HS_from_MQbrain_29_l 198.1116988

Hsd_64_r 202.1734743 HS_from_MQbrain_311_l 198.0432726

HS_46_r 202.1680761 HS_from_MQbrain_869_l 197.9550289

HS_from_MQbrain_131_r 202.0595323 HSbrain_341_r 197.8276264

HS_from_MQbrain_2689_l 202.035201 HS_from_MQbrain_1212_r 197.7890273

HS_from_PT_211_l 201.8006639 HS_from_MQbrain_1721J 197.7591475

HS_from_MQbrain_1676_r 201.7301962 HS_from_MQbrain_288_l 197.7437468

HS_from_MQbrain_1767J 201.6583037 HS_from_MQbrain_693_r 197.7309441

HSbrain_699_r 201.6052561 HSbrain_31_l 197.7117785

HS_29_I 201.5999875 HSbrain_459_l 197.6806078

HS_from_MQbrain_882_r 201.5350781 HS_from_MM_292_r 197.6376855

HSJ 50J 201.5054656 HS_from_MQbrain_281_l 197.384259

HSbrain_691_l 201.4670994 HS_from_MM_350_l 197.3458346

HS_from_MQbrain_1303_r 201.3209506 HSJ 06J 197.2533991

HS_from_PT_220_l 201.2064584 Hsd_from_Mmd_176_l 197.2483957

HSJ 36J 201.0664033 Hsd_58_l 197.2050795

Hsd_from_Mmd_456_l 200.9559735 HS_from_MQbrain_14_r 197.1450347

HS_from_MQbrain_545_l 200.7706369 HS_from_MQbrain_1863J 197.0519986

Hsd_77_r 200.6733718 HS_from_MM_126_l 197.0061583

HSbrain_23_r 200.6525784 HS_from_MQbrain_508_l 196.9051127

HSbrain_63_l 200.6399322 HS_from_MM_5_r 196.7804505

HSbrain_84_l 200.5841432 HS_from_MQbrain_1288J 196.6983091

HSbrain_1431_l 200.5748738 HS_94_r 196.6181992

HS_180_r 200.4582411 HSbrain_1263_r 196.5803079

HSbrain_91_l 200.4180855 HS_from_MQbrain_497_l 196.4669787

HSbrain_102_r 200.4155278 HS_259_r 196.3066632

HSbrain_153_l 200.2905692 HS_from_MQbrain_1395_r 196.1672376

HSbrain_526_r 200.2642793 HSJ46J 196.0465543

HSJ 09J 200.1919676 HS_from_MQbrain_1785_r 196.0389525

HSbrain_126_l 200.1325332 HS_from_MM_304_r 195.9761008

HS_from_MQbrain_1283J 200.1271847 HS_from_MQbrain_1802J 195.9391667

HS_from_MQbrain_405_l 200.083515 HSbrain_801_r 195.7930985

Hsd_from_Mmd_330_l 200.078931 HS_from_MQbrain_936_r 195.7842152

Hsd_from_Mmd_429_l 200.0012831 HSbrain_175_l 195.7623447

Hsd_from_Mmd_438_r 199.9189326 Hsd_105_r 195.7175747

HSbrain_463_l 199.836684 HS_from_MM_150_l 195.706453

HSbrain_193_l 199.7083811 HSbrain_616_r 195.4635888

HSbrain_289_l 199.6939274 HS_from_MQbrain_613_l 195.43094

HS_from_MQbrain_1717_l 199.667607 HSJ 83J 195.3964293

HS_from_MM_79_l 199.5386163 HS_from_MQbrain_1480_r 195.3327536

HS_from_PT_38_r 199.4482749 HSbrain_517_l 195.2983762

Hsd_from_Mmd_470_l 199.418794 HSbrain_1407_l 195.1893199

HSbrain_373_l 199.3527183 HSbrain_350_l 195.1163033

HS_35_I 199.2603922 HS_from_MQbrain_629_l 195.1102679

HSbrain_720_r 199.2261851 HSbrain_562_r 195.1029577

HSbrain_124_l 199.2157195 HSbrain_114_l 194.9449919

HSbrain_275_l 199.2030892 HSbrain_1236_l 194.855173

HS_from_MQbrain_943_l 199.1939949 HS_from_MQbrain_228_r 194.8222137

HS_from_MQbrain_1456J 199.1014452 HS_from_MQbrain_128_r 194.6783323

HSbrain 642 r 198.8901506 HS 74 I 194.632323 HS_from_MQbrain_922_r 194.5272878 HS _from_MQbrain_1311 J 190.8001726

HS_from_MQbrain_1298_r 194.5026983 HSbrain_651_r 190.7821606

HS_from_MM_266_r 194.4374232 HSbrain_488J 190.6199449

Hsd_32_l 194.403086 HSbrain_324J 190.5828506

HS_from_PT_161_r 194.3462227 HS_201J 190.5393273

HS_from_MQbrain_818_l 194.3299932 HS_from_MQbrain_464J 190.5025514

HS_from_MQbrain_1088_l 194.3140687 HS_90J 190.4770169

HSbrain_630_l 194.2979437 HSJ85J 190.419054

HS_from_MQbrain_379_l 194.2799743 HSJrom_MQbrain_529_r 190.4031906

Hsd_from_M md_31 J 194.1021626 HSJ2J 190.383325

HSbrain_570_l 194.0529436 HSbrain_223_r 190.3224269

HS_from_MM_165_l 194.0305909 HS_from_MMJ3J 190.1275732

HS_from_MQbrain_1423J 193.964167 Hsd Jrom_Mmd_519_r 190.1006667

HSbrain_248_l 193.8830045 HSJrom_MQbrainJ394J 190.0849242

Hsd_from_Mmd_94_l 193.7657691 HSbrain_164_r 189.9523775

HSbrain_162_l 193.6282482 HsdJrom_Mmd_433_r 189.8742828

HS_from_MQbrain_170 OJ 193.6041577 HSbrain_528_r 189.872647

HSbrain_360_r 193.590164 HSJrom_MQbrain_666_r 189.8608917

HS _from_MQbrain_1573J 193.4803504 HSbrain_375_r 189.8348043

HSJ 16J 193.4215677 HSJrom_MQbrain_1145_r 189.8259778

HSJrom_PT_218_r 193.3522736 HSJrom_MQbrainJ381J 189.779606

HSJrom_MQbrain_271_r 193.3227472 HSJromJVIQbrain_955J 189.6235242

HSJrom_MQbrain_222J 193.1226274 HSJrom_MQbrain_350J 189.461419

HS _from_MQbrain_1548J 193.0711482 HS Jrom_MQbrain_1888_r 189.3084792

HSbrain_362J 192.9404754 HSJrom_MQbrain_406_r 189.233991

HSbrain_1174J 192.7667477 HS_126_r 189.1558613

HS _from_MQbrain_1478J 192.6931886 Hsd_from_Mmd_416J 189.0597441

HS _from_MQbrain_1346J 192.6458383 HS Jrom_MQbrain_1243_r 189.054122

HSbrain_599J 192.6183943 HSJromJVIQbrain_981J 188.9895746

Hsd_from_Mmd_413J 192.5190937 HSbrain_659_r 188.9836496

HsdJrom_Mmd_33_r 192.4364738 HS _from_MQbrain_1280J 188.9766392

HSJrom_MQbrain_403J 192.404673 HSJrom_MQbrainJ932_r 188.8437058

HS _from_MQbrain_1624J 192.3884805 HSbrain_172_r 188.8196379

HS Jrom_MQbrain_1112_r 192.3632878 HS Jrom_MQbrain_1730_r 188.7832532

Hsd_from_Mmd_172J 192.143029 HSJrom_MQbrain_291J 188.7078132

HSJrom_MM_299_r 192.1411625 HSJrom_MQbrain_485_r 188.6613768

HS_from_MQbrainJ921J 192.1335465 HSbrain_280J 188.6563025

HS Jrom_MQbrain_1818_r 192.1179163 HS _from_MQbrain_1674J 188.625056

HSJrom_MQbrain_658_r 192.0124629 HSJrom_MQbrainJ370J 188.497046

HSJrom_MQbrain_674_r 191.9044513 HSJrom_PT_20_r 188.3393313

HsdJrom_Mmd_383J 191.7899174 HSbrainJ592_r 188.3237767

Hsd_63_r 191.7137571 HSJrom_MQbrain_383J 188.3158756

HSJrom_MQbrain_885_r 191.5324794 HS Jrom_MQbrain_1175_r 188.3144325

HSJrom_MQbrain_58_r 191.522255 HSJrom_PT_162_r 188.2819118

HS Jrom_MQbrain_1745_r 191.5196529 HSbrain_786_r 188.2594341

HS _from_MQbrain_1569J 191.4989985 HSbrain_348J 188.1407447

HSbrain_752J 191.3899851 Hsd_99_r 188.1035755

HSbrain_635_r 191.3323113 HS_17_r 187.9339119

HSbrain_313_r 191.3288742 HSJrom_PT_95_r 187.7990727

HSJrom_MQbrain_535J 191.3094563 HS Jrom_MQbrain_1659_r 187.7357442

HS _from_MQbrain_1361 J 191.1427072 HSJrom_MQbrain_39_r 187.6304469

HSJrom_PT_204_r 191.0832874 HS Jrom_MQbrain_1844_r 187.6108805

HSbrain_352J 191.0286866 HSbrain_710_r 187.4520996

HS_9J 191.0245696 HSJrom_MQbrain_2380_r 187.2947993

HSJrom_MQbrainJ325J 191.0142911 HSJrom_MQbrain_1834_r 187.1781356

HSbrain 590 r 190.8385095 HS from MQbrain 22 r 187.1051151 HSbrain_594_l 186.9175668 HSJ 52J 183.0697159

HS_from_MQbrain_83_l 186.9062136 Hsd_from_Mmd_169_r 182.7898422

HS_from_MQbrain_433_l 186.8433165 HS_from_MQbrain_273_l 182.7573142

HS_from_MQbrain_1062_r 186.7629184 HS_257_r 182.6194298

HSbrain_495_l 186.7445849 Hsd_43_l 182.6106383

HS_from_MQbrain_918_l 186.6733108 HSbrain_300_l 182.522588

HS_from_MQbrain_1852_r 186.6102831 HS_from_MQbrain_216_l 182.4516418

H S_from_M Qbra i n_57_l 186.5917929 HSbrain_435_r 182.3583857

HSbrain_1066_l 186.5290013 HSbrain_502_l 182.3121978

HS_4_r 186.5048701 HS_from_MQbrain_659_l 182.2736817

HS_from_MM_49_l 186.4616319 Hsd_from_Mmd_80_r 182.267229

Hsd_from_Mmd_93_l 186.4505924 HSbrain_243_l 182.2549801

HSbrain_474_l 186.4221505 HSbrain_185_l 182.1563176

HS_215_I 186.3533099 HS_from_MQbrain_1859J 181.9056424

HS_from_MQbrain_1839J 186.2075177 HS_91_r 181.8851129

HSbrain_564_r 186.0420534 HS_from_MQbrain_1315_l 181.848048

HS_54_I 185.9367326 Hsd_108_r 181.7633595

HS_from_MM_251_l 185.8137117 HS_from_MQbrain_1427J 181.7148181

HS_from_MQbrain_1566J 185.7444631 HSbrain_503_r 181.710235

HS_from_MQbrain_25_r 185.7440636 H S_from_M Qbra i n_592_l 181.6866459

HS_from_MQbrain_186_r 185.6953187 HS_from_MQbrain_1602_r 181.6482095

HSbrain_805_l 185.674964 HSbrain_346_l 181.6254174

HS_from_MQbrain_1383_r 185.5897107 HS_from_MQbrain_819_l 181.598646

HS_from_MQbrain_332_r 185.5839917 HSJ 96J 181.591622

HSbrain_771_l 185.5150257 HS_from_PT_234_l 181.4676297

HSbrain_591_l 185.5052057 HS_from_MM_307_l 181.4274115

HSbrain_548_l 185.4850722 HSbrain_135_r 181.3044184

HS_51_I 185.3456287 HS_from_PT_71_l 181.2957273

HS_from_PT_170_l 185.2808375 HS_from_MQbrain_1_l 181.2744529

HS_from_MM_70_r 185.0757794 HSbrain_606_l 181.1992813

HS_from_MQbrain_1422_r 184.9614981 HSbrain_165_l 181.1832002

HS_76_I 184.9599379 HS_from_MQbrain_567_l 181.141058

HSbrain_675_l 184.9297939 Hsd_79_l 181.0929049

HS_290_l 184.9148333 Hsd_from_Mmd_129_r 181.0451576

HS_from_MQbrain_347_l 184.9027155 HS_from_MQbrain_931_r 180.928267

HS_from_MQbrain_631_l 184.728 HS_from_PT_310_l 180.8331695

HSbrain_1168_l 184.7243845 HS_from_MQbrain_1051J 180.7987744

Hsd_from_Mmd_261_l 184.5887939 HSbrain_255_l 180.7521066

Hsd_65_r 184.3852713 HS_from_MQbrain_324_r 180.6614293

HS_from_MQbrain_1061J 184.3228969 HSbrain_716_l 180.5676912

HS_from_MM_161_l 184.2770352 Hsd_from_Mmd_189_l 180.4050764

HS_from_MM_191_l 184.213433 Hsd_from_Mmd_225_r 180.272844

HS_from_MQbrain_63_l 184.1670148 HS_from_MQbrain_1484J 180.1270647

HS_from_MQbrain_401_r 184.1230274 HSbrain_722_l 180.1260425

Hsd_from_M md_85_r 184.0986177 HSbrain_133_l 180.0609243

HS_from_MQbrain_640_l 183.9955145 HSbrain_71_l 180.0336735

HS_from_PT_25_l 183.9374174 HS_from_MQbrain_883_r 179.9509263

HS_from_PT_31_r 183.634517 HS_from_MQbrain_1229_r 179.8888306

HSJ 07J 183.5837434 HSbrain_187_r 179.7554723

HSJ 33J 183.5586928 HSbrain_1420_l 179.7305997

HS_from_MQbrain_740_l 183.5545321 HS_from_PT_255_l 179.6028399

HS_from_MM_123_r 183.4779998 HS_from_MQbrain_1831_r 179.507715

HSbrain_38_r 183.4285032 HS_from_MQbrain_1443_r 179.1434855

HSbrain_596_r 183.4234846 HSbrain_125_r 179.1019231

HSbrain_383_r 183.4226045 HS_125_I 178.9732196

HS from MQbrain 1565 r 183.33017 HS 1 r 178.872361 HSbrain_762_r 178.772043 HSbrain_143J 173.8367679

HSbrain_21 1 J 178.6326198 HSbrain_768_r 173.759433

HS_from_MM_316_r 178.5854649 HSJ247J 173.7058625

HS_from_MQbrain_90_r 178.3364821 HSbrain_696J 173.6647619

Hsd_from_Mmd_418_r 178.3089976 HS_from_MM_229_r 173.5953652

HSbrain_455_r 178.2419961 HS_from_MQbrain_1372J 173.5611463

HSbrain_917_l 178.1737031 Hsd_from_Mmd_259J 173.2971944

HS_from_MQbrain_148_l 178.0297049 HS_from_MQbrain_1773J 173.1308074

HS_from_MQbrain_1235_r 177.9273987 HSJrom_PT_176_r 173.0044578

HS_from_MQbrain_1481_r 177.8686795 HSbrain_139J 172.7598914

HS_178_r 177.8554461 HSJrom_MQbrain_316_r 172.2218294

HS_15_I 177.8515513 HSbrain_325J 172.2192259

Hsd_from_M md_101 _r 177.7313602 HS_from_MQbrain_251_r 172.0989873

HS_from_MQbrain_265_r 177.7026523 HSbrain_748_r 171.8187407

HS_from_MQbrain_1670_r 177.6818982 HSbrain_258_r 171.6509812

HS_from_MQbrain_1551 J 177.6424473 HS_288J 171.5705836

HS_from_MQbrain_1 199_l 177.5515382 HSJrom_MQbrain_37J 171.5557838

HSbrain_608_r 177.4299183 HSbrain_351J 171.4897107

HS_from_MM_91_r 177.3134135 HSJrom_MQbrain_385_r 171.4739179

HSbrain_112_l 177.2992267 HSJrom_MQbrain_755_r 171.2982582

HS_from_MQbrain_969_r 177.1203053 Hsd Jrom_M md _91 _r 171.053764

HS_from_PT_338_r 177.0554098 HS _from_MQbrain_1716_r 170.9229787

HS_from_MQbrain_107 OJ 176.9299998 H S _f rom_M Qbra i n_555 J 170.9056939

HS _from_MQbrain_1649J 176.9183979 HS_from_MM_199J 170.7212373

HS _from_MQbrain_1374J 176.8739274 HSbrain_409_r 170.7071739

Hsd_46_r 176.8539101 HSbrain_618_r 170.6474893

HSbrain_69_r 176.5948307 HSJrom_PT_197J 170.5694359

HS_from_MM_12J 176.3473845 HS_from_MQbrain_1516 J 170.5258671

HSbrain_430_r 176.1827887 HS_from_MQbrain_374_r 170.5241907

HSbrain_470J 176.1759915 HSJrom_MM_242J 170.2575956

HS_from_MQbrain_948_r 176.1262044 HS _from_MQbrain_1640_r 170.1535918

HSbrain_751J 176.064141 Hsd_from_M md_466 J 169.8854018

HSbrain_403_r 175.9332671 HS_from_MQbrainJ558_r 169.8311892

HS _from_MQbrain_1678J 175.9249049 HSJrom_PT_250_r 169.7827673

HSbrain_622J 175.8456587 HSJrom_PT_22J 169.7548575

HSbrain_1363J 175.794645 HSbrain_712J 169.7417362

HSbrain_601_r 175.7896102 HS Jrom JVIQbrainJ 612J 169.5239608

HSbrain_595_r 175.7116832 HS_from_MQbrain_1592J 169.5192576

HS_from_MQbrain_388_r 175.6904319 HSbrain_158J 169.343928

Hsd_from_Mmd_183J 175.6720566 HS_from_MQbrain_1091 J 169.2750909

HSbrain_282J 175.6138018 HSJrom_PT_256J 169.2425116

HS_from_MQbrainJ557J 175.6113323 HSbrain_232J 169.1546875

Hsd_102J 175.5645249 HSJrom_MQbrain_572_r 168.9083431

HSbrain_79J 175.383712 HSbrain_464J 168.8249078

HS_299J 175.2031924 HSJrom_PT_135J 168.7144836

HS _from_MQbrain_1322J 175.1994814 HSJrom_MQbrain_669J 168.6377915

HS_from_MQbrain_322J 174.888304 HSJ277J 168.4332786

HSJ38J 174.7354278 Hsd_from_Mmd_488J 168.4228866

HSJrom_MM_226_r 174.3878926 HSbrain_450J 168.2657456

HS _from_MQbrain_1415 J 174.2147826 HSbrain_715_r 168.0598281

HS_143J 174.1874239 HS_from_MQbrain_1556J 168.0497925

HSbrain_330J 174.1826185 HSJromJVIQbrain_934_r 167.9322779

HS_from_MQbrainJ378J 174.1494734 HSJromJVIQbrain_930_r 167.8363796

HS _from_MQbrain_1181_r 173.9702444 HSJrom_PT_122J 167.7150986

HSJrom_MQbrain_239_r 173.8939829 HSJrom_PT_191_r 167.6796712

HS from MQbrain 1660 r 173.8610519 HSbrain 575 I 167.6062921 HS_from_PT_156_r 167.4729776 HS_from_MQbrain_1884_r 159.9476968

HSbrain_392_l 166.9784741 HS_from_MQbrain_1589_r 159.9022236

HSbrain_892_r 166.9224826 HS_from_MQbrain_1002J 159.8709917

HS_from_MQbrain_31_l 166.7933398 HSbrain_636_l 159.8695431

HS_from_MQbrain_1450J 166.7771396 HS_from_MQbrain_834_r 159.8605199

HS_from_MQbrain_1775_r 166.5855528 HS_from_MQbrain_771_r 159.7398798

HS_from_MQbrain_101 OJ 166.5364922 HSbrain_369_r 159.7073641

Hsd_97_l 165.882963 Hsd_84_l 159.0858523

Hsd_68_l 165.8584582 HS_from_PT_299_l 158.8812184

HS_from_MQbrain_26_l 165.627724 HS_from_MQbrain_1520_r 158.8609156

HS_from_MM_334_l 165.3471372 HS_from_MQbrain_1 128J 158.837926

HS_from_MQbrain_1 100_l 165.2906308 HS_from_MQbrain_1419_r 158.7663804

HS_from_MM_38_l 165.2486961 HS_from_MQbrain_1740J 158.6793211

HSbrain_340_r 165.2419641 HS_from_MQbrain_1692J 158.6415708

HS_164_r 165.1061854 HS_from_MQbrain_21_r 158.5410847

Hsd_from_Mmd_492_l 164.980004 HS_from_MM_170_l 158.4309229

HSbrain_310_l 164.9263788 HS_from_MQbrain_1684J 158.2373516

HSbrain_807_r 164.7541547 HS_from_MQbrain_1 182_l 158.0679011

HS_2_I 164.7210266 Hsd_93_l 157.9972237

HS_from_MQbrain_774_r 164.6264718 HSbrain_27_r 157.9786387

HSbrain_216_r 164.5910344 HSbrain_1437_l 157.9722323

HS_from_MQbrain_1223J 164.5470949 HS_from_MQbrain_207_l 157.9140691

Hsd_from_Mmd_193_l 164.5279208 H S_from_M Qbra i n_962_l 157.9046002

Hsd_11_l 164.5093304 HS_from_PT_108_l 157.8559179

HS_from_MQbrain_1150_r 164.4702221 HS_from_MQbrain_1340J 157.6981977

HS_from_MQbrain_1757J 164.4509948 Hsd_from_Mmd_174_r 157.3796566

HS_from_MQbrain_1030J 164.3970563 HSbrain_206_l 157.3663037

HS_from_MQbrain_282_l 163.9894054 HS_from_MQbrain_1654J 157.3073263

HS_from_MQbrain_1724J 163.9516624 HS_from_MQbrain_41_r 157.2475269

HS_from_MQbrain_1590J 163.8114142 HSbrain_694_r 157.1044149

HS_from_MQbrain_904_l 163.7759063 Hsd_from_Mmd_499_l 157.0871197

HS_from_MQbrain_492_l 163.6962297 Hsd_from_Mmd_284_r 156.9741681

HS_from_MQbrain_1529_r 163.6110496 HSbrain_809_r 156.7134677

HSbrain_524_r 163.4332942 HS_from_MQbrain_192_l 156.563744

HSbrain_342_l 163.2902244 HSbrain_698_l 156.4505714

HSbrain_1412_l 163.2097745 HSbrain_59_l 156.0696115

HS_from_MQbrain_1289J 163.1398143 HS_from_MQbrain_178_l 155.9319043

HSbrain_121_l 163.1114217 HSbrain_663_r 155.8547049

HS_from_MQbrain_165_l 162.7040346 HSJ 12J 155.7901438

HS_from_MQbrain_490_r 162.3944533 HS_from_MQbrain_135_l 155.6010506

HS_from_MQbrain_1228_r 162.3489481 HS_from_MQbrain_1445J 154.9673281

HSbrain_448_l 162.0375436 HS_from_MQbrain_1304_r 154.625417

Hsd_49_r 162.0054723 HS_from_MQbrain_1546_r 154.5895228

Hsd_85_l 161.9749751 HS_from_MQbrain_1708J 154.1529962

HS_from_MQbrain_346_r 161.9458653 HS_from_MQbrain_1332_r 154.1525563

HSbrain_208_r 161.7157386 H S_from_M Qbra i n_92_l 153.9678306

HS_from_MQbrain_45_r 161.291101 HSJ69J 153.6041594

HS_255_I 161.1405598 HS_from_MQbrain_1300J 153.3945718

HS_from_MQbrain_1985_r 161.0836782 HSbrain_433_l 153.3062571

HS_60_r 161.0640676 HSbrain_169_l 153.1622142

HSbrain_658_r 160.8896254 HS_from_MQbrain_1656_r 153.0682586

Hsd_from_Mmd_468_r 160.8479695 HS_from_MQbrain_1462_r 152.9071604

Hsd_from_Mmd_354_l 160.6920656 Hsd_73_r 152.8453072

HS_from_MQbrain_1064_r 160.6505983 H S_from_M Qbra i n_24_r 152.6756691

Hsd_from_Mmd_228_r 160.5314694 HS_from_MQbrain_501_l 152.6321911

HS from MQbrain 256 I 160.009102 HS from MQbrain 327 r 151.8340882 HS_from_MM_58_r 151.5998526 Hsd_24_l 141.5777402

HS_from_PT_148_l 151.4484249 Hsd_67_l 141.5629903

HS_from_MQbrain_317 J 151.2288813 HS_from_MQbrain_154 OJ 141.3634303

HS_from_MM_155_r 150.7239817 HSJrom_PT_180J 141.1839728

HS_from_MQbrain_536_r 150.565992 HS_from_MM_136_r 140.3205599

Hsd_from_Mmd_148_l 150.4939664 HS_53_r 140.0976088

HS_from_MM_349_l 149.9283767 HSbrain_568J 139.1797861

HS_from_MM_203_l 149.6945717 HSbrain_253_r 138.9562066

HS_from_MQbrain_64_r 149.6181093 HSJrom_PT_190_r 138.4453126

HSbrain_415_l 148.8998605 HS Jrom_MQbrain_1108_r 138.2280125

HS_from_MM_301_l 148.8813987 HS_20_r 137.9175851

HS_from_MQbrain_661_l 148.8113189 HSJ37J 137.6760885

HSbrain_1399_l 148.5693182 HSbrain_423J 137.5975104

HSbrain_436_l 148.4603877 HS_from_MQbrain_494J 137.4594214

HSbrain_734_r 147.8679536 HSJrom_MQbrain_295J 137.1824078

HS_from_MQbrain_1751_r 147.8048267 HS_203_r 137.1520157

HS_from_MQbrain_1835_r 147.7399163 HS Jrom_MQbrain_1809_r 137.1399241

HS_from_MQbrain_1547J 147.2749783 HS_from_MM_160J 137.0116145

HS_22_I 147.2714514 Hsd_from_Mmd_439_r 136.90383

HS_from_MQbrain_1637_r 147.2561547 HS_from_MQbrain_1143_r 136.8939224

Hsd_from_Mmd_229_l 147.2551129 Hsd_from_Mmd_145J 136.8745882

Hsd_from_Mmd_235_r 145.886021 HSbrain_760J 136.864711

HS_from_PT_340_r 145.5808035 HS_from_MQbrainJ31_r 136.5784067

HSbrain_353_r 145.5612086 HSbrain_655_r 136.4458282

HS_from_MQbrain_486_l 145.4138995 HS _from_MQbrain_1213 J 136.145634

Hsd_47_l 145.2279529 HS_from_MQbrain_264_r 136.066419

HS_from_MQbrain_1 17_l 145.1372697 HSbrain_727J 136.0474595

HS_from_MQbrain_1744_r 145.1169393 HS_from_MQbrain_1790_r 136.0259392

HS_from_MQbrain_1 18_l 145.0981054 HS_from_MQbrain_1658_r 135.9727881

HSbrain_1305_l 145.0316211 HSbrain_790_r 135.8835342

HS_from_MQbrain_500_l 144.96318 HS _from_MQbrain_1858_r 135.4615782

HS_81_I 144.8341455 HS_from_MMJ33_r 135.3503595

Hsd_from_Mmd_326_r 144.7386621 HS_from_MQbrain_1739_r 135.304321

HS_from_MQbrain_585_r 144.4245525 HS_from_MQbrainJ349J 135.3020631

HS_from_PT_61_l 144.2294271 HSbrain_77_r 135.0441482

HS_from_MQbrain_1231_r 144.0677966 Hsd_52J 134.5688394

HSbrain_557_r 143.8626534 HS_from_MQbrainJ399_r 134.2391978

HS_from_MQbrain_143_r 143.5053792 HSbrain_230_r 134.2244602

HSbrain_251_l 143.3515241 HS _from_MQbrain_100J 133.6513061

Hsd_from_M md_49_r 143.2298967 HS _from_MQbrain_1558_r 133.4364824

HS_from_MQbrain_841_l 143.150258 HS _from_MQbrain_1886_r 133.3451731

Hsd_from_Mmd_515_l 143.0976097 HS_from_MM_326J 133.0145352

HS_from_MM_310_r 143.0476245 HS_from_MQbrainJ332J 132.6729821

HS_from_MQbrain_287_r 143.0394094 HSbrain_177_r 132.197755

HS_from_MQbrain_1555J 143.0040258 HSbrain_197J 132.1670897

HS_from_PT_4_r 142.9952763 H S _f rom_M Qbra i n_34_r 132.0668399

HS_from_MQbrain_1209_r 142.9625798 HSJrom_MM_74J 131.7543823

HSbrain_473_r 142.4884603 HSbrain_811_r 131.6313177

HS_from_MQbrain_1749_r 142.2592046 HSbrain_286J 131.389336

HS_from_MM_303_l 142.2483555 HS_251J 131.2661176

Hsd_89_r 142.2147592 HS_from_MQbrainJ348_r 131.2552614

HS_from_MQbrain_1722_r 141.984292 HS_from_MQbrain_470J 131.1632076

HSbrain_721_l 141.8888402 H S _f rom_M Qbra i n _946 J 131.0628786

HSJ41J 141.8565157 HS_from_MM_163_r 130.6907731

HS_from_MM_120_l 141.8371708 Hsd_44J 130.5671893

HS from MQbrain 663 r 141.7046002 Hsd 13 I 130.4556358 HSbrain_787_r 129.6934291 HS_from_MM_98_r 118.6872322

HS_from_MQbrain_1560J 129.614049 HS_from_MQbrain_502_r 118.3776111

HS_from_PT_269_l 129.2301469 HS_from_PT_303_l 118.2462387

HS_from_MM_122_r 129.1183074 Hsd_from_Mmd_324_r 118.2362331

HS_from_MQbrain_1513_r 128.9407151 HSbrain_764_r 117.9645256

HS_267_r 128.8526 HSJ 89J 117.9592496

HS_from_MQbrain_1610_r 128.7979365 HSbrain_297_r 117.8391655

HSJ 84J 128.6974233 HSbrain_763_r 117.7544498

HS_from_MQbrain_1097_r 128.6204149 HS_from_PT_205_r 117.5534749

HS_from_PT_187_l 128.3298072 Hsd_from_Mmd_328_r 117.324613

HS_from_MM_184_l 128.1210167 HS_from_MQbrain_579_r 117.2839857

HS_from_MQbrain_151_r 128.117498 HSbrain_40_r 117.0487953

HSbrain_773_l 127.1133192 HSbrain_574_r 116.9214286

HS_from_MQbrain_1875J 126.9680493 HS_from_MQbrain_608_r 116.612101

HS_from_MQbrain_1350_r 126.8032255 Hsd_from_Mmd_178_r 116.4898429

Hsd_from_Mmd_527_r 126.3935973 HSbrain_505_l 116.4569543

HSJ 10J 126.3504225 HS_from_MQbrain_1801_r 116.3921742

HSbrain_730_l 126.2182555 HS_from_MQbrain_1657_r 116.3148049

HS_from_MQbrain_772_r 126.0000486 Hsd_from_Mmd_505_r 116.0776309

HS_from_MQbrain_296_r 125.6165669 HSbrain_41 1_l 116.0440512

HS_from_MQbrain_1517_l 125.3704261 HSbrain_173_r 115.8303113

HS_282_I 125.3637264 HS_43_r 115.809889

HS_from_MQbrain_842_r 125.3022173 HSbrain_58_l 115.8018906

HS_from_MQbrain_1788_r 125.1671429 Hsd_from_Mmd_509_l 115.5595143

Hsd_from_M md_482_r 124.9021202 HSbrain_339_l 115.4702672

HS_from_MM_317_l 124.2047934 HS_from_MQbrain_1662J 114.9208166

HS_from_MQbrain_253_l 124.158129 Hsd_from_M md_81 J 114.8866476

HSbrain_585_l 124.1437027 HSbrain_605_r 114.7989073

HS_from_MM_124_r 124.074717 Hsd_87_r 114.6751896

HSbrain_491_r 123.9139471 Hsd_from_M md_34_r 114.2335916

Hsd_from_Mmd_21 1_r 123.6363171 HS_from_MQbrain_300_r 114.1433066

HS_from_MQbrain_1497_r 123.458136 HS_from_MQbrain_530_l 113.6020847

HS_from_MQbrain_564_r 123.2670175 HSbrain_705_r 113.5172383

Hsd_from_Mmd_333_r 122.8958947 HS_from_MQbrain_874_r 113.4583818

HS_from_MQbrain_1896J 122.7981574 HS_from_MQbrain_468_l 113.3244619

HS_from_MQbrain_619_r 122.6749499 HS_from_PT_313_l 113.037452

HSbrain_697_l 122.5351278 HS_from_MQbrain_132_l 112.7869161

Hsd_from_Mmd_39_l 122.3556843 HS_41_r 112.6985514

Hsd_27_l 122.1520322 HS_from_MQbrain_154_l 112.5010282

HS_from_MQbrain_1292_r 121.9448163 HSbrain_498_l 112.3225684

HS_216_r 121.8875355 HS_from_MQbrain_1522_r 112.3011721

HS_from_MQbrain_1535J 121.7711186 HSbrain_274_r 112.2207143

HS_162_I 121.3153743 HS_231_r 112.1781 103

HS_from_MQbrain_578_l 121.0148576 HS_from_MQbrain_1765_r 111.7808146

HS_from_MM_198_l 120.6300187 Hsd_from_Mmd_161_l 111.7055777

HS_232_I 120.592551 HS_from_MQbrain_1207J 111.657586

Hsd_from_Mmd_274_l 120.5723322 HSbrain_262_l 111.641823

HS_63_I 120.5119395 HS_from_MQbrain_1377J 110.9676187

HS_from_MQbrain_777_r 120.2896834 HS_from_MQbrain_949_l 110.9567782

HS_from_MQbrain_1205_r 120.077252 HSbrain_523_r 110.6926143

Hsd_from_Mmd_367_l 120.0545039 HSbrain_733_l 110.4880393

HS_from_MM_359_r 120.0491134 Hsd_from_Mmd_182_l 110.3509492

HS_from_MQbrain_1895J 119.7422297 HS_from_MQbrain_1408J 110.2916582

HSbrain_443_r 119.5321197 HSbrain_482_l 110.0149117

HS_from_MQbrain_1487_r 119.4385433 HS_from_MQbrain_194_l 110.0069304

HS from PT 333 I 119.2922172 HS from MQbrain 797 I 109.7202558 Hsd_from_Mmd_187_r 109.5214584 HSbrain_157_r 100.3340918

HS_from_MQbrain_790_r 109.3000205 Hsd_from_Mmd_534_l 100.2946832

HS_from_MQbrain_687_r 109.1779088 HSbrain_747_l 100.2134098

HSbrain_563_l 109.1569505 HS_from_MQbrain_509_r 100.1137811

HS_from_MQbrain_1208J 108.8734707 HS_from_MQbrain_713_r 99.8596546

HS_from_MQbrain_1503_r 108.6188834 HSbrain_653_r 99.76505351

HS_from_MQbrain_517_r 108.5936311 HS_from_MM_193_l 99.7576611

HS_from_MM_28_l 108.5425494 HS_from_MQbrain_622_r 99.6479399

HSbrain_263_r 108.4481826 HS_from_MM_158_l 99.547531

HS_from_MQbrain_382_r 108.3108904 HSbrain_14_r 99.51998497

HS_254_r 108.0512602 HSbrain_82_r 99.35128086

HS_from_MQbrain_361_l 108.0467095 HS_from_MQbrain_293_l 99.25916842

HS_from_MQbrain_1072_r 107.9850118 HS_from_MQbrain_110_r 98.94375

HS_from_MQbrain_1769_r 107.9535881 HS_from_MQbrain_1851_r 98.90373913

Hsd_60_l 107.914618 HS_from_MQbrain_799_l 98.83429895

HS_from_MM_93_l 107.7887026 HSbrain_418_l 98.58964973

HS_from_MM_210_r 107.730886 HS_from_MM_287_l 98.35019506

HSbrain_471_l 107.7098195 HSbrain_239_l 98.26806599

HS_from_MQbrain_804_l 107.584966 HSbrain_42_l 97.38728405

HS_from_MQbrain_593_r 107.4432597 Hsd_16_l 97.34868547

HS_from_MQbrain_1457J 107.3708718 Hsd_from_Mmd_197_r 97.00385398

HS_from_PT_74_r 107.2883837 HS_85_I 96.48110294

Hsd_from_Mmd_481_l 107.0549259 HSbrain_94_l 96.33702157

Hsd_from_Mmd_69_l 106.5131657 HSbrain_294_l 96.30247326

Hsd_from_Mmd_195_r 106.3658909 Hsd_from_Mmd_485_r 95.1476108

HS_from_MM_294_l 106.3355438 Hsd_from_Mmd_156_r 94.89926352

HSbrain_272_r 106.1087732 HS_from_MQbrain_1034_r 94.58788064

HS_from_MQbrain_1 169J 105.7095098 HSbrain_624_l 94.53967575

HSbrain_9_l 105.6311858 HS_from_MQbrain_1326_r 94.53541538

Hsd_from_Mmd_271_r 105.5217433 HS_from_MQbrain_91_l 94.2325

HS_from_MQbrain_606_r 105.4640055 Hsd_from_Mmd_410_l 94.2059708

HS_from_MQbrain_1466_r 105.3355825 HS_from_MQbrain_112_l 94.04683229

HS_from_MQbrain_575_r 105.2312305 Hsd_86_l 93.94420635

HS_from_MQbrain_628_l 105.1976832 HS_from_MQbrain_1646_r 93.89323261

HS_from_MQbrain_1 13_l 105.1838551 HS_from_MQbrain_839_r 92.94488973

Hsd_from_Mmd_136_r 104.7410844 HS_from_PT_136_l 92.74159284

HSbrain_128_r 104.3537561 HS_177_r 92.49572239

HS_from_MM_314_l 103.7363449 HS_from_PT_217_r 92.06195569

HSbrain_336_l 103.7156038 HSbrain_1384_l 91.87184624

HS_from_MQbrain_1793_r 103.5900968 HS_from_MQbrain_355_r 91.78580467

HS_from_MQbrain_244_l 102.9921795 HS_36_I 91.72099648

HSbrain_782_r 102.9919045 HSbrain_633_r 91.40733696

HS_from_PT_291_l 102.8033399 Hsd_from_Mmd_436_r 90.76582879

HSbrain_466_l 102.7199119 HS_from_MQbrain_997_l 90.55621189

HS_from_PT_182_r 102.5770161 HS_from_MQbrain_1485_r 90.24185865

HS_213_r 102.5631518 Hsd_from_M md_76_r 90.16068804

HS_from_MQbrain_1892J 102.5141646 HS_from_MM_187_l 90.14742716

HSbrain_754_l 102.2895853 HS_from_MQbrain_1703J 89.75751515

HS_from_MQbrain_537_l 101.9504176 HS_from_MM_86_l 89.48891073

HS_from_MQbrain_1037_r 101.466981 HSbrain_97_l 89.025924

Hsd_35_r 101.1446856 HS_from_MQbrain_1958_r 88.93893093

HS_from_PT_1_l 101.0084568 HS_from_MQbrain_2670_r 88.75898562

HSbrain_117_r 100.8429431 HSbrain_427_r 88.68101495

HS_from_MM_109_r 100.8350177 H S_from_M Qbra i n_96_r 88.6327113

HSbrain_1400_r 100.7941952 Hsd_from_M md_74_r 88.62981818

HSbrain 113 r 100.6056081 HS from MQbrain 769 r 87.406602 HSbrain_195_l 87.10754423 HS_from_MQbrain_1760J 73.58132161

HS_from_MQbrain_792_l 87.00610998 HS_from_MQbrain_141J 73.5043697

HS_from_MQbrain_1334J 86.86195926 HS Jrom_MQbrain_1206_r 73.21400029

HS_from_MM_178_r 86.39079121 HSbrain_648_r 73.09661808

HS_from_MQbrain_315_l 85.77155971 HSJrom_MQbrain_525_r 72.8823751

HS_from_PT_139_l 85.75830736 Hsd_from_Mmd_476J 72.68804749

HSbrain_337_l 85.40127884 HSJrom_MQbrain_991_r 72.5119085

Hsd_from_Mmd_388_r 85.25768575 HS_from_MQbrain_1354J 72.49188083

HS_from_MQbrain_129 OJ 84.29078309 HSbrain_582_r 72.28969575

HSJrom_MQbrain_261_r 84.17408031 HSJrom_MQbrain_641_r 72.1752804

HS Jrom_MQbrain_1197_r 83.62885897 HS Jrom_MQbrain_1642_r 71.93220437

HS_158_r 83.42896638 HS Jrom_MQbrain_1772_r 71.75524419

HSbrain_261J 83.18937251 HS_from_MQbrain_1056J 71.54390765

HS _from_MQbrain_1527J 83.08155754 HSbrain_1436_r 71.34269518

HSJrom_MQbrain_212_r 83.02395006 HSbrain_278_r 71.09610068

HS Jrom_MQbrain_15 J 82.91376316 HSbrain_707_r 70.97237044

HS_from_MM_135_r 82.76328898 HS_from_MM_118_r 70.86890311

HsdJrom_Mmd_90_r 82.48617419 HSbrain_13_r 70.64600087

HS _from_MQbrain_1779J 82.35801621 HSJrom_MQbrain_304_r 70.56355992

HSbrain_343J 82.34298795 HSbrain_1391J 70.35762568

HSJ 93J 82.06496463 HS Jrom_MQbrain_1080J 70.18685041

HSJrom_MQbrain_923J 81.9527027 HSbrain_553J 69.73500772

HSbrain_224_r 81.77304743 HS_from_MQbrainJ224J 69.6781412

HSbrain_506J 81.68257158 HSJrom_PT_157J 69.35695138

HSJrom_PT_251_r 81.54576842 HS_from_MQbrain_1600_r 69.30857587

HS _from_MQbrain_1791 J 81.49102222 HS Jrom JVIQbrain_915 J 68.77873899

Hsd_76_r 80.46787511 HS_from_MM_185_r 68.74396066

HS_from_MM_40J 80.43791933 HS_from_MM_119J 68.49168012

HsdJrom_Mmd_525_r 80.02408705 HS _from_MQbrain_1410_r 68.45911099

HSJromJVIQbrain_952J 79.24788235 HSbrain_25_r 68.45071483

Hsd_from_Mmd_343J 79.17022973 HSbrain_689J 68.40960966

HS _from_MQbrain_1 139J 79.05020237 HSJrom_MQbrain_68J 68.40129245

HSJrom_MM_285_r 79.00004832 HSbrain_1337_r 68.28435609

HSJrom_MQbrainJ332J 78.79201419 HS_172_r 66.96978425

HSJrom_MM_260_r 78.59914649 Hsd_92J 66.70992407

HsdJrom_Mmd_455_r 78.59609185 HS _from_MQbrain_1396J 66.69299102

HSJrom_MQbrain_483_r 78.46549193 HSbrain_1417_r 66.48280656

HSJrom_MQbrain_506J 78.43916484 HSJ32J 66.38174565

HS_from_MM_106_r 78.0376375 HSbrain_1410J 66.2043953

HSbrain_329J 77.87290923 HSJ59J 66.17528144

HSJ38J 77.85150167 HSbrain_672J 65.33492962

HSJrom_MQbrain_240J 77.63282587 HS_96J 65.1735359

HSbrain_254J 77.56906513 HSJrom_MQbrain_255J 64.86378183

HSbrain_458J 77.3089971 HSbrain_1387J 64.82240984

HSbrain_358J 77.25165627 HSbrainJ572_r 64.68912173

HSbrainJJ 76.8373873 HSJrom_PT_328J 64.37288073

HSJrom_PT_284J 76.78239533 HSbrain_756J 64.23391136

HS_from_MM_13_r 76.61267549 Hsd_from_Mmd_532J 63.98178984

HS_from_MM_149_r 75.91523091 HS_from_MQbrainJ2050J 63.61829063

HS _from_MQbrain_1525J 75.43714328 HSJrom_MQbrain_465J 63.48237355

HSbrain_106_r 74.6228739 HSJromJVIQbrain_235J 63.18667666

HS Jrom_MQbrain_1089_r 74.25842215 HSbrain_178J 63.1279546

HSJrom_PT_103J 74.08268376 HSJrom_MQbrainJ335_r 62.94556533

HsdJrom_Mmd_296_r 74.00030271 HSbrain_429_r 62.78468363

HS _from_MQbrain_1092J 73.98551161 HS_from_MQbrain_1109J 62.73503843

HS from MQbrain 820 I 73.70641218 Hsd from Mmd 461 I 62.47532833 HS_from_MQbrain_80_l 62.18301452 HSbrain_678_l 54.10203966

Hsd_19_l 62.00218054 HSbrain_12_l 53.76557022

Hsd_from_M md_68_l 61.78328125 HSbrain_449_l 53.67127059

HS_from_MQbrain_1048_r 61.35298515 Hsd_88_l 53.39128816

HS_from_MQbrain_838_l 60.49841307 HSbrain_737_r 53.36757802

HSbrain_295_r 60.35523089 HS_from_MQbrain_1248_r 53.19833147

HS_from_MQbrain_1250_r 60.18097983 Hsd_6_l 53.15042029

HS_from_PT_320_l 60.05463755 Hsd_from_Mmd_507_r 52.61515894

HS_from_PT_196_r 59.89771429 HSbrain_758_l 52.56138123

HS_from_MQbrain_1314_r 59.71438986 HS_from_MQbrain_676_r 52.19716118

HSbrain_617_l 59.52352443 HS_from_MQbrain_1782J 52.131107

HSbrain_529_l 59.40625213 Hsd_from_Mmd_219_l 51.9531264

Hsd_from_Mmd_170_r 59.3789276 Hsd_from_Mmd_222_r 51.80246158

HSbrain_700_r 59.35494614 Hsd_from_Mmd_159_l 51.66519936

HSbrain_666_l 58.90254095 Hsd_from_Mmd_263_r 51.62052609

HSbrain_670_l 58.71863975 HS_from_MQbrain_552_r 51.35410703

HS_from_MM_159_r 58.25485462 HSbrain_3_l 51.24508411

HS_from_MQbrain_625_l 58.16380903 HSJ OOJ 51.22672886

HSbrain_170_r 58.09549284 HSbrain_131_l 51.07910404

HSbrain_736_r 57.98906648 HSbrain_1390_l 50.92997516

HSbrain_512_r 57.96648247 HS_214_I 50.60281362

HS_from_MQbrain_1603_r 57.86596708 HS_from_MM_201_l 50.5621644

HSbrain_604_r 57.67387084 HSbrain_314_r 50.36125959

HS_from_MQbrain_193_r 57.49416629 HS_69_I 50.17481884

HSbrain_686_l 57.37727461 HSbrain_674_l 50.10105834

HS_from_MQbrain_800_r 57.33831283 HS_from_MQbrain_435_l 50.08067692

HS_from_MM_194_r 57.30809246 HS_from_MQbrain_91 OJ 50.04935128

HS_from_MQbrain_1734J 57.12642239 HSbrain_1389J 49.94495038

HS_from_MQbrain_453_l 57.09533664 HSbrain_1392J 49.93511597

HSbrain_806_l 56.98000317 HSJrom_PT_32J 49.84882629

Hsd_3_l 56.90308663 H S Jrom JVI Qbra i n_72 J 49.84100507

HS_from_MQbrain_759_r 56.84789382 HSbrain_795J 49.81882127

Hsd_from_Mmd_340_r 56.81841128 HSbrain_2J 49.67189807

HS_from_MQbrain_1058_r 56.74296423 HS Jrom JVIQbrairM 53J 49.32700101

HSbrain_354_r 56.5121469 HSbrainJ530J 49.2660315

HSbrain_89_l 56.40365692 HS Jrom_MQbrain_1628J 49.23189915

HSbrain_1398_l 56.38379162 HSJromJVIQbrain_478_r 49.18860716

Hsd_40_r 56.20399334 HSJromJVIQbrain_353_r 49.02897584

Hsd_51_r 56.05310726 HSJrom_PT_130_r 49.02454902

HS_276_r 56.05146797 HS_187_r 48.74477955

HS_from_MQbrain_808_r 55.94239194 HSbrain_163_r 48.59342229

HSbrain_200_l 55.88350406 HSbrain_1386J 48.57929064

HS_from_MM_114_r 55.53559367 HSbrain_667J 48.3302073

HSbrain_405_l 55.37192181 HsdJromJVImdJ-98_r 48.27315482

HSbrain_1388_l 55.06423423 HSbrain_683J 48.21895122

HS_from_MQbrain_809_r 54.98604134 HSJrom_MQbrain_79_r 48.19976833

HS_from_MQbrain_1378J 54.95023303 HSbrain_236_r 47.93509812

HS_from_MQbrain_972_l 54.8749493 HSJromJVIQbrain_970J 47.65771607

HSbrain_380_r 54.63237608 HSJromJVIM_219J 47.65091531

HS_from_MQbrain_833_r 54.62093985 HSbrain_662_r 47.55963248

HS_from_MQbrain_907_r 54.46335077 H S Jrom JVI Qbra i n J364 J 47.52132335

HS_from_MQbrain_1815_r 54.40047492 HSJromJVIQbrain_701J 47.39067123

HS_from_MQbrain_791_l 54.34606891 HSJromJVIQbrain_906_r 47.10729944

HSbrain_333_l 54.27871271 HS_252J 46.90321783

Hsd_from_Mmd_358_l 54.15061703 HSbrain_127J 46.52896356

HS from MQbrain 1502 I 54.14110189 HSbrain 246 r 46.43534933 HSbrain_681_l 46.40728223 HSbrain_235_r 36.73133147

Hsd_from_Mmd_280_l 46.29319877 HSbrain_378_l 36.4906662

HSbrain_660_l 45.8415198 HSbrain_180_r 36.33126606

HSbrain_370_r 45.65991936 HS_from_MQbrain_984_l 36.17853558

HSbrain_285_l 45.49193279 HSbrain_619_l 35.93463694

HSbrain_504_r 45.47207589 HSJ 74J 35.20952323

HSbrain_704_l 45.12744924 HS_from_MQbrain_573_l 34.88927084

HS_from_PT_48_r 44.70075948 Hsd_from_Mmd_231_l 34.74078503

HS_from_MQbrain_1638J 44.5951134 HSbrain_338_l 34.72414818

HS_from_MQbrain_1823_r 44.43291919 Hsd_from_Mmd_355_l 34.42795833

HS_from_MQbrain_227_l 44.22949556 Hsd_from_M md_41 _r 34.27587083

HS_from_MQbrain_168_l 44.17804845 Hsd_from_Mmd_486_r 34.15274704

HSbrain_344_l 44.15992199 HS_from_MQbrain_549_l 34.06783333

HS_from_MQbrain_526_r 44.11167126 HS_from_MQbrain_1269J 33.96400251

HS_from_MM_96_l 44.0116193 HSbrain_382_l 33.54888194

HS_from_MQbrain_895_l 43.98720722 HS_from_MQbrain_1296J 33.13683698

HS_from_MQbrain_1671_r 43.89097046 Hsd_33_l 33.05107162

HS_8_I 43.81193213 Hsd_59_r 33.04438013

HSbrain_1434_r 43.6359673 HS_103_r 32.96905528

Hsd_from_Mmd_391_l 43.63503635 HS_from_MQbrain_339_l 32.88359006

HS_239_r 43.51954011 HS_from_MM_101_l 32.5944636

HSbrain_119_l 43.4608124 HS_from_MQbrain_1541J 32.58806331

HS_from_MM_313_l 43.35911147 H S_from_M Qbra i n_594_l 32.57661566

HSbrain_46_r 42.59001781 HS_from_MQbrain_441_l 32.28225695

HS_from_MQbrain_912_l 42.57025194 HS_from_MQbrain_1180_r 32.20670401

HSbrain_332_l 42.50762875 Hsd_from_Mmd_311_l 32.03234884

HSbrain_492_r 42.32362121 Hsd_from_M md_51 _l 31.73933766

HS_from_MQbrain_1595J 42.27660177 HS_from_MQbrain_945_l 31.71875825

HS_from_MM_1_r 42.18437325 HSbrain_407_l 31.47421874

HS_from_MQbrain_1461_l 42.18381426 HS_from_MQbrain_1728_r 31.38135841

HS_from_MM_298_l 41.95783366 HS_from_MM_63_l 31.12592861

HSbrain_753_r 41.77257724 HS_from_MQbrain_476_r 30.32765965

HS_from_PT_140_r 41.76036155 Hsd_22_l 30.26306383

HSbrain_447_r 41.25875347 Hsd_from_Mmd_190_l 30.1853939

HS_from_MQbrain_1723J 41.19154968 HSbrain_481_r 29.96985078

HS_from_MQbrain_634_r 40.90596624 HS_from_MQbrain_813_l 29.85107308

HS_from_MQbrain_195_l 40.82226933 HSbrain_81_l 29.82507402

HS_from_MQbrain_451_l 39.84713568 HS_from_MQbrain_760_r 29.64730363

HS_from_MQbrain_816_l 39.60354675 HS_from_MQbrain_836_l 29.14988914

HS_from_MM_146_l 39.24758442 HS_from_MM_116_r 29.14631328

HSbrain_645_r 39.08920999 HS_from_MQbrain_1405J 28.83096971

HS_from_PT_254_r 38.90953686 Hsd_from_Mmd_536_r 28.65654394

HS_from_MQbrain_1439J 38.7147919 HS_from_MQbrain_1528J 28.63818767

HSbrain_577_r 38.5784199 HSbrain_62_l 28.38621466

HSbrain_142_l 38.55033479 HS_from_MQbrain_1469_r 28.13492378

HS_from_MQbrain_1872J 38.54135356 HS_from_MM_147_l 27.93559808

HSJ47J 38.35905769 HS_from_MQbrain_811_l 27.92339435

HS_from_MQbrain_334_l 37.94381448 HS_from_PT_257_r 27.728139

HSbrain_789_r 37.88985765 Hsd_from_M md_59_l 27.70423359

Hsd_from_Mmd_533_l 37.74138535 HS_from_MQbrain_1 147J 27.67089026

HS_from_MM_168_l 37.71479168 HS_from_MQbrain_1531_r 27.40554145

HS_153_r 37.62053177 HS_from_MQbrain_1404_r 27.3954386

HS_from_MQbrain_778_r 37.2177956 HSbrain_1419_l 27.03021687

HSbrain_412_l 37.17793298 HS_from_MQbrain_187_l 26.83013233

HSbrain_603_l 37.11164773 Hsd_98_r 26.78596273

HS from MQbrain 1168 r 37.02284436 HS from MQbrain 358 r 26.721815 HS_from_MQbrain_1268_r 26.46384108 HSbrain_661_r 19.37627406

HS_from_MQbrain_444_l 26.41588909 HSbrain_214J 19.36197308

HS_from_MQbrain_1384_r 26.20937179 HSbrain_540_r 19.28862768

HSbrain_543_r 26.09736904 HSbrain_399_r 19.20558511

HS_from_MQbrain_484_r 25.86881457 HSbrain_394J 19.15960956

HS_from_MQbrain_377_r 25.55774768 HSbrain_159J 19.09259883

Hsd_from_Mmd_426_l 25.5337463 HSbrain_11 1J 19.09214846

HSbrain_422_r 25.49910218 HS_from_MQbrain_954J 19.05644186

HS_from_MM_89_r 25.15500847 HSJrom_MQbrain_2441J 19.05254542

HS_from_MQbrain_1301J 25.12455997 HS_from_MQbrain_1234J 18.99466667

HS_from_MQbrain_717_r 25.09002247 HSbrain_302J 18.95338066

HS_from_MQbrain_1762_r 24.82824464 HSbrain_654J 18.757945

Hsd_from_Mmd_478_l 24.52473283 HS_from_MQbrain_137J 18.64970611

HSbrain_561_r 24.46565743 HS_from_MQbrain_1606_r 18.62823269

HS_from_MQbrain_829_l 24.39741191 HS_from_MQbrain_1327_r 18.53143133

HS_from_MM_90_r 24.1951004 HS Jrom_MQbrain_215 J 18.49178278

HS_from_MQbrain_986_r 24.18087433 HS_from_MQbrain_462_r 18.48192995

HS_from_MQbrain_1201_r 23.9141836 HSbrain_1338J 18.40400866

HS_from_MQbrain_157_r 23.7389583 HS_from_MQbrain_1698J 18.29146104

HS_from_MQbrain_1571 J 23.40380682 HSJrom_PT_221_r 18.28911853

Hsd_7_r 23.39907905 HS_from_MQbrain_1317 J 18.27878358

Hsd_104_l 23.30618615 HSJrom_MM_268_r 18.2673582

HS_from_MQbrain_854_l 23.28901375 HS _from_MQbrain_1256J 18.09586294

Hsd_from_Mmd_275_r 23.18305355 HSbrain_442_r 18.08359556

HS_from_MQbrain_979_l 23.09100891 HS_from_MQbrain_1648_r 18.04974603

HSbrain_417_l 23.07219376 Hsd_26_r 17.92523385

HS_from_MQbrain_1320J 22.94039627 HSbrain_225J 17.89446706

Hsd_from_Mmd_389_r 22.408902 HS_from_MQbrain_1308_r 17.83505344

HSbrain_497_l 22.40769173 HSbrain_238J 17.83400503

HS_from_MQbrain_1312J 22.37619915 Hsd_from_Mmd_149_r 17.76480562

HSbrain_671_r 22.1043858 HS_from_MQbrain_1474J 17.62620625

HSbrain_281_l 21.97857516 HS_from_MQbrain_1286J 17.57104529

Hsd_from_Mmd_452_l 21.7681635 HSbrain_379_r 17.51053422

HS_from_MM_276_l 21.75172107 HSbrain_542J 17.47601898

HS_from_MQbrain_402_r 21.71995828 HS_93_r 17.4404153

HS_from_PT_272_l 21.71160257 HSJrom_MM_9_r 17.31753403

HS_from_MQbrain_169 OJ 21.66605198 HS_from_MMJ31J 17.28975439

HS Jrom_MQbrain_16J 21.18417377 HS_from_MQbrain_471_r 17.2822643

HSJrom_MQbrainJ312_r 21.17953556 HS_295_r 17.2634514

HS _from_MQbrain_1883J 21.12907054 HS_272_r 17.21224979

HSJrom_MQbrain_1081_r 20.97667628 HSbrain_381_r 17.19500195

HSbrainJ348J 20.79326706 Hsd_91J 17.19147953

HSbrain_237_r 20.78891804 HSbrain_374J 17.14555494

Hsd_15J 20.57501838 HSJrom_PT_247J 17.14193784

HsdJrom_Mmd_297_r 20.55327833 HS _from_MQbrain_1087_r 17.09295407

HSbrain_742_r 20.55270084 HSbrain_1406J 17.08291783

HS _from_MQbrain_1783J 20.23594438 HSbrain_499_r 16.86242407

HsdJrom_Mmd_272_r 19.9884149 HSJ273J 16.84876947

HS_from_MM_156_r 19.97104349 HS _from_MQbrain_105J 16.80746034

HSbrainJ546_r 19.96726522 H S _f rom_M Qbra i n_554 J 16.7813907

HSJrom_PT_40_r 19.96645961 HSJ45J 16.69161607

HsdJrom_Mmd_223_r 19.94197059 HS_11_r 16.56965243

HS_from_MM_236J 19.92500437 HS_from_MQbrain_1778_r 16.56308131

Hsd_from_Mmd_409J 19.84694165 HS_from_MQbrain_1901 J 16.55251009

HSbrain_1422J 19.73606411 HS_298_r 16.37083451

HS from MQbrain 601 I 19.43288221 HS from PT 125 I 16.20117613 HS_297_r 16.18088267 HS_from_MQbrain_542_l 12.4589606

HSbrain_5_l 16.1038857 Hsd_from_Mmd_490_l 12.34090149

HS_from_MQbrain_814_r 16.03485169 HS_202_l 12.33606455

HSbrain_357_l 15.97090807 Hsd_from_Mmd_325_l 12.27846175

HS_from_MQbrain_65_r 15.88380756 HSbrain_641_l 12.19531359

HS_13_I 15.87695915 HS_from_MQbrain_1805_r 12.08133366

HSbrain_649_l 15.85119362 HSbrain_222_l 12.01722409

H S_from_M Qbra i n_55_l 15.80840103 HS_from_MQbrain_1214J 11.99962527

HS_260_l 15.63834526 HSbrain_486_r 11.92687298

Hsd_from_Mmd_262_l 15.61807712 HSbrain_190_l 11.90155086

HS_from_MM_39_l 15.46864042 HS_from_PT_282_l 11.85767781

HS_from_MQbrain_1882_r 15.42159484 HS_from_MQbrain_1857J 11.81637718

HS_192_r 15.41603426 HS_from_PT_253_l 11.63356298

HS_from_PT_123_r 15.33202181 HS_82_I 11.58743783

HS_from_PT_128_r 15.33190969 HS_from_MQbrain_992_l 11.55219844

HSbrain_507_r 15.19580403 HS_27_I 11.5189217

HSbrain_706_l 15.17246512 Hsd_55_l 11.47708921

Hsd_from_Mmd_473_l 15.1413037 HS_from_MQbrain_1217_l 11.46181019

HS_from_MQbrain_1753_r 15.00695265 HS_from_MQbrain_182_l 11.36963928

HS_from_MQbrain_420_r 15.00394554 HS_from_PT_301_r 11.35875076

HS_from_PT_292_l 14.96523543 HS_from_PT_13_r 11.28505999

HS_204_r 14.93137289 HS_from_PT_126_r 11.24987161

HSbrain_247_l 14.87371333 HS_from_MQbrain_1694_r 11.24856812

HSbrain_533_r 14.81805007 HSbrain_532_l 11.20284123

HSbrain_140_l 14.80953804 HS_from_PT_315_l 11.14257669

HS_from_MQbrain_1494J 14.7687191 HS_from_MQbrain_656_l 11.0380573

HSbrain_1423_r 14.73538059 HS_from_MQbrain_1264_r 10.9879875

Hsd_from_M md_524_r 14.7018346 HS_from_MQbrain_179_l 10.93508111

HSbrain_602_r 14.66781038 HSbrain_122_r 10.91049034

HS_262_I 14.64955868 HSbrain_791_l 10.8880558

HS_from_MM_254_r 14.60568724 HSbrain_792_l 10.74841217

HS_from_MQbrain_1746_r 14.49926674 H S_from_M Qbra i n_8_r 10.6772637

HS_from_MQbrain_1893_r 14.47922582 HS_from_MQbrain_1432J 10.63790696

HSbrain_16_l 14.42037004 Hsd_from_Mmd_523_l 10.60175496

HS_from_MQbrain_1879_r 14.39648047 HS_from_MQbrain_787_l 10.45276823

HSbrain_446_l 14.33402718 HSbrain_271_r 10.39774564

HSbrain_137_l 14.29565616 HS_from_PT_297_l 10.3817856

HS_294_r 14.28845143 HS_from_MQbrain_389_l 10.36562841

HSbrain_356_l 14.19629964 Hsd_from_Mmd_306_r 10.35597869

HS_from_PT_155_r 14.06410331 HS_from_MQbrain_140_r 10.33466558

HSbrain_24_l 14.04788368 HSJ 30J 10.32443146

HS_from_MQbrain_1811_l 13.90556328 Hsd_from_Mmd_336_r 10.26104082

HS_from_MQbrain_1799J 13.49508607 Hsd_from_Mmd_243_r 10.21164464

HS_16_r 13.45833857 HS_from_MQbrain_827_r 10.04636996

HS_from_PT_113_l 13.41746343 Hsd_from_Mmd_217_l 10.0411297

HS_from_MQbrain_1880_r 13.37337073 HS_from_MM_271_r 9.974500263

Hsd_9_l 13.04883428 HSbrain_174_l 9.914419841

HSbrain_732_r 12.92048191 HS_from_MQbrain_1059_r 9.903606705

HSbrain_432_l 12.91311938 HSbrain_451_r 9.891359358

HSbrain_454_r 12.81394683 HS_from_MM_30_l 9.828879468

Hsd_from_Mmd_249_r 12.73986084 HSbrain_389_l 9.742590244

HS_from_PT_195_l 12.68428891 Hsd_from_Mmd_334_l 9.461092816

HSbrain_256_r 12.675 HSbrain_539_r 9.402802755

HS_from_MM_72_l 12.60592101 HS_from_MQbrain_172_r 9.3950049

HS_from_MQbrain_1195_l 12.59863883 Hsd_from_Mmd_491_r 9.356107716

HS from MQbrain 1188 r 12.51525581 HS from PT 321 r 9.355284488 HS_from_MM_214_r 9.312015244 HSbrain_615_r 7.513083761

HS_181_r 9.247606951 HS_from_PT_7_r 7.471471439

HSbrain_242_l 9.140095581 HSbrain_22_l 7.394968873

HSbrain_719_l 9.057424006 HSbrain_296_r 7.377471663

HS_from_PT_216_r 9.04533293 HSJ 32J 7.348116533

Hsd_106_l 9.004764262 HS_253_r 7.309083262

HS_from_MQbrain_1216_l 8.977281937 HS_269_I 7.231720764

HS_49_r 8.969465473 HS_261_I 7.115946746

HS_from_MQbrain_521_r 8.94922503 HS_from_MQbrain_1414_r 7.115880718

HSbrain_76_r 8.849660075 Hsd_from_Mmd_437_r 7.1 12646234

HS_from_PT_309_l 8.806106342 HS_from_MQbrain_603_r 7.108558771

HS_from_MM_275_r 8.801848936 HS_293_I 7.088759746

HS_from_MQbrain_1784_r 8.765325591 HS_from_PT_193_l 7.000684

HSbrain_320_l 8.739860007 HSbrain_345_l 6.991513121

HS_from_MM_169_r 8.697594288 HS_from_MQbrain_1636J 6.953922141

HSbrain_414_r 8.667025277 HS_from_MQbrain_365_l 6.941331531

HSbrain_468_r 8.648929144 HS_from_MQbrain_367_r 6.938384447

HS_from_MQbrain_597_l 8.606774472 Hsd_from_Mmd_318_r 6.911841179

HS_from_MQbrain_1238_r 8.560768136 HS_from_PT_35_r 6.863541091

HS_from_MQbrain_1576_r 8.509211792 HSbrain_519_l 6.827428395

HSbrain_711_r 8.507528601 HSbrain_83_r 6.664458888

HS_270_l 8.500056129 HSbrain_99_r 6.64726838

HS_from_MQbrain_189_r 8.458412909 HSbrain_397_l 6.63113271

HSbrain_803_r 8.436925155 HS_from_MQbrain_1110_r 6.60657006

HS_from_MQbrain_354_l 8.378373604 HS_from_MQbrain_1428_r 6.548707334

HS_from_MQbrain_1514_r 8.3514592 HS_from_MQbrain_855_r 6.514975985

Hsd_23_l 8.323337473 HS_from_MQbrain_1127_r 6.478685264

HS_from_MQbrain_329_r 8.298733963 Hsd_from_Mmd_300_l 6.467880633

HS_from_MQbrain_694_l 8.295833858 HS_from_MQbrain_1444J 6.459126984

HS_from_PT_168_r 8.28827405 HS_from_MM_186_r 6.438164347

HS_from_MQbrain_209_l 8.267384678 HSbrain_726_l 6.434813111

HS_from_MQbrain_1 124J 8.263702597 Hsd_from_Mmd_378_l 6.433733047

HS_from_MQbrain_581_r 8.223408593 HS_from_MQbrain_1196_r 6.432257948

HS_from_MQbrain_796_r 8.179623288 HS_from_MQbrain_1792_r 6.412117504

Hsd_from_M md_464_r 8.134582867 Hsd_from_M md_314_r 6.401270974

HS_from_MQbrain_995_l 8.045505431 HS_from_MQbrain_161_r 6.387946973

HSbrain_609_r 8.027284091 HS_from_MQbrain_176_r 6.3337272

HS_296_I 8.020342859 HS_from_MQbrain_728_r 6.311020118

HS_from_MM_164_r 8.01189659 HS_from_MQbrain_584_r 6.293457493

Hsd_from_Mmd_422_r 8.004189538 HS_250_l 6.287211447

HS_from_MM_34_l 7.978839103 HS_from_MQbrain_1726J 6.286472819

Hsd_53_l 7.976949043 HS_from_MQbrain_1836J 6.267799948

Hsd_from_Mmd_58_l 7.966323875 HSbrain_770_l 6.241026808

HS_from_MM_256_l 7.965453015 Hsd_from_M md_75_r 6.235422423

HSbrain_501_l 7.947790019 HS_from_PT_99_l 6.209015876

HS_from_MQbrain_817_l 7.907551804 HS_80_l 6.188564855

HS_from_PT_138_r 7.906213461 Hsd_from_Mmd_37_l 6.088255723

HS_264_r 7.905646906 HS_from_MM_331_l 6.063144444

HS_from_MQbrain_1203_r 7.900397573 HS_from_PT_63_l 6.041521667

HSbrain_598_r 7.899656198 HS_from_MM_129_l 5.994127046

HS_from_MM_92_l 7.887171356 HSbrain_312_r 5.989098244

Hsd_from_Mmd_117_r 7.718924828 HS_from_MQbrain_1287J 5.969747859

Hsd_54_l 7.702137509 HS_from_PT_287_l 5.921804778

HS_271_I 7.649964483 HS_from_MQbrain_1442J 5.874225415

Hsd_from_Mmd_506_l 7.638500912 HS_from_MQbrain_1626_r 5.841073155

HSbrain 100 r 7.597636684 Hsd from Mmd 431 r 5.823283134 HSbrain_587_l 5.720693567 HS_from_MM_263_r 4.175244885

Hsd_from_Mmd_286_r 5.6723549 HS_from_MQbrain_1946J 4.165279786

HS_from_MM_241_r 5.640741712 HSbrain_1404_l 4.149119572

HSbrain_884_r 5.628250928 HS_from_PT_73_r 4.147610682

HS_from_MQbrain_1362_r 5.601980717 Hsd_from_Mmd_372_r 4.138862422

HS_from_MM_342_r 5.590510164 Hsd_45_r 4.133836037

HS_from_MQbrain_681_r 5.585694118 HS_from_MQbrain_1550_r 4.129298294

HSbrain_149_r 5.583342412 HS_from_MQbrain_1840J 4.101477435

HS_from_MQbrain_1325_r 5.47614768 HS_302_l 4.060716908

HS_from_MM_20_l 5.47139804 HS_210_r 4.043610319

HS_from_MQbrain_843_l 5.455426554 HSbrain_695_r 4.015688972

HSbrain_625_l 5.435431773 Hsd_from_Mmd_319_r 3.975166738

HSbrain_322_r 5.365626693 HSbrain_538_r 3.973394819

HS_from_MQbrain_1330_r 5.28181558 HSbrain_775_r 3.957435197

HS_from_PT_332_l 5.2733498 HS_from_PT_172_r 3.955677596

Hsd_from_Mmd_260_l 5.210287976 HSbrain_714_r 3.916807584

Hsd_from_Mmd_105_l 5.193639257 Hsd_94_r 3.914560357

HSbrain_438_l 5.166472999 HSbrain_34_l 3.900138034

Hsd_96_r 5.165955532 HS_from_MQbrain_1817_l 3.888478757

Hsd_from_M md_54_l 5.159018659 HS_from_MQbrain_133_l 3.872882828

HS_from_MQbrain_637_l 5.142521242 Hsd_from_Mmd_316_l 3.862039898

HSbrain_777_r 5.13504626 HS_from_MM_353_l 3.859645753

HS_from_MM_320_l 5.118764197 HSbrain_199_r 3.848060046

HSbrain_646_l 5.06314414 HS_from_PT_177_l 3.844770953

HS_from_MM_108_l 5.025117442 HS_from_MM_131_l 3.843700557

HSbrain_17_l 4.967438933 HS_from_MM_283_l 3.835559931

HS_from_MM_173_r 4.943371194 HSbrain_327_r 3.828446699

HS_from_MM_99_l 4.941226582 HS_from_MQbrain_237_l 3.827625487

HS_from_MM_54_l 4.939670275 HS_from_MQbrain_1489J 3.827197683

HS_from_MM_180_l 4.925462788 HS_from_PT_242_r 3.826482783

HS_301_l 4.918434367 HS_from_MQbrain_675_l 3.821332516

HSbrain_215_r 4.813707447 HSJ27J 3.813883173

HS_from_MQbrain_144_l 4.773009427 HSbrain_26_r 3.807676617

Hsd_from_Mmd_363_l 4.747442615 HS_from_MM_47_r 3.767205302

HS_from_MQbrain_1806_l 4.715008642 Hsd_from_Mmd_115_l 3.754433136

HS_from_PT_224_r 4.699668621 HSbrain_489_r 3.754378803

Hsd_from_Mmd_516_l 4.635744497 HSbrain_566_r 3.737039243

HSbrain_384_l 4.544181943 HSbrain_623_l 3.719892174

HSbrain_437_l 4.53872403 Hsd_101_l 3.714373078

HS_from_MQbrain_1020_r 4.533028897 HSbrain_444_l 3.697175272

HSbrain_416_l 4.50890556 HS_from_MQbrain_768_l 3.670091279

HS_from_MQbrain_653_l 4.501537159 HSbrain_552_l 3.649272388

Hsd_from_M md_48_r 4.488918042 HS_from_MQbrain_236_l 3.625507462

Hsd_from_Mmd_163_r 4.482580882 HSbrain_779_l 3.584724644

HSbrain_298_l 4.466165605 Hsd_from_Mmd_382_l 3.519705525

HS_from_MQbrain_779_r 4.449613618 HS_from_PT_206_l 3.499387091

Hsd_from_Mmd_264_l 4.418448309 HSbrain_395_r 3.49723377

HS_from_MQbrain_1518_r 4.395289501 HSbrain_28_r 3.479753348

HS_from_MQbrain_1849J 4.347274863 HS_from_MQbrain_1770J 3.46187934

HSbrain_4_r 4.32906393 HS_from_MM_41_l 3.445933309

HS_from_PT_188_r 4.316585673 Hsd_from_M md_67_l 3.440647552

Hsd_from_Mmd_253_r 4.315801417 Hsd_81_r 3.432967686

HS_from_MQbrain_366_r 4.292586708 HSbrain_234_r 3.407293997

HS_from_MM_50_r 4.289479841 HSbrain_583_l 3.381538102

HSbrain_579_l 4.276586895 HS_175_r 3.357952232

HS from MM 270 r 4.214386428 HSbrain 1405 I 3.356703194 HSbrain_36_l 3.355223023 Hsd_10_r 2.526022642

HSbrain_799_r 3.32764451 HS_from_MM_354_l 2.51152459

HSbrain_156_r 3.316412833 Hsd_from_M md_35_l 2.507108516

HS_292_r 3.304463889 HS_14_I 2.504007921

HSbrain_270_l 3.298294118 Hsd_from_Mmd_503_r 2.500865194

HSbrain_120_l 3.289133711 HS_from_MQbrain_1042J 2.492234297

HS_from_MQbrain_393_r 3.278433239 HS_from_MQbrain_1 137_l 2.48333526

HSbrain_413_l 3.253659453 HS_from_MQbrain_967_r 2.462255581

HS_from_MQbrain_571_l 3.230584236 HSbrain_453_l 2.447562054

HS_from_PT_36_l 3.220412941 HS_from_MQbrain_1004_r 2.444952219

HS_37_I 3.206393454 HSbrain_970_r 2.440271917

HS_52_r 3.202332911 Hsd_from_Mmd_361_l 2.438145559

Hsd_from_Mmd_137_l 3.199011474 HS_from_MQbrain_1 114_l 2.428090643

HS_30_l 3.198916759 HS_from_MQbrain_1 16_r 2.413035295

HS_from_MQbrain_241_r 3.185534964 HSbrain_650_r 2.37442311

HS_from_MQbrain_961_l 3.171813525 HS_from_PT_201_r 2.367251208

Hsd_from_Mmd_126_r 3.136748756 HS_from_MM_84_l 2.359765653

Hsd_from_Mmd_294_l 3.120693079 HS_from_MM_35_l 2.357250026

HS_from_MQbrain_1381J 3.05930194 HS_from_MM_218_l 2.349494942

HS_from_MQbrain_309_r 3.055368101 H S_from_M Qbra i n_822_l 2.343923008

HS_from_MQbrain_1453J 2.994679273 Hsd_from_Mmd_184_r 2.326116517

HS_from_PT_271_l 2.99221888 HS_205_r 2.316073448

HSbrain_198_r 2.990967111 HSbrain_682_l 2.31200622

Hsd_from_Mmd_293_l 2.967120325 HS_from_PT_118_r 2.299993921

HS_from_MQbrain_1598_r 2.953508283 HS_66_I 2.296381916

HS_from_MM_48_r 2.942281873 HS_from_MQbrain_1294J 2.290891026

HS_from_MM_230_l 2.933799334 HS_from_MQbrain_384_l 2.290767433

Hsd_from_Mmd_321_r 2.930696257 HS_73_I 2.284341705

HSJ20J 2.924334019 HSbrain_567_r 2.278153257

Hsd_75_r 2.904138309 HS_23_r 2.270142822

HSbrain_179_r 2.892784879 Hsd_48_r 2.234838488

HSbrain_766_l 2.881094354 Hsd_41_r 2.227383669

Hsd_from_Mmd_376_l 2.856829716 HSbrain_644_r 2.20892511

Hsd_from_Mmd_154_l 2.836322667 HSbrain_308_l 2.202113484

HS_from_MQbrain_77_l 2.793426308 HS_from_MM_288_r 2.194320275

HS_from_MM_105_l 2.764361009 HS_209_r 2.177385602

HS_from_MQbrain_600_r 2.759134838 HSbrain_477_l 2.16939955

HS_from_PT_288_l 2.734365188 HS_from_MQbrain_1570_r 2.155106437

HS_from_MQbrain_689_l 2.726769607 Hsd_from_Mmd_162_r 2.145184152

HS_241_r 2.716303039 HS_from_MQbrain_748_l 2.128371426

HS_from_PT_84_l 2.714709014 HS_from_MM_127_r 2.123969014

HSbrain_86_r 2.701204062 Hsd_from_Mmd_302_l 2.116616569

HSbrain_245_r 2.699435997 HS_from_MQbrain_876_l 2.116156997

Hsd_from_Mmd_373_r 2.690929354 Hsd_from_Mmd_276_l 2.097724083

HSbrain_377_r 2.687263122 HSbrain_21_r 2.096124188

HSbrain_20_r 2.643971939 HS_from_MM_323_l 2.074777286

HSbrain_755_l 2.63850582 Hsd_from_Mmd_82_l 2.072192829

HS_from_MQbrain_1146_r 2.637847458 HSbrain_725_r 2.042955708

HS_from_MQbrain_314_l 2.61540593 HS_237_I 2.042459608

Hsd_57_r 2.605334909 HS_from_MM_68_l 2.035960337

HS_from_MQbrain_1343_r 2.598031533 HSbrain_264_r 2.028164366

HSbrain_87_r 2.5925368

Hsd_from_Mmd_346_l 2.586537564 1CUt off signal/background >2

Hsd from Mmd 396 r 2.565770876 Table 9a Small RNAs recovered from faeces and differentially expressed in adenoma vs control tissue: hairpin with highest expression adenoma vs control

Systematic name signal/background1 (adj p)2

HS_217_I 228.449758 0.000489293

HSJ69J 153.6041594 0.000489293

HSJ41J 141.8565157 0.000489293

HS_218_r 235.8613357 0.000704567

HS_255_I 161.1405598 0.001129352

HS_232_I 120.592551 0.001129352

HS_262_I 14.64955868 0.001446314

HS_from_MM_118_r 70.86890311 0.003939952

HS_from_MM_309_r 208.0343975 0.004006907

HS_from_MM_178_r 86.39079121 0.004006907

HS_from_MM_169_r 8.697594288 0.004006907

HS_from_MM_319_l 202.6221234 0.004431894

HS_from_MM_334_l 165.3471372 0.004431894

HS_from_MM_339_r 327.2871875 0.004575487

HS_from_MQbrain_100_l 133.6513061 0.004575487

HS_from_MM_63_l 31.12592861 0.004575487

HS_from_MM_39_l 15.46864042 0.004575487

HS_from_MQbrain_1043_r 281.5762963 0.004799641

HS_from_MQbrain_1056J 71.54390765 0.004799641

HS_from_MQbrain_1183_l 198.4935006 0.004957702

HS_from_MQbrain_1100_l 165.2906308 0.004957702

HS_from_MQbrain_1 128J 158.837926 0.004957702

HS_from_MQbrain_1297_l 270.3967365 0.006601644

HS_from_MQbrain_1292_r 121.9448163 0.006601644

HS_from_MQbrain_1393_r 223.7656716 0.00676609

HS_from_MQbrain_131_r 202.0595323 0.00676609

HS_from_MQbrain_1444_l 6.459126984 0.007781761

HS_from_MQbrain_1456_l 199.1014452 0.008573112

HS_from_MQbrain_1630_l 245.6614642 0.008946182

HS_from_MQbrain_1625_r 238.0330045 0.008946182

HS_from_MQbrain_1624J 192.3884805 0.008946182

HS_from_MQbrain_1522_r 112.3011721 0.008946182

HS_from_MQbrain_1485_r 90.24185865 0.008946182

HS_from_MQbrain_1657_r 116.3148049 0.009734613

HS_from_MQbrain_1808_r 253.1879056 0.01044887

HS_from_MQbrain_191_l 203.1756555 0.01044887

HS_from_MQbrain_1884_r 159.9476968 0.01044887

HS_from_MQbrain_1823_r 44.43291919 0.01044887

HS_from_MQbrain_1792_r 6.412117504 0.01044887

HS_from_MQbrain_671_r 263.6821505 0.010727702

HS_from_MQbrain_71_r 252.4897985 0.010727702

HS_from_MQbrain_330_r 236.6286556 0.010727702

HS_from_MQbrain_20_r 229.8506554 0.010727702

HS_from_MQbrain_629_l 195.1102679 0.010727702

HS_from_MQbrain_350_l 189.461419 0.010727702

HS_from_MQbrain_2380_r 187.2947993 0.010727702

HS_from_MQbrain_207_l 157.9140691 0.010727702

HS_from_MQbrain_349_l 135.3020631 0.010727702

HS_from_MQbrain_619_r 122.6749499 0.010727702

HS_from_MQbrain_194_l 1 10.0069304 0.010727702

HS from MQbrain 212 r 83.02395006 0.010727702 HS_from_MQbrain_549_l 34.06783333 0.010727702

HS_from_MQbrain_441_l 32.28225695 0.010727702

H S_fro m_M Qbra i n_55_l 15.80840103 0.010727702

HS_from_MQbrain_839_r 92.94488973 0.011699489

HS_from_MQbrain_79_r 48.19976833 0.011699489

HS_from_MQbrain_917_r 280.5140354 0.012506309

HS_from_MQbrain_940_r 239.4870149 0.012506309

HS_from_MQbrain_965_l 235.4627068 0.012506309

HS_from_PT_237_r 288.8596386 0.013034759

HS_from_PT_190_r 138.4453126 0.013034759

HS_from_PT_257_r 27.728139 0.013034759

HS_from_PT_40_r 19.96645961 0.013034759

HS_from_PT_36_l 3.220412941 0.013034759

HS_from_PT_201_r 2.367251208 0.013034759

HSbrain_171_l 255.6856718 0.017198956

HSbrain_148_r 224.0526161 0.017198956

HSbrain_102_r 200.4155278 0.017198956

HSbrain_158_l 169.343928 0.017198956

HSbrain_1305_l 145.0316211 0.017198956

HSbrainJJ 76.8373873 0.017198956

HSbrain_106_r 74.6228739 0.017198956

HSbrain_12_l 53.76557022 0.017198956

HSbrain_231_l 226.0585846 0.018600058

HSbrain_321_r 211.435012 0.018600058

HSbrain_243_l 182.2549801 0.018600058

HSbrain_224_r 81.77304743 0.018600058

HSbrain_2_l 49.67189807 0.018600058

HSbrain_426_r 262.208223 0.019454312

HSbrain_420_r 228.3614012 0.019454312

HSbrain_359_r 226.1695269 0.019454312

HSbrain_337_l 85.40127884 0.019454312

HSbrain_446_l 14.33402718 0.019454312

HSbrain_377_r 2.687263122 0.019454312

HSbrain_485_r 258.4877461 0.021088597

HSbrain_527_r 228.8704808 0.021088597

HSbrain_483_l 220.2067855 0.021088597

HSbrain_503_r 181.710235 0.021088597

HSbrain_540_r 19.28862768 0.021088597

HSbrain_583_l 3.381538102 0.021088597

HSbrain_709_l 274.820351 0.022745616

HSbrain_629_l 254.3371274 0.022745616

HSbrain_6_r 244.8860331 0.022745616

HSbrain_597_r 208.6310714 0.022745616

HSbrain_636_l 159.8695431 0.022745616

HSbrain_617_l 59.52352443 0.022745616

Hsd_18_l 237.5322474 0.023736962

HSbrain_723_l 236.0439796 0.023736962

HSbrain_8_r 227.4862458 0.023736962

HSbrain_75_l 227.0689221 0.023736962

HSbrain_916_l 211.4233793 0.023736962

HSbrain_801_r 195.7930985 0.023736962

HSbrain_722_l 180.1260425 0.023736962

HSbrain_727_l 136.0474595 0.023736962

HSbrain_811_r 131.6313177 0.023736962

HSbrain_753_r 41.77257724 0.023736962

Hsd 70 I 292.1907862 0.024762366 Hsd_from_M md_92_r 212.1087908 0.024762366

Hsd_49_r 162.0054723 0.024762366

Hsd_from_Mmd_527_r 126.3935973 0.024762366

Hsd_from_Mmd_485_r 95.1476108 0.024762366

Hsd_from_Mmd_298_r 48.27315482 0.024762366

Hsd_from_Mmd_533_l 37.74138535 0.024762366

Hsd_from_Mmd_452_l 21.7681635 0.024762366

Hsd_from_Mmd_473_l 15.1413037 0.024762366

Hsd_from_Mmd_117_r 7.718924828 0.024762366

HS_from_MQbrain_734_l 272.5872546 0.026800941

HS_from_MQbrain_1684J 158.2373516 0.026800941

HS_from_MQbrain_509_r 100.1137811 0.026800941

HS_from_MM_131_l 3.843700557 0.026800941

HS_from_MQbrain_74_r 225.8922409 0.028655448

HSbrain_318_l 221.848446 0.028655448

HS_from_MQbrain_391_r 219.2029092 0.028655448

HS_from_PT_139_l 85.75830736 0.028655448

HSbrain_259_r 334.9867442 0.02997784

HS_from_MQbrain_1832J 275.5897539 0.02997784

HSbrain_713_l 225.8656496 0.02997784

HSJ 06J 197.2533991 0.02997784

HS_from_MQbrain_918_l 186.6733108 0.02997784

HS_from_PT_299_l 158.8812184 0.02997784

HS_from_MQbrain_1169J 105.7095098 0.02997784

HSbrain_546_r 19.96726522 0.02997784

HS_from_MQbrain_1392_r 288.9210201 0.03224042

HSJ 18J 214.1827525 0.03224042

HS_from_MQbrain_1863J 197.0519986 0.03224042

HS_from_MQbrain_1443_r 179.1434855 0.03224042

HS_from_MQbrain_1445_l 154.9673281 0.03224042

HS_from_PT_103_l 74.08268376 0.03224042

HS_from_MQbrain_1469_r 28.13492378 0.03224042

HSbrain_316_l 339.4367001 0.03374871

HSbrain_41_l 239.6624516 0.03374871

HSbrain_165_l 181.1832002 0.03374871

HSbrain_760_l 136.864711 0.03374871

Hsd_from_Mmd_81_l 114.8866476 0.03374871

HS_231_r 112.1781103 0.03374871

HSbrain_458_l 77.3089971 0.03374871

HS_from_MQbrain_800_r 57.33831283 0.03374871

HS_from_MQbrain_435_l 50.08067692 0.03374871

HS_from_MQbrain_1690_l 21.66605198 0.03374871

Hsd_102_l 175.5645249 0.036099692

HS_from_MQbrain_1340J 157.6981977 0.036099692

HS_from_MQbrain_1513_r 128.9407151 0.036099692

HS_from_MQbrain_498_r 342.07876 0.038273758

HS_from_MQbrain_1315_l 181.848048 0.038273758

HS_from_MQbrain_282_l 163.9894054 0.038273758

HSbrain_261_l 83.18937251 0.038273758

HSbrain_700_r 59.35494614 0.038273758

HSbrain_543_r 26.09736904 0.038273758

HSbrain_92_l 290.3024103 0.040151024

HSbrain_109_l 284.6354613 0.040151024

HS_from_PT_43_l 279.7988575 0.040151024

HS_from_MQbrain_1747_r 278.4365165 0.040151024

HS 56 r 243.5447343 0.040151024 HS_from_MQbrain_951_l 230.432556 0.040151024

HS_from_MQbrain_470_l 131.1632076 0.040151024

HSJ 89J 1 17.9592496 0.040151024

Hsd_from_Mmd_436_r 90.76582879 0.040151024

HS_from_MQbrain_1080J 70.18685041 0.040151024

HS_from_MM_276_l 21.75172107 0.040151024

HS_from_MQbrain_782_r 261.0759728 0.042549287

Hsd_42_r 260.2142458 0.042549287

HS_from_MQbrain_1227J 243.816199 0.042549287

HS_from_MQbrain_1388J 214.966548 0.042549287

HS_from_MQbrain_1844_r 187.6108805 0.042549287

Hsd_from_Mmd_261_l 184.5887939 0.042549287

HS_15_I 177.8515513 0.042549287

HSbrain_1410_l 66.2043953 0.042549287

HSbrain_284_l 257.0803228 0.045725655

HS_from_PT_70_r 202.4337957 0.045725655

Hsd_63_r 191.7137571 0.045725655

HS_from_MQbrain_1143_r 136.8939224 0.045725655

Hsd_from_M md_34_r 114.2335916 0.045725655

HS_from_MQbrain_1075J 258.9475578 0.048378078

HSbrain_703_l 247.3420423 0.048378078

HS_from_MQbrain_539_r 234.1938897 0.048378078

HS_from_MQbrain_472_r 225.3108408 0.048378078

HSbrain_1362_l 215.6819962 0.048378078

HSJ 14J 214.0153294 0.048378078

HS_from_MQbrain_1773J 173.1308074 0.048378078

HS_from_MQbrain_92_l 153.9678306 0.048378078

HSbrain_25_r 68.45071483 0.048378078

HS_from_MM_1_r 42.18437325 0.048378078

HS_from_MQbrain_1686_l 381.0649897 0.050130838

HSbrain_652_l 240.7492888 0.050130838

HS_from_MQbrain_343_l 214.8585663 0.050130838

HS_from_MQbrain_901_l 214.2516994 0.050130838

HSbrain_84_l 200.5841432 0.050130838

HS_from_MQbrain_1283J 200.1271847 0.050130838

HS_215_I 186.3533099 0.050130838

HS_from_MQbrain_774_r 164.6264718 0.050130838

HS_from_MQbrain_1610_r 128.7979365 0.050130838

HSbrain_585_l 124.1437027 0.050130838

HS_from_PT_136_l 92.74159284 0.050130838

HS_from_MQbrain_315_l 85.77155971 0.050130838

HS_93_r 17.4404153 0.050130838

HS_from_MQbrain_1239_l 225.7278011 0.053159859

Hsd_37_l 213.5626033 0.053159859

HS_131_r 209.6414321 0.053159859

HS_from_MQbrain_873_r 206.5787776 0.053159859

HS_from_MQbrain_1395_r 196.1672376 0.053159859

HS_from_MQbrain_1484_l 180.1270647 0.053159859

Hsd_76_r 80.46787511 0.053159859

Hsd_6_l 53.15042029 0.053159859

HSbrain_442_r 18.08359556 0.053159859

HS_from_MQbrain_1620_l 307.2296305 0.05566524

HSbrain_85_l 264.5381922 0.05566524

HS_from_MM_115_l 244.343368 0.05566524

HS_from_MQbrain_56_l 221.5946492 0.05566524

HSbrain 419 I 219.8793357 0.05566524 HS_from_MQbrain_664_l 217.4766553 0.05566524

HS_from_MQbrain_1674J 188.625056 0.05566524

HS_from_MM_49_l 186.4616319 0.05566524

HSbrain_239_l 98.26806599 0.05566524

HS_62_I 66.38174565 0.05566524

HS_59_I 66.17528144 0.05566524

HSbrain_704_l 45.12744924 0.05566524

HSbrain_671_r 22.1043858 0.05566524

HS_from_PT_321_r 9.355284488 0.05566524

HSbrain_719_l 9.057424006 0.05566524

HS_from_MQbrain_1119_l 316.6560497 0.058253679

HSbrain_35_r 279.8399868 0.058253679

HS_from_MQbrain_974_l 247.9593335 0.058253679

HSJ 90J 245.2188679 0.058253679

HS_from_MQbrain_81 OJ 225.1889153 0.058253679

HS_from_PT_121_r 221.5383439 0.058253679

HSbrain_123_l 203.4486322 0.058253679

HSbrain_300_l 182.522588 0.058253679

HS_from_MQbrain_883_r 179.9509263 0.058253679

HS_from_MQbrain_1374J 176.8739274 0.058253679

HS_from_MQbrain_1300J 153.3945718 0.058253679

Hsd_7_r 23.39907905 0.058253679

HS_from_MQbrain_70_l 285.3653998 0.061046963

HS_304_r 244.034349 0.061046963

HSJ 50J 201.5054656 0.061046963

HS_from_MQbrain_128_r 194.6783323 0.061046963

HSbrain_409_r 170.7071739 0.061046963

HS_36_I 91.72099648 0.061046963

HS_from_MQbrain_991_r 72.5119085 0.061046963

HS_from_MQbrain_1354J 72.49188083 0.061046963

HS_from_MQbrain_1404_r 27.3954386 0.061046963

HSbrain_214_l 19.36197308 0.061046963

HS_from_MQbrain_750_r 237.0499841 0.064770288

HS_180_r 200.4582411 0.064770288

HSbrain_116_l 198.8454747 0.064770288

HSbrain_506_l 81.68257158 0.064770288

Hsd_81_r 3.432967686 0.064770288

HSbrain_755_l 2.63850582 0.064770288

HS_from_MQbrain_745_r 271.8779897 0.067503134

HS_from_PT_112_l 227.4432793 0.067503134

HSbrain_212_l 224.1025327 0.067503134

HS_from_PT_339_l 214.3823639 0.067503134

Hsd_62_l 208.0883252 0.067503134

HS_from_MQbrain_1427_l 181.7148181 0.067503134

HSbrain_330_l 174.1826185 0.067503134

HS_from_MQbrain_239_r 173.8939829 0.067503134

HSbrain_139_l 172.7598914 0.067503134

HS_203_r 137.1520157 0.067503134

HSbrain_572_r 64.68912173 0.067503134

Hsd_from_Mmd_31 1_l 32.03234884 0.067503134

Hsd_from_M md_524_r 14.7018346 0.067503134

HS_from_MM_342_r 5.590510164 0.067503134

HS_from_MQbrain_1376J 319.0687179 0.069749265

Hsd_50_l 297.3692697 0.069749265

HS_from_MQbrain_1771_r 247.8706875 0.069749265

HS from MQbrain 723 r 237.156234 0.069749265 HSbrain_610_r 220.5552561 0.069749265

HS_from_MQbrain_1841_r 214.8445757 0.069749265

Hsd_from_M md_330_l 200.078931 0.069749265

HS_from_MQbrain_251_r 172.0989873 0.069749265

HS_from_PT_187_l 128.3298072 0.069749265

HS_from_MQbrain_997_l 90.55621189 0.069749265

HS_from_MQbrain_641_r 72.1752804 0.069749265

HSbrain_777_r 5.13504626 0.069749265

HS_from_MQbrain_366_r 4.292586708 0.069749265

HSbrain_245_r 2.699435997 0.069749265

HS_from_MQbrain_1219_l 301.2674923 0.072349461

HS_from_MM_289_r 285.4582707 0.072349461

HS_from_MQbrain_1082J 265.0804535 0.072349461

HS_from_MM_295_r 264.8300478 0.072349461

HSbrain_1364_l 251.9113433 0.072349461

HSbrain_749_r 231.9379385 0.072349461

HSbrain_301_l 226.109583 0.072349461

HS_from_MQbrain_1561 J 207.9055923 0.072349461

HS_from_MQbrain_1280J 188.9766392 0.072349461

HS_from_MQbrain_433_l 186.8433165 0.072349461

HS_from_PT_170_l 185.2808375 0.072349461

HS_from_MQbrain_1565_r 183.33017 0.072349461

HSbrain_1363_l 175.794645 0.072349461

HS_from_MQbrain_1658_r 135.9727881 0.072349461

Hsd_from_Mmd_333_r 122.8958947 0.072349461

HSbrain_747_l 100.2134098 0.072349461

HS_49_r 8.969465473 0.072349461

HSbrain_788_l 249.4670383 0.076797167

HSbrain_767_r 227.1006295 0.076797167

HS_from_MQbrain_930_r 167.8363796 0.076797167

HS_from_MQbrain_687_r 109.1779088 0.076797167

HS_from_MQbrain_224_l 69.6781412 0.076797167

HS_from_MM_219_l 47.65091531 0.076797167

HSbrain_344_l 44.15992199 0.076797167

HS_from_MQbrain_1414_r 7.115880718 0.076797167

HS_from_MM_353_l 3.859645753 0.076797167

HS_from_MQbrain_1777J 271.5768067 0.079954597

H S_f ro m_M Qbra i n_576_l 267.323134 0.079954597

Hsd_from_Mmd_204_l 251.2502954 0.079954597

HS_from_PT_102_l 248.6580593 0.079954597

HSbrain_317_l 234.263649 0.079954597

HSJ 19J 233.7784735 0.079954597

HS_from_MQbrain_1700J 193.6041577 0.079954597

HS_from_MQbrain_1745_r 191.5196529 0.079954597

HSbrain_455_r 178.2419961 0.079954597

Hsd_1 1_l 164.5093304 0.079954597

HS_from_MQbrain_1520_r 158.8609156 0.079954597

HS_from_PT_148_l 151.4484249 0.079954597

HS_from_MQbrain_1637_r 147.2561547 0.079954597

Hsd_33_l 33.05107162 0.079954597

HSbrain_1406_l 17.08291783 0.079954597

Hsd_101_l 3.714373078 0.079954597

HS_from_MQbrain_1102_l 303.4601583 0.083930001

HS_from_MM_195_r 276.4162313 0.083930001

HS_57_I 250.390488 0.083930001

Hsd from Mmd 501 r 243.1733615 0.083930001 HS_from_MQbrain_715_l 216.9853807 0.083930001

HSbrain_56_l 210.9521542 0.083930001

HS_from_PT_20_r 188.3393313 0.083930001

HSbrain_548_l 185.4850722 0.083930001

HSbrain_286_l 131.389336 0.083930001

HS_from_MQbrain_154_l 1 12.5010282 0.083930001

HS_from_MQbrain_769_r 87.406602 0.083930001

HSbrain_389_l 9.742590244 0.083930001

HSbrain_711_r 8.507528601 0.083930001

HS_from_MQbrain_1325_r 5.47614768 0.083930001

HS_from_MM_347_l 350.4004069 0.088143181

HS_from_MQbrain_686_r 259.8101317 0.088143181

HS_from_MQbrain_806_l 220.5421957 0.088143181

HSJ 02J 205.6195359 0.088143181

HSbrain_124_l 199.2157195 0.088143181

HS_from_MM_165_l 194.0305909 0.088143181

HSbrain_590_r 190.8385095 0.088143181

HS_from_MQbrain_291_l 188.7078132 0.088143181

HS_from_MQbrain_948_r 176.1262044 0.088143181

HS_from_MM_229_r 173.5953652 0.088143181

HS_from_MQbrain_1064_r 160.6505983 0.088143181

HSbrain_170_r 58.09549284 0.088143181

HSbrain_530_l 49.2660315 0.088143181

HS_from_PT_254_r 38.90953686 0.088143181

HS_80_l 6.188564855 0.088143181

HS_from_MQbrain_1626_r 5.841073155 0.088143181

HSbrain_637_l 278.8901829 0.09152926

Hsd_from_Mmd_120_r 256.1765933 0.09152926

HS_from_MQbrain_550_l 253.7757692 0.09152926

HS_from_MQbrain_1758_r 252.4287529 0.09152926

HSbrain_1360_l 246.1741425 0.09152926

HS_from_MQbrain_1885_r 208.5987571 0.09152926

HSbrain_642_r 198.8901506 0.09152926

HS_from_PT_95_r 187.7990727 0.09152926

HS_4_r 186.5048701 0.09152926

HS_from_MQbrain_1592J 169.5192576 0.09152926

Hsd_from_Mmd_161_l 111.7055777 0.09152926

HS_from_MQbrain_1037_r 101.466981 0.09152926

HSbrain_237_r 20.78891804 0.09152926

HS_from_MQbrain_1494J 14.7687191 0.09152926

Hsd_from_Mmd_378_l 6.433733047 0.09152926

HS_from_MQbrain_1726J 6.286472819 0.09152926

HSJ29J 287.8783772 0.095394629

HSbrain_717_l 241.5872727 0.095394629

HSbrain_708_l 229.246264 0.095394629

HSbrain_691_l 201.4670994 0.095394629

Hsd_from_Mmd_519_r 190.1006667 0.095394629

Hsd_79_l 181.0929049 0.095394629

HS_288_I 171.5705836 0.095394629

HS_from_MQbrain_1228_r 162.3489481 0.095394629

HSbrain_557_r 143.8626534 0.095394629

HS_from_PT_74_r 107.2883837 0.095394629

HSbrain_113_r 100.6056081 0.095394629

HS_from_MQbrain_255_l 64.86378183 0.095394629

HSbrain_481_r 29.96985078 0.095394629

HS from MQbrain 1201 r 23.9141836 0.095394629 Hsd_from_Mmd_223_r 19.94197059 0.095394629

HS_from_MQbrain_1648_r 18.04974603 0.095394629

HS_from_MQbrain_574_l 287.7017103 0.098921026

HSbrain_1425_l 283.5640729 0.098921026

Hsd_from_Mmd_480_r 278.0451339 0.098921026

HS_from_MQbrain_868_l 260.4645119 0.098921026

HSbrain_240_l 253.8771621 0.098921026

HSJ 57J 250.822208 0.098921026

HS_from_MM_103_l 246.9217731 0.098921026

HSbrain_769_r 228.6374424 0.098921026

HSbrain_305_r 219.5650075 0.098921026

HS_from_MQbrain_1382J 216.2287654 0.098921026

Hsd_from_Mmd_176_l 197.2483957 0.098921026

HSbrain_415_l 148.8998605 0.098921026

HS_from_MQbrain_1213_l 136.145634 0.098921026

HS_from_MQbrain_2670_r 88.75898562 0.098921026

HS_from_MM_313_l 43.35911147 0.098921026

HS_from_MQbrain_1753_r 15.00695265 0.098921026

Hsd_from_Mmd_325_l 12.27846175 0.098921026

HS_from_MM_34_l 7.978839103 0.098921026

HSbrain_86_r 2.701204062 0.098921026

HS_from_MQbrain_1355_r 309.6691714 0.103393572

HS_from_MQbrain_1459_l 257.1079597 0.103393572

HSbrain_677_l 223.7296488 0.103393572

HS_from_MQbrain_609_l 213.1909341 0.103393572

HS_from_MQbrain_943_l 199.1939949 0.103393572

HSbrain_596_r 183.4234846 0.103393572

HS_from_PT_22_l 169.7548575 0.103393572

HS_from_MQbrain_1744_r 145.1169393 0.103393572

HSbrain_482_l 110.0149117 0.103393572

HSbrain_94_l 96.33702157 0.103393572

HSbrain_343_l 82.34298795 0.103393572

HS_68_I 77.85150167 0.103393572

HS_172_r 66.96978425 0.103393572

HS_from_MQbrain_906_r 47.10729944 0.103393572

HSbrain_504_r 45.47207589 0.103393572

HS_from_MQbrain_1784_r 8.765325591 0.103393572

HS_from_MQbrain_1442_l 5.874225415 0.103393572

HS_from_MQbrain_114_r 298.9587162 0.108118292

HS_from_MQbrain_546_l 288.7897335 0.108118292

HSbrain_536_r 269.1404787 0.108118292

Hsd_from_Mmd_291_r 266.1652183 0.108118292

HS_from_MQbrain_1627_l 251.4373669 0.108118292

HSJ 01J 239.0332153 0.108118292

HSbrain_643_l 212.7527559 0.108118292

HS_from_MQbrain_1366J 212.34134 0.108118292

HS_from_PT_220_l 201.2064584 0.108118292

HSbrain_280_l 188.6563025 0.108118292

HS_from_MQbrain_374_r 170.5241907 0.108118292

HS_from_MQbrain_80_l 62.18301452 0.108118292

Hsd_from_Mmd_478_l 24.52473283 0.108118292

Hsd_from_Mmd_249_r 12.73986084 0.108118292

HS_from_PT_7_r 7.471471439 0.108118292

HSbrain_384_l 4.544181943 0.108118292

HS_from_MQbrain_1840J 4.101477435 0.108118292

HS from MQbrain 604 I 289.730194 0.113099484 HSbrain_328_l 280.7719926 0.113099484

HSbrain_520_l 236.1868036 0.113099484

HSbrain_227_r 226.199823 0.113099484

HSbrain_267_l 214.022333 0.113099484

HS_from_MQbrain_1478_l 192.6931886 0.113099484

HS_from_MQbrain_921_l 192.1335465 0.113099484

HSbrain_764_r 117.9645256 0.113099484

HS_from_MQbrain_1502J 54.14110189 0.113099484

Hsd_from_Mmd_391_l 43.63503635 0.113099484

HSbrain_412_l 37.17793298 0.113099484

HSbrain_159_l 19.09259883 0.113099484

HS_from_MQbrain_105_l 16.80746034 0.113099484

HSbrain_145_l 267.9664391 0.11858389

HS_from_MQbrain_1889J 262.029435 0.11858389

HS_from_MQbrain_999_l 259.1426385 0.11858389

Hsd_from_Mmd_518_r 238.0578899 0.11858389

HS_289_I 236.2167396 0.11858389

HSbrain_664_r 222.5408696 0.11858389

HS_from_MQbrain_1750_r 217.7023298 0.11858389

HS_from_MQbrain_1834_r 187.1781356 0.11858389

Hsd_from_Mmd_93_l 186.4505924 0.11858389

HS_from_MQbrain_592_l 181.6866459 0.11858389

HS_from_MQbrain_1590J 163.8114142 0.11858389

HS_from_MQbrain_1487_r 119.4385433 0.11858389

HS_from_MQbrain_502_r 118.3776111 0.11858389

HS_98_r 330.803132 0.12422104

HS_25_r 313.2035431 0.12422104

Hsd_from_Mmd_237_l 306.9716516 0.12422104

Hsd_17_l 255.7570196 0.12422104

HS_from_MM_87_l 240.7726111 0.12422104

HS_from_MQbrain_789_l 239.2174834 0.12422104

HS_from_MQbrain_1184_r 208.6202764 0.12422104

HSbrain_50_l 203.7449536 0.12422104

HS_287_I 203.2812692 0.12422104

HS_from_MM_79_l 199.5386163 0.12422104

HSbrain_570_l 194.0529436 0.12422104

HS_from_MQbrain_490_r 162.3944533 0.12422104

HS_from_MQbrain_1304_r 154.625417 0.12422104

Hsd_from_Mmd_328_r 117.324613 0.12422104

HS_from_MQbrain_1109_l 62.73503843 0.12422104

HSbrain_131_l 51.07910404 0.12422104

HS_from_MQbrain_1384_r 26.20937179 0.12422104

HS_from_MQbrain_161_r 6.387946973 0.12422104

HSbrain_152_l 261.0331392 0.129399391

HS_from_MQbrain_36_r 247.5789144 0.129399391

HS_from_MQbrain_1574J 236.4214286 0.129399391

HS_from_MQbrain_1794_r 227.1557202 0.129399391

HSbrain_204_r 217.0811451 0.129399391

HSbrain_72_l 206.0852876 0.129399391

HS_from_MQbrain_1776J 205.2456623 0.129399391

HSJ 09J 200.1919676 0.129399391

HS_from_MM_304_r 195.9761008 0.129399391

HS_from_MQbrain_1839J 186.2075177 0.129399391

HSbrain_448_l 162.0375436 0.129399391

HS_85_I 96.48110294 0.129399391

HS from MQbrain 597 I 8.606774472 0.129399391 Hsd_from_Mmd_363_l 4.747442615 0.129399391

HSbrain_970_r 2.440271917 0.129399391

HS_from_MQbrain_684_r 341.5414126 0.134970683

Hsd_74_r 274.0203487 0.134970683

HS_from_MQbrain_1523_r 272.3792039 0.134970683

HS_from_MQbrain_540_l 268.4654883 0.134970683

HS_from_MQbrain_1318_l 223.6306158 0.134970683

HS_from_MQbrain_99_r 220.3197222 0.134970683

HS_from_MQbrain_234_r 205.0056018 0.134970683

Hsd_from_Mmd_101_r 177.7313602 0.134970683

HS_from_PT_250_r 169.7827673 0.134970683

HS_from_MQbrain_1692_l 158.6415708 0.134970683

HS_from_MQbrain_1097_r 128.6204149 0.134970683

HS_from_MM_185_r 68.74396066 0.134970683

HS_from_MQbrain_1081_r 20.97667628 0.134970683

HS_261_I 7.115946746 0.134970683

HS_from_MQbrain_1806_l 4.715008642 0.134970683

HSbrain_108_l 266.7753944 0.140323812

HS_219_I 254.6760586 0.140323812

HS_from_PT_178_l 242.7023061 0.140323812

HS_from_MQbrain_1855J 238.2044165 0.140323812

HS_168_r 235.6020265 0.140323812

HSbrain_361_l 234.5281831 0.140323812

HS_121_r 231.1610876 0.140323812

Hsd_from_Mmd_123_l 230.1089517 0.140323812

HSbrain_144_r 224.6332678 0.140323812

HS_161_r 216.0695424 0.140323812

HS_from_MQbrain_467_l 209.268142 0.140323812

HS_from_MQbrain_22_r 187.1051151 0.140323812

HSbrain_716_l 180.5676912 0.140323812

HS_53_r 140.0976088 0.140323812

HS_41_r 112.6985514 0.140323812

HSbrain_737_r 53.36757802 0.140323812

Hsd_from_Mmd_523_l 10.60175496 0.140323812

HS_241_r 2.716303039 0.140323812

HS_from_MQbrain_1675_r 288.3970715 0.146822481

HS_from_MQbrain_67_l 255.5891945 0.146822481

HS_from_PT_219_l 253.1829244 0.146822481

HS_from_MQbrain_1807J 220.9858095 0.146822481

HS_from_MQbrain_97_r 220.2493082 0.146822481

HSbrain_130_l 216.1273018 0.146822481

HS_from_MQbrain_1222_r 214.0598655 0.146822481

HS_from_MQbrain_1493_r 207.5291507 0.146822481

HS_from_MQbrain_1695_r 204.2688796 0.146822481

HS_from_MQbrain_1036_r 203.1951911 0.146822481

Hsd_77_r 200.6733718 0.146822481

HS_from_MQbrain_1030J 164.3970563 0.146822481

HSbrain_663_r 155.8547049 0.146822481

HS_from_MQbrain_1462_r 152.9071604 0.146822481

HSbrain_705_r 113.5172383 0.146822481

HSbrain_624_l 94.53967575 0.146822481

HS_from_MQbrain_1250_r 60.18097983 0.146822481

Hsd_96_r 5.165955532 0.146822481

HS_from_PT_271_l 2.99221888 0.146822481

HS_from_PT_92_l 303.3056853 0.152858542

Hsd 38 r 285.7326061 0.152858542 HSbrain_266_l 271.4320379 0.152858542

HS_from_MQbrain_6_r 264.8578117 0.152858542

HS_from_PT_238_l 251.4029293 0.152858542

HSbrain_306_r 226.3244274 0.152858542

HS_from_MQbrain_707_l 224.9895326 0.152858542

HS_from_MQbrain_693_r 197.7309441 0.152858542

HSbrain_752_l 191.3899851 0.152858542

HS_from_MQbrain_969_r 177.1203053 0.152858542

HS_from_MQbrain_1072_r 107.9850118 0.152858542

HS_from_MQbrain_355_r 91.78580467 0.152858542

HSbrain_604_r 57.67387084 0.152858542

HS_from_MQbrain_153_l 49.32700101 0.152858542

Hsd_from_Mmd_280_l 46.29319877 0.152858542

HSbrain_22_l 7.394968873 0.152858542

HS_from_MQbrain_1127_r 6.478685264 0.152858542

HSbrain_695_r 4.015688972 0.152858542

HS_from_MQbrain_1817_l 3.888478757 0.152858542

HS_from_MQbrain_689_l 2.726769607 0.152858542

Hsd_from_Mmd_346_l 2.586537564 0.152858542

HSbrain_783_l 345.0006901 0.158799149

HSbrain_673_l 313.971615 0.158799149

HS_from_MQbrain_1018_l 312.5603857 0.158799149

HS_18_I 244.6303758 0.158799149

HS_from_MQbrain_1501_r 242.0224401 0.158799149

HS_from_PT_158_l 238.7177237 0.158799149

HSbrain_347_l 211.107069 0.158799149

HS_from_MQbrain_1204_r 209.9240502 0.158799149

HSbrain_248_l 193.8830045 0.158799149

HS_from_MQbrain_631_l 184.728 0.158799149

HS_from_PT_255_l 179.6028399 0.158799149

HS_from_MQbrain_1831_r 179.507715 0.158799149

HSbrain_121_l 163.1114217 0.158799149

HS_from_MQbrain_382_r 108.3108904 0.158799149

HS_from_MQbrain_625_l 58.16380903 0.158799149

HS_from_MQbrain_912_l 42.57025194 0.158799149

HSbrain_320_l 8.739860007 0.158799149

HS_from_MQbrain_675_l 3.821332516 0.158799149

HSbrain_413_l 3.253659453 0.158799149

HS_from_MM_35_l 2.357250026 0.158799149

HSbrain_402_l 349.5145921 0.163891418

HS_from_MQbrain_996_l 302.9472283 0.163891418

HS_from_MQbrain_824_r 298.2022039 0.163891418

HS_from_MQbrain_566_r 291.1249796 0.163891418

HSbrain_95_l 253.768018 0.163891418

HSbrain_680_l 245.548398 0.163891418

Hsd_from_M md_52_r 243.7569251 0.163891418

HS_from_MQbrain_1426_l 242.4325995 0.163891418

HS_from_MQbrain_1028J 239.0895004 0.163891418

HSbrain_784_r 234.6735882 0.163891418

HS_from_MQbrain_650_r 218.5666187 0.163891418

HS_from_MQbrain_449_l 213.7795306 0.163891418

HSbrain_304_l 204.8368425 0.163891418

HS_from_MQbrain_1721_l 197.7591475 0.163891418

HS_from_MQbrain_936_r 195.7842152 0.163891418

H sd_f ro m_M m d_94_l 193.7657691 0.163891418

HS from MQbrain 529 r 190.4031906 0.163891418 Hsd_108_r 181.7633595 0.163891418

HS_from_PT_234_l 181.4676297 0.163891418

HS_from_MQbrain_1223J 164.5470949 0.163891418

HS_from_MQbrain_1724J 163.9516624 0.163891418

HS_from_PT_196_r 59.89771429 0.163891418

HSbrain_598_r 7.899656198 0.163891418

HS_from_MM_218_l 2.349494942 0.163891418

HSbrain_467_l 335.0856427 0.170271053

HS_from_MQbrain_1846_r 333.0341838 0.170271053

HS_197_r 299.8398179 0.170271053

HS_212_r 293.7948013 0.170271053

HSbrain_53_l 247.0890399 0.170271053

HSbrain_701_l 245.9313661 0.170271053

HS_128_r 214.1983377 0.170271053

HSbrain_364_r 211.3556115 0.170271053

HS_from_MQbrain_281_l 197.384259 0.170271053

HS_from_MQbrain_1199_l 177.5515382 0.170271053

HSbrain_143_l 173.8367679 0.170271053

HSbrain_216_r 164.5910344 0.170271053

Hsd_from_Mmd_235_r 145.886021 0.170271053

HS_from_MQbrain_841_l 143.150258 0.170271053

Hsd_from_Mmd_367_l 120.0545039 0.170271053

HS_from_MQbrain_468_l 113.3244619 0.170271053

HS_from_MQbrain_1377J 110.9676187 0.170271053

Hsd_from_Mmd_410_l 94.2059708 0.170271053

HS_192_r 15.41603426 0.170271053

HS_from_MQbrain_1893_r 14.47922582 0.170271053

HS_264_r 7.905646906 0.170271053

HS_from_MQbrain_603_r 7.108558771 0.170271053

HSbrain_726_l 6.434813111 0.170271053

Hsd_from_Mmd_35_l 2.507108516 0.170271053

H sd_f ro m_M m d_344_r 309.0726717 0.176183859

HSbrain_626_l 275.7891397 0.176183859

HS_from_PT_27_r 221.573516 0.176183859

HSbrain_32_l 216.2330231 0.176183859

HS_186_r 203.9246728 0.176183859

HSbrain_771_l 185.5150257 0.176183859

Hsd_65_r 184.3852713 0.176183859

HS_from_MQbrain_135_l 155.6010506 0.176183859

HS_from_MQbrain_628_l 105.1976832 0.176183859

HSbrain_707_r 70.97237044 0.176183859

HS_from_MQbrain_984_l 36.17853558 0.176183859

HS_204_r 14.93137289 0.176183859

HSJ 30J 10.32443146 0.176183859

HS_from_MQbrain_365_l 6.941331531 0.176183859

HS_from_MQbrain_855_r 6.514975985 0.176183859

HS_from_MQbrain_314_l 2.61540593 0.176183859

HS_from_MM_84_l 2.359765653 0.176183859

HS_from_MQbrain_1349J 328.4193266 0.182758186

HS_from_MQbrain_162_r 314.656125 0.182758186

HS_from_MQbrain_850_l 288.5662281 0.182758186

HS_from_MQbrain_1509_r 283.4583708 0.182758186

HS_from_MQbrain_1380_r 253.5211282 0.182758186

HSbrain_388_r 213.3920423 0.182758186

HS_from_MM_6_l 190.1275732 0.182758186

HS from MQbrain 881 I 189.779606 0.182758186 HS_from_MM_160_l 137.0116145 0.182758186

HS_from_MM_124_r 124.074717 0.182758186

Hsd_from_Mmd_187_r 109.5214584 0.182758186

HS_from_MQbrain_361_l 108.0467095 0.182758186

HS_from_MM_149_r 75.91523091 0.182758186

Hsd_from_Mmd_68_l 61.78328125 0.182758186

HS_from_MQbrain_676_r 52.19716118 0.182758186

HS_from_MQbrain_1883J 21.12907054 0.182758186

HSbrain_706_l 15.17246512 0.182758186

HS_from_MQbrain_1576_r 8.509211792 0.182758186

HSJ 32J 7.348116533 0.182758186

HS_from_MQbrain_1 137_l 2.48333526 0.182758186

HS_from_MQbrain_1596_r 435.4766611 0.188867139

HS_from_MQbrain_1073_r 319.8894959 0.188867139

HS_from_MQbrain_487_r 282.9624273 0.188867139

HSbrain_210_l 218.1425564 0.188867139

HSbrain_627_r 214.4670798 0.188867139

HS_77_I 209.1463931 0.188867139

HS_from_MM_182_r 208.0844095 0.188867139

HS_from_MQbrain_1208J 108.8734707 0.188867139

HS_from_MM_86_l 89.48891073 0.188867139

HSbrain_553_l 69.73500772 0.188867139

HS_from_PT_328_l 64.37288073 0.188867139

HS_from_MQbrain_1734J 57.12642239 0.188867139

HSbrain_370_r 45.65991936 0.188867139

HS_from_MM_298_l 41.95783366 0.188867139

HS_from_MQbrain_1234J 18.99466667 0.188867139

HS_from_PT_247_l 17.14193784 0.188867139

HSbrain_242_l 9.140095581 0.188867139

Hsd_from_Mmd_314_r 6.401270974 0.188867139

HS_from_MQbrain_768_l 3.670091279 0.188867139

HSbrain_270_l 3.298294118 0.188867139

HSbrain_810_l 274.8805235 0.19639408

HS_124_I 273.022187 0.19639408

HSJ 98J 239.6726 0.19639408

HSbrain_616_r 195.4635888 0.19639408

HS_from_PT_204_r 191.0832874 0.19639408

HS_from_MQbrain_406_r 189.233991 0.19639408

HS_from_MQbrain_383_l 188.3158756 0.19639408

Hsd_19_l 62.00218054 0.19639408

HSbrain_295_r 60.35523089 0.19639408

HS_from_PT_130_r 49.02454902 0.19639408

HS_from_MQbrain_389_l 10.36562841 0.19639408 Cut off Sιgnal/background>2 Cut off adj p<0 2 Table 9b Small RNAs recovered from faeces and differentially expressed in adenoma vs control tissue: hairpin with lowest expre

2nd arm adenoma vs control

Systematic name signal/background1 (adj p)2

HSbrain_70_r 228.1310199 0.19639408

HS_from_MQbrain_648_l 158.7568209 0.19639408

HSbrain_658_l 129.0251642 0.19639408

HS_203_l 94.83523983 0.19639408

Hsd_from_Mmd_399_r 81.10162309 0.19639408

Hsd_from_Mmd_326_l 36.19385915 0.19639408

HSbrain_180_l 9.145529202 0.19639408

HS_from_MQbrain_84_r 9.015220167 0.19639408

HS_from_MQbrain_1883_r 6.77899065 0.19639408

HSbrain_433_r 6.513823308 0.19639408

HS_from_MQbrain_1783_r 5.660060677 0.19639408

HS_from_MQbrain_1671J 2.718046822 0.19639408

HSbrain_403_l 130.6652289 0.188867139

HS_from_MQbrain_1760_r 68.93637025 0.188867139

Hsd_from_Mmd_120_l 6.012536709 0.188867139

HS_from_MM_331_r 5.344166534 0.188867139

Hsd_from_Mmd_325_r 2.644428741 0.188867139

HS_from_PT_271_r 2.554264498 0.188867139

HS_from_MQbrain_999_r 2.263925063 0.188867139

HS_from_PT_3_l 2.115103843 0.188867139

HS_from_PT_161_l 171.1553574 0.182758186

HS_from_MQbrain_694_r 5.319743993 0.182758186

HS_from_MQbrain_635_l 3.030934579 0.182758186

Hsd_from_Mmd_333_l 2.003374918 0.182758186

Hsd_from_Mmd_92_l 116.8521775 0.176183859

HS_from_MQbrain_1566_r 28.34610003 0.176183859

HS_from_MM_123_l 25.84005888 0.176183859

HS_from_MQbrain_1565J 11.415781 0.176183859

Hsd_from_Mmd_123_r 3.109340734 0.176183859

Hsd_from_Mmd_328_l 2.054062827 0.176183859

HSbrain_745_l 199.5248523 0.170271053

HS_from_MM_304_l 44.91042461 0.170271053

Hsd_47_r 15.14357414 0.170271053

HS_78_r 3.599814983 0.170271053

HS_from_PT_280_l 230.7126831 0.163891418

HS_from_MQbrain_1090_r 148.6783798 0.163891418

Hsd_84_r 14.08450328 0.163891418

HS_from_MQbrain_941_r 2.300164622 0.163891418

HS_from_MM_340_r 2.08874036 0.163891418

HS_from_MQbrain_6_l 224.1267133 0.158799149

HS_from_MQbrain_414_l 178.1375421 0.158799149

HSbrain_653_l 40.34177825 0.158799149

HS_from_MQbrain_140_l 5.24618389 0.158799149

HS_from_MQbrain_68_r 3.894404987 0.158799149

Hsd_67_r 2.507940384 0.158799149

HS_from_MQbrain_340_l 2.901321612 0.152858542

HS_from_MQbrain_1759J 210.0656412 0.146822481

HS_from_MQbrain_260_r 190.0240714 0.146822481

HS_from_PT_284_r 27.92056913 0.146822481

HS_268_I 6.398871252 0.146822481

HSbrain 126 r 185.8597074 0.140323812 HS_from_MQbrain_266_r 7.219897398 0.140323812

Hsd_from_Mmd_291_l 44.20392105 0.134970683

HS_from_MQbrain_1376_r 12.27563489 0.134970683

Hsd_from_M md_388_l 4.044215903 0.134970683

HSbrain_267_r 187.7274337 0.129399391

H S_f ro m_M Qbra i n_466_l 173.774731 0.129399391

HS_from_MQbrain_1712_r 148.9640462 0.129399391

HS_from_MQbrain_1722J 110.8769733 0.129399391

HS_from_MQbrain_137_r 9.243852235 0.129399391

HS_from_MQbrain_1377_r 2.685212414 0.129399391

Hsd_from_Mmd_183_r 148.0528441 0.12422104

HSJ 35J 131.4469186 0.12422104

HS_from_MQbrain_485_l 8.243037088 0.12422104

HS_from_PT_237_l 3.488690264 0.12422104

HSbrain_383_l 11.26061345 0.11858389

Hsd_60_r 5.759084269 0.11858389

HS_from_MQbrain_1051_r 2.890006235 0.11858389

HS_106_r 2.537522063 0.11858389

HS_from_MM_251_r 168.6680712 0.113099484

HS_204_l 14.86560477 0.113099484

HS_from_MQbrain_824_l 2.021767126 0.113099484

HSJ64J 113.9895739 0.108118292

HSbrain_299_r 26.59238777 0.108118292

HS_from_MQbrain_594_r 2.753205678 0.108118292

HS_from_MM_124_l 2.285310959 0.108118292

Hsd_111_r 204.558847 0.103393572

HS_from_MQbrain_751_l 171.7203726 0.103393572

HSbrain_319_l 27.65786021 0.103393572

HS_from_MQbrain_1633_r 10.30485548 0.103393572

HS_from_MQbrain_1410_l 47.23710024 0.098921026

HS_from_MQbrain_1139_r 27.78815761 0.098921026

HSbrain_209_l 5.831860813 0.095394629

HS_from_MQbrain_932_l 2.123754543 0.095394629

HS_from_MQbrain_1678_r 148.7689177 0.09152926

Hsd_from_Mmd_371_r 131.2157622 0.09152926

HS_from_MQbrain_1031J 46.34701799 0.09152926

HS_from_MQbrain_1602J 35.32112193 0.09152926

HS_from_MQbrain_770_r 5.072552769 0.09152926

HSbrain_619_r 4.2712614 0.09152926

HSbrain_19_l 3.145160187 0.09152926

HS_from_MQbrain_1437J 2.717424689 0.09152926

HS_from_PT_126_l 6.759793869 0.088143181

HS_11_I 6.010655386 0.088143181

HS_from_MM_202_l 65.31801875 0.083930001

HS_from_MQbrain_814_l 11.67524525 0.083930001

HS_from_MQbrain_597_r 4.765274065 0.083930001

HS_from_MQbrain_1706J 213.0219833 0.079954597

HS_from_MQbrain_1665_r 87.0752453 0.079954597

HS_from_MQbrain_253_r 75.90944638 0.072349461

HS_81_r 55.61137135 0.072349461

HS_from_MQbrain_1748_r 19.48179132 0.072349461

HSbrain_635_l 6.819097351 0.072349461

HS_from_MQbrain_1268J 5.668043125 0.072349461

HS_from_PT_235_l 208.8800625 0.069749265

HS_from_MM_47_l 2.919273938 0.067503134

HS from MQbrain 1696 I 154.0498567 0.064770288 HS_from_MQbrain_1450_r 130.7495827 0.064770288

HSbrain_776_l 114.3914887 0.064770288

HS_from_MQbrain_435_r 2.200043662 0.064770288

HS_from_MM_6_r 2.160347119 0.064770288

HS_from_PT_41_r 2.157415789 0.064770288

Hsd_from_Mmd_439_l 80.82870283 0.061046963

HS_from_PT_340_l 17.88452337 0.061046963

HS_from_MQbrain_1500J 15.2774537 0.061046963

HS_from_MQbrain_1412_l 4.664856717 0.061046963

HS_from_PT_242_l 2.025087308 0.061046963

HSJ 56J 16.10230692 0.058253679

HS_from_MQbrain_1794J 34.34325904 0.053159859

HS_from_MQbrain_1771J 188.7899392 0.050130838

HS_from_MQbrain_691_l 30.90923016 0.050130838

Hsd_65_l 5.317412014 0.050130838

HS_from_MQbrain_842_l 2.595893731 0.050130838

HS_from_MQbrain_1752J 22.86665735 0.048378078

HS_from_MM_289_l 40.04595101 0.042549287

HSJ 77J 39.31124871 0.042549287

HS_from_PT_91_r 11.52114628 0.042549287

HS_from_MQbrain_1087J 8.47223421 0.038273758

Hsd_from_Mmd_410_r 2.908576361 0.036099692

Hsd_105_l 5.399875994 0.03224042

HSbrain_296_l 2.843440689 0.02997784

Hsd_from_Mmd_219_r 42.949196 0.024762366

Hsd_from_Mmd_519_l 32.14358853 0.024762366

Hsd_26_l 5.446771505 0.024762366

HSbrain_778_r 85.0377047 0.023736962

HSbrain_794_r 74.07648688 0.023736962

HSbrain_703_r 11.82131557 0.022745616

HSbrain_362_r 9.722304379 0.019454312

HSbrain_268_r 158.6132777 0.018600058

HSbrain_253_l 11.33164065 0.018600058

HS_from_MQbrain_825_r 3.634806505 0.011699489

HS_from_MQbrain_1628_r 3.67815753 0.008946182

HS_from_MQbrain_1462J 135.9829616 0.008573112

HS_from_MQbrain_1317_r 11.20285772 0.00676609

HS_from_MQbrain_131 1_r 2.389862917 0.00676609

HS_from_MQbrain_1070_r 19.32265622 0.004799641

HS_21_r 216.9668884 0.000489293 Cut off Sιgnal/background>2 Cut off adj p<0 2

Table 10a Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with highest expression

1st arm carcinoma vs control

Systematic name signal/background1 (adj p)2

HS_from_MQbraιn_1393_r 223 7656716 0016433541 HS_from_MM_334_l 165 3471372 0016433541 Hsd_from_Mmd_473_l 15 1413037 0019274533 HSbraιn_377_r 2 687263122 0019274533 HSbraιn_617_l 59 52352443 0022921248 HS_from_MM_178_r 86 39079121 0030988376 HS_from_MQbraιn_1056_l 71 54390765 0031989408 HS_from_MQbraιn_1823_r 44 43291919 00342406 HS_from_MM_39_l 1546864042 00342406 Hsd_102_l 175 5645249 0035303066 HS_from_PT_190_r 138 4453126 0045228199 HSbraιn_171_l 255 6856718 0067337504 HS_262_I 14 64955868 0067337504

HS_from_MQbraιn_343_l 214 8585663 007566513 HS_from_MQbraιn_1169 1 105 7095098 0084904114 HSbraιn_629_l 254 3371274 0086503988 HSbraιn_597_r 208 6310714 0086503988 HS_from_MQbraιn_350_l 189 461419 0086503988 HSbraιn_12_l 53 76557022 0086503988

HS_from_MQbraιn_2380_r 187 2947993 0090694253 HS_255_I 161 1405598 0090694253

HS_from_MQbraιn_1128 1 158 837926 0090694253 HS_from_MQbraιn_349_l 135 3020631 0090694253 Hsd_from_Mmd_328_r 117 324613 0090694253 HSbraιn_753_r 41 77257724 0090694253 HS_from_MQbraιn_55_l 15 80840103 0090694253 HSbraιn_177_r 132 197755 0104922786 HSbraιn_446_l 14 33402718 0104922786 HSbraιn_483_l 220 2067855 0110995143 HS_from_MQbraιn_128_r 194 6783323 0110995143 HSbraιn_709_l 274 820351 0120015634 HS_from_MM_309_r 208 0343975 0120015634 HS_217_I 228 449758 0120843678

HS_from_MQbraιn_930_r 167 8363796 0120843678 HS 141 I 141 8565157 0120843678

HS_from_MQbraιn_1657_r 116 3148049 0120843678 HS_from_MQbraιn_769_r 87 406602 0120843678 HS_from_PT_257_r 27 728139 0120843678 HS_from_PT_201_r 2 367251208 0120843678 HSbraιn_801_r 195 7930985 0149145996 HS_from_MQbraιn_1624_l 192 3884805 0149145996 HSbraιn_158_l 169 343928 0149145996 HSbraιn_1_l 768373873 0149145996 Hsd_18_l 2375322474 0159103307 HSbraιn_261_l 8318937251 0159103307 HS_from_MQbraιn_1459_l 2571079597 0166408872 HSbraιn_458_l 773089971 0166408872 HS_from_MM_339_r 3272871875 0179914563 HS_304_r 244034349 0179914563

HS_from_MQbraιn_1513_r 1289407151 019263196 Hsd_from_Mmd_298_r 4827315482 019263196 1 Cut off Sιgnal/background>2 Cut off adj p<0 2

Table 10b Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with lowest expression

2nd arm carcinoma vs control systematic name signal/background1 (adj p)2

HS_21_r 216.9668884 0.099652833

Hsd_111_r 204.558847 0.149145996

HS_from_MQbrain_1696J 154.0498567 0.126655157

HS_from_MM_289_l 40.04595101 0.104922786

HSbrain_299_r 26.59238777 0.159103307

HS_from_PT_340_l 17.88452337 0.090694253

HS_156_I 16.10230692 0.120015634

HS_from_MQbrain_1317_r 11.20285772 0.008895418

Cut off Sιgnal/background>2

Cut off adj p<0 2

Table 11a Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs adenoma: hairpin arm with highest expression carcinoma vs

1st arm adenoma

Systematic name signal/background1 (adj p)2

HS_from_MM_118_r 70.86890311 0.012664553

HSJ69J 153.6041594 0.014416465

HS_299_I 175.2031924 0.016786613

HS_from_MQbrain_1137_l 2.48333526 0.016904198

HS_from_MQbrain_1082J 265.0804535 0.018319912

HS_from_MQbrain_1522_r 112.3011721 0.020545593

HSbrain_306_r 226.3244274 0.023919533

HS_from_MQbrain_629_l 195.1102679 0.026776445

HS_from_MQbrain_1456J 199.1014452 0.028202169

HS_from_MQbrain_828_l 223.2821181 0.032034428

HS_from_PT_40_r 19.96645961 0.032034428

HSbrain_384_l 4.544181943 0.034662803

HSbrain_1425_l 283.5640729 0.035941334

HS_from_MQbrain_1750_r 217.7023298 0.037874034

HS_from_MQbrain_984_l 36.17853558 0.039250091

HS_from_MQbrain_686_r 259.8101317 0.044599949

HSJ41J 141.8565157 0.044599949

HS_from_MQbrain_603_r 7.108558771 0.044599949

HS_218_r 235.8613357 0.045945376

HS_from_MM_169_r 8.697594288 0.048205391

HS_217_I 228.449758 0.050135128

HSbrain_226_r 225.405043 0.050135128

HSbrain_187_r 179.7554723 0.050135128

HSbrain_538_r 3.973394819 0.055185029

HS_from_MM_218_l 2.349494942 0.055185029

HS_from_MQbrain_1340J 157.6981977 0.058254254

HSbrain_337_l 85.40127884 0.059897432

HSbrain_791_l 10.8880558 0.059897432

HSbrain_25_r 68.45071483 0.062381992

HS_from_MQbrain_330_r 236.6286556 0.0659723

Hsd_from_Mmd_391_l 43.63503635 0.070590475

Hsd_from_Mmd_237_l 306.9716516 0.071451516

HS_from_MQbrain_93_r 290.7380082 0.071451516

HS_from_MQbrain_1832J 275.5897539 0.071451516

HSbrain_468_r 8.648929144 0.071451516

HSbrain_182_r 228.0472357 0.072275086

HSbrain_2_l 49.67189807 0.072275086

HS_from_MQbrain_869_l 197.9550289 0.072654718

HSbrain_1406_l 17.08291783 0.072654718

HS_from_MQbrain_74_r 225.8922409 0.074901054

HSbrain_419_l 219.8793357 0.074901054

HS_219_I 254.6760586 0.075028175

HS_from_MM_103_l 246.9217731 0.075028175

HS_from_MQbrain_1001_r 223.8116976 0.075028175

HS_from_MQbrain_470_l 131.1632076 0.075028175

Hsd_from_Mmd_189_l 180.4050764 0.07641095

Hsd_from_Mmd_527_r 126.3935973 0.07641095

HSJ 19J 233.7784735 0.07715065

HSbrain 204 r 217.0811451 0.077150