Abstract

Tension-type headache is treated by interacting with neuronal transmission in relation to pain in connection with headache in a way which prevents or decreases sensitization of second order nociceptive neurons. In particular, treatment is performed by administration of an effective amount of a substance which prevents or decreases central sensitization. Important examples of such substances are substances which interact with nitric oxide, such as nitric oxide synthase (NOS) inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA. According to a broader aspect of the invention tension-type headache is treated by administration of substances which are effective in preventing or decreasing pain in connection with tension-type headache, such as the substances mentioned above. Accordingly, the invention relates to treatment of tension-type headache by administration of substances which substantially inhibit the activity of nitric oxide synthase (NOS), such as NOS inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA.


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Document History
  • Publication: Sep 4, 2001
  • Application: May 4, 1999
    US US 30411599 A
  • Priority: May 4, 1999
    US US 30411599 A
  • Priority: May 14, 1998
    US US 8541398 P
  • Priority: Nov 4, 1997
    DK DK 9700502 W
  • Priority: Nov 5, 1996
    US US 3029496 P

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