Recombinant Bicistronic Flaviviruses And Methods Of Use Thereof


The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an exogenous nucleotide sequence that encodes an exogenous polypeptide, and a viral 3′UTR. Infection of a host cell with a recombinant flavivirus provides for expression of the exogenous nucleic acid in a host cell. Such recombinant flavivirus are useful for delivering a protein to a mammalian host; and for eliciting an immune response to the exogenous polypeptide.

CPC Classifications
Download PDF
Document Preview
Document History
  • Publication: Jan 18, 2011
  • Application: Jul 14, 2004
    US US 47750404 A
  • Priority: Jul 14, 2004
    US US 47750404 A
  • Priority: May 9, 2002
    US US 0214783 W
  • Priority: May 10, 2001
    US US 29041201 P

Sign in to the Lens

Release 5.10.0: Improved patent search performance, saved query alerts, increased user privacy and more!

Improved Search Performance

Upgraded patent search index servers to improve search performance.

Saved Query Alerts.

Improvements to in saved query alerts emails and better formatting of links.

Increased User Privacy.

Removed Google Maps dependency in a Patents Family page.