Therapeutic Coating For An Intravascular Implant


The invention relates to a coating for an intravascular implant that prevents hyperproliferative vascular disease after a mechanical injury, such as angioplasty. The coating includes first and second agents, with the first agent acting on a calcium independent cellular pathway and the second agent acting on a calcium dependent cellular pathway. In an exemplary embodiment, the first agent is rapamycin and the second agent is cyclosporine A. The agents can be incorporated in a polymeric agent and can be applied either directly to the implant or on top of a primer layer placed on the implant. A top coat can be applied to the therapeutic coating, if desired.

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Document History
  • Publication: Nov 4, 2003
  • Application: Nov 26, 2001
    US US 99425301 A
  • Priority: Nov 26, 2001
    US US 99425301 A

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